Publication Information

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2804, 2862, 2979, 3044, 3052, 3174, 3182, 3223, 3287, 3357, 3389, 3410, 3494, 3574, 3602, 3852, 3920, 3981, 4194, 4235], 'the': [2, 55, 72, 89, 137, 143, 153, 206, 223, 240, 288, 294, 309, 313, 319, 337, 348, 354, 395, 399, 403, 466, 471, 490, 497, 504, 508, 519, 544, 569, 575, 586, 615, 657, 689, 693, 716, 751, 755, 777, 795, 815, 868, 904, 917, 939, 992, 1054, 1059, 1122, 1158, 1182, 1186, 1196, 1201, 1207, 1220, 1274, 1281, 1317, 1338, 1351, 1357, 1493, 1496, 1517, 1533, 1602, 1903, 1933, 1946, 2006, 2026, 2148, 2281, 2309, 2327, 2330, 2345, 2376, 2477, 2522, 2541, 2689, 2829, 2941, 2963, 3053, 3118, 3121, 3183, 3318, 3335, 3356, 3419, 3436, 3637, 3744, 3941, 3944, 3959, 4034, 4043, 4108, 4186], 'genes': [3, 39, 154, 190, 771], 'coding': [4, 155], 'for': [5, 25, 80, 156, 176, 231, 633, 660, 1314, 1492, 1936, 2113, 2308, 2326, 2375, 2901, 2955, 3114, 3222, 3332, 3416, 3448, 3521, 3538, 3580, 3816], 'patatin-like': [6, 157, 1507, 2029, 4070], 'phospholipase': [7, 158, 1508, 2030, 4071], 'domain-containing': [8, 13, 159, 164, 1224, 1509, 2031], '1': [9, 160, 2032, 3293, 3296, 3305, 3505, 3516, 4075], '(PNPLA1)': [10, 161, 2033], 'and': [11, 51, 87, 162, 202, 238, 312, 325, 331, 341, 405, 423, 468, 541, 608, 613, 664, 792, 861, 912, 985, 1058, 1117, 1151, 1203, 1213, 1347, 1353, 1379, 1409, 1567, 1620, 1640, 1681, 1756, 1797, 2015, 2042, 2079, 2098, 2141, 2240, 2251, 2270, 2393, 2398, 2500, 2504, 2521, 2574, 2616, 2668, 2703, 2743, 2877, 2947, 2967, 2983, 2989, 3001, 3046, 3094, 3133, 3176, 3202, 3216, 3241, 3243, 3285, 3322, 3330, 3349, 3364, 3383, 3492, 3536, 3572, 3584, 3610, 3619, 3690, 3697, 3701, 3707, 3743, 3793, 3850, 3881, 3931, 3943, 4050, 4079, 4118, 4133, 4150, 4224], 'α/β-hydrolase': [12, 163, 1223], '5': [14, 165, 1225, 2956, 3333, 3449, 3539], '(ABHD5),': [15, 166, 1226], 'also': [16, 167, 1227, 1242, 1344, 1504, 1626, 4261], 'known': [17, 168, 517, 1486, 1505, 3141], 'as': [18, 65, 169, 216, 329, 333, 335, 518, 1229, 1245, 1487, 1506, 2111, 2300, 2304, 2422, 2581, 2708, 2839, 3003, 3018, 3148, 3205, 3248, 3351, 3460, 3482, 3630, 3916, 4076, 4136], 'comparative': [19, 170, 1230, 1417, 1689, 1805], 'gene': [20, 171, 1231, 1275, 1418, 1690, 1725, 1806, 2028], 'identification': [21, 172, 1232, 3119], '58,': [22, 173, 1233], 'are': [23, 174, 413, 686, 773, 1115, 1188, 1526], 'causative': [24, 175], 'ichthyosis,': [26, 177], 'a': [27, 41, 66, 146, 178, 192, 217, 297, 305, 416, 501, 596, 630, 787, 1048, 1277, 1488, 1513, 1596, 1759, 1941, 2145, 2190, 2277, 2323, 2805, 2913, 2970, 3004, 3050, 3081, 3102, 3180, 3234, 3257, 3352, 3390, 3411, 3527, 3561, 3654, 3672, 3679, 3786, 3803, 3917, 3926, 3976, 4077, 4104, 4156], 'severe': [28, 179, 2278], 'skin': [29, 148, 180, 299, 303, 431, 661, 789, 1318, 1411, 1638, 1651, 1683, 1753, 1799, 1926, 2016, 2094, 2194, 2252, 2282, 2331], 'barrier': [30, 181, 307, 392, 441, 488, 582, 662, 783, 791, 812, 936, 1320, 1412, 1458, 1684, 1800, 1846, 1976, 2017, 2195, 2284, 2332, 4006], 'disorder.': [31, 182], 'Individuals': [32, 183], 'with': [33, 77, 85, 108, 129, 184, 228, 236, 259, 280, 1239, 1622, 1738, 2100, 2235, 2290, 2391, 2791, 2800, 2816, 2837, 2865, 2923, 2930, 3145, 3233, 3245, 3256, 3267, 3283, 3375, 3468, 3473, 3550, 3569, 3612, 3642, 3678, 3764, 3785, 3873, 3897, 3910, 3973, 4039, 4057, 4103, 4222], 'mutations': [34, 106, 185, 257, 2024, 2069, 2658, 2696], 'either': [36, 187, 776], 'of': [37, 68, 74, 102, 