A <scp>RAD</scp> 51 assay feasible in routine tumor samples calls <scp>PARP</scp> inhibitor response beyond <scp>BRCA</scp> mutation

Name: Work Video:
Duration: 3 min 30 s
Marta Castroviejo‐Bermejo; Cristina Cruz; Alba Llop‐Guevara; Sara Gutiérrez‐Enríquez; Mandy Ducy; Yasir H. Ibrahim; Albert Gris‐Oliver; Benedetta Pellegrino; Alejandra Bruna; Marta Guzmán; Olga Rodríguez; Judit Grueso; Sandra Bonache; Alejandro Moles‐Fernández; Guillermo Villacampa; Cristina Viaplana; Patricia Gómez; María Vidal; Vicente Peg; Xavier Serres; Graham Dellaire; Jacques Simard; Paolo Nucíforo; Isabel T. Rubio; Rodrigo Dienstmann; J. Carl Barrett; Carlos Caldas; José Baselga; Cristina Saura; Javier Cortés; Olivier Déas; Jos Jonkers; Jean‐Yves Masson; Stefano Cairo; Jean‐Gabriel Judde; Mark J. O’Connor; Orland Dı́ez; Judith Balmañà; Violeta Serra
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784, 822, 858, 894, 908, 934, 974, 988, 1002, 1027, 1061, 1103, 1137, 1158, 1205, 1226, 1246, 1301, 1324, 1345, 1376, 1405, 1426, 1447, 1468, 1488, 1508, 1531, 1554, 1590, 1645, 1672, 1695, 1714, 1740, 1769, 1805, 1847, 1864, 1905, 1943, 1979, 2015, 2029, 2055, 2095, 2109, 2123, 2148, 2182, 2224, 2258], 'for': [38, 85, 106, 126, 181, 204, 225, 256, 285, 306, 327, 348, 368, 388, 411, 434, 470, 525, 552, 575, 594, 620, 649, 685, 727, 744, 785, 823, 859, 895, 909, 935, 975, 989, 1003, 1028, 1062, 1104, 1138, 1159, 1206, 1227, 1247, 1302, 1325, 1346, 1377, 1406, 1427, 1448, 1469, 1489, 1509, 1532, 1555, 1591, 1646, 1673, 1696, 1715, 1741, 1770, 1806, 1848, 1865, 1906, 1944, 1980, 2016, 2030, 2056, 2096, 2110, 2124, 2149, 2183, 2225, 2259, 3062, 3310, 3350, 3355], 'more': [39, 86, 107, 127, 182, 205, 226, 257, 286, 307, 328, 349, 369, 389, 412, 435, 471, 526, 553, 576, 595, 621, 650, 686, 728, 745, 786, 824, 860, 896, 910, 936, 976, 990, 1004, 1029, 1063, 1105, 1139, 1160, 1207, 1228, 1248, 1303, 1326, 1347, 1378, 1407, 1428, 1449, 1470, 1490, 1510, 1533, 1556, 1592, 1647, 1674, 1697, 1716, 1742, 1771, 1807, 1849, 1866, 1907, 1945, 1981, 2017, 2031, 2057, 2097, 2111, 2125, 2150, 2184, 2226, 2260], 'papers': [40, 87, 108, 128, 183, 206, 227, 258, 287, 308, 329, 350, 370, 390, 413, 436, 472, 527, 554, 577, 596, 622, 651, 687, 729, 746, 787, 825, 861, 897, 911, 937, 977, 991, 1005, 1030, 1064, 1106, 1140, 1161, 1208, 1229, 1249, 1304, 1327, 1348, 1379, 1408, 1429, 1450, 1471, 1491, 1511, 1534, 1557, 1593, 1648, 1675, 1698, 1717, 1743, 1772, 1808, 1850, 1867, 1908, 1946, 1982, 2018, 2032, 2058, 2098, 2112, 2126, 2151, 2185, 2227, 2261], 'by': [41, 88, 109, 129, 184, 207, 228, 259, 288, 309, 330, 351, 371, 391, 414, 437, 473, 528, 555, 578, 597, 623, 652, 688, 730, 747, 788, 826, 862, 898, 912, 938, 978, 992, 1006, 1031, 1065, 1107, 1141, 1162, 1209, 1230, 1250, 1305, 1328, 1349, 1380, 1409, 1430, 1451, 1472, 1492, 1512, 1535, 1558, 1594, 1649, 1676, 1699, 1718, 1744, 1773, 1809, 1851, 1868, 1909, 1947, 1983, 2019, 2033, 2059, 2099, 2113, 2127, 2152, 2186, 2228, 2262, 2882, 3054, 3161, 3272, 3665, 3809, 4126], 'this': [42, 89, 110, 130, 185, 208, 229, 260, 289, 310, 331, 352, 372, 392, 415, 438, 474, 529, 556, 579, 598, 624, 653, 689, 731, 748, 789, 827, 863, 899, 913, 939, 979, 993, 1007, 1032, 1066, 1108, 1142, 1163, 1210, 1231, 1251, 1306, 1329, 1350, 1381, 1410, 1431, 1452, 1473, 1493, 1513, 1536, 1559, 1595, 1650, 1677, 1700, 1719, 1745, 1774, 1810, 1852, 1869, 1910, 1948, 1984, 2020, 2034, 2060, 2100, 2114, 2128, 2153, 2187, 2229, 2263, 2904, 2942, 3526], 'author': [43, 90, 111, 131, 186, 209, 230, 261, 290, 311, 332, 353, 373, 393, 416, 439, 475, 515, 530, 557, 580, 599, 625, 654, 690, 717, 732, 749, 790, 828, 864, 900, 914, 940, 980, 994, 1008, 1033, 1067, 1109, 1143, 1164, 1211, 1232, 1252, 1307, 1330, 1351, 1382, 1411, 1432, 1453, 1474, 1494, 1514, 1537, 1560, 1596, 1636, 1651, 1678, 1701, 1720, 1746, 1775, 1811, 1838, 1853, 1870, 1911, 1949, 1985, 2021, 2035, 2061, 2101, 2115, 2129, 2154, 2188, 2230, 2264, 2722], 'Cristina': [44, 