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'Urinary': [8, 37, 1557, 3389, 3983, 4234], 'mRNA': [9, 38, 501, 591, 607, 1971, 2964, 3563, 3757, 4334], 'as': [10, 39, 522, 622, 673, 724, 888, 1316, 1322, 1431, 1647, 1861, 2782, 2828, 2902, 2986, 3157, 3819, 4369], 'a': [11, 40, 583, 623, 659, 674, 725, 747, 758, 949, 1010, 1062, 1123, 1128, 1255, 1260, 1265, 1302, 1317, 1344, 1363, 1432, 1473, 1500, 1515, 1828, 1838, 1847, 1877, 1910, 1927, 1975, 2008, 2055, 2149, 2363, 2492, 2541, 2647, 2702, 2740, 2773, 2790, 2846, 2919, 2987, 3099, 3188, 3203, 3374, 3391, 3711, 3820], 'Biomarker': [12, 41], 'of': [13, 42, 47, 88, 92, 118, 137, 141, 177, 201, 205, 214, 243, 265, 269, 314, 331, 375, 407, 421, 480, 518, 537, 548, 569, 574, 579, 597, 600, 617, 626, 644, 662, 671, 676, 689, 718, 722, 727, 734, 750, 776, 801, 809, 830, 845, 867, 898, 916, 945, 948, 992, 1003, 1012, 1043, 1086, 1093, 1108, 1134, 1195, 1220, 1233, 1244, 1249, 1290, 1295, 1301, 1304, 1325, 1332, 1340, 1366, 1373, 1383, 1385, 1394, 1420, 1443, 1472, 1475, 1514, 1520, 1526, 1543, 1605, 1696, 1840, 1849, 1852, 1873, 1885, 1904, 1921, 1936, 1943, 1994, 2000, 2036, 2048, 2051, 2072, 2084, 2095, 2124, 2180, 2185, 2190, 2219, 2225, 2259, 2362, 2381, 2405, 2408, 2442, 2456, 2462, 2483, 2500, 2514, 2557, 2591, 2596, 2619, 2663, 2675, 2686, 2705, 2767, 2775, 2808, 2812, 2815, 2825, 2837, 2845, 2865, 2918, 2984, 3002, 3032, 3077, 3085, 3088, 3105, 3119, 3126, 3135, 3148, 3152, 3160, 3163, 3171, 3187, 3202, 3215, 3222, 3248, 3279, 3326, 3368, 3376, 3429, 3445, 3469, 3474, 3494, 3520, 3585, 3653, 3657, 3733, 3738, 3755, 3763, 3779, 3889, 3894, 3994, 4002, 4030, 4047, 4051, 4277, 4286, 4307, 4374, 4403, 4423], 'Cardiovascular': [14, 43, 4255, 4365], 'Disease': [15], 'Open': [16], 'AccessResearch': [17, 35], 'ArticlePDF/EPUBAboutView': [18], 'PDFView': [19], 'EPUBSections': [20], 'ToolsAdd': [21], 'to': [22, 344, 399, 445, 532, 702, 780, 787, 833, 861, 924, 964, 1090, 1349, 1440, 1626, 1738, 1764, 1892, 2090, 2520, 2537, 2625, 2643, 2683, 2722, 2731, 2745, 2769, 2789, 2800, 2832, 2895, 2908, 2944, 2971, 3049, 3121, 3192, 3305, 3394, 3611, 3677, 3702, 3817, 3852, 4023, 4056, 4232], 'favoritesDownload': [23], 'citationsTrack': [24], 'citationsPermissionsDownload': [25], 'Articles': [26], '+': [27], 'Supplements': [28], 'ShareShare': [29], 'onFacebookTwitterLinked': [30], 'InMendeleyReddit': [31], 'Jump': [32], 'toSupplemental': [33], 'MaterialOpen': [34], 'ArticlePDF/EPUBHuman': [36], 'DiseaseA': [44], 'Proof-of-Principle': [45], 'Study': [46, 3664], 'Sodium': [48, 2272], 'Loading': [49], 'in': [50, 293, 320, 363, 490, 500, 502, 514, 594, 610, 658, 712, 736, 746, 764, 806, 836, 880, 913, 929, 958, 981, 984, 1019, 1024, 1034, 1052, 1061, 1193, 1206, 1334, 1353, 1359, 1388, 1416, 1445, 1458, 1484, 1534, 1537, 1550, 1553, 1570, 1598, 1649, 1652, 1684, 1721, 1748, 1769, 1846, 1953, 1969, 1972, 1984, 2026, 2061, 2104, 2177, 2187, 2504, 2701, 2717, 2727, 2739, 2779, 2834, 2867, 2877, 2887, 2898, 2931, 2940, 2957, 2975, 2997, 3040, 3055, 3091, 3107, 3143, 3212, 3328, 3398, 3449, 3454, 3503, 3516, 3589, 3670, 3725, 3812, 4155, 4183, 4207, 4214, 4364, 4435], 'Prehypertension': [51], 'Brian': [52, 78, 82, 233, 235, 238, 3243], 'G.': [53, 83, 85], 'Bazzell,': [54], 'MS,': [55, 241, 3246], 'William': [56, 108], 'E.': [57, 109, 111], 'Rainey,': [58, 3182], 'PhD,': [59, 64, 67, 70], 'Richard': [60, 131], 'J.': [61, 132, 134], 'Auchus,': [62], 'MD,': [63, 74, 80, 240, 3245], 'Davide': [65, 157], 'Zocco,': [66], 'Marco': [68, 173], 'Bruttini,': [69], 'Scott': [71, 195], 'L.': [72, 196, 198], 'Hummel,': [73], 'MS': [75, 81], 'James': [77, 232, 237], 'Byrd,': [79, 239, 3181, 3244], 'BazzellBrian': [84], 'Bazzell': [86], 'Departments': [87, 136, 200, 264], 'Internal': [89, 138, 202, 266], 'Medicine,': [90, 139, 203, 267], 'University': [91, 117, 140, 204, 242, 268, 866, 3247], 'Michigan,': [93, 119, 142, 206, 244, 270, 3249], 'Ann': [94, 120, 143, 207, 216, 255, 271, 3260], 'Arbor': [95, 121, 144, 208, 217, 272], '(B.G.B.,': [96, 145, 209, 273], 'R.J.A.,': [97, 146, 210, 274], 'S.L.H.,': [98, 147, 211, 275], 'J.B.B.)': [99, 148, 212, 276], 'Search': [100, 123, 149, 165, 187, 224, 277], 'for': [101, 124, 150, 166, 188, 225, 278, 371, 451, 510, 1274, 1282, 1329, 1590, 1673, 1678, 1776, 1785, 1827, 1837, 1913, 1931, 1978, 2098, 2116, 2167, 2201, 2207, 2213, 2229, 2249, 2403, 2411, 2454, 2550, 2656, 2857, 3046, 3133, 3352, 3581, 3707, 3760, 3822, 3998, 4282], 'more': [102, 125, 151, 167, 189, 226, 279, 1188, 1662, 2045, 2551, 2657, 3086], 'papers': [103, 126, 152, 168, 190, 227, 280], 'by': [104, 127, 153, 169, 191, 228, 281, 498, 864, 995, 1423, 1478, 1752, 1802, 2416, 2507, 2784, 2821, 2915, 2951, 3052, 3168, 3225, 3542, 3989, 4409], 'this': [105, 128, 154, 170, 192, 229, 282, 414, 694, 846, 959, 1395, 1481, 2664, 2718, 2870, 3041, 3226, 3239, 3508], 'author': [106, 129, 155, 171, 193, 230, 283, 853], ',': [107, 130, 156, 172, 194], 'RaineyWilliam': [110], 'Rainey': [112], 