Publication Information

{'id': 'https://openalex.org/W2898334442', 'doi': 'https://doi.org/10.1128/aac.01692-18', 'title': 'Spontaneous Mutational Frequency and <i>FKS</i> Mutation Rates Vary by Echinocandin Agent against <i>Candida glabrata</i>', 'display_name': 'Spontaneous Mutational Frequency and <i>FKS</i> Mutation Rates Vary by Echinocandin Agent against <i>Candida glabrata</i>', 'publication_year': 2018, 'publication_date': '2018-10-26', 'ids': {'openalex': 'https://openalex.org/W2898334442', 'doi': 'https://doi.org/10.1128/aac.01692-18', 'mag': '2898334442', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30373796', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6325211'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aac.01692-18', 'pdf_url': 'https://aac.asm.org/content/aac/63/1/e01692-18.full.pdf', 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://aac.asm.org/content/aac/63/1/e01692-18.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5090336151', 'display_name': 'Ryan K. Shields', 'orcid': 'https://orcid.org/0000-0001-9794-5665'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}, {'id': 'https://openalex.org/I4210134769', 'display_name': 'University of Pittsburgh Medical Center', 'ror': 'https://ror.org/04ehecz88', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210098814', 'https://openalex.org/I4210134769']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ryan K. Shields', 'raw_affiliation_strings': ['Antibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA', 'Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA', 'institution_ids': ['https://openalex.org/I170201317']}, {'raw_affiliation_string': 'Antibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA', 'institution_ids': ['https://openalex.org/I4210134769']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007617323', 'display_name': 'Ellen G Kline', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ellen G. Kline', 'raw_affiliation_strings': ['Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085517971', 'display_name': 'Kelley R. Healey', 'orcid': 'https://orcid.org/0000-0001-5636-256X'}, 'institutions': [{'id': 'https://openalex.org/I102322142', 'display_name': 'Rutgers, The State University of New Jersey', 'ror': 'https://ror.org/05vt9qd57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I102322142']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kelley R. Healey', 'raw_affiliation_strings': ['Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA'], 'affiliations': [{'raw_affiliation_string': 'Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA', 'institution_ids': ['https://openalex.org/I102322142']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009008559', 'display_name': 'Milena Kordalewska', 'orcid': 'https://orcid.org/0000-0001-8479-0721'}, 'institutions': [{'id': 'https://openalex.org/I102322142', 'display_name': 'Rutgers, The State University of New Jersey', 'ror': 'https://ror.org/05vt9qd57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I102322142']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Milena Kordalewska', 'raw_affiliation_strings': ['Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA'], 'affiliations': [{'raw_affiliation_string': 'Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA', 'institution_ids': ['https://openalex.org/I102322142']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005383633', 'display_name': 'David S. Perlin', 'orcid': 'https://orcid.org/0000-0002-9503-3184'}, 'institutions': [{'id': 'https://openalex.org/I102322142', 'display_name': 'Rutgers, The State University of New Jersey', 'ror': 'https://ror.org/05vt9qd57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I102322142']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David S. Perlin', 'raw_affiliation_strings': ['Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA'], 'affiliations': [{'raw_affiliation_string': 'Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA', 'institution_ids': ['https://openalex.org/I102322142']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112040008', 'display_name': 'M. Hong Nguyen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}, {'id': 'https://openalex.org/I4210134769', 'display_name': 'University of Pittsburgh Medical Center', 'ror': 