Publication Information

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1357, 1457, 1526, 1577, 1606, 2603], 'that': [642, 745, 1269, 1305, 1395, 1429, 1446, 1494, 1507, 1569, 1601, 2749], 'is': [643, 657, 711, 1496, 1516, 1554, 1560, 1617, 1934, 2230], 'closely': [644], 'related': [645], 'the': [647, 680, 769, 772, 780, 796, 807, 828, 842, 863, 898, 903, 912, 924, 1004, 1081, 1166, 1173, 1183, 1194, 1237, 1260, 1279, 1296, 1300, 1307, 1320, 1325, 1362, 1367, 1378, 1426, 1430, 1447, 1508, 1519, 1522, 1570, 1575, 1585, 1592, 1597, 1603, 1609, 1646, 1652, 1659, 1663, 1735, 1743, 1747, 1880, 1983, 2143, 2280, 2346, 2605], 'severity': [648], 'prognosis': [650, 684], 'HF.1': [652], 'This': [653, 1463], 'reduction': [654, 1523], 'caused': [658], 'by': [659, 787, 826, 929, 1055, 1151, 1161, 1165, 1221, 1278, 1470, 1537, 1645, 1936], 'peripheral': [660], 'skeletal': [661, 727, 740, 870, 951, 1178, 1379, 1419, 1438, 1459, 1514, 1528, 1538, 1565, 1589, 1824, 1886, 1937, 2033, 2353, 2514, 2608, 2652], 'muscle': [662, 728, 871, 914, 952, 990, 1048, 1075, 1179, 1298, 1380, 1420, 1439, 1460, 1515, 1529, 1825, 1887, 1938, 2034, 2354, 2515, 2609, 2653], 'abnormalities,': [663], 'including': [664], 'mitochondrial': [665, 867, 909, 948, 1180, 1388, 1398, 1461, 1499, 1586, 2743], 'dysfunction,': [666], 'as': [667, 669, 714, 927, 1705, 1707, 2547], 'well': [668, 1706], 'disturbed': [670], 'cardiac': [671, 1801, 2087], 'function': [672, 1274, 1587], 'central': [674], 'hemodynamics.2': [675], 'training': [677, 700, 719, 1632, 1849], 'can': [678], 'improve': [679, 749, 1608], 'patients': [686, 691, 1614, 1805], 'HF,3': [688], 'but': [689, 2700], 'some': [690], 'severe': [693], 'HF': [694, 857, 1441, 1579, 1594, 1616], 'cannot': [695], 'engage': [696], 'sufficient': [698], 'because': [701, 1483], 'their': [703, 1455], 'severely': [704], 'impaired': [705, 1174], 'daily': [706, 1223], 'life.': [707], 'Effective': [708], 'pharmacological': [709], 'therapy': [710], 'strongly': [712], 'desired': [713], 'an': [715, 886, 1226, 1405, 1582, 2076], 'alternative': [716], 'for': [720, 771, 806, 1108, 1172, 1225, 1662, 1797, 2032, 2552], 'individuals': [721], 'limited': [723, 944], 'abnormalities.Exercise': [729], 'has': [730], 'been': [731], 'reported': [732], 'increase': [734], 'brain-derived': [735, 1031, 1979], 'neurotrophic': [736, 940, 1032, 1932, 1980, 2841], 'factor': [737, 941, 1033, 1933, 1981], '(BDNF)': [738, 942], 'muscle.4,5': [741], 'We': [742, 861, 1392], 'thus': [743, 1424], 'hypothesized': [744], 'BDNF': [746, 1043, 1205, 1294, 1317, 1344, 1396, 1434, 1490, 1495, 1511, 1545, 1559, 1624, 1629, 1883, 2546], 'treatment': [747, 1171, 1465], 'could': [748], 'capacity;': [751], 'we': [752, 1191, 1505], 'tested': [753], 'this': [754, 1738], 'hypothesis': [755], 'using': [756, 1336, 2746], 'a': [757, 815, 882, 1170, 1314, 1618, 1626, 1636, 1991, 2416, 2548, 2614], 'mouse': [758], 'model': [759, 2616], 'HF.': [761, 1532], 'All': [762, 1730], 'experiments': [763, 1256, 1333, 1567], 'animal': [765, 790], 'care': [766], 'accorded': [767], 'Guide': [770], 'Care': [773, 804, 808], 'Use': [775, 810], 'Laboratory': [777, 812], 'Animals': [778], 'from': [779, 953, 992, 1440, 1564, 