46, 417, 419, 829, 831, 1165, 1167, 1538, 1540, 1950, 1952, 2269, 2298, 2326], 'Cruz': [45, 47, 1166, 1168], 'High': [58, 1077, 1179, 2198], 'Risk': [59, 1078, 1180, 2199, 2363], 'and': [60, 154, 271, 459, 495, 759, 797, 848, 924, 963, 1018, 1048, 1079, 1181, 1275, 1392, 1580, 1616, 1880, 1918, 1969, 2045, 2084, 2139, 2169, 2200, 2348, 2364, 2415, 2456, 2483, 2572, 2621, 2634, 2644, 2703, 2721, 2790, 2802, 2824, 2867, 2896, 2911, 3164, 3176, 3183, 3234, 3240, 3293, 3316, 3326, 3508, 3546, 3550, 3669, 3678, 3688, 3702, 3721, 3728, 3763, 3805, 3819, 3830, 3903, 3919, 3967, 3971, 3986, 3992, 4010, 4012, 4040, 4072, 4087, 4092, 4106, 4119, 4132, 4142], 'Familial': [61, 1080, 1182, 2201, 2365], 'Cancer': [62, 158, 266, 458, 494, 673, 754, 773, 775, 780, 804, 816, 847, 925, 929, 967, 1081, 1183, 1279, 1387, 1579, 1615, 1794, 1875, 1894, 1896, 1901, 1925, 1937, 1968, 2046, 2050, 2088, 2202, 2366, 2419, 2482, 2543, 2559, 2561, 2566, 2579, 2591, 2622, 2626], 'Department': [71, 148, 245, 272, 444, 480, 562, 585, 760, 810, 833, 877, 957, 1090, 1192, 1269, 1366, 1393, 1565, 1601, 1683, 1706, 1881, 1931, 1954, 1998, 2078, 2211, 2457], 'Medical': [73, 152, 247, 446, 482, 835, 961, 1092, 1194, 1273, 1368, 1567, 1603, 1956, 2082, 2213, 2377, 2413, 2443], 'Hospital': [75, 250, 448, 484, 565, 675, 837, 1052, 1094, 1196, 1371, 1569, 1605, 1686, 1796, 1958, 2173, 2215, 2379, 2446, 2512, 2545, 2648], "d'Hebron,": [77, 450, 486, 567, 677, 839, 1054, 1096, 1198, 1571, 1607, 1688, 1798, 1960, 2175, 2217, 2381, 2514, 2547, 2650], 'Universitat': [78, 451, 487, 568, 678, 840, 1055, 1097, 1199, 1572, 1608, 1689, 1799, 1961, 2176, 2218, 2382, 2515, 2548, 2651], 'Autònoma': [79, 452, 488, 569, 679, 841, 1056, 1098, 1200, 1573, 1609, 1690, 1800, 1962, 2177, 2219, 2383, 2516, 2549, 2652], 'de': [80, 140, 166, 453, 489, 545, 570, 605, 632, 663, 680, 842, 871, 949, 1057, 1099, 1131, 1201, 1261, 1287, 1574, 1610, 1666, 1691, 1726, 1753, 1784, 1801, 1963, 1992, 2070, 2178, 2220, 2252, 2384, 2401, 2427, 2503, 2517, 2550, 2653], 'Alba': [91, 93, 1212, 1214, 2271], 'Llop-Guevara': [92, 94, 1213, 1215], 'Sara': [112, 114, 1233, 1235, 2273], 'Gutiérrez-Enríquez': [113, 115, 1234, 1236], 'Oncogenetics': [116, 358, 378, 1038, 1237, 1479, 1499, 2159], 'Mandy': [132, 134, 1253, 1255, 2275], 'Ducy': [133, 135, 1254, 1256], 'Genome': [136, 945, 1257, 2066], 'Stability': [137, 946, 1258, 2067, 2398], 'Laboratory,': [138, 947, 1259, 2068, 2399], 'CHU': [139, 165, 604, 948, 1260, 1286, 1725, 2069, 2400], 'Québec': [141, 144, 161, 176, 615, 950, 953, 970, 1262, 1265, 1282, 1297, 1736, 2071, 2074, 2091, 2402, 2405, 2422, 2437], 'Center,': [143, 160, 172, 174, 611, 613, 674, 805, 817, 952, 969, 1264, 1281, 1293, 1295, 1732, 1734, 1795, 1926, 1938, 2073, 2090, 2404, 2421, 2433, 2435, 2544, 2580, 2592], 'City,': [145, 162, 177, 616, 954, 971, 1266, 1283, 1298, 1737, 2075, 2092, 2406, 2423, 2438], 'QC,': [146, 163, 178, 617, 955, 972, 1267, 1284, 1299, 1738, 2076, 2093, 2407, 2424, 2439], 'Canada': [147, 164, 179, 592, 618, 956, 973, 1268, 1285, 1300, 1713, 1739, 2077, 2094, 2408, 2425, 2440, 2528], 'Molecular': [150, 638, 922, 959, 1049, 1271, 1759, 2043, 2080, 2170, 2411, 2619, 2645], 'Biology,': [151, 960, 1272, 2081, 2412], 'Biochemistry': [153, 962, 1274, 2083, 2414], 'Pathology,': [155, 587, 964, 1276, 1708, 2085, 2416, 2523], 'Laval': [156, 170, 609, 965, 1277, 1291, 1730, 2086, 2417, 2431], 'University': [157, 249, 279, 539, 767, 883, 966, 1278, 1370, 1400, 1660, 1888, 2004, 2087, 2418, 2445, 2464, 2497, 2603], 'Quebec': [167, 606, 1288, 1727, 2428], '-': [168, 607, 1289, 1728, 2429], 'Université': [169, 608, 1290, 1729, 2430], 'Genomics': [173, 612, 1294, 1733, 2434], 'CHUL,': [175, 614, 1296, 1735, 2436], 'Yasir': [187, 190, 1308, 1311, 2277], 'Hussein': [188, 191, 1309, 1312, 2278], 'Ibrahim': [189, 192, 1310, 1313], 'Albert': [210, 212, 1331, 1333, 2280], 'Gris-Oliver': [211, 213, 1332, 1334], 'Benedetta': [231, 233, 1352, 1354, 2282], 'Pellegrino': [232, 