125, 139, 145, 188, 219, 225, 253, 276, 290, 296, 323, 339, 347, 353, 402, 407, 420, 435, 463, 470, 507, 511, 543, 561, 571, 579, 591, 617, 712, 715, 724, 750, 782, 797, 810, 819, 863, 867, 906, 909, 919, 934, 943, 987, 991, 1024, 1051, 1053, 1056, 1061, 1094, 1153, 1157, 1185, 1219, 1280, 1310, 1316, 1340, 1359, 1495, 1499, 1519, 1532, 1559, 1604, 1751, 1761, 1905, 1943, 1949, 2009, 2092, 2150, 2280, 2311, 2329, 2349, 2481, 2540, 2608, 2735, 2857, 2917, 2943, 2972, 3011, 3055, 3120, 3138, 3185, 3320, 3338, 3362, 3369, 3378, 3395, 3453, 3543, 3658, 3789, 3807, 3842, 3955, 3979, 4037, 4046, 4092, 4107, 4116, 4189, 4232], 'these': [38, 140, 189, 291, 580, 1065, 2291], 'show': [40, 191, 1636, 2387], 'defect': [42, 193, 1413, 1685, 1801, 2107, 2146, 3051, 3181], 'epidermal': [44, 134, 195, 285, 436, 757, 899, 1311, 2012, 2248], 'ω-O-acylceramide': [45, 196], '(AcylCer)': [46, 197], 'biosynthesis,': [47, 198, 2110], 'suggesting': [48, 199, 2358, 3975], 'that': [49, 70, 200, 221, 412, 772, 901, 1343, 1525, 1644, 2034, 2096, 2359, 2380, 2388, 3894, 3970, 4122, 4153, 4259], 'PNPLA1': [50, 69, 86, 130, 201, 220, 237, 281, 2102, 2244, 2265, 2293, 2321, 2350, 2360, 2392, 3258, 3363, 3618, 3801, 3880, 3899, 3930, 3971, 4038, 4049], 'ABHD5': [52, 64, 83, 103, 126, 203, 215, 234, 254, 277, 1360, 1484, 1645, 1944, 2010, 2114, 2389, 3260, 3625, 3808, 3884, 3895, 3908, 3957, 3980, 4052, 4154, 4260], 'act': [53, 204, 2299], 'same': [56, 207], 'metabolic': [57, 208], 'pathway.': [58, 209], 'In': [59, 210, 1355, 1923, 2288, 3251], 'this': [60, 211, 562, 1111, 3889, 3921], 'report,': [61, 212], 'we': [62, 213, 2022, 2386, 3127, 3869, 3892, 4041, 4120], 'identified': [63, 214, 2023], 'coactivator': [67, 218, 1222], 'stimulates': [71, 222, 2394], 'esterification': [73, 224], 'ω-hydroxy': [75, 226, 515, 703, 1931, 2273, 3218], 'ceramides': [76, 227, 516, 704], 'linoleic': [78, 229, 609, 2872, 3213, 3269, 3385], 'acid': [79, 230, 610, 710, 2881, 2933, 3147, 3214, 3247, 3386, 3429, 3646], 'AcylCer': [81, 116, 232, 267, 1762, 1937, 1950, 2109, 2269, 2312, 2395, 3225, 3359, 3455, 3982], 'biosynthesis.': [82, 117, 233, 268, 2396], 'interacts': [84, 235, 2390, 3972, 4221], 'recruits': [88, 239], 'enzyme': [90, 241, 1515], 'to': [91, 113, 131, 242, 264, 282, 688, 707, 786, 794, 916, 1200, 1244, 1337, 1367, 1374, 1897, 1902, 2037, 2144, 2276, 2298, 2364, 2370, 2536, 2828, 2849, 2907, 3008, 3049, 3101, 3125, 3142, 3179, 3589, 3648, 3660, 3715, 3810, 3901, 3958, 4191, 4227], 'its': [92, 243], 'putative': [93, 244], 'triacylglycerol': [94, 245, 1312, 1405, 1522, 1677, 1793], 'substrate': [95, 246, 3221, 3388], 'onto': [96, 247, 3605], 'cytosolic': [97, 248, 4105], 'lipid': [98, 249, 521, 546, 564, 631, 654, 820, 944, 1236, 1346, 1630, 1735, 1894, 2013, 2333, 3122, 3129, 3206, 3381, 3662, 4127, 4159, 4192, 4228], 'droplets.': [99, 250, 4229], 'Conversely,': [100, 251], 'alleles': [101, 252, 1218, 1625], 'carrying': [104, 255, 1216], 'point': [105, 256, 2695], 'associated': [107, 258], 'ichthyosis': [109, 260, 665, 798, 1124, 1240, 2038, 2074, 2239, 2453, 2663], 'humans': [111, 262, 1619, 1757, 2041, 2097, 2142, 3047, 3177], 'failed': [112, 263], 'accelerate': [114, 265], 'PNPLA1-mediated': [115, 266], 'Our': [118, 269], 'findings': [119, 270], 'establish': [120, 271], 'an': [121, 272, 379, 601, 1027, 1647, 2105, 2305, 3937, 4097], 'important': [122, 273, 1308], 'biochemical': [123, 274], 'function': [124, 275, 346, 663, 2008, 2103, 2196, 2246], 'interacting': [128, 