1651, 1684, 1710, 1746], 'National': [781], 'Institutes': [782], 'Health,': [784], 'were': [785, 833, 894, 1242, 1257, 1275, 1491], 'approved': [786], 'our': [788, 1331], 'institutional': [789], 'research': [791, 1708], 'committee,': [792], 'conformed': [794], 'Animal': [803], 'Guidelines': [805], 'Animals.We': [813], 'induced': [814], 'myocardial': [816, 968, 2350, 2656], 'infarction': [817, 969, 2351, 2657], '(MI)': [818], '10-': [820], '12-week-old': [822], 'male': [823], 'C57BL/6J': [824], 'mice': [825, 844, 900, 905, 921, 926, 996, 1090, 1196, 1241, 1322, 1327, 1364, 1369, 1442, 1453, 1580], 'ligating': [827], 'coronary': [829], 'artery.': [830], 'Sham': [831], 'operations': [832], 'conducted': [834], 'controls.': [836], 'At': [837, 1186, 1246], '2': [838, 961, 1020, 1187, 1198, 1228, 2041], 'weeks': [839, 962, 1022, 1188, 1248, 1252], 'after': [840, 963, 1023, 1189, 1249, 1253, 1443], 'surgery,': [841, 1190], 'MI': [843, 899, 920, 995, 1184, 1195, 1444, 1452], 'exhibited': [845], 'left': [846, 851, 1270, 2465], 'ventricular': [847, 852, 1271, 2466], 'dilation': [848], 'depressed': [850], 'function,': [853], 'they': [855], 'developed': [856], '(data': [858, 1282, 1352, 1421], 'not': [859, 1276, 1283, 1353, 1422, 1555], 'shown).': [860, 1284, 1354], 'assessed': [862], 'respiration': [868, 910, 949, 986, 1071, 1101, 1133, 1373, 1389], '(Figure': [872, 906, 1266, 1328, 1370, 1390], '[A]).': [873], 'The': [874, 908, 1355, 1717, 2413, 2555, 2806], 'work': [875, 974, 1059], 'peak': [877, 976, 1061, 1793], 'oxygen': [878, 977, 1062, 1795], 'uptake': [879, 978, 1063, 1347], 'evaluated': [880], 'motorized': [883], 'treadmill': [884], 'expired': [887], 'gas': [888], 'analyzer': [889], '(Oxymax': [890], '2,': [891], 'Columbus': [892], 'Instruments)': [893], 'significantly': [895, 917, 1289, 1315, 1359, 1375, 1386], 'lower': [896, 918, 1290, 1376], 'compared': [901, 922, 1303, 1323, 1365], 'sham': [904, 925, 966, 993, 1015, 1150, 1240], '[B]).': [907], 'gastrocnemius': [913, 989, 1047, 1074, 1297], 'was': [915, 1358, 1374, 1435, 1468, 1641], 'also': [916, 1393], 'measured': [928], 'high-resolution': [930], 'respirometry': [931], '(Oxygraph-2k,': [932], 'Oroboros': [933], 'Instruments;': [934], 'Figure': [935], '[C]).Download': [936], 'figureDownload': [937], 'PowerPointFigure.': [938], 'Brain-derived': [939, 1931], 'improves': [943, 2275], 'mice.A,': [956], 'Study': [957, 1018], 'protocol': [958, 1019], '1': [959], '(at': [960], 'surgery': [964, 1250], '[MI]': [970], 'mice).': [971], 'B,': [972, 2245, 2259], 'Total': [973, 1058], 'exhaustion': [980, 1065], '(n=6': [981, 997], 'per': [982, 998, 1050, 1067, 1092, 1211], 'group).': [983, 999, 1051, 1068, 1093], 'C,': [984, 1912, 1914, 2263], 'Mitochondrial': [985, 1070, 1372], 'permeabilized': [988, 1073], 'fibers': [991], 'Values': [1000, 1052, 1077], 'are': [1001, 1053, 1078, 1095, 1535, 1740], 'relative': [1002, 1079], 'O2': [1005, 1082], 'flux': [1006, 1083], 'complex': [1008, 1085, 1103, 1111, 1116, 1120, 1123, 1129, 1135, 1141, 1145], 'I+II': [1009, 1086, 1121, 1130], 'electron': [1010], 'transfer': [1011], 'system': [1012, 2745], '(ETS)': [1013], 'mice.': [1016, 1185, 1309], 'D,': [1017, 1837], '(2': [1021, 