234, 1353, 1355, 3072], 'Parma,': [252, 253, 1373, 1374, 2448, 2449], 'Italy': [254, 1375, 2450], 'Alejandra': [262, 264, 1383, 1385, 2284], 'Bruna': [263, 265, 1384, 1386], 'UK': [268, 283, 756, 771, 777, 783, 1026, 1389, 1404, 1877, 1892, 1898, 1904, 2147, 2453, 2468, 2563, 2569, 2642], 'Cambridge': [269, 757, 779, 1390, 1878, 1900, 2454, 2565], 'Li': [275, 763, 1396, 1884, 2460], 'Ka': [276, 764, 1397, 1885, 2461], 'Shing': [277, 765, 1398, 1886, 2462], 'Centre,': [278, 766, 781, 1399, 1887, 1902, 2463, 2567], 'Cambridge,': [281, 282, 769, 770, 782, 1025, 1402, 1403, 1890, 1891, 1903, 2146, 2466, 2467, 2568, 2641], 'Guzmán': [292, 294, 1413, 1415], 'Olga': [312, 314, 1433, 1435, 2288], 'Rodríguez': [313, 315, 1434, 1436], 'Judit': [333, 335, 1454, 1456, 2290], 'Grueso': [334, 336, 1455, 1457], 'Sandra': [354, 356, 1475, 1477, 2292], 'Bonache': [355, 357, 1476, 1478], 'Alejandro': [374, 376, 1495, 1497, 2294], 'Moles-Fernández': [375, 377, 1496, 1498], 'Guillermo': [394, 396, 1515, 1517, 2296], 'Villacampa': [395, 397, 1516, 1518], 'Oncology': [398, 421, 639, 695, 796, 1015, 1519, 1542, 1760, 1816, 1917, 2136, 2530, 2571], 'Data': [399, 422, 696, 1520, 1543, 1817, 2470], 'Science': [400, 423, 697, 1521, 1544, 1818, 2471], '(OdysSey': [401, 424, 698, 1522, 1545, 1819, 2472], 'Group),': [402, 425, 699, 1523, 1546, 1820, 2473], 'Viaplana': [418, 420, 1539, 1541], 'Patricia': [440, 442, 1561, 1563, 2300], 'Gómez': [441, 443, 1562, 1564], 'Breast': [457, 493, 669, 672, 772, 846, 1578, 1614, 1790, 1793, 1893, 1967, 2542], 'Melanoma': [460, 496, 849, 1581, 1617, 1970, 2484], 'Maria': [476, 478, 1597, 1599, 2302], 'Vidal': [477, 479, 1598, 1600], 'SpainCorrection': [504, 706, 1625, 1827], 'added': [505, 707, 1626, 1828], 'on': [506, 708, 1627, 1829, 3801], '16': [507, 1628], 'January': [508, 1629], '2019,': [509, 711, 1630, 1832], 'after': [510, 712, 1631, 1833, 3470, 3718, 3740, 3905], 'first': [511, 713, 1632, 1834, 3958], 'online': [512, 714, 1633, 1835], 'publication:': [513, 715, 1634, 1836], 'the': [514, 716, 1635, 1837, 2663, 2666, 2711, 2774, 2777, 2817, 2821, 2825, 2835, 2839, 2869, 2883, 2891, 2898, 2929, 3038, 3050, 3113, 3137, 3141, 3162, 3211, 3232, 3252, 3278, 3294, 3322, 3337, 3370, 3376, 3386, 3426, 3436, 3450, 3460, 3463, 3515, 3565, 3586, 3633, 3637, 3714, 3787, 3798, 3814, 3831, 3835, 3843, 3846, 3876, 3927, 3960, 3990, 4022, 4049, 4067, 4084, 4120], 'name': [516, 718, 1637, 1839], '"Marc': [517, 1638], 'Vidal"': [518, 523, 1639, 1644], 'was': [519, 721, 1640, 1842, 2855, 3753], 'corrected': [520, 722, 1641, 1843], 'to': [521, 723, 1642, 1844, 2724, 2727, 2758, 2765, 2927, 2971, 3037, 3095, 3157, 3220, 3249, 3313, 3318, 3556, 3606, 3629, 3724, 3755, 3797, 3812, 3908, 4048], '"Maria': [522, 1643], 'Vicente': [531, 533, 1652, 1654, 2304], 'Peg': [532, 534, 1653, 1655], 'Pathology': [535, 923, 1656, 2044, 2620], 'Department,': [536, 1657, 2494], 'Hospital,': [540, 884, 1661, 2005, 2498, 2604], 'CIBERONC,': [543, 630, 661, 869, 1129, 1664, 1751, 1782, 1990, 2250], 'Instituto': [544, 631, 662, 870, 1130, 1665, 1752, 1783, 1991, 2251, 2502], 'Salud': [546, 633, 664, 872, 1132, 1667, 1754, 1785, 1993, 2253, 2504], 'Carlos': [547, 634, 665, 750, 752, 873, 1133, 1668, 1755, 1786, 1871, 1873, 1994, 2254, 2322, 2505], 'III,': [548, 635, 666, 874, 1134, 1669, 1756, 1787, 1995, 2255, 2506], 'Madrid,': [549, 636, 667, 875, 885, 1135, 1670, 1757, 1788, 1996, 2006, 2256, 2507, 2605], 'Xavier': [558, 560, 1679, 1681, 2306], 'Serres-Créixams': [559, 561, 1680, 1682], 'Radiology,': [564, 1685, 2511], 'Graham': [581, 583, 1702, 1704, 2308], 'Dellaire': [582, 584, 1703, 1705], 'Dalhousie': [588, 1709, 2524], 'University,': [589, 1710, 2525], 'Halifax,': [590, 1711, 2526], 'NS,': [591, 1712, 2527], 'Jacques': [600, 602, 1721, 1723, 2310], 'Simard': [601, 603, 1722, 1724], 'Paolo': [626, 628, 1747, 1749, 2312], 'Nuciforo': [627, 629, 1748, 1750], 'Isabel': [655, 658, 1776, 1779, 2314], 'T': [656, 659, 1777, 1780, 