'https://ror.org/04ehecz88', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210098814', 'https://openalex.org/I4210134769']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'M. Hong Nguyen', 'raw_affiliation_strings': ['Antibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA', 'Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA', 'institution_ids': ['https://openalex.org/I170201317']}, {'raw_affiliation_string': 'Antibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA', 'institution_ids': ['https://openalex.org/I4210134769']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5024677215', 'display_name': 'Cornelius J. Clancy', 'orcid': 'https://orcid.org/0000-0003-1505-4119'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}, {'id': 'https://openalex.org/I4210134769', 'display_name': 'University of Pittsburgh Medical Center', 'ror': 'https://ror.org/04ehecz88', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210098814', 'https://openalex.org/I4210134769']}, {'id': 'https://openalex.org/I4210133905', 'display_name': 'VA Pittsburgh Healthcare System', 'ror': 'https://ror.org/02qm18h86', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210133905', 'https://openalex.org/I4210147340']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Cornelius J. Clancy', 'raw_affiliation_strings': ['Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA', 'VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA', 'XDR Pathogen Laboratory, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA', 'institution_ids': ['https://openalex.org/I170201317']}, {'raw_affiliation_string': 'XDR Pathogen Laboratory, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA', 'institution_ids': ['https://openalex.org/I4210134769']}, {'raw_affiliation_string': 'VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA', 'institution_ids': ['https://openalex.org/I4210133905']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.532, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 39, 'citation_normalized_percentile': {'value': 0.999918, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '63', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10150', 'display_name': 'Antifungal resistance and susceptibility', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10150', 'display_name': 'Antifungal resistance and susceptibility', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11037', 'display_name': 'Fungal Infections and Studies', 'score': 0.9896, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13160', 'display_name': 'Synthesis and Biological Evaluation', 'score': 0.9821, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/anidulafungin', 'display_name': 'Anidulafungin', 'score': 0.9715313}, {'id': 'https://openalex.org/keywords/echinocandin', 'display_name': 'Echinocandins', 'score': 0.9248364}, {'id': 'https://openalex.org/keywords/candida-glabrata', 'display_name': 'Candida glabrata', 'score': 0.67230016}, {'id': 'https://openalex.org/keywords/echinocandins', 'display_name': 'Echinocandins', 'score': 0.6171643}], 'concepts': [{'id': 'https://openalex.org/C2779020398', 'wikidata': 'https://www.wikidata.org/wiki/Q6827850', 'display_name': 'Micafungin', 'level': 4, 'score': 0.9734884}, {'id': 'https://openalex.org/C2776222947', 'wikidata': 'https://www.wikidata.org/wiki/Q4764531', 'display_name': 'Anidulafungin', 'level': 5, 'score': 0.9715313}, {'id': 'https://openalex.org/C2780402444', 'wikidata': 'https://www.wikidata.org/wiki/Q420875', 'display_name': 'Caspofungin', 'level': 4, 'score': 0.9488808}, {'id': 'https://openalex.org/C2779320740', 'wikidata': 'https://www.wikidata.org/wiki/Q3718510', 'display_name': 'Echinocandin', 'level': 4, 'score': 0.9248364}, {'id': 'https://openalex.org/C2780670043', 'wikidata': 'https://www.wikidata.org/wiki/Q139137', 'display_name': 'Candida glabrata', 'level': 3, 'score': 0.67230016}, {'id': 'https://openalex.org/C2910751997', 'wikidata': 'https://www.wikidata.org/wiki/Q3718510', 'display_name': 'Echinocandins', 'level': 5, 'score': 0.6171643}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5400212}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.5261918}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.44932467}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4298657}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.23996782}, {'id': 'https://openalex.org/C2780651595', 