1251], 'administration': [1024, 1281, 1311, 1448, 1571], 'vehicle': [1026, 1219], 'or': [1027, 1625, 1745], 'recombinant': [1028, 1203], 'human': [1029, 1204], '[rh]': [1030], '[BDNF]).': [1034], 'E,': [1035], 'Representative': [1036], 'Western': [1037, 1285], 'blots': [1038], 'summary': [1040], 'data': [1041, 1731], 'protein': [1044, 1291, 1409, 1431, 1474, 1487, 1952], 'expression': [1045, 1292, 1318, 1351, 1432, 1512, 1878, 2229], '(n=7': [1049, 1066], 'normalized': [1054], 'GAPDH.': [1056], 'F,': [1057, 1967, 2267, 2799], 'G,': [1069, 1839], 'fibers.': [1076], 'ETS': [1087], 'sham+vehicle': [1089, 1308], '(n=5–7': [1091], 'Data': [1094], 'mean±SEM.': [1096], 'Complex': [1097], 'I': [1098, 1104, 1112, 1124, 1136], 'leak': [1099], 'indicates': [1100], 'on': [1102, 1750, 1855, 2421], 'substrates': [1105], 'compensate': [1107], 'proton': [1109], 'leak;': [1110], 'oxidative': [1113, 1118, 1127], 'phosphorylation': [1114], '(OXPHOS),': [1115], 'I–dependent': [1117], 'phosphorylation;': [1119, 1128], 'OXPHOS,': [1122], 'II–dependent': [1126, 1146], 'ETS,': [1131, 1143], 'noncoupled': [1132, 1144], 'II': [1138, 1142], 'substrates;': [1139], 'respiration.': [1147], '*P<0.05': [1148], 'vs': [1149, 1156, 1159], 'unpaired': [1152], 't': [1153], 'test.': [1154], '†P<0.05': [1155], 'sham+vehicle.': [1157], '‡P<0.05': [1158], 'MI+vehicle': [1160, 1301, 1326, 1368, 1382], '1-way': [1162], 'ANOVA': [1163], 'followed': [1164], 'Tukey': [1167], 'test.We': [1168], 'designed': [1169], 'dysfunction': [1181, 1826, 2467], 'randomly': [1192], 'divided': [1193], 'into': [1197], 'groups:': [1199], 'those': [1200, 1216], 'treated': [1201, 1217, 1243, 1340], '(rhBDNF;': [1206], '5': [1207, 1213], 'mg/kg': [1208], 'body': [1209], 'weight': [1210], 'day,': [1212], 'times/wk)': [1214], '(PBS)': [1220], 'subcutaneous': [1222], 'injection': [1224], 'additional': [1227], 'weeks.': [1229], 'Dainippon': [1230], 'Sumitomo': [1231], 'Pharma': [1232], '(Osaka,': [1233], 'Japan)': [1234], 'kindly': [1235], 'provided': [1236], 'rhBDNF.': [1238], 'Non-MI': [1239], 'vehicle.': [1245], '4': [1247], 'treatment),': [1254], 'all': [1255], 'performed': [1258], 'sham+vehicle,': [1261], 'MI+vehicle,': [1262], 'MI+rhBDNF': [1264, 1321, 1363], 'groups': [1265], '[D]).Echocardiography': [1267], 'revealed': [1268, 1288], 'morphology': [1272], 'affected': [1277], 'rhBDNF': [1280, 1310, 1341, 1385, 1450, 1467, 1573], 'blot': [1286], 'analyses': [1287], 'group': [1302], 'resulted': [1312], 'higher': [1316], '[E]).': [1329], 'In': [1330, 1591], 'preliminary': [1332], 'vitro': [1335], 'C2C12': [1337], 'myotubes,': [1338], 'exogenously': [1339], 'increased': [1342, 1397], 'endogenous': [1343], 'via': [1345, 1404, 1581, 1948, 2084, 2604], 'cellular': [1346], 'rather': [1348], 'than': [1349], 'gene': [1350], 'improved': [1360, 1387, 1454, 1574], '[F]).': [1371], 'mice,': [1383, 2469, 2519, 2658], '[G]).': [1391], 'clarified': [1394], 'biogenesis': [1399, 1500], 'fatty': [1401, 1502, 2610], 'acid': [1402, 1503, 2078, 2611], 'oxidation': [1403, 1947, 2612], 'upregulation': [1406], 'AMP-activated': [1408, 1473, 1486, 1951], 'kinase': [1410, 1475, 1488], 'α–peroxisome': [1411, 1476], 'proliferator-activated': [1412, 