2315], 'Rubio': [657, 660, 1778, 1781], 'Surgical': [670, 1791, 2540], 'Unit,': [671, 1023, 1792, 2144, 2541, 2639], 'Rodrigo': [691, 693, 1812, 1814, 2317], 'Dienstmann': [692, 694, 1813, 1815], '12': [709, 1830], 'July': [710, 1831], '"Rodrigo': [719, 724, 1840, 1845], 'Dientsmann"': [720, 1841], 'Dienstmann"': [725, 1846], 'J': [733, 736, 1010, 1013, 1854, 1857, 2131, 2134, 2319, 2341], 'Carl': [734, 737, 1855, 1858, 2320], 'Barrett': [735, 738, 1856, 1859], 'AstraZeneca,': [739, 1024, 1860, 2145, 2640], 'Waltham,': [740, 1861, 2555], 'MA,': [741, 1862, 2556], 'USA': [742, 809, 821, 1863, 1930, 1942, 2557, 2584, 2596], 'Caldas': [751, 753, 1872, 1874], 'Programme,': [774, 1895, 2560], '(CRUK)': [778, 1899, 2564], 'José': [791, 793, 1912, 1914, 2324], 'Baselga': [792, 794, 1913, 1915], 'Human': [795, 1916], 'Pathogenesis': [798, 1919, 2573], 'Program': [799, 1920, 2574], '(HOPP),': [800, 1921, 2575], 'Memorial': [801, 813, 1922, 1934, 2576, 2588], 'Sloan': [802, 814, 1923, 1935, 2577, 2589], 'Kettering': [803, 815, 1924, 1936, 2578, 2590], 'New': [806, 818, 1927, 1939, 2581, 2593], 'York,': [807, 819, 1928, 1940, 2582, 2594], 'NY,': [808, 820, 1929, 1941, 2583, 2595], 'Medicine,': [812, 1933, 2587], 'Saura': [830, 832, 1951, 1953], 'Javier': [865, 867, 1986, 1988, 2328], 'Cortés': [866, 868, 1987, 1989], 'Ramón': [880, 2001, 2600], 'y': [881, 2002, 2601], 'Cajal': [882, 2003, 2602], 'Olivier': [901, 903, 2022, 2024, 2330], 'Déas': [902, 904, 2023, 2025], 'XenTech,': [905, 985, 999, 2026, 2106, 2120], 'Evry,': [906, 986, 1000, 2027, 2107, 2121, 2615], 'France': [907, 987, 1001, 2028, 2108, 2122, 2616], 'Jos': [915, 917, 2036, 2038, 2332], 'Jonkers': [916, 918, 2037, 2039], 'orcid.org/0000-0002-9264-9792': [919, 2040], 'Division': [920, 2041], 'Genomics,': [926, 2047, 2623], 'The': [927, 932, 2048, 2053, 2624, 2629, 2852, 2886, 2937, 2946, 2958, 3690, 3732, 3770, 3821], 'Netherlands': [928, 933, 2049, 2054, 2625, 2630], 'Institute,': [930, 2051, 2627], 'Amsterdam,': [931, 2052, 2628], 'Jean-Yves': [941, 943, 2062, 2064, 2334], 'Masson': [942, 944, 2063, 2065], 'Stefano': [981, 983, 2102, 2104, 2336], 'Cairo': [982, 984, 2103, 2105], 'Jean-Gabriel': [995, 997, 2116, 2118, 2338], 'Judde': [996, 998, 2117, 2119], 'Mark': [1009, 1012, 2130, 2133, 2340], "O'Connor": [1011, 1014, 2132, 2135], 'Innovative': [1016, 2137, 2632], 'Medicines': [1017, 2138, 2633], 'Early': [1019, 2140, 2635], 'Clinical': [1020, 1047, 2141, 2168, 2636], 'Development': [1021, 2142, 2637], 'Biotech': [1022, 2143, 2638], 'Orland': [1034, 1036, 2155, 2157, 2343], 'Díez': [1035, 1037, 2156, 2158], 'Genetics': [1050, 2171, 2646], 'Area,': [1051, 2172, 2647], 'Judith': [1068, 1072, 2189, 2193, 2345], 'Balmaña': [1069, 1073, 2190, 2194, 2346], 'Corresponding': [1070, 1112, 2191, 2233], 'Author': [1071, 1113, 2192, 2234, 2265], '[email': [1074, 1116, 2195, 2237, 2679, 2692], 'protected]': [1075, 1117, 2196, 2238, 2680, 2693], 'orcid.org/0000-0002-0762-6415': [1076, 2197], 'Violeta': [1110, 1114, 2231, 2235, 2349], 'Serra': [1111, 1115, 2232, 2236, 2350], 'orcid.org/0000-0001-6620-1065': [1118, 2239], 'Information': [2266], 'Castroviejo-Bermejo1,': [2268], 'Cruz1,2,3,': [2270], 'Llop-Guevara1,': [2272], 'Gutiérrez-Enríquez4,': [2274], 'Ducy5,6,7,': [2276], 'Ibrahim1,': [2279], 'Gris-Oliver1,': [2281], 'Pellegrino1,8,': [2283], 'Bruna9,': [2285], 'Guzmán1,': [2287], 'Rodríguez1,': [2289], 'Grueso1,': [2291], 'Bonache4,': [2293], 'Moles-Fernández4,': [2295], 'Villacampa10,': [2297], 'Viaplana10,': [2299], 'Gómez3,11,': [2301], 'Vidal3,11,': [2303], 'Peg12,13,': [2305], 'Serres-Créixams14,': [2307], 'Dellaire15,': [2309], 'Simard7,': [2311], 'Nuciforo13,16,': [2313], 'Rubio13,17,': [2316], 'Dienstmann10,': [2318], 'Barrett18,': [2321], 'Caldas9,19,': [2323], 'Baselga20,21,': [2325], 'Saura3,11,': [2327], 'Cortés13,22,23,': [2329], 'Déas24,': [2331], 'Jonkers25,': [2333], 'Masson5,6,': [2335], 'Cairo24,': [2337], 'Judde24,': [2339], "O'Connor26,": [2342], 