'Molecular': [113], 'Integrative': [115], 'Physiology,': [116], '(W.E.R.)': [122], 'AuchusRichard': [133], 'Auchus': [135, 3184], 'ZoccoDavide': [158], 'Zocco': [159, 3198], 'Exosomics': [160, 3205], 'Siena,': [161, 162, 184], 'Italy': [163, 185], '(D.Z.).': [164], 'BruttiniMarco': [174], 'Bruttini': [175], 'Department': [176], 'Life': [178], 'Sciences,': [179, 4238], 'Università': [180], 'degli': [181], 'Studi': [182], 'di': [183], '(M.B.).': [186], 'HummelScott': [197], 'Hummel': [199, 4013], 'Section': [213], 'Cardiology,': [215], 'Veterans': [218], 'Affairs': [219], 'Medical': [220, 250, 3255], 'Center,': [221], 'MI': [222, 257, 3262], '(S.L.H.).': [223], 'ByrdJames': [234], 'Byrd': [236, 3165, 3915, 4043, 4175, 4249, 4299, 4323], '5570C': [245, 3250], 'MSRB': [246, 3251], 'II,': [247, 3252], '1150': [248, 3253], 'West': [249, 3254], 'Center': [251, 3256], 'Dr,': [252, 3257], 'SPC': [253, 3258], '5678,': [254, 3259], 'Arbor,': [256, 3261], '48109-5678.': [258, 3263], 'Email': [259, 3264], 'E-mail': [260], 'Address:': [261], '[email': [262, 3265], 'protected]': [263], 'Originally': [284], 'published13': [285], 'Sep': [286], '2018https://doi.org/10.1161/CIRCGEN.118.002213Circulation:': [287], 'Medicine.': [291], '2018;11:e002213AbstractBackgroundmRNA': [292], 'urine': [294, 370, 386, 503, 580, 611, 810, 918, 952, 1489, 1613, 1973, 2976], 'supernatant': [295, 575, 612, 915, 2977], '(US-mRNA)': [296, 613], 'might': [297, 2490], 'encode': [298], 'information': [299, 627, 819, 927], 'about': [300, 628, 2734, 3102], 'renal': [301, 315, 321, 338, 364, 539, 602, 629, 636, 664, 677, 690, 714, 728, 737, 770, 837, 907, 966, 1064, 1094, 1221, 1238, 1354, 2715, 2735, 3281, 3301, 3353, 3399], 'cardiorenal': [303, 541, 679, 730, 2737], 'pathophysiology,': [304], 'including': [305, 3150], 'hypertension.': [306, 524], 'H,': [307, 3928], 'whether': [308, 318, 359, 632, 682, 1351, 2077, 2160, 2373], 'the': [309, 442, 565, 588, 601, 641, 669, 683, 687, 704, 719, 754, 768, 781, 825, 828, 843, 851, 865, 881, 895, 914, 926, 971, 985, 990, 1004, 1020, 1041, 1084, 1091, 1109, 1132, 1138, 1154, 1202, 1218, 1224, 1231, 1341, 1380, 1417, 1421, 1521, 1527, 1538, 1544, 1554, 1571, 1591, 1599, 1609, 1618, 1622, 1653, 1658, 1669, 1685, 1693, 1715, 1722, 1736, 1759, 1832, 1841, 1871, 1922, 1937, 1944, 1954, 1992, 2014, 2027, 2049, 2062, 2069, 2073, 2078, 2085, 2105, 2113, 2172, 2178, 2188, 2197, 2230, 2237, 2254, 2360, 2382, 2409, 2438, 2588, 2673, 2684, 2689, 2747, 2755, 2822, 2835, 2843, 2916, 2982, 3029, 3083, 3103, 3117, 3123, 3127, 3144, 3176, 3213, 3277, 3446, 3472, 3495, 3517, 3521, 3538, 3586, 3681, 3704, 3734, 3780, 3886, 3990, 3995, 4280, 4305, 4404, 4421, 4424, 4440], 'US-mRNA': [310, 326, 360, 415, 633, 645, 655, 672, 684, 723, 745, 802, 817, 832, 901, 1226, 1326, 2002, 2694, 2985, 3120, 3129], 'transcriptome': [311, 685, 688, 1227, 2674, 2685], 'reflects': [312, 361, 634, 686], 'that': [313, 816, 841, 1048, 1184, 1217, 1617, 1795, 1901, 2013, 2175, 2498, 2540, 2555, 2646, 2672, 2692, 2709, 2757, 2939, 2956, 3208, 4439], 'tissues': [316, 3431], 'changes': [319, 362, 499, 735, 835, 1352, 2176, 2186, 2710, 2996, 3397, 3669], 'physiology': [322, 637, 680, 731, 738, 1355, 1483, 2738], 'are': [323, 604, 848, 885, 979, 1320, 1548, 1690, 1882, 1959, 2183, 2666, 2696, 2725, 2751, 3185, 3349, 3758], 'detectable': [324, 1928, 2697, 2726], 'using': [325, 379, 739, 831, 1008, 1362, 2669], 'is': [327, 638, 681, 910, 919, 1228, 1348, 1532, 2194, 2496, 2503, 2681, 2766, 2772, 2797, 2842, 2855, 2913, 2937, 3034, 3199, 3219, 3236, 3499, 3511, 3579, 3815, 4026, 4399, 4415, 4443], 'unknown.MethodsWe': [328], 'compared': [329, 955, 1080, 1667], 'transcriptomes': [330, 1248, 1294], 'human': [332, 337, 417, 487, 491, 647, 707, 713, 782, 965, 1053, 1063, 1225, 1237, 1250, 1256, 1261, 1267, 1296, 2001, 2693, 3300, 3329, 3369, 3430, 4208], 'urinary': [333, 477, 481, 1054, 1099, 1251, 1297, 1528, 1583, 1640, 1703, 1708, 1730, 2571, 2606, 2621, 2679, 2838, 2853, 2878, 2888, 2909, 2925, 2963, 2998, 3067, 3347, 3370, 3756, 3788, 3813, 3890, 4332], 'extracellular': [334, 482, 555, 1252, 1298, 2839, 3274, 3891, 3984, 4333], 'vesicles': [335, 483, 556, 1100, 1253, 1299, 3275], 'cortex.': [339], 'To': [340, 357, 692, 772, 988, 1855], 'avoid': [341], 'similarities': [342], 'attributable': [343], 'ubiquitously': [345, 351, 431, 1030, 1110, 1283], 'expressed': [346, 352, 432, 763, 1031, 1111, 1284], 'genes,': [347, 997, 2216, 2565, 3081], 'we': [348, 367, 696, 742, 790, 998, 1046, 1126, 1486, 1594, 1615, 1772, 1796, 1863, 1869, 2011, 2032, 2065, 2075, 2872, 4330], 'separately': [349], 'analyzed': [350], 'highly': [354, 423, 1014, 1275], 'kidney-enriched': [355, 424, 1015, 1044, 1160, 1185, 1276], 'genes.': [356, 1286, 1782], 'determine': [358, 3122, 3633, 3703], 'gene': [365, 710, 778, 838, 908, 956, 1163, 1245, 1291, 1834, 1894, 2056, 2182, 2192, 2459, 2548, 2560, 2599, 2654, 3109, 3400, 3478, 3535, 3588], 'expression,': [366], 'assayed': [368, 657, 744, 1487, 