1477], 'receptor': [1413, 1478], 'γ': [1414, 1479], 'coactivator': [1415, 1480], '1α': [1416, 1481], 'signaling': [1417, 2283], 'shown).We': [1423], 'provide': [1425], 'first': [1427], 'report': [1428, 1720], 'decreased': [1436], 'dysfunction.': [1462], 'effective': [1464], 'accompanied': [1469], 'activation': [1471, 1949, 2606], 'signaling,': [1482], 'links': [1484], 'between': [1485], 'identified.5': [1492], 'Given': [1493], 'involved': [1497], 'metabolism,': [1504], 'speculate': [1506], 'decrease': [1509], 'one': [1517, 1548], 'mechanisms': [1520], 'underlying': [1521], 'abnormalities': [1530, 2035, 2355], 'Various': [1533], 'hormones': [1534], 'secreted': [1536, 1563], 'muscles,': [1539], 'resulting': [1540], 'various': [1542], 'physiological': [1543], 'effects;': [1544], 'may': [1546, 1633], 'be': [1547, 1634], 'these': [1550], 'hormones.': [1551], 'However,': [1552], 'it': [1553], 'yet': [1556], 'known': [1557], 'how': [1558], 'regulated': [1561], 'muscle.Our': [1566], 'demonstrated': [1568], 'improvement': [1583], 'muscle.': [1590], 'present': [1593], 'pandemic': [1595], 'era,': [1596], 'development': [1598], 'treatments': [1600], 'reverse': [1602], 'quality': [1610, 1858], 'life': [1612], 'very': [1619], 'important': [1620], 'task.': [1621], 'Treatment': [1622], 'combination': [1627], 'plus': [1630], 'such': [1635], 'treatment.Sources': [1637], 'FundingThis': [1639], 'study': [1640, 1739], 'supported': [1642], 'part': [1644], 'Center': [1647], 'Innovation': [1649], 'Program': [1650], 'Science': [1654, 1666, 2846], 'Technology': [1656], 'Agency': [1657], 'Society': [1661], 'Promotion': [1664], '(KAKENHI': [1667], 'grants': [1668], 'JP26750331': [1669], 'JP17H04758': [1671], 'Dr': [1673, 1678], 'JP18H03187': [1676], 'Kinugawa).DisclosuresH.': [1679], 'received': [1681], 'lecture': [1682], 'fees': [1683], 'Astellas': [1685, 1715], 'Pharma,': [1686, 1694, 1699], 'Pharmaceutical,': [1688, 1690], 'Takeda': [1689], 'Daiichi-Sankyo,': [1691, 1713], 'Mitsubishi': [1692], 'Tanabe': [1693], 'Nippon': [1695], 'Boehringer': [1696], 'Ingelheim,': [1697], 'Novartis': [1698], 'Bayer': [1700], 'Yakuhin,': [1701], 'Bristol-Myers': [1703], 'Squibb,': [1704], 'funding': [1709], 'Actelion': [1711], 'Pharmaceuticals,': [1712], 'Pharma.': [1716], 'other': [1718], 'authors': [1719], 'no': [1721], 'conflicts.Footnotes*Drs': [1722], 'J.': [1723, 1830], 'contributed': [1727], 'equally.https://www.ahajournals.org/journal/circData': [1728], 'sharing:': [1729], 'materials': [1733], 'supporting': [1734], 'findings': [1736], 'available': [1741], 'article': [1744], 'corresponding': [1748], 'author': [1749], 'reasonable': [1751], 'request.Shintaro': [1752], 'protected]hokudai.ac.jpReferences1.': [1778], 'Mancini': [1779], 'DM,': [1780], 'Eisen': [1781], 'H,': [1782, 1874, 1926, 2111, 2127, 2208, 2218, 2247, 2294, 2328, 2451, 2485, 2489, 2567, 2636, 2672, 2793], 'Kussmaul': [1783], 'W,': [1784, 2117, 2198], 'Mull': [1785], 'R,': [1786, 1835, 2064, 2306, 2453, 2579], 'Edmunds': [1787], 'LH,': [1788], 'Wilson': [1789], 'JR.': [1790], 'Value': [1791], 'consumption': [1796], 'optimal': [1798], 'timing': [1799], 'transplantation': [1802], 'ambulatory': [1804], 