'Díez4,27,': [2344], '*,2,3': [2347], '*,1,13': [2351], '1Experimental': [2352], '2High': [2362], '3Department': [2375], '4Oncogenetics': [2388], '5Genome': [2397], '6Department': [2409], '7CHU': [2426], '8Department': [2441], '9Cancer': [2451], '10Oncology': [2469], '11Breast': [2481], '12Pathology': [2493], '13CIBERONC,': [2501], '14Department': [2509], '15Department': [2521], '16Molecular': [2529], '17Breast': [2539], '18AstraZeneca,': [2554], '19Breast': [2558], '20Human': [2570], '21Department': [2585], '22Department': [2597], '23Vall': [2607], '24XenTech,': [2614], '25Division': [2617], '26Oncology': [2631], '27Clinical': [2643], '‡1–27': [2657], 'Affiliations': [2658], 'can': [2659, 3269], 'be': [2660, 3216, 3270, 3503], 'found': [2661, 3945], 'at': [2662, 3834], 'end': [2664], 'article': [2667, 2701], '*Corresponding': [2668, 2681], 'author.': [2669, 2682], 'Tel:': [2670, 2683], '+34': [2671, 2675, 2684, 2688], '93': [2672, 2676, 2685, 2689], '2746000;': [2673], 'Fax:': [2674, 2687], '4894212;': [2677, 2690], 'E-mail:': [2678, 2691], '2543450;': [2686], 'EMBO': [2694], 'Mol': [2695], 'Med': [2696], '(2018)10:e9172https://doi.org/10.15252/emmm.201809172': [2697], 'PDFDownload': [2698], 'PDF': [2699], 'text': [2702], 'main': [2704], 'figures.': [2705], 'Peer': [2706], 'ReviewDownload': [2707], 'a': [2708, 2976, 2982, 3059, 3149, 3221, 3241, 3599, 3614, 3623, 3778], 'summary': [2709], 'editorial': [2712, 2716], 'decision': [2713, 2717], 'including': [2715, 2753, 2807, 2848, 2994, 3081], 'letters,': [2718], 'reviewer': [2719], 'comments': [2720], 'responses': [2723], 'feedback.': [2725], 'ToolsAdd': [2726], 'favoritesDownload': [2728], 'CitationsTrack': [2729], 'CitationsPermissions': [2730], 'ShareFacebookTwitterLinked': [2731], 'InMendeleyWechatReddit': [2732], 'Figures': [2733], '&': [2734, 3031, 3329], 'Info': [2735], 'Abstract': [2736], 'Poly(ADP-ribose)': [2737, 2986], 'polymerase': [2738], '(PARP)': [2739], 'inhibitors': [2740, 2933, 3097], '(PARPi)': [2741], 'are': [2742, 2925, 2989, 3052, 3092, 3347, 3807, 3891, 4128, 4135], 'effective': [2743], 'cancers': [2745, 3952], 'with': [2746, 2981, 2991, 3016, 3077, 3083, 3510, 3592, 3603, 3654, 3893, 4083], 'defective': [2747, 3383], 'homologous': [2748, 2826, 3055], 'recombination': [2749, 2827, 3056], 'DNA': [2750, 2972, 2997, 3015, 3041, 3066, 3471, 3581], 'repair': [2751, 2995, 3007, 3057, 3064], '(HRR),': [2752, 3058], 'BRCA1/2-related': [2754, 2907, 2935], 'cancers.': [2755, 2851, 2908, 2936], 'test': [2757], 'identify': [2759, 3598], 'additional': [2760], 'HRR-deficient': [2761, 2881, 3590], 'tumors': [2762, 2877, 3239, 3432, 3626, 3782, 3795, 3869], 'will': [2763], 'help': [2764, 3597], 'extend': [2766, 2928], 'their': [2767], 'use': [2768, 2930, 3212, 3371], 'new': [2770], 'indications.': [2771], 'We': [2772, 3631, 3924], 'evaluated': [2773], 'activity': [2775, 3178, 3612, 3635, 3658, 3772], 'PARPi': [2778, 2859, 2862, 3117, 3142, 3171, 3214, 3340, 3356, 3511, 3558, 3607, 3630, 3638, 3761, 3898, 3920, 4107], 'olaparib': [2779, 3143, 3639, 3655, 3725, 3774, 3883, 3909, 3937, 4068], 'patient-derived': [2781, 3617], 'xenografts': [2783], '(PDXs)': [2784], 'from': [2785, 2903, 3382, 3645, 3711, 3867, 3887, 3989], 'breast': [2786, 2845, 2965, 3134, 3851, 3857, 3951], 'cancer': [2787, 3135, 3185], '(BC)': [2788], 'patients': [2789, 3147, 3226, 3354, 3648], 'investigated': [2791, 3926], 'mechanisms': [2792, 3759], 'sensitivity': [2794, 2860, 3605, 3762, 3921], 'through': [2795], 'exome': [2796], 'sequencing,': [2797], 'BRCA1': [2798, 3087, 3325, 3453, 3456, 3538, 3541, 3543, 3941, 3966, 3969, 3983, 4018, 4037, 4043, 4054, 4078, 4089, 4093, 4112, 4117, 4123], 'promoter': [2799, 3454, 3539, 3942, 3984, 4019, 4055, 4079, 4113], 'methylation': [2800, 3943, 3985, 4030], 'analysis,': [2801], 'immunostaining': [2803], 'HRR': [2805, 3080, 3259, 3267, 3437, 3464, 3476, 3519, 3531], 'proteins,': [2806], 'nuclear': [2809, 3314, 3468, 3972, 4044, 4094, 