1595, 1633, 1784], 'cell-depleted': [369, 1488, 1612, 3092], 'transcription': [372, 760, 795, 1434, 1442, 3479], 'factor': [373, 761], 'activity': [374, 402, 409, 823, 1676], 'mineralocorticoid': [376, 519, 755, 2356, 3194, 3447, 3631, 3735, 4057], 'receptors': [377], '(MR)': [378], 'probe-based': [380, 1377, 1963], 'quantitative': [381, 793], 'polymerase': [382, 796], 'chain': [383, 797], 'reaction.': [384], 'The': [385, 857, 883, 1368, 1397, 2093, 2199, 2528, 2634, 2729, 3037, 3228, 3412, 3492, 3807, 4028, 4156, 4392], 'was': [387, 496, 859, 1088, 1204, 1559, 1580, 1661, 1711, 1746, 1835, 2102, 2152, 2233, 2448, 2584, 2613, 3166], 'collected': [388, 1491], 'from': [389, 576, 850, 970, 1075, 1098, 1144, 1608, 1735, 1997, 2678, 2688, 3299], 'prehypertensive': [390], 'individuals': [391], '(n=18)': [392], 'after': [393, 405, 458, 614, 1496, 1508, 1565, 1629, 1699, 3017, 3111], '4': [394, 1497, 2250, 2412, 2563], 'days': [395, 1498], 'on': [396, 854, 940, 1040, 1158, 1499, 1991, 4401], 'low-sodium': [397, 1501, 1562, 1665], 'diet': [398, 1504, 1563, 1666], 'stimulate': [400], 'MR': [401, 408, 1425, 1697, 1803, 2099, 2384, 2417, 2465, 2723, 2777, 2791, 2794, 3025, 3053, 3079, 3154], 'again': [404], 'suppression': [406, 1695], 'via': [410, 572, 943, 1464, 3513, 3730], 'sodium': [411, 446, 459, 478, 1411, 1452, 1455, 1468, 1510, 1566, 1627, 1630, 1641, 1700, 1704, 1731, 1765, 2091, 2136, 2508, 3112, 3497, 3540, 3790, 3809], 'infusion.ResultsIn': [412], 'comparing': [413], 'kidney': [418, 648, 1072, 1141, 1169, 1196, 1257, 1262, 1268, 1305, 3765], 'cortex,': [419, 1258], 'expression': [420, 711, 779, 909, 957, 1051, 1060, 1133, 1219, 1232, 1246, 1292, 1471, 1895, 2179, 2189, 2499, 2549, 2655, 3110, 3414], '55': [422, 1013], 'genes': [425, 433, 1016, 1032, 1038, 1112, 1136, 1186, 1192, 1222, 1235, 1387, 1444, 1476, 1779, 1792, 1794, 1808, 1817, 2101, 2118, 2232, 2320, 2414, 2486, 2502, 3047], 'correlated': [426, 434, 469, 1056], 'strongly': [427, 762, 1057, 1189], '(rs=0.82)': [428], 'while': [429, 1940], '8457': [430, 1029], 'moderately': [435], '(rs=0.63).': [436], 'Standard': [437], 'renin-angiotensin-aldosterone': [438, 1398, 1460, 1659, 1726, 3782], 'system': [439, 1399, 1660, 1727, 3783], 'phenotyping': [440, 2811], 'confirmed': [441, 1183], 'expected': [443, 1623, 1760], 'response': [444, 1625, 1763, 2089, 2788, 3510], 'loading.': [447, 2092, 3113], 'Cycle': [448], 'threshold': [449, 1587, 2218, 2441, 2516, 2590, 2627], 'values': [450, 1881, 1890, 1996, 2016, 2038, 2081, 2097, 2115, 2453, 2518, 2930, 3076], 'MR-regulated': [452, 462, 777, 1386, 1777, 1791, 1807, 2126, 2215, 2564, 3108], 'targets': [453, 463, 1789, 3016, 3090], '(SCNN1A,': [454, 464], 'SCNN1G,': [455, 465, 1813], 'TSC22D3)': [456, 468], 'changed': [457, 1733], 'loading,': [460], 'SGK1,': [466, 1814], 'significantly': [470, 1712, 1734, 2132, 2234, 2394, 2567, 2602], 'with': [471, 476, 486, 516, 785, 821, 905, 1058, 1081, 1230, 1668, 1692, 1961, 1981, 2021, 2068, 2253, 2369, 2378, 2393, 2427, 2451, 2487, 2524, 2546, 2569, 2604, 2630, 2652, 2698, 2712, 2720, 2802, 2906, 3073, 3097, 3238], 'serum': [472, 1634, 1679, 2379, 2389, 2445, 2488, 2522, 3062], 'aldosterone': [473, 1462, 1635, 1680, 2390, 2446, 2489, 3006, 3009, 3063, 3583, 3785], 'inversely': [475], 'excretion.ConclusionsRNA-sequencing': [479], 'shows': [484], 'concordance': [485], 'kidney.': [488, 3128], 'Perturbation': [489], 'endocrine': [492], 'signaling': [493, 1463, 1698, 1728], '(MR': [494], 'activation)': [495], 'accompanied': [497], 'supernatant.': [504, 953], 'Our': [505, 813, 1214], 'findings': [506, 814, 844, 1215, 1958, 2162, 2662, 3095], 'could': [507, 529, 1356], 'be': [508, 530, 1357, 1800, 2819, 2947, 2966, 3050, 3131], 'useful': [509, 3132, 3759], 'individualizing': [511], 'pharmacological': [512], 'therapy': [513], 'patients': [515, 2801, 4048], 'disorders': [517], 'signaling,': [520], 'such': [521, 2827, 3156], 'resistant': [523, 2809, 3161, 3671], 'More': [525, 2805], 'generally,': [526], 'these': [527, 2161, 2501, 2758], 'insights': [528, 4062], 'used': [531, 697, 2856], 'noninvasively': [533], 'identify': [534, 2763], 'putative': [535], 'biomarkers': [536, 2841, 3351], 'disordered': [538], 'physiology.Urine': [542], 'contains': [543], 'RNA,': [544, 4378], 'within': [545, 824, 1137, 1223, 1236, 1790, 1831, 2039, 2054, 2562, 3346], 'outside': [547], 'cells.': [549], 'Renal': [550, 899, 1336, 3271, 3595, 3617], 'tubular': [551, 3272], 'epithelial': [552, 595, 765, 1448, 3496, 3539], 'cells': [553, 596, 618, 766, 1449, 3304], 'secrete': [554], '(EVs),1,2': [557], 'which': [558, 2170, 2463, 2475, 3033, 4429], 'shuttle': [559], 'proteins,': [560], 'lipids,': [561], 'RNA': [563, 912, 1097, 1529, 1592, 1606, 2676, 2687, 3372, 4159, 4206], 'into': [564], 'urine.3,4': [566], 'RNA-sequencing': [567], '(RNA-Seq)': [568], 'EVs': [570, 891, 941, 1055, 1166, 1199, 2680, 2999], 'concentrated': [571], 'ultracentrifugation': [573, 944], '>3': [577], 'L': [578], 'has': [581, 654, 