279], 'synthesize': [132, 283], 'crucial': [133, 284, 2191], 'lipids,': [135, 286], 'emphasizing': [136, 287], 'significance': [138, 289], 'proteins': [141, 292, 714, 1063, 2363, 2976, 3545, 3761, 4124], 'formation': [144, 295, 467, 560, 905, 1768, 2018], 'functional': [147, 298], 'permeability': [149, 300, 306, 440, 473, 487, 790, 811, 935, 1319, 2253, 2283], 'barrier.': [150, 301], 'The': [302, 377, 433, 559, 577, 722, 748, 1307, 1724, 2694, 2958, 3432, 3451], 'forms': [304, 1184], 'between': [308, 3705, 3929, 3940], 'external': [310, 505, 690], 'environment': [311], "individual's": [314], 'internal': [315], 'milieu,': [316], 'thereby': [317], 'protecting': [318], 'individual': [320], 'from': [321, 336, 1628, 1754, 2403, 2407, 2415, 2510, 3131], 'invasion': [322], 'pathogens': [324], 'harmful': [326], 'substances': [327], 'such': [328], 'chemicals': [330], 'allergens': [332], 'well': [334], 'loss': [338, 1378], 'water': [340, 1377, 2946, 3095, 3412], 'electrolytes': [342], '(1.Madison': [343], 'K.C.': [344], 'Barrier': [345], 'skin:': [349, 378], '"la': [350], 'raison': [351], 'd\'etre"': [352], 'epidermis.J.': [355], 'Invest.': [356, 1469, 1857, 1908, 1987, 2152, 3057, 3187, 4017], 'Dermatol.': [357, 382, 636, 667, 878, 1002, 1030, 1067, 1168, 1470, 1858, 1909, 1988, 2153, 3058, 3188, 4018], '2003;': [358], '121:': [359], '231-241Abstract': [360], 'Full': [361, 363, 448, 450, 641, 643, 672, 674, 827, 829, 882, 884, 951, 953, 1006, 1008, 1172, 1174, 1293, 1295, 1426, 1428, 1474, 1476, 1576, 1578, 1698, 1700, 1814, 1816, 1862, 1864, 1913, 1915, 1992, 1994, 2157, 2159, 2625, 2627, 2752, 2754, 3062, 3064, 3192, 3194, 3859, 3861, 4022, 4024, 4202, 4204, 4243, 4245], 'Text': [362, 364, 449, 451, 642, 644, 673, 675, 828, 830, 883, 885, 952, 954, 1007, 1009, 1173, 1175, 1294, 1296, 1427, 1429, 1475, 1477, 1577, 1579, 1699, 1701, 1815, 1817, 1863, 1865, 1914, 1916, 1993, 1995, 2158, 2160, 2626, 2628, 2753, 2755, 3063, 3065, 3193, 3195, 3860, 3862, 4023, 4025, 4203, 4205, 4244, 4246], 'PDF': [365, 452, 645, 676, 831, 886, 955, 1010, 1176, 1297, 1430, 1478, 1580, 1702, 1818, 1866, 1917, 1996, 2161, 2629, 2756, 3066, 3196, 3863, 4026, 4206, 4247], 'PubMed': [366, 386, 453, 480, 554, 646, 677, 733, 764, 832, 887, 956, 1011, 1071, 1102, 1177, 1298, 1327, 1431, 1479, 1581, 1613, 1703, 1744, 1819, 1867, 1918, 1997, 2085, 2162, 2205, 2260, 2339, 2460, 2630, 2674, 2757, 3067, 3197, 3864, 4027, 4085, 4207, 4248], 'Scopus': [367, 387, 454, 481, 555, 647, 678, 734, 765, 833, 888, 957, 1012, 1072, 1103, 1178, 1299, 1328, 1432, 1480, 1582, 1614, 1704, 1745, 1820, 1868, 1919, 1998, 2086, 2163, 2206, 2261, 2340, 2461, 2631, 2675, 2758, 3068, 3198, 3865, 4028, 4086, 4208, 4249], '(812)': [368], 'Google': [369, 389, 456, 483, 557, 649, 680, 736, 767, 835, 890, 959, 1014, 1035, 1074, 1105, 1180, 1301, 1330, 1434, 1482, 1584, 1616, 1706, 1747, 1822, 1870, 1921, 2000, 2088, 2165, 2208, 2263, 2342, 2463, 2633, 2677, 2760, 3070, 3200, 3867, 4030, 4088, 4210, 4251], 'Scholar,': [370, 457, 650, 737, 836, 960, 1015, 1036, 1075, 1302, 1435, 1585, 1707, 1823, 1871, 2166, 2209, 2634, 4211], '2.Proksch': [371], 'E.': [372, 849, 973, 1139, 1713, 2049, 2055, 2229, 2638, 2644], 'Brandner': [373], 'J.M.': [374], 'Jensen': [375], 'J.': [376, 857, 981, 1019, 1087, 1096, 1147, 1269, 1287, 1306, 1709, 1879, 2127, 2227, 3032, 3162], 'indispensable': [380], 'barrier.Exp.': [381], '2008;': [383, 638, 824, 948], '17:': [384], '1063-1072Crossref': [385], '(1172)': [388], 