4124], 'foci.': [2810], 'In': [2811, 2872, 3133, 3264, 3491, 3525, 4033], 'an': [2812], 'independent': [2813, 3868], 'BC': [2814, 2865, 2895, 3225, 3601, 3616, 3647, 3751], 'PDX': [2815, 3642, 3661, 3693, 3747, 3838, 3923, 3976, 4024, 4104], 'panel,': [2816], 'predictive': [2818], 'capacity': [2819, 2952], 'score': [2823, 2830, 2854, 2939, 2948, 2960], 'deficiency': [2828, 3268], '(HRD)': [2829], 'were': [2831, 2878, 3695, 3709, 4046, 4144], 'compared.': [2832], 'To': [2833], 'examine': [2834], 'clinical': [2836, 2873, 2943, 3114, 3177, 3233, 3832], 'feasibility': [2837], 'assay,': [2841], 'we': [2842, 3494, 3528, 3561, 3957], 'scored': [2843], 'archival': [2844], 'samples,': [2847, 2874], 'PALB2-related': [2849, 2876], 'hereditary': [2850], 'highly': [2856, 2912, 3627], 'discriminative': [2857, 2951], 'versus': [2861], 'resistance': [2863, 3512, 3765, 3899], 'PDXs': [2866, 3717, 3776, 3886], 'outperformed': [2868], 'genomic': [2870, 3379], 'test.': [2871], 'all': [2875], 'classified': [2879], 'as': [2880, 3118, 3287, 3321, 3473, 3663, 4146], 'score.': [2885], 'functional': [2887], 'biomarker': [2888], 'enables': [2890], 'identification': [2892, 3587], 'PARPi-sensitive': [2894, 3781], 'broadens': [2897], 'population': [2899, 3602], 'who': [2900], 'may': [2901, 2940, 3254, 3596], 'benefit': [2902], 'therapy': [2905, 3357], 'Synopsis': [2909], 'Sensitive': [2910], 'specific': [2913], 'biomarkers': [2914, 3346, 3532], 'usable': [2915], 'archived': [2917], 'formalin': [2918], 'fixed': [2919], 'parafin': [2920], 'embedded': [2921], '(FFPE)': [2922, 3574], 'tumour': [2923], 'needed': [2926, 3349], 'satisfy': [2941], 'unmet': [2944], 'need.': [2945], 'shows': [2949], 'complete': [2950, 3671], 'predicting': [2954], 'response.': [2957, 3559], 'is': [2961, 2979, 3308, 3425, 3568, 3910, 3944], 'without': [2968, 3577], 'prior': [2969, 3578], 'exposure': [2970, 3720, 3907], 'damaging': [2973], 'agents.': [2974], 'Carrying': [2975], 'PALB2': [2977, 3307], 'associated': [2980], 'low': [2983, 4027], 'RAD51score.': [2984], 'Introduction': [2985], 'polymerases': [2987], '(PARPs)': [2988], 'enzymes': [2990], 'diverse': [2992], 'functions,': [2993], 'single-strand': [2998], 'breaks': [2999, 3043], '(SSBs).': [3000], 'inhibition': [3002], 'not': [3003, 3738], 'only': [3004], 'impairs': [3005], 'SSB': [3006], 'but': [3008], 'also': [3009, 3173, 3255], 'results': [3010, 3139, 3988], 'trapping': [3013], 'onto': [3014], 'subsequent': [3017], 'stalling': [3018], 'replication': [3020], 'forks': [3021], '(Plummer,': [3022], '2006;': [3023, 3189], 'Helleday,': [3024], '2011;': [3025, 3361], 'Murai': [3026], 'et': [3027, 3069, 3073, 3100, 3104, 3108, 3122, 3126, 3130, 3168, 3187, 3191, 3195, 3199, 3203, 3207, 3261, 3299, 3303, 3333, 3359, 3363, 3396, 3400, 3404, 3408, 3412, 3416, 3440, 3444, 3479, 3483, 3488, 3522, 3954, 3996], 'al,': [3028, 3070, 3074, 3101, 3105, 3109, 3123, 3127, 3131, 3169, 3188, 3192, 3196, 3200, 3204, 3208, 3262, 3300, 3304, 3334, 3360, 3364, 3397, 3401, 3405, 3409, 3413, 3417, 3441, 3445, 3480, 3484, 3489, 3523, 3955, 3997], '2012;': [3029, 3331, 3402, 3406], 'Lord': [3030], 'Ashworth,': [3032], '2017).': [3033, 3075, 3170, 3209, 3365, 3418], 'Both': [3034], 'effects': [3035], 'contribute': [3036], 'formation': [3039, 3974, 4096], 'double-strand': [3042], '(DSBs)': [3044], 'that,': [3045, 3496], 'replicated': [3047], 'areas': [3048], 'genome,': [3051], 'repaired': [3053], 'conservative': [3060], 'mechanism': [3061, 3517], 'error-free': [3063], 'damage': [3067], '(Saredi': [3068], '2016;': [3071, 3201], 'Cells': [3076], 'defects': [3078, 3257], 'those': [3082], 'deleterious': [3084], 'variants': [3085], 'or': [3088, 3277, 3385, 3459, 3680], 'BRCA2': [3089, 3311, 3327], '(BRCA1/2)': [3090], 'genes': [3091, 3285, 3297, 3394, 3933], 'particularly': [3093], 'sensitive': [3094, 3628], '(PARPi;': [3098], 'Bryant': [3099], '2005;': [3102, 3106], 'Farmer': [3103], 'Rottenberg': [3107], '2008),': [3110], 'which': [3111, 