902, 2532, 2638], 'revealed': [582, 1113], 'predominantly': [584], 'noncoding': [585, 589], 'transcriptome.5': [586], 'Beyond': [587], 'transcriptome,': [590], 'transcripts': [592, 608, 3045], 'enriched': [593], 'each': [598, 1082, 3071], 'segment': [599], 'tubule': [603, 1419, 1447, 3303, 3307], 'detected.4,5': [605], 'These': [606, 1688, 1843, 1957, 3011, 3094], 'found': [609, 1047, 1127, 1900, 2033], 'gentle': [615], 'pelleting': [616], 'have': [619, 649, 2004, 2890, 2978, 2993], 'been': [620, 651, 656, 2005, 2533, 2639, 2891, 2979], 'proposed': [621], 'noninvasive': [624, 2742], 'source': [625], 'physiology.4,6': [630], 'But': [631], 'intracellular': [635, 906, 2714], 'unknown': [639], 'because': [640], 'transcriptional': [642, 822, 2840, 3035, 3509], 'profiles': [643], 'not': [650, 1799, 2121, 2196, 2798, 3022], 'compared.': [652], 'Nor': [653], 'clinical': [660, 720, 748, 788, 3141, 3455], 'study': [661, 749, 847, 858, 1619, 1770, 2896, 2933, 2950, 2983], 'changing': [663], 'physiology.A': [665], 'fundamental': [666], 'question': [667], 'informing': [668], 'potential': [670, 3350], 'biomarker': [675, 726, 1985, 2988, 3136], 'tissues.': [691], 'answer': [693], 'question,': [695], 'publicly': [698], 'available': [699, 849, 887, 3237], 'RNA-Seq': [700, 939, 961, 968, 1005, 2670], 'data': [701, 840, 962, 969, 976, 1006, 1689, 1990, 2671], 'evaluate': [703, 1350], 'relationship': [705, 1579, 2923], 'between': [706, 1131, 1165, 1247, 1293, 1582, 2236, 2924], 'US-mRNA5': [708], 'cortex.7': [715], 'Further': [716], 'proof-of-concept': [717, 2668], 'usefulness': [721], 'requires': [732], 'detection': [733], 'US-mRNA.': [740, 930, 2728], 'Thus,': [741], 'also': [743], 'activation—and': [751], 'subsequent': [752, 1509], 'suppression—of': [753], 'receptor': [756, 3195, 3448, 3607, 4058], '(MR),': [757], 'ligand-activated': [759, 1433], 'lining': [767], 'distal': [769, 1418, 1446, 3306, 3634], 'tubule.': [771], 'translate': [773], 'preclinical': [774], 'models': [775], 'setting,': [783], 'attention': [786], 'feasibility,': [789], 'developed': [791], 'targeted': [792, 2464, 2476], 'reverse': [794], 'reaction': [798], '(RT-qPCR)': [799], 'assays': [800, 1775, 1844, 1965, 1999, 2053, 2129, 2200, 2228, 2410, 2430, 2600, 4273], 'applied': [804, 1773], 'them': [805], 'small': [807, 1364, 2703], 'volumes': [808], '(5': [811], 'mL).': [812], 'suggest': [815, 1216], 'encodes': [818], 'concordant': [820, 1229, 2711], 'kidney,': [826, 2690], 'supporting': [827], 'feasibility': [829], 'detect': [834], 'expression.MethodsThe': [839], 'support': [842], 'corresponding': [852], 'reasonable': [855], 'request.': [856], 'submitted': [860], 'approved': [863], 'Michigan’s': [868], 'institutional': [869], 'review': [870], 'board.': [871], 'All': [872], 'participants': [873, 1620, 2900], 'provided': [874, 1549, 4438], 'written': [875], 'informed': [876], 'consent': [877], 'before': [878], 'inclusion': [879], 'study.': [882], 'methods': [884, 2759, 3013], 'now': [886], 'Data': [889, 986, 1021, 1539, 1555, 1572, 1600, 1654, 1686, 1723, 1955, 2028, 2063, 3234], 'Supplement.ResultsUrinary': [890], 'Carry': [892], 'Information': [893], 'About': [894], 'Transcriptional': [896], 'State': [897], 'TissuesWhether': [900], 'any': [903, 1979, 4436], 'correlation': [904, 1087, 1130, 1156, 1281, 2035, 2047, 2526, 2632], 'unknown.': [911], 'centrifuged': [917], 'scant,': [920], 'presenting': [921], 'technical': [922, 933, 1853, 1874, 1906, 1916, 1923, 1938, 1945, 2070], 'barriers': [923], 'understanding': [925], 'encoded': [928], 'Overcoming': [931], 'several': [932, 2484, 3078], 'obstacles,': [934], 'Miranda': [935, 3340, 3361], 'et': [936, 2953, 3269, 3295, 3320, 3342, 3363, 3387, 3425, 3441, 3465, 3490, 3531, 3554, 3574, 3604, 3626, 3647, 3694, 3721, 3748, 3776, 3805, 3831], 'al5': [937], 'performed': [938, 1000, 1836, 1864], 'isolated': [942, 1607, 2677], '3300': [946], 'mL': [947, 1611], 'healthy': [950], 'volunteer’s': [951], 'We': [954, 1152, 1632, 1783, 1899, 2158], 'unique': [960, 1787], 'set': [963, 1474], 'cortex': [967, 1065, 1073, 1095, 1120, 1142, 1170, 1197, 1263, 1269], 'Genotype-Tissue': [972, 1025, 1035, 1139], 'Expression': [973, 1140], 'project.7': [974], 'Samples’': [975], 'accession': [977], 'numbers': [978], 'listed': [980], 'Table': [982, 1551, 1650, 1682], 'I': [983, 1536], 'Supplement.': [987, 1556, 1655], 'exclude': [989], 'possibility': [991, 2756], 'similarity': [993], 'driven': [994], 'housekeeping': [996], 'subsequently': [999], 'separate': [1001, 1146], 'comparisons': [1002, 1194], 'sets': [1007, 1164, 1851, 1908, 1925, 2041], '(1)': [1009, 1495, 2667], 'subset': [1011, 1839], '(Table': [1017], 'II': [1018, 1569], 'Supplement)': [1022], 'identified': [1023, 1033], 'Expression,': [1026], '(2)': [1028, 1507, 2691], 'Expression.8': [1036], 'For': [1037, 4326], 'selected': [1039], 'basis': [1042], 'expression,8': [1045], 'their': [1049, 2903], 'relative': [1050, 1059, 3753], 'sample': [1066, 3210], '(rs=0.82;': [1067], 