'Scholar).': [390, 484, 558, 681, 768, 891, 1106, 1331, 1483, 1617, 1748, 1922, 2001, 2089, 2264, 2343, 2678, 2761, 3071, 4031], 'This': [391, 892, 1332, 3967], 'resides': [393], 'stratum': [396, 587], 'corneum': [397], '(SC),': [398], 'outermost': [400], 'layer': [401], 'epidermis,': [404], 'consists': [406], 'terminally': [408], 'differentiated': [409, 2418], 'keratinocytes': [410, 2421], '(corneocytes)': [411], 'embedded': [414], 'lipid-enriched': [417], 'matrix': [418], 'consisting': [419, 510, 3788], 'ceramides,': [421, 1932, 2274], 'cholesterol,': [422], 'nonesterified': [424], 'FAs': [425, 2904], '(3.Feingold': [426], 'K.R.': [427, 459], 'Thematic': [428], 'review': [429], 'series:': [430], 'lipids.': [432], 'role': [434, 723, 1060, 1309, 1649, 1942, 2192, 3978], 'lipids': [437, 464, 492, 583, 784, 1935, 2925, 2964, 3073, 3437], 'cutaneous': [439, 472], 'homeostasis.J.': [442], 'Lipid': [443, 822, 946, 1608], 'Res.': [444, 823, 947, 1609], '2007;': [445, 1068, 1741], '48:': [446], '2531-2546Abstract': [447], '(303)': [455], '4.Feingold': [458], 'Elias': [460, 854, 978, 1041, 1144, 2130, 3035, 3165], 'P.M.': [461, 525, 800, 924, 1042, 2131, 3036, 3166], 'Role': [462], 'maintenance': [469, 1315], 'barrier.Biochim.': [474, 758], 'Biophys.': [475, 549, 728, 759, 1322], 'Acta.': [476, 550, 729, 760, 1323], '2014;': [477, 551, 730, 761, 1032, 1324], '1841:': [478, 552, 731, 762, 1325], '280-294Crossref': [479], '(242)': [482], 'To': [485, 3208, 3354, 3798, 4032], 'provide': [486], 'function,': [489, 1641], 'extracellular': [491], 'form': [493], 'lamellar': [494], 'membranes': [495], 'SC,': [498], 'which': [499, 1195, 1642, 1939, 3139, 3913], 'requires': [500, 614, 2361], 'scaffold': [502], 'on': [503, 568, 1461, 1849, 1979, 2004, 2795, 3074, 3526, 3560, 4009], 'surface': [506], 'corneocytes': [509, 717, 910], 'protein-bound': [512], 'ultra-long-chain': [513], '(ULC)': [514], 'corneocyte-bound': [520], 'envelope': [522, 547, 655], '(CLE)': [523], '(5.Elias': [524], 'Gruber': [526, 1039, 1088, 1448, 1836, 1966, 3996], 'R.': [527, 1040, 1089, 1261, 1449, 1538, 1554, 1589, 1593, 1723, 1837, 1967, 2135, 2215, 2587, 2603, 2714, 2730, 3040, 3170, 3821, 3837, 3997, 4179], 'Crumrine': [528, 1882, 2128, 3033, 3163], 'D.': [529, 1443, 1831, 1883, 1961, 2123, 2129, 3028, 3034, 3158, 3164, 3991], 'Menon': [530], 'G.': [531, 721, 840, 964, 1130, 1386, 1394, 1540, 1544, 1552, 1658, 1666, 1774, 1782, 2133, 2589, 2593, 2601, 2716, 2720, 2728, 3038, 3168, 3823, 3827, 3835, 4177], 'Williams': [532, 801, 925, 1043], 'M.L.': [533, 802, 926, 1044], 'Wakefield': [534], 'J.S.': [535], 'Holleran': [536, 627, 803, 927], 'W.M.': [537, 628, 804, 928], 'Uchida': [538], 'Y.': [539, 626, 745, 1873, 1875, 2174, 2182, 2314], 'Formation': [540], 'functions': [542], 'corneocyte': [545, 1062], '(CLE).Biochim.': [548], '314-318Crossref': [553], '(100)': [556], 'hydrophobic': [563, 581], 'monolayer': [565], 'largely': [566], 'depends': [567, 1460, 1848, 1978, 4008], 'presence': [570], 'ω-O-acylceramides': [572], '(AcylCers)': [573], 'SC.': [576], 'biosynthesis': [578, 1951, 3983], 'occurs': [584], 'granulosum': [588], 'by': [589, 898, 1565, 2197, 2383, 2508, 2614, 2688, 2741, 2940, 3015, 3079, 3099, 3310, 3325, 3423, 3440, 3458, 3519, 3783, 3848, 4053, 4139], 'condensation': [590], 'three': [592, 2928, 3281], 'different': [593, 621], 'carbon': [594, 606], 'chains,': [595], 'long-chain': [597], 'base': [598], '(mainly': [599], 'sphingosine),': [600], 'ω-hydroxylated': [602], 