3552, 3595], 'prompted': [3112], 'development': [3115], 'anticancer': [3119], 'therapies': [3120], '(Fong': [3121], '2009;': [3124], 'Audeh': [3125], '2010;': [3128, 3398, 3481], 'Tutt': [3129], '2010).': [3132], '(BC),': [3136], 'efficacy': [3138], '(Lynparza®)': [3144], 'metastatic': [3146], 'carrying': [3148], 'germline': [3150], 'BRCA1/2': [3151, 3276], '(gBRCA)': [3152], 'pathogenic': [3153], 'variant': [3154], 'have': [3155, 3172, 3256, 3434], 'led': [3156, 3248], 'its': [3158], 'recent': [3159], 'approval': [3160], 'Food': [3163], 'Drug': [3165], 'Administration': [3166], '(Robson': [3167], 'shown': [3174, 4129, 4136], 'preclinical': [3175], 'gBRCA': [3180, 3219, 3343, 3498], 'ovarian': [3182], 'prostate': [3184], '(McCabe': [3186], 'Kaufman': [3190], '2014;': [3193, 3410, 3442, 3485], 'Mateo': [3194], '2015;': [3197, 3301], 'Mirza': [3198], 'Coleman': [3202], '2017;': [3205, 3414], 'Pujade-Lauraine': [3206], 'Similarly,': [3210], 'could': [3215, 3502, 3935], 'extended': [3217], 'wider': [3222, 3600], 'group': [3223], 'harboring': [3227], 'dysfunctional': [3228], 'HRR.': [3229], 'For': [3230], 'example,': [3231], 'molecular': [3235], 'similarities': [3236], 'between': [3237, 3324], 'BRCA1-associated': [3238], 'subset': [3242, 3624, 3779], 'triple': [3244, 3849], 'negative': [3245, 3850], 'BCs': [3246, 3591], '(TNBC)': [3247], 'postulate': [3250], 'that': [3251, 3433, 3564, 3934, 4001, 4052], 'latter': [3253], '(Turner': [3260], '2004).': [3263], 'such': [3265, 3286], 'cases,': [3266], 'explained': [3271], 'epigenetic': [3273, 3963], 'silencing': [3274, 3964], 'genetic': [3279, 3390], 'inactivation': [3280], 'several': [3282], 'other': [3283], 'HRR-related': [3284, 3393, 3536, 3916, 3932, 4101], 'ATM,': [3288], 'ATR,': [3289], 'CHEK1,': [3290], 'CHEK2,': [3291], 'PALB2,': [3292], 'FANC': [3295], 'family': [3296], '(Konstantinopoulos': [3298, 3395], 'Shakeri': [3302], '2016).': [3305, 3490, 3998], 'Specifically,': [3306], 'essential': [3309], 'anchorage': [3312], 'structures': [3315], 'recruitment': [3317], 'DSBs,': [3319], 'acting': [3320], 'link': [3323], '(Buisson': [3328], 'Masson,': [3330], 'Pauty': [3332], '2014).': [3335], 'Despite': [3336], 'success': [3338], 'monotherapy': [3341], 'BC,': [3344], 'appropriate': [3345], 'still': [3348], 'selection': [3351], 'non-gBRCA': [3353, 3589, 3615, 3646], '(Gelmon': [3358], 'Mutter': [3362], 'Some': [3366], 'proposed': [3367], 'approaches': [3368, 3424, 3448], 'include': [3369], 'mRNA': [3373, 3457, 4038, 4090], 'expression': [3374, 3970, 3987, 4039, 4091], 'signatures,': [3375], 'analysis': [3377, 3388], 'scars': [3380], 'derived': [3381, 3644], 'HRR,': [3384], 'individual': [3387], 'alterations': [3391, 3534, 3918, 3930, 4102], 'Abkevich': [3399], 'Wagle': [3403], 'Watkins': [3407], 'Davies': [3411], 'Polak': [3415], 'potential': [3420], 'limitation': [3421], 'these': [3423, 3492], 'lack': [3427, 4041], 'specificity': [3429], 'HRR-altered': [3431], 'restored': [3435], 'function': [3438, 3520], '(Watkins': [3439], 'Konstantinopoulos': [3443], '2015).': [3446], 'Other': [3447], 'entail': [3449], 'quantification': [3451], 'hypermethylation,': [3455, 4020, 4114], 'expression,': [3458, 3542], 'detection': [3461], 'protein': [3465], 'forming': [3467], 'foci': [3469, 3501, 3544, 3548, 3973, 4045, 4095, 4125], 'damage,': [3472], 'surrogate': [3474], 'functionality': [3477], '(Graeser': [3478], 'Naipal': [3482], 'ter': [3486], 'Brugge': [3487], 'sense,': [3493], 'showed': [3495, 4000, 4026, 4053], 'tumors,': [3499], 'detected': [3504], 'untreated': [3506], 'correlated': [3509], 'regardless': [3513], 'underlying': [3516], 'restoring': [3518], '(Cruz': [3521], '2018).': [3524], 'work,': [3527], 'analyzed': [3529, 3968], 'five': [3530], '(genetic': [3533], 'genes,': [3537], 'methylation,': [3540], 'formation,': [3545], 'formation)': [3549], 'tested': [3551], 'one': [3553, 4013], 'performed': [3554], 'better': [3555], 'predict': [3557], 'Importantly,': [3560], 