'wikidata': 'https://www.wikidata.org/wiki/Q411478', 'display_name': 'Fluconazole', 'level': 3, 'score': 0.1624479}, {'id': 'https://openalex.org/C2779548794', 'wikidata': 'https://www.wikidata.org/wiki/Q578726', 'display_name': 'Antifungal', 'level': 2, 'score': 0.14305484}], 'mesh': [{'descriptor_ui': 'D000077612', 'descriptor_name': 'Anidulafungin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000935', 'descriptor_name': 'Antifungal Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D041221', 'descriptor_name': 'Candida glabrata', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000077336', 'descriptor_name': 'Caspofungin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D025141', 'descriptor_name': 'Drug Resistance, Fungal', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D005964', 'descriptor_name': 'Glucosyltransferases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000077551', 'descriptor_name': 'Micafungin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000077612', 'descriptor_name': 'Anidulafungin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000935', 'descriptor_name': 'Antifungal Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D041221', 'descriptor_name': 'Candida glabrata', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D041221', 'descriptor_name': 'Candida glabrata', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D041221', 'descriptor_name': 'Candida glabrata', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D041221', 'descriptor_name': 'Candida glabrata', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D002177', 'descriptor_name': 'Candidiasis', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': False}, {'descriptor_ui': 'D002177', 'descriptor_name': 'Candidiasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058365', 'descriptor_name': 'Candidiasis, Invasive', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': False}, {'descriptor_ui': 'D058365', 'descriptor_name': 'Candidiasis, Invasive', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077336', 'descriptor_name': 'Caspofungin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025141', 'descriptor_name': 'Drug Resistance, Fungal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025141', 'descriptor_name': 'Drug Resistance, Fungal', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005656', 'descriptor_name': 'Fungal Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005656', 'descriptor_name': 'Fungal Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005656', 'descriptor_name': 'Fungal Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056426', 'descriptor_name': 'Genetic Loci', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005964', 'descriptor_name': 'Glucosyltransferases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005964', 'descriptor_name': 'Glucosyltransferases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077551', 'descriptor_name': 'Micafungin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008826', 'descriptor_name': 'Microbial Sensitivity Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059645', 'descriptor_name': 'Mutation Rate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aac.01692-18', 'pdf_url': 'https://aac.asm.org/content/aac/63/1/e01692-18.full.pdf', 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6325211', 'pdf_url': 'https://europepmc.org/articles/pmc6325211?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325211', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30373796', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aac.01692-18', 'pdf_url': 'https://aac.asm.org/content/aac/63/1/e01692-18.full.pdf', 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'R21 AI121555'}], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W1576223091', 'https://openalex.org/W1946090000', 'https://openalex.org/W1968846907', 'https://openalex.org/W1978783455', 'https://openalex.org/W1979356733', 'https://openalex.org/W2014409681', 'https://openalex.org/W2085708633', 'https://openalex.org/W2109261304', 'https://openalex.org/W2112597664', 'https://openalex.org/W2122363207', 'https://openalex.org/W2127997803', 'https://openalex.org/W2128160648', 'https://openalex.org/W2128917111', 'https://openalex.org/W2130198427', 'https://openalex.org/W2130900751', 'https://openalex.org/W2139043187', 