'ULC': [603, 702, 1930, 2272, 3217], 'FA': [604, 2484], '(28–36': [605], 'atoms),': [607], '(Fig.': [611, 623, 1952, 3885, 4112, 4129, 4144], '1A),': [612], 'action': [616], 'at': [618, 2766, 2811, 2899, 2912, 2949, 2952, 2986, 3112, 3327, 3414, 3442, 3445, 3524, 3533, 3558, 3578, 3653, 3695, 4126], 'least': [619], 'five': [620], 'enzymes': [622], '1B)': [624, 1953], '(6.Uchida': [625], 'Omega-O-acylceramide,': [629], 'essential': [632, 2325], 'mammalian': [634, 756, 3235], 'survival.J.': [635], 'Sci.': [637, 668], '51:': [639], '77-87Abstract': [640], '(142)': [648], '7.Akiyama': [651], 'M.': [652, 808, 842, 932, 966, 1038, 1077, 1132, 1388, 1390, 1542, 1546, 1591, 1660, 1662, 1721, 1776, 1778, 1887, 1889, 2062, 2125, 2211, 2217, 2440, 2591, 2595, 2651, 2718, 2722, 3030, 3160, 3825, 3829], 'Corneocyte': [653], '(CLE),': [656], 'key': [658, 1514], 'structure': [659], 'pathogenesis.J.': [666], '2017;': [669, 1471, 1859, 1989, 2154, 2202, 2257, 2336, 3059, 3189, 4019], '88:': [670], '3-9Abstract': [671], '(69)': [679], 'For': [682, 3117, 3595], 'CLE': [683, 1767], 'formation,': [684, 1938], 'AcylCers': [685], 'transferred': [687], 'SC': [691, 921], 'where': [692, 1206], 'ω-esterified': [694], 'linoleoyl': [695], 'moiety': [696], 'is': [697, 896, 1198, 1362, 1485, 1512, 1563, 1731, 2322, 2381, 2612, 2739, 3140, 3802, 3846, 4155, 4225], 'further': [698], 'processed,': [699], 'resulting': [700, 1764], 'covalently': [705], 'bound': [706, 3900], 'specific': [708, 3927], 'amino': [709], 'residues': [711], 'structural': [713], '(8.Krieg': [718], 'P.': [719, 851, 855, 975, 979, 1141, 1145, 1451, 1548, 1717, 1839, 1969, 2430, 2597, 2724, 3831, 3999], 'Fürstenberger': [720], 'lipoxygenases': [725], 'epidermis.Biochim.': [727], '390-400Crossref': [732], '(83)': [735], '9.Muñoz-Garcia': [738], 'A.': [739, 1085, 1259, 1265, 1536, 1587, 1719, 2047, 2172, 2176, 2213, 2320, 2585, 2636, 2712, 3819, 4165, 4171], 'Thomas': [740], 'C.P.': [741], 'Keeney': [742], 'D.S.': [743], 'Zheng': [744], 'Brash': [746], 'A.R.': [747, 1081], 'importance': [749], 'lipoxygenase-hepoxilin': [752], 'pathway': [753], '401-408Crossref': [763], '(82)': [766], 'involved': [774], 'synthesis,': [778, 1763], 'secretion,': [779], 'or': [780, 2410, 2414, 2566, 2776, 2890, 3259, 3470, 3476, 3724, 3732, 3953], 'processing': [781], 'lead': [785], 'defective': [788, 1568, 1766, 2101, 2617, 2744, 3851], 'concomitantly': [793], 'pathophysiology': [796], '(10.Elias': [799, 923], 'Jiang': [805, 929], 'Y.J.': [806, 930], 'Schmuth': [807, 931, 2124, 3029, 3159], 'Pathogenesis': [809, 933], 'abnormalities': [813, 937], 'ichthyoses:': [816, 865, 940, 989, 1155], 'inherited': [817, 864, 941, 988, 1154], 'disorders': [818, 942, 1055, 1093], 'metabolism.J.': [821, 945], '49:': [825, 949], '697-714Abstract': [826, 950], '(154)': [834, 958], '11.Oji': [837, 961], 'V.': [838, 962, 1021, 1079, 1128, 2225, 4163], 'Tadini': [839, 963, 1129], 'Akiyama': [841, 965, 1131, 1888], 'Blanchet': [843, 967, 1133], 'Bardon': [844, 968, 1134], 'C.': [845, 847, 969, 971, 1083, 1135, 1137, 1251, 1453, 1711, 1841, 1971, 2059, 2064, 2186, 2648, 2653, 4001, 4167], 'Bodemer': [846, 970, 1136], 'Bourrat': [848, 972, 1138, 2054, 2643], 'Coudiere': [850, 974, 1140], 'Digiovanna': [852, 976, 1142], 'J.J.': [853, 977, 1143], 'Fischer': [856, 980, 1018, 1146, 1305, 2126, 3031, 3161], 'et': [858, 982, 1148, 1270, 1401, 1456, 1673, 1789, 1844, 1892, 1974, 2067, 2136, 2187, 2230, 2445, 2656, 3041, 3171, 4004, 4182], 