'further': [3562], 'show': [3563], 'formalin-fixed': [3572], 'paraffin-embedded': [3573], 'induction': [3579], 'damage.': [3582], 'Scoring': [3583], 'allowed': [3585], 'high': [3593], 'accuracy,': [3594], 'intrinsic': [3604], 'therapy.': [3608], 'Results': [3609, 3999], 'Olaparib': [3610], 'antitumor': [3611, 3634, 3657, 3771], 'xenograft': [3619], '(PDX)': [3620], 'panel': [3621], 'distinguishes': [3622], 'assessed': [3632, 3664], '18': [3641, 3750], 'models': [3643, 3662, 3694, 3708, 3752, 3890, 3994, 4007, 4025, 4051, 4070], '(PDX': [3649], 'cohort-1,': [3650], 'Table': [3651, 3704], 'EV1).': [3652], 'Treatment': [3653], 'revealed': [3656], 'four': [3660, 3715, 4005, 4050], 'mRECIST': [3666], '(see': [3667], 'Materials': [3668], 'Methods):': [3670], '(CR,': [3673], 'n': [3674, 3684], '=': [3675, 3685], '2:': [3676, 3686], 'PDX093': [3677, 3904], 'PDX197)': [3679, 4011], 'partial': [3681], '(PR,': [3683], 'PDX302': [3687], 'STG201).': [3689], 'remaining': [3691, 4023], 'eleven': [3692], 'olaparib-resistant': [3696, 4014], '(PD,': [3697], 'progressive': [3698], 'disease;': [3699], 'Fig': [3700, 3730, 4063, 4139], '1A': [3701], 'Appendix': [3703, 4062, 4138], 'S1).': [3705, 4064, 4140], 'Additional': [3706], 'resistant': [3707], 'generated': [3710], 'three': [3712, 4002], 'olaparib-sensitive': [3716, 3734, 4006, 4085], 'prolonged': [3719, 3741, 3906], 'steep': [3722], 'progression': [3723], '(STG201OR,': [3726], 'PDX093OR,': [3727], 'PDX302OR;': [3729], '1B).': [3731], 'fourth': [3733], 'model': [3735, 3829, 4015], 'PDX197': [3736], 'did': [3737], 'grow': [3739], 'treatment': [3742, 3884], '(>': [3743], '120': [3744], 'days).': [3745], 'This': [3746], 'collection': [3748], 'used': [3754, 4145], 'study': [3756], 'clinically': [3757], 'relevant': [3758], 'acquired': [3764], 'vivo.': [3767], 'Figure': [3768, 4099], '1.': [3769, 3803], 'identifies': [3777], 'A.': [3783, 4109], 'Waterfall': [3784], 'plot': [3785], 'showing': [3786, 3875], 'percentage': [3788, 3877], 'volume': [3791, 3800, 3880], 'change': [3792, 3881], 'olaparib-treated': [3794], 'compared': [3796], 'day': [3802], '+20%': [3804], '−30%': [3806], 'marked': [3808], 'dotted': [3810], 'lines': [3811], 'indicate': [3813, 3842, 3865], 'range': [3815], 'PR,': [3817], 'SD,': [3818], 'PD.': [3820], 'box': [3822], 'underneath': [3823], 'summarizes': [3824], 'different': [3825], 'characteristics': [3826], 'each': [3828], 'context': [3833], 'moment': [3836], 'implantation.': [3839], 'Black': [3840], 'boxes': [3841], 'presence': [3844, 3928, 4121], 'phenotype.': [3847], 'TNBC,': [3848], 'cancer;': [3852, 3858], 'ER+BC,': [3853], 'estrogen': [3854], 'receptor': [3855], 'positive': [3856, 4147], 'P,': [3859], 'primary;': [3860], 'M,': [3861], 'metastasis.': [3862], 'Error': [3863], 'bars': [3864], 'SEM': [3866], '(n': [3870], '≥': [3871], '3).': [3872], 'B.': [3873], 'Graph': [3874], 'during': [3882], 'cohort-1.': [3888], 'Olaparib-sensitive': [3889], 'represented': [3892], 'discontinuous': [3894], 'lines.': [3895], 'Acquisition': [3896], 'PDX302,': [3901], 'STG201,': [3902, 4009], 'shown.': [3911], 'Download': [3912, 3914], 'figure': [3913], 'PowerPoint': [3915], 'somatic': [3917], 'next': [3925], 'explain': [3936], 'sensitivity.': [3938], 'As': [3939], 'aberrant': [3940], 'approximately': [3947], '10%': [3948], 'sporadic': [3950], '(Shakeri': [3953], '2016),': [3956], 'measured': [3959], 'levels': [3961, 4028, 4076, 4115], 'samples.': [3977], 'Our': [3978], 'approach': [3979], 'validated': [3980], 'previously': [3981], 'reported': [3982], 'STG139': [3991], 'STG201': [3993], '(Bruna': [3995], 'out': [4003], '(PDX302,': [4008], '(PDX270)': [4016], 'presented': [4017], 'while': [4021], '(Fig': [4031, 4057, 4097], '2A).': [4032, 4098], 'agreement,': [4034], 'absence': [4035], 'restricted': [4047], 'hypermethylation': [4056, 4080], '2A,': [4058], 'larger': [4059], 'views': [4060, 4131], 'Of': [4065], 'note,': [4066], 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