'https://openalex.org/W2140227964', 'https://openalex.org/W2146599281', 'https://openalex.org/W2149166791', 'https://openalex.org/W2150431004', 'https://openalex.org/W2163061527', 'https://openalex.org/W2163948261', 'https://openalex.org/W2164149772', 'https://openalex.org/W2165481914', 'https://openalex.org/W2179911245', 'https://openalex.org/W2216117396', 'https://openalex.org/W2314754341', 'https://openalex.org/W2565723463', 'https://openalex.org/W2736416755', 'https://openalex.org/W2771120167', 'https://openalex.org/W2782671107'], 'related_works': ['https://openalex.org/W3049451044', 'https://openalex.org/W2160221941', 'https://openalex.org/W2079874851', 'https://openalex.org/W2072639782', 'https://openalex.org/W2046768677', 'https://openalex.org/W2034599708', 'https://openalex.org/W2024537462', 'https://openalex.org/W1979356733', 'https://openalex.org/W180752962', 'https://openalex.org/W1782451125'], 'abstract_inverted_index': {'Echinocandins': [0], 'are': [1, 10], 'front-line': [2], 'agents': [3, 238], 'for': [4, 71, 74, 95, 99, 113, 132, 263], 'treatment': [5], 'of': [6, 19, 29, 86, 103, 141, 194, 200, 217, 243, 266], 'invasive': [7], 'candidiasis.': [8], 'There': [9], 'no': [11], 'reported': [12], 'agent-specific': [13], 'differences': [14], 'in': [15, 147, 186, 233, 239], 'Candida': [16, 41], 'mutational': [17], 'frequency': [18], 'resistance': [20, 87, 244, 256], 'or': [21, 50, 109, 122, 152, 162, 173], 'propensity': [22], 'to': [23, 33, 235, 254], 'develop': [24], 'FKS': [25, 37, 189], 'mutations.': [26], 'The': [27, 204], 'objective': [28], 'this': [30], 'study': [31], 'was': [32, 207], 'measure': [34], 'spontaneous': [35], 'and': [36, 65, 79, 97, 134, 209, 219, 224], 'mutation': [38, 66], 'rates': [39], 'among': [40, 245], 'glabrata': [42, 247], 'strains.': [43], 'Twenty': [44], 'bloodstream': [45], 'isolates': [46, 105, 142, 182], 'from': [47], 'patients': [48], 'with': [49, 171, 176], 'without': [51, 188], 'prior': [52], 'echinocandin': [53, 269], 'exposure': [54, 249], 'were': [55, 69, 93, 106, 130, 166, 221], 'included.': [56], 'Minimum': [57], 'inhibitory': [58, 215], 'concentrations': [59, 63, 68, 216], '(MICs),': [60], 'minimum': [61], 'fungicidal': [62], '(MFCs),': [64], 'prevention': [67], 'higher': [70], 'caspofungin': [72, 96, 114, 177, 218], 'than': [73, 175], 'anidulafungin': [75, 118, 133, 172], '(P': [76, 81, 178], '<': [77, 82], '0.0001)': [78], 'micafungin': [80, 123, 174, 220, 229], '0.0001).': [83], 'Mutational': [84], 'frequencies': [85], 'at': [88, 108, 158], '3×': [89], 'the': [90, 111, 159, 213, 236, 241], 'baseline': [91], 'MIC': [92, 128], 'highest': [94], 'lowest': [98], 'micafungin.': [100, 138], 'A': [101], 'total': [102], '247': [104], 'recovered': [107], 'above': [110], 'MFC': [112], '(n': [115, 119, 124, 149, 154], '=': [116, 120, 125, 150, 155, 179], '159),': [117], '74),': [121], '14).': [126], 'Agent-specific': [127], 'increases': [129, 185], 'noted': [131], 'caspofungin,': [135], 'but': [136, 212], 'not': [137], 'Thirty-three': [139], 'percent': [140], 'harbored': [143, 196], 'hot': [144, 190, 201], 'spot': [145, 191, 202], 'mutations': [146, 198], 'FKS1': [148, 208], '6)': [151], 'FKS2': [153, 210], '76).': [156], 'Mutations': [157], 'Ser629': [160], '(Fks1)': [161], 'Ser663': [163], '(Fks2)': [164], 'loci': [165], 'more': [167], 'common': [168], 'after': [169], 'selection': [170], '0.003).': [180], 'Four': [181], 'demonstrated': [183], '>4-fold': [184], 'MICs': [187], 'mutations;': [192], 'three': [193], 'these': [195], 'Fks2': [197], 'upstream': [199], '1.': [203], 'final': [205], 'isolate': [206], 'wild-type,': [211], '50%': [214], 'increased': [222], '2.7-': [223], '8-fold,': [225], 'respectively.': [226], 'In': [227], 'conclusion,': [228], 'may': [230, 250], 'be': [231, 251], 'superior': [232], 'vitro': [234], 'other': [237], 'limiting': [240], 'emergence': [242], 'C.': [246], 'Caspofungin': [248], 'most': [252], 'likely': [253], 'promote': [255], 'development.': [257], 'These': [258], 'data': [259], 'provide': [260], 'a': [261], 'foundation': [262], 'future': [264], 'investigations': [265], 'newly': [267], 'developed': [268], 'agents.': [270]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2898334442', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2025-01-09T04:10:14.340676', 'created_date': '2018-11-02'}