'failure.Circulation.': [1808], '1991;': [1809], '83:778–786.LinkGoogle': [1810], 'Scholar2.': [1811], 'Okita': [1812], 'K,': [1813, 2066, 2312, 2330, 2404, 2491, 2587], 'S,': [1815, 2024, 2107, 2115, 2125, 2188, 2192, 2206, 2216, 2296, 2298, 2406, 2445, 2447, 2483, 2487, 2499, 2569, 2577, 2634, 2670, 2678, 2723, 2725, 2762], 'H.': [1817], 'intolerance': [1819], 'chronic': [1821, 1851, 1986], 'failure:': [1823, 1853, 2038], 'potential': [1828], 'therapies.Circ': [1829], '2013;': [1831], '77:293–300.CrossrefMedlineGoogle': [1832], 'Scholar3.': [1833], 'Belardinelli': [1834], 'Georgiou': [1836], 'Cianci': [1838], 'Purcaro': [1840], 'A.': [1841], 'Randomized,': [1842], 'controlled': [1843], 'trial': [1844], 'long-term': [1846], 'moderate': [1847], 'effects': [1854], 'functional': [1856], 'capacity,': [1857], 'life,': [1860], 'clinical': [1862], 'outcome.Circulation.': [1863], '1999;': [1864], '99:1173–1182.LinkGoogle': [1865], 'Scholar4.': [1866], 'Yu': [1867], 'T,': [1868, 1910, 2109, 2123, 2186, 2202, 2214, 2257, 2304, 2308, 2310, 2324, 2334, 2443, 2501, 2583, 2585, 2640, 2642, 2676, 2721, 2727, 2731, 2733], 'Chang': [1869], 'Y,': [1870, 2210, 2261, 2314, 2332, 2402, 2493, 2497, 2589, 2682], 'Gao': [1871], 'XL,': [1872], 'Li': [1873, 1970, 2248, 2794], 'Zhao': [1875, 2246, 2800], 'P.': [1876], 'Dynamic': [1877], 'role': [1881], 'exercise-induced': [1885], 'regeneration.Int': [1888], 'J': [1889, 2272, 2801], 'Sports': [1890, 2017, 2179, 2537], 'Med.': [1891], '2017;': [1892], '38:959–966.': [1893], 'doi:': [1894, 1956], '10.1055/s-0043-118343CrossrefMedlineGoogle': [1895], 'Scholar5.': [1896], 'Matthews': [1897], 'VB,': [1898], 'Aström': [1899], 'MB,': [1900], 'Chan': [1901], 'MH,': [1902], 'Bruce': [1903], 'CR,': [1904], 'Krabbe': [1905], 'KS,': [1906], 'Prelovsek': [1907], 'O,': [1908], 'Akerström': [1909], 'Yfanti': [1911], 'Broholm': [1913], 'Mortensen': [1915], 'OH,': [1916], 'Penkowa': [1917], 'M,': [1918, 2060, 2194, 2318, 2735], 'Hojman': [1919], 'P,': [1920, 2791, 2795], 'Zankari': [1921], 'A,': [1922, 2121, 2200, 2320, 2322, 2369, 2371, 2503, 2571, 2591, 2674, 2729], 'Watt': [1923], 'MJ,': [1924], 'Bruunsgaard': [1925], 'Pedersen': [1927], 'BK,': [1928], 'Febbraio': [1929], 'MA.': [1930], 'produced': [1935], 'cells': [1939], 'response': [1941], 'contraction': [1943], 'enhances': [1945], 'fat': [1946], 'kinase.Diabetologia.': [1953], '2009;': [1954], '52:1409–1418.': [1955], '10.1007/s00125-009-1364-1CrossrefMedlineGoogle': [1957], 'Scholar': [1958], 'Previous': [1959], 'Back': [1960], 'top': [1962], 'Next': [1963], 'FiguresReferencesRelatedDetailsCited': [1964], 'By': [1965], 'Fang': [1966], 'Zhang': [1968, 2250, 2256, 2262], 'X,': [1969, 2255], 'B': [1971], 'Gan': [1973], 'S': [1974, 2029, 2132, 2223, 2339, 2458, 2508, 2596, 2647, 2767], '(2022)': [1975, 2009, 2030, 2074], 'miR-182-5p': [1976], 'combined': [1977], 'assists': [1982], 'diagnosis': [1984], 'predicts': [1990], 'poor': [1992], 'prognosis,': [1993], 'Journal': [1994, 2012, 2046, 2093, 2174, 2532, 2556, 2621], 'Cardiothoracic': [1996], 'Surgery,': [1997], '10.1186/s13019-022-01802-0,': [1998], '17:1,': [1999], 'Online': [2000, 2055, 2100, 2167, 2240, 2289, 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