'al.Revised': [859, 983, 1149], 'nomenclature': [860, 984, 1150], 'classification': [862, 986, 1152], 'Results': [866, 990, 1156], 'First': [869, 993, 1159], 'Ichthyosis': [870, 994, 1045, 1160], 'Consensus': [871, 995, 1161], 'Conference': [872, 996, 1162], 'Sorze': [874, 998, 1164], '2009.J.': [875, 999, 1165], 'Am.': [876, 1000, 1166], 'Acad.': [877, 1001, 1167], '2010;': [879, 1003, 1169, 1423, 1695, 1811, 1910], '63:': [880, 1004, 1170], '607-641Abstract': [881, 1005, 1171], '(527)': [889, 1013, 1179], 'rare': [893, 1333], 'scaling': [894], 'disorder': [895, 1208, 1335], 'characterized': [897], 'hyperplasia': [900], 'results': [902], 'multiple': [907], 'layers': [908], '(hyperkeratosis)': [911], 'abnormal': [913], 'desquamation': [914], 'leading': [915, 1366, 2275], 'detachment': [918], 'large': [920], 'flakes': [922], '12.Traupe': [1016], 'H.': [1017, 1263, 1447, 1835, 1891, 1965, 2178, 2442, 3995], 'Oji': [1020], 'Nonsyndromic': [1022], 'types': [1023], 'ichthyoses': [1025, 1108, 1342], '-': [1026, 1595], 'update.J.': [1028], 'Dtsch.': [1029], 'Ges.': [1031], '12:': [1033], '109-121PubMed': [1034], '13.Schmuth': [1037], 'update:': [1046], 'towards': [1047], 'function-driven': [1049], 'model': [1050], 'pathogenesis': [1052, 1904], 'cornification': [1057], 'disorders.Adv.': [1066], '23:': [1069], '231-256Crossref': [1070], '(75)': [1073], '14.Schmuth': [1076], 'Martinz': [1078], 'Janecke': [1080], 'Fauth': [1082], 'Schossig': [1084], 'Zschocke': [1086], 'Inherited': [1090], 'ichthyoses/generalized': [1091], 'Mendelian': [1092], 'cornification.Eur.': [1095], 'Hum.': [1097, 1288], 'Genet.': [1098, 1289, 1740, 2081, 2256, 2456, 2670], '2013;': [1099, 2457], '21:': [1100], '123-133Crossref': [1101], '(61)': [1104], 'Although': [1107], 'always': [1109], 'display': [1110], 'visible': [1112], 'scaling,': [1113], 'they': [1114], 'phenotypically': [1116], 'genetically': [1118], 'extremely': [1119], 'heterogeneous.': [1120], 'Since': [1121], 'first': [1123], 'consensus': [1125], 'conference': [1126], '(11.Oji': [1127], 'Scholar),': [1181, 3868, 4089], 'various': [1183], 'disease': [1187, 1197, 1238, 1632, 1737], 'now': [1189], 'classified': [1190], 'into': [1191, 2578], 'nonsyndromic': [1192], 'ichthyoses,': [1193, 1205], 'limited': [1199], 'skin,': [1202], 'syndromic': [1204, 1341], 'additionally': [1209], 'affects': [1210], 'other': [1211], 'tissues': [1212, 1531], 'organs.': [1214], 'Humans': [1215], 'mutant': [1217, 1623, 1925, 2266], 'lipolytic': [1221], 'designated': [1228], 'develop': [1234, 2104], 'neutral': [1235, 1629, 1734], 'storage': [1237, 1631, 1736, 1895], '[NLSDI;': [1241], 'referred': [1243], 'Chanarin-Dorfman': [1246, 1285, 1570, 2619, 2746, 3853, 4236], 'syndrome': [1247], '(OMIM:': [1248, 1633], '275630)]': [1249], '(15.Lefèvre': [1250], 'Jobard': [1252], 'F.': [1253, 1255, 2434], 'Caux': [1254], 'Bouadjar': [1256], 'B.': [1257, 2436], 'Karaduman': [1258], 'Heilig': [1260], 'Lakhdar': [1262], 'Wollenberg': [1264], 'Verret': [1266], 'J.L.': [1267], 'Weissenbach': [1268], 'al.Mutations': [1271, 2446], 'CGI-58,': [1273], 'encoding': [1276, 1726, 3238], 'new': [1278], 'protein': [1279, 1463, 1490, 1851, 1981, 2378, 2990, 3012, 3336, 3368, 3615, 3622, 4011, 4035, 4074, 4111, 4161], 'esterase/lipase/thioesterase': [1282], 'subfamily,': [1283], 'syndrome.Am.': [1286], '2001;': [1290], '69:': [1291], '1002-1012Abstract': [1292], '(392)': [1300], '16.Radner': [1303], 'F.P.W.': [1304, 1382, 1439, 1654, 1770, 1827, 1957, 2426, 3987], 