'P<2.2e−16;': [1068, 1102, 1116, 1149], 'Figure': [1069, 1103, 1117, 1150, 1535, 1719], '1A).': [1070], 'When': [1071], 'samples': [1074, 1311, 1490], '2': [1076, 1145, 1313, 1493, 1935, 2461], 'different': [1077, 2052, 2133, 2235], 'people': [1078, 1147], 'were': [1079, 2017, 2066, 2082, 2131, 2566, 2601, 3070], 'other,': [1083], 'strength': [1085], 'similar': [1089, 1560, 2682], 'comparison': [1092], '(rs=0.84;': [1101], '1B).': [1104], 'In': [1105, 2030, 2221, 2593, 2753, 2850, 2869, 3833], 'contrast,': [1106, 2222, 2594], 'analysis': [1107, 1157, 1604], 'moderate': [1114], '(rs=0.63;': [1115], '1C)': [1118], 'EV-kidney': [1119], 'correlation.': [1121], 'As': [1122, 1656], 'positive': [1124, 2536, 2642], 'control,': [1125], 'strong': [1129, 2920], 'ubiquitous': [1135, 1162, 1191], 'cohort': [1143], '(rs=0.96;': [1148], '1D).': [1151], 'replicated': [1153], 'same': [1155, 1522], 'both': [1159], '28': [1168], 'samples,': [1171, 1175, 1614], '10': [1172, 2226, 2457, 2597], 'uncorrelated': [1173, 1178], 'brain': [1174, 1207, 1308], '5': [1177, 1610], 'bladder': [1179, 1210, 1310], 'samples.': [1180], 'Kolmogorov-Smirnov': [1181], 'test': [1182], 'correlate': [1187], 'than': [1190], 'versus': [1198, 2137, 3697], '(Figure': [1200, 1568, 1596, 1951, 2024, 2418, 2574], '1E);': [1201], 'opposite': [1203], 'noted': [1205, 1747], 'tissue': [1208], 'tissue,': [1211], 'our': [1212, 1392, 1774, 1857, 1962, 1987, 2374, 2932, 3098], 'controls.': [1213], 'those': [1234, 3089], 'tissues.Download': [1239], 'figureDownload': [1240, 2510, 2615], 'PowerPointFigure': [1241, 2511, 2616], '1.': [1242], 'Correlation': [1243, 1273, 1288], 'or': [1259, 1577, 1793, 1934, 2736, 2921, 3008, 3679, 3784], 'second': [1266], 'sample.A': [1270], 'B,': [1272, 3646, 3693, 3914, 4354], 'genes;': [1277], '(C': [1278], 'D),': [1280], '(housekeeping)': [1285], 'E,': [1287, 3930, 3942, 3954, 4076, 4088, 4117], 'coefficients': [1289], 'series': [1303], '(top)': [1306], '(lower': [1312], 'rows,': [1314], 'respectively,': [1315], 'control).': [1318], 'Correlations': [1319], 'calculated': [1321], 'Spearman': [1323], 'ρ.RT-qPCR': [1324], 'Provides': [1327], 'Proof-of-Concept': [1328], 'Noninvasive': [1330], 'Detection': [1331, 4046, 4337], 'Changes': [1333], 'Human': [1335, 4157, 4215], 'Gene': [1337], 'TranscriptionIn': [1338], 'view': [1339], 'preceding': [1342], 'evidence,': [1343], 'logical': [1345], 'next': [1346, 2371], 'step': [1347], 'detected': [1358, 1948, 2079, 2928], 'US-mRNA,': [1360], 'ideally': [1361], 'volume': [1365, 2704, 2785], 'urine.': [1367, 2868, 3093], 'high': [1369, 1516, 1739, 1967, 2034, 2043, 2108, 2240, 2699, 3003], 'sensitivity': [1370], 'specificity': [1372], 'locked': [1374], 'nucleic': [1375], 'acid': [1376], 'RT-qPCR': [1378, 1603, 1788, 1829, 1858, 1964, 1998, 2128, 2227], 'excellent': [1381], 'state': [1382, 2774, 3125], 'knowledge': [1384], 'animal': [1389, 3056], 'studies': [1390, 2992], 'facilitated': [1391, 2820], 'investigation': [1393], 'question.': [1396], 'regulates': [1400, 1410, 3537], 'plasma': [1401, 1404, 1637, 1674], 'sodium,': [1402], 'circulating': [1403], 'volume,': [1405], 'blood': [1407, 1755, 3674], 'pressure.': [1408], 'Aldosterone': [1409, 3556], 'reabsorption': [1412], 'water': [1414], 'retention': [1415], 'nephron': [1422], 'binding': [1424], 'which—like': [1426], 'other': [1427, 1644, 2255, 2429, 2813, 3012, 3229], 'nuclear': [1428], 'hormone': [1429], 'receptors—serves': [1430], 'factor.9,10': [1435], 'This': [1436, 2793, 2911, 3114, 4414], 'well-characterized': [1437], 'event': [1438], 'leads': [1439], 'altered': [1441, 2506], 'and,11–15': [1450], 'ultimately,': [1451], 'reabsorption.16': [1453], 'Low': [1454], 'intake': [1456, 1469], 'results': [1457, 2050, 2368, 2375], 'increased': [1459], 'system–mediated': [1461], 'MR,': [1465, 2355], 'whereas': [1466, 2112], 'excess': [1467, 2776, 3153], 'downregulates': [1470], 'controlled': [1477], 'MR.': [1479], 'With': [1480, 3659], 'well-established': [1482], 'mind,': [1485], 'under': [1492, 2134, 3000, 4420], 'conditions:': [1494], '(20': [1502], 'mmol/d)': [1503], '(n=18),': [1505], 'infusion': [1511], 'consumption': [1513], 'salt': [1517, 1740, 2109, 2241, 3635, 4022], 'meal': [1518], '(n=17': [1519, 1919], 'participants).': [1523], 'An': [1524], 'overview': [1525], 'extraction': [1530], 'workflow': [1531], 'included': [1533], 'Supplement,': [1540], 'details': [1542], 'primers': [1545], 'probes': [1547], 'III': [1552, 1597], 'creatinine': [1558, 1584, 2854, 2879, 2926, 2945], 'during': [1561, 1664, 1714, 2880], 'loading': [1567, 1628, 1766], 'Supplement).': [1573, 1687, 1724, 1956, 2029], 'Moreover,': [1574], 'no': [1575, 1742, 1949, 1989, 2874, 3232], 'clear': [1576], 'consistent': [1578, 1691, 1960, 2922], 'observed': [1581, 2554, 2873], 'cycle': [1586, 2352, 2515, 2626], '(Ct)': [1588, 2517, 2628], 'value': [1589, 1912, 1930, 1983, 2358, 2544, 2612, 2650], 'molecules': [1593, 2003, 2695], 'Supplement).Before': [1601], 'performing': [1602], 'established': [1616, 3280], 'exhibited': [1621], 'hormonal': [1624], 'restriction.': [1631], 'concentration,': [1636], 'renin': [1638, 1675], 'activity,': [1639], 'excretion,': [1642], 'relevant': [1645], 'parameters': [1646, 1750], 'shown': [1648], 'IV': [1651, 1683, 1720], 'expected,': [1657, 1862], 'active': [1663], 'sodium-loaded': [1670, 1716, 2138], 'condition': [1671, 1717, 2139], '(P<0.001': [1672], 'concentration;': [1681], 'anticipated': [1694, 1797], 'infusion.': [1701], 'Consequently,': [1702], 'excretion': [1705, 1732, 3887], '(ie,': [1706], 'log': [1707], 'sodium-creatinine': [1709, 2572, 2607, 2622, 3068], 'ratio)': [1710], 'higher': [1713, 1893, 2400, 3061], '(P<0.001;': [1718], 'Although': [1725, 2481], 'low': [1737, 2106, 2135, 2238, 3005], 'condition,': [1741, 3060], 'clinically': [1743], 'significant': [1744, 2367, 2875], 'change': [1745, 3106], 'hemodynamic': [1749], 'measured': [1751], '24-hour': [1753], 'ambulatory': [1754], 'pressure': [1756, 3675], 'monitoring.After': [1757], 'confirming': [1758], 'MR-mediated': [1761, 2087], 'physiological': [1762, 2088, 3124], 'had': [1767], 'occurred': [1768], 'participants,': [1771], 'target': [1778, 1830, 2100, 2127, 2277, 2413, 2559, 3080], 'control': [1781, 1805, 1866, 2117, 2231, 2251, 2458, 2485, 2598], '24': [1786], 'would': [1798, 2163], 'regulated': [1801, 2415, 3051], '(as': [1804], 'genes).': [1806], 'include': [1809, 1818], 'AQP2,': [1810], 'SCNN1A,': [1811], 'SCNN1B,': [1812], 'andTSC22D3.': [1815], 'Control': [1816], 'AQP1,': [1819], 'HSD11B2,': [1820], 'NR3C2,': [1821], 'UMOD.': [1823], 'A': [1824, 2949, 3978, 3986, 4230], '25th': [1825], 'assay': [1826, 2151], 'GAPDH': [1833], 'participants.': [1842], 'resulted': [1845], 'total': [1848], '858': [1850], 'triplicates.': [1854], 'ensure': [1856], 'experiment': [1859], 'worked': [1860], 'quality': [1865, 1977], 'analyses.': [1867], 'First,': [1868], 'determined': [1870, 2012, 2372], 'proportion': [1872], 'triplicates': [1875, 1939, 1946], 'yielding': [1876], 'Ct': [1878, 1880, 1889, 1911, 1929, 1995, 2015, 2037, 2080, 2096, 2114, 2260, 2396, 2452, 2529, 2543, 2635, 2649, 2929, 3075], 'value.': [1879], 'indirect': [1883, 3630], 'measures': [1884, 3044], 'transcript': [1886, 2401, 3502], 'abundance;': [1887], 'lower': [1888, 2395, 3066, 3074], 'correspond': [1891], 'vice': [1897], 'versa.': [1898], '645': [1902], '(75.2%)': [1903], 'all': [1905, 1914], 'triplicate': [1907, 1924, 2040], 'yielded': [1909, 1926], '3': [1915, 2428, 2455], 'replicates.': [1917], 'Few': [1918], '[2.0%])': [1920], 'only': [1932, 2223], '1': [1933, 2224, 2474], '196': [1941], '(22.8%)': [1942], 'uniformly': [1947], 'signal': [1950], 'V': [1952], 'having': [1966], 'repeatability': [1968], 'detecting': [1970, 3193], 'supernatant,': [1974], 'desirable': [1976], 'method': [1980, 3038], 'prospective': [1982], 'identification.To': [1986], 'knowledge,': [1988], 'distribution': [1993, 2094], 'published.': [2006], 'Using': [2007], 'Q-Q': [2009], 'plot,': [2010], 'essentially': [2018, 2862], 'normally': [2019], 'distributed,': [2020], 'few': [2022], 'outliers': [2023], 'VI': [2025], 'addition,': [2031], 'but': [2044, 2436, 2586], 'variable': [2046], '(Figures': [2057], 'VII': [2058], 'VIII': [2060], 'Supplement).After': [2064], 'satisfied': [2067], 'merits': [2071], 'assays,': [2074, 2460, 2561], 'assessed': [2076], 'reflective': [2083], 'known': [2086, 2713, 3048], 'distinct': [2103, 3514], 'conditions': [2110, 2242], '(Table),': [2111], 'generally': [2119], 'did': [2120], 'change.': [2122], 'Four': [2123], '14': [2125, 2406, 2558], '(29%)': [2130], '(SCNN1A-2,': [2140], 'P=0.01;': [2141], 'SCNN1G-1,': [2142], 'P=0.007;': [2143], 'SCNN1G-3,': [2144], 'P=0.006;': [2145], 'TSC22D3-2,': [2146], 'P=0.03),': [2147], 'fifth': [2150], 'near': [2153], 'statistical': [2154], 'significance': [2155, 2217], '(SGK1-2;': [2156], 'P=0.07).': [2157], 'evaluated': [2159], 'withstand': [2164], 'Bonferroni': [2165, 2211, 2247, 2425, 2439, 2577, 2581], 'correction': [2166, 2206, 2212, 2248, 2440, 2589], 'multiple': [2168, 2208], 'testing,': [2169], 'makes': [2171], 'conservative': [2173], 'assumption': [2174], 'one': [2181], 'independent': [2184], 'another': [2191, 2972], '(which': [2193], 'likely': [2195], 'case).': [2198], 'SCNN1G-1': [2202], 'SCNN1G-3': [2204, 2423], 'withstood': [2205, 2424, 2580], 'testing': [2209], '(per': [2210], '6': [2214, 2556], 'P<0.008).': [2220], '(NR3C2-1,': [2243, 2467], 'P=0.003,': [2244], 'likewise': [2245], 'withstanding': [2246], 'genes),': [2252], '9': [2256, 4386], 'P>0.25.Table.': [2257], 'Comparison': [2258], 'Values': [2261], 'Under': [2262], 'Low-Sodium': [2263, 2268], 'Diet': [2264], 'Sodium-Loaded': [2266], 'ConditionGeneCt': [2267], 'Diet,': [2269], 'Mean±SD': [2270, 2274], '(n)Ct': [2271], 'Loaded,': [2273], '(n)P': [2275], 'Value*MR': [2276], 'genesAQP2-122.1±1.2': [2278], '(8)23.4±2.7': [2279], '(13)0.48': [2280], 'SCNN1A-124.8±1.4': [2281], '(16)26.1±2.8': [2282], '(15)0.21': [2283], 