'metabolism': [1313, 2014], 'function.Biochim.': [1321], '409-415Crossref': [1326], '(41)': [1329], 'genetic': [1334], 'belongs': [1336], 'subgroup': [1339], 'affect': [1345], 'energy': [1348], 'homeostasis': [1349], 'liver': [1352], 'brain.': [1354], 'mice,': [1356], 'phenotype': [1358], 'deficiency': [1361, 2115, 2138, 3043, 3173], 'even': [1363], 'more': [1364], 'severe,': [1365], 'premature': [1368], 'death': [1369], 'soon': [1370], 'after': [1371, 2843, 3487, 3635], 'birth': [1372], 'due': [1373], 'increased': [1375], 'transepidermal': [1376], 'desiccation': [1380], '(17.Radner': [1381, 1653, 1769], 'Streith': [1383, 1655, 1771], 'I.E.': [1384, 1656, 1772], 'Schoiswohl': [1385, 1543, 1657, 1773, 2592, 2719, 3826], 'Schweiger': [1387, 1545, 1659, 1775, 2594, 2721, 3828], 'Kumari': [1389, 1661, 1777], 'Eichmann': [1391, 1440, 1663, 1779, 1828, 1958, 2118, 3023, 3153, 3988], 'T.O.': [1392, 1441, 1664, 1780, 1829, 1959, 2119, 3024, 3154, 3989], 'Rechberger': [1393, 1665, 1781], 'Koefeler': [1395, 1667, 1783], 'H.C.': [1396, 1668, 1784], 'Eder': [1397, 1669, 1785], 'S.': [1398, 1400, 1437, 1455, 1670, 1672, 1786, 1788, 1825, 1843, 1877, 1955, 1973, 2051, 2053, 2117, 2121, 2219, 2318, 2428, 2640, 2642, 3022, 3026, 3152, 3156, 3985, 4003, 4173, 4217], 'Schauer': [1399, 1454, 1671, 1787, 1842, 1972, 4002], 'al.Growth': [1402, 1674, 1790], 'retardation,': [1403, 1675, 1791], 'impaired': [1404, 1676, 1792], 'catabolism,': [1406, 1678, 1794], 'hepatic': [1407, 1679, 1795], 'steatosis,': [1408, 1680, 1796], 'lethal': [1410, 1682, 1798], 'mice': [1415, 1621, 1687, 1755, 1803, 2099, 2140, 2242, 3045, 3175], 'lacking': [1416, 1688, 1804], 'identification-58': [1419, 1691, 1807], '(CGI-58).J.': [1420, 1692, 1808], 'Biol.': [1421, 1693, 1809, 4197, 4238], 'Chem.': [1422, 1694, 1810, 4198, 4239], '285:': [1424, 1696, 1812], '7300-7311Abstract': [1425, 1697, 1813], '(151)': [1433, 1705, 1821], '18.Grond': [1436, 1824], 'Radner': [1438, 1826, 1956, 3986], 'Kolb': [1442, 1830, 1960, 2122, 3027, 3157, 3990], 'Grabner': [1444, 1832, 1962, 3992], 'G.F.': [1445, 1833, 1963, 3993], 'Wolinski': [1446, 1834, 1964, 3994], 'Hofer': [1450, 1838, 1968, 3998], 'Heier': [1452, 1840, 1970, 4000], 'al.Skin': [1457, 1845, 1975, 4005], 'development': [1459, 1639, 1847, 1977, 2039, 4007], 'CGI-58': [1462, 1566, 1850, 1980, 2615, 2742, 3849, 4010, 4190, 4220, 4233], 'expression': [1464, 1852, 1982, 2544, 3236, 3261, 4012], 'during': [1465, 1853, 1983, 4013], 'late-stage': [1466, 1854, 1984, 4014], 'keratinocyte': [1467, 1855, 1985, 4015], 'differentiation.J.': [1468, 1856, 1986, 4016], '137:': [1472, 1860, 1990, 2155, 3060, 3190, 4020], '403-413Abstract': [1473, 1861, 1991, 4021], '(27)': [1481, 1869, 1999, 4029], 'coactivating': [1489], 'required': [1491], 'stimulation': [1494], 'hydrolytic': [1497], 'activity': [1498, 2348, 2368, 3361], 'adipose': [1500, 1727, 2412], 'triglyceride': [1501, 1556, 1728, 2605, 2732, 3839], 'lipase': [1502, 1729], '(ATGL;': [1503], '2).': [1510], 'ATGL': [1511, 1624, 2379, 3817], 'catabolism': [1518, 1603], 'intracellular,': [1520], 'nonlysosomal': [1521], '(TAG)': [1523], 'depositions': [1524], 'present': [1527], 'virtually': [1529], 'all': [1530], 'body': [1534], '(19.Lass': [1535, 2584, 2711, 3818], 'Zimmermann': [1537, 1588, 2586, 2713, 3820], 'Haemmerle': [1539, 2132, 2588, 2715, 3037, 3167, 3822], 'Riederer': [1541, 2590, 2717, 3824], 'Kienesberger': [1547, 2596, 2723, 3830], 'Strauss': [1549, 2598, 2725, 3832], 'J.G.': [1550, 2599, 2726, 3833], 'Gorkiewicz': [1551, 2600, 2727, 3834], 'Zechner': [1553, 1592, 2134, 2602, 2729, 3039, 3169, 3836], 'Adipose': [1555, 2604, 2731, 3838], 'lipase-mediated': [1557, 2606, 2733, 3840], 'lipolysis': [1558, 2607, 2734, 3841], 'cellular': [1560, 1605, 2609, 2736, 2975, 3843], 'fat': [1561, 1606, 2610, 2737, 3844], 'stores': [1562, 2611, 2738, 3845], 'activated': [1564, 2382, 2613, 2740, 3847], 'Syndrome.Cell': [1571, 2620, 2747, 3854], 'Metab.': [1572, 2621, 2748, 3855], '2006;': [1573, 2622, 2749, 3856], '3:': [1574, 2623, 2750, 3857], '309-319Abstract': [1575, 2624, 2751, 3858], '(676)': [1583, 2632, 2759, 3866], '20.Lass': [1586], 'Oberer': [1590], 'Lipolysis': [1594], 'highly': [1597], 'regulated': [1598], 'multi-enzyme': [1599], 'complex': [1600], 'mediates': [1601, 4185], 'stores.Prog.': [1607], '2011;': [1610], '50:': [1611], '14-27Crossref': [1612], '(451)': [1615], 'Remarkably,': [1618], 'suffer': [1627], '610717)': [1634], 'but': [1635, 3263], 'normal': [1637], 'indicates': [1643, 1940], 'exerts': [1646], 'ATGL-independent': [1648, 2007], 'physiology': [1652], '21.Fischer': [1708], 'Lefèvre': [1710], 'Morava': [1712], 'Mussini': [1714], 'J-M.': [1715], 'Laforêt': [1716], 'Negre-Salvayre': [1718], 'Lathrop': [1720], 'Salvayre': [1722], '(PNPLA2)': [1730], 'mutated': [1732], 'myopathy.Nat.': [1739], '39:': [1742], '28-30Crossref': [1743], '(368)': [1746], 'Functional': [1749, 2090], 'analyses': [1750, 2091, 2763, 3591, 3711], 'ABHD5-deficient': [1752], 'revealed': [1758, 4096], 'lack': [1760, 3143], '22.Uchida': [1872], 'Cho': [1874], 'Moradian': [1876], 'Kim': [1878, 2065, 2431, 2654], 'Nakajima': [1880], 'K.': [1881, 1885, 2180], 'Park': [1884], 'Ujihara': [1886], 'Shimizu': [1890], 'al.Neutral': [1893], 'leads': [1896, 2143, 3048, 3178], 'acylceramide': [1898, 2199], 'deficiency,': [1899], 'likely': [1900], 'contributing': [1901], 'Dorfman-Chanarin': [1906], 'syndrome.J.': [1907, 4237], '130:': [1911], '2497-2499Abstract': [1912], '(47)': [1920], 'parallel,': [1924, 3252], 'accumulated': [1927, 2271], 'free': [1928], 'extractable': [1929], 'precursor': [1934], 'final': [1947], 'step': [1948], '(18.Grond': [1954, 3984], 'Important': [2002], 'progress': [2003], 'elucidating': [2005], 'was': [2019, 2351, 2686, 2847, 2938, 2965, 2992, 3341, 3421, 3438, 3456, 3640, 3703, 3751, 3914], 'made': [2020], 'when': [2021], 'ATGL-homologous': [2027], 'were': [2035, 2401, 2506, 2534, 2576, 2706, 2764, 2781, 2814, 2835, 2860, 2905, 2926, 2977, 3013, 3077, 3231, 3254, 3264, 3275, 3373, 3466, 3490, 3531, 3548, 3566, 3587, 3600, 3669, 3693, 3712, 3762], 'linked': [2036], 'golden': [2043, 2076, 2665], 'retriever': [2044, 2077, 2666], 'dogs': [2045, 2078, 2667], '(23.Grall': [2046], 'Guaguère': [2048, 2637], 'Planchais': [2050, 2639], 'Grond': [2052, 2641], 'Hausser': [2056, 2645], 'I.': [2057, 2646], 'Hitte': [2058, 2647], 'Le': [2060, 2649], 'Gallo': [2061, 2650], 'Derbois': [2063, 2652], 'G.J.': [2066, 2655], 'al.PNPLA1': [2068, 2137, 2188, 2231, 2657, 3042, 3172], 'cause': [2070, 2449, 2659], 'autosomal': [2071, 2236, 2450, 2660], 'recessive': [2072, 2237, 2451, 2661], 'congenital': [2073, 2238, 2452, 2662], 'humans.Nat.': [2080, 2669], '2012;': [2082, 2671], '44:': [2083, 2672], '140-147Crossref': [2084, 2673], '(177)': [2087, 2676], 'affected': [2093, 2286], 'demonstrated': [2095, 2374], 'identical': [2106], 'shown': [2112], '(24.Grond': [2116, 3021, 3151], 'Dubrac': [2120, 3025, 3155], 'synthesis': [2149, 2250, 2310, 3054, 