'SCNN1A-227.0±1.1': [2284], '(16)28.2±1.2': [2285], '(16)0.012†': [2286], 'SCNN1A-326.1±1.4': [2287], '(17)27.2±4.0': [2288], '(16)0.25': [2289], 'SCNN1B-128.4±1.5': [2290], '(7)29.8±2.9': [2291], '(3)0.90': [2292], 'SCNN1B-226.4±1.3': [2293], '(14)26.8±2.9': [2294], '(7)0.81': [2295], 'SCNN1B-325.8±1.1': [2296], '(15)27.1±2.6': [2297], '(13)0.22': [2298], 'SCNN1G-124.2±1.3': [2299], '(16)26.1±2.5': [2300], '(16)0.007†': [2301], 'SCNN1G-225.7±1.7': [2302], '(16)26.7±1.8': [2303], '(12)0.11': [2304], 'SCNN1G-324.0±1.0': [2305], '(17)26.6±3.4': [2306], '(15)0.006†': [2307], 'SGK1-223.0±1.3': [2308], '(15)25.4±3.0': [2309], '(11)0.07': [2310], 'SGK1-324.5±1.7': [2311], '(17)25.9±3.2': [2312], '(10)0.15': [2313], 'TSC22D3-124.2±2.6': [2314], '(14)25.6±2.4': [2315], '(13)0.21': [2316], 'TSC22D3-219.5±2.0': [2317], '(17)21.8±2.6': [2318], '(15)0.03†Control': [2319], 'AQP1-126.1±1.7': [2321], '(15)26.7±4.3': [2322], '(9)0.67': [2323], 'AQP1-225.7±2.2': [2324], '(16)26.6±2.7': [2325], '(7)0.68': [2326], 'GAPDH-124.3±1.5': [2327], '(6)24.9±2.1': [2328], '(4)0.97': [2329], 'HSD11B2-122.8±1.2': [2330], '(17)23.4±2.8': [2331], '(16)0.43': [2332], 'NR3C2-125.0±1.6': [2333], '(13)28.0±3.0': [2334], '(12)0.003†': [2335], 'NR3C2-223.9±1.3': [2336], '(15)24.9±2.8': [2337], '(9)0.35': [2338], 'NR3C2-323.2±0.78': [2339], '(16)24.1±2.5': [2340], '(10)0.33': [2341], 'UMOD-125.5±3.3': [2342], '(17)26.7±2.4': [2343], '(16)0.26': [2344], 'UMOD-224.6±1.6': [2345], '(15)25.7±3.4': [2346], '(12)0.47': [2347], 'UMOD-325.3±3.4': [2348], '(17)26.4±2.9': [2349], '(15)0.28Ct': [2350], 'indicates': [2351], 'threshold;': [2353], 'receptor.*P': [2357], 'represents': [2359], 'result': [2361], 'paired': [2364], 't': [2365], 'test.†Statistically': [2366], 'P<0.05.We': [2370], 'tracked': [2376], 'well': [2377], 'levels': [2380], 'canonical': [2383], 'ligand,': [2385], 'aldosterone.': [2386], 'Higher': [2387], 'log-transformed': [2388, 2521, 2570, 2605, 2620], 'concentration': [2391, 2447, 2889], 'associated': [2392, 2450, 2568, 2603, 3072], 'values,': [2397], 'thus': [2399], 'abundance,': [2402], '7': [2404], '(50%)': [2407], '2).': [2419], 'SCNN1A-1,': [2420], 'SCNN1A-2,': [2421], 'correction,': [2426, 2578], '(SCNN1G-1,': [2431], 'SCNN1G-2,': [2432], 'TSC22D3-2)': [2433], 'close': [2434], 'to,': [2435], 'above,': [2437, 2587], 'P<0.008.': [2443, 2592], 'Log-transformed': [2444], 'negatively': [2449], 'itself': [2466], 'r=−0.52,': [2468], 'P=0.008;': [2469], 'NR3C2-2,': [2470], 'r=−0.48,': [2471], 'P=0.002)': [2472], 'uromodulin': [2477], '(UMOD-2,': [2478], 'r=−0.43,': [2479], 'P=0.03).': [2480], 'association': [2482], 'represent': [2491], 'chance': [2493], 'finding,': [2494], 'it': [2495, 2936], 'possible': [2497, 2938], 'fact': [2505], 'loading.Download': [2509], '2.': [2512], 'Scatterplots': [2513, 2618], 'according': [2519, 2624], 'aldosterone,': [2523], 'Pearson': [2525, 2631], 'coefficients.': [2527, 2633], 'values’': [2530, 2636], 'sign': [2531, 2637], 'reversed': [2534, 2640], '(from': [2535, 2641], 'negative)': [2538, 2644], 'so': [2539, 2645], 'larger': [2542, 2648], 'corresponds': [2545, 2651], 'greater': [2547, 2653], 'intuitive': [2552, 2658], 'interpretation.We': [2553], 'ratio': [2573, 2608, 2623, 3069], '3).': [2575], 'After': [2576], 'TSC22D3-2': [2579], 'correction;': [2582], 'SGK1-2': [2583], 'near,': [2585], '0': [2595], '(the': [2609], 'lowest': [2610], 'P': [2611, 4150], '0.14).Download': [2614], '3.': [2617], 'value,': [2629], 'interpretation.DiscussionThe': [2659], 'major': [2660], 'new': [2661, 3452, 4061], 'work': [2665, 3115, 4442], 'fidelity': [2700], 'urine,': [2706], '(3)': [2708], 'physiology,': [2716], 'case': [2719], 'regard': [2721, 2907], 'activation,': [2724, 3155], 'ability': [2730], 'draw': [2732], 'inferences': [2733], 'new,': [2741], 'way': [2743, 2748], 'promises': [2744], 'impact': [2746], 'cardiovascular': [2749, 4278], 'diseases': [2750], 'diagnosed.': [2752], 'particular,': [2754], 'will': [2760, 2946, 2965], 'help': [2761], 'us': [2762], 'mineralocorticoid-induced': [2764], 'hypertension': [2765, 2771, 3709], 'interest': [2768], 'us.Resistant': [2770], 'activation': [2778, 3026, 3054, 3732], 'many': [2780, 2851, 3158], 'instances,': [2781], 'judged': [2783], 'expansion17': [2786], 'antagonist.18': [2792], 'antagonist': [2795], 'responsiveness': [2796], 'limited': [2799], 'primary': [2803, 3834], 'aldosteronism.': [2804], 'tailored': [2806], 'treatment': [2807, 3147, 3706], 'hypertension—and': [2810], 'forms': [2814], 'potentially': [2816], 'MR-related': [2817], 'hypertension19—will': [2818], 'further': [2823], 'development': [2824], 'approaches': [2826], 'ours.A': [2829], 'key': [2830], 'barrier': [2831], 'progress': [2833], 'field': [2836, 3214], 'identification': [2844, 3137], 'proper': [2847], 'normalization': [2848, 2858, 2943, 2970], 'strategy.': [2849], 'cases,': [2852], 'purposes': [2859, 3134], 'given': [2860], 'its': [2861], 'constant': [2863], 'rate': [2864, 3888], 'accumulation': [2866], 'study,': [2871], 'difference': [2876], 'low-': [2881], 'high-sodium': [2883], 'diet.': [2884], 'Therefore,': [2885], 'differences': [2886], 'avoided,': [2892], 'perhaps': [2893], 'owing': [2894], 'design;': [2897], 'essence,': [2899], 'served': [2901], 'own': [2904], 'controls': [2905], 'concentration.': [2910], 'hypothesis': [2912], 'supported': [2914, 3167], 'lack': [2917], 'population.': [2934], 'However,': [2935], 'random': [2941], 'populations,': [2942], 'useful.': [2948], 'Seo': [2952, 3746], 'al20': [2954], 'suggests': [2955], 'some': [2958], 'settings,': [2959], 'even': [2960], 'cross-sectional': [2961], 'studies,': [2962], 'accurately': [2967], 'quantifiable': [2968], 'without': [2969], 'molecule.Although': [2973], 'proteins': [2974], 'extensively': [2980], 'studied,': [2981], 'remains': [2989], 'novel.': [2990], 'Previous': [2991, 3850], 'characterized': [2994], 'protein': [2995, 3018, 3402], 'states': [3001, 3151], 'secretion': [3007], 'infusion.21–23': [3010], 'measure': [3014, 3024], 'MR-associated': [3015], 'translation.': [3019], 'They': [3020], 'do': [3021], 'directly': [3023, 3043], 'per': [3027], 'se,': [3028], 'immediate': [3030], 'consequence': [3031], 'activity.': [3036], 'outlined': [3039], 'article': [3042, 3240, 4419], 'models.': [3057], 'Low-sodium': [3058], 'dietary': [3059], 'concentrations,': [3064], 'indicating': [3082], 'presence': [3084], 'copies': [3087], 'agree': [3096], 'priori': [3100], 'expectation': [3101], 'direction': [3104], 'supports': [3116], 'use': [3118], 'may': [3130], 'aimed': [3138], 'at': [3139, 3241, 4049], 'improving': [3140], 'precision': [3142, 4275], 'diagnosis': [3145, 3762], 'diseases,': [3149], 'instances': [3159], 'hypertension.Sources': [3162], 'FundingDr': [3164], 'National': [3169], 'Institutes': [3170], 'Health': [3172, 4216], 'grant': [3173], 'K23HL128909': [3174], 'Michigan': [3177], 'MTRAC': [3178], 'Kickstart': [3179], 'Award.DisclosuresDrs': [3180], 'inventors': [3186], 'provisional': [3189], 'patent': [3190], 'related': [3191], 'activation.': [3196], 'Dr': [3197], 'an': [3200, 3220, 3500, 4416], 'employee': [3201], 'company,': [3204], 'Siena': [3206], 'SpA,': [3207], 'develops': [3209], 'preps': [3211], 'liquid': [3216], 'biopsy.': [3217], 'He': [3218], 'inventor': [3221], 'patents': [3223], 'owned': [3224], 'company.': [3227], 'authors': [3230], 'report': [3231], 'conflicts.FootnotesThe': [3233], 'Supplement': [3235], 'https://www.ahajournals.org/doi/suppl/10.1161/CIRCGEN.118.002213.https://www.ahajournals.org/journal/circgenJames': [3242], 'protected]umich.eduReferences1.': [3266], 'Dominguez': [3267], 'JH,': [3268], 'al.': [3270, 3296, 3321, 3343, 3364, 3388, 3426, 3442, 3466, 3491, 3532, 3555, 3575, 3605, 3627, 3695, 3722, 3749, 3777, 3806, 3832], 'cell-derived': [3273], 'accelerate': [3276], 'recovery': [3278], 'ischemia': [3282], 'reperfusion': [3283], 'injury.J': [3284], 'Am': [3285, 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[3818], 'marker': [3821], 'aldosteronism.Hypertension.': [3823], '2012;': [3824], '60:741–748.': [3825], '10.1161/HYPERTENSIONAHA.112.198135LinkGoogle': [3827], 'Scholar23.': [3828], 'Wolley': [3829], 'MJ,': [3830], 'aldosteronism,': [3835], 'mineralocorticoids': [3836], 'influence': [3837], 'sodium-chloride': [3839], 'abundance.J': [3841], '28:56–63.': [3846], '10.1681/ASN.2015111221CrossrefMedlineGoogle': [3848], 'Scholar': [3849], 'Back': [3851], 'top': [3853], 'Next': [3854], 'FiguresReferencesRelatedDetailsCited': [3855], 'By': [3856], 'Blijdorp': [3857, 3905], 'C,': [3858, 3906, 3924, 3934, 3960, 3962, 4113, 4135, 4348], 'Hartjes': [3859], 'Wei': [3861], 'K,': [3862, 3936, 3972, 4083, 4102, 4115, 4121], 'Heugten': [3863], 'Bovée': [3865], 'D,': [3866, 3912, 4119], 'Budde': [3867], 'R,': [3868, 3876, 4139], 'Wetering': [3869], 'J,': [3870, 3872, 3916, 3920, 3922, 3938, 3944, 3948, 3970, 4085, 4092, 4141], 'Hoenderop': [3871], 'Royen': [3873, 3957], 'Zietse': [3875], 'Severs': [3877], 'D': [3878], 'Hoorn': [3880, 3929], 'E': [3881, 3981, 4356], '(2022)': [3882], 'Nephron': [3883], 'mass': [3884], 'determines': [3885], 'vesicles,': [3892], 'Journal': [3893, 4001, 4029, 4285], 'Extracellular': [3895, 3999, 4003, 4153, 4181, 4205, 4235], 'Vesicles,': [3896, 4000, 4004, 4236], '10.1002/jev2.12181,': [3897], '11:1,': [3898], 'Online': [3899, 4007, 4036, 4071, 4166, 4193, 4242, 4260, 4292, 4314, 4343], 'publication': [3900, 4008, 4037, 4072, 4167, 4194, 4243, 4261, 4293, 4315, 4344], 'date:': [3901, 4009, 4038, 4073, 4168, 4195, 4244, 4262, 4294, 4316, 4345], '1-Jan-2022.': [3902], 'Erdbrügger': [3903, 4178], 'U,': [3904], 'Bijnsdorp': [3907], 'I,': [3908, 3950], 'Borràs': [3909], 'Burger': [3911], 'Bussolati': [3913], 'Clayton': [3917], 'Dear': [3919], 'Falcón‐Pérez': [3921], 'Grange': [3923], 'Hill': [3925], 'Holthöfer': [3927], 'Jenster': [3931], 'G,': [3932, 3968, 4100, 4145, 4265], 'Jimenez': [3933], 'Junker': [3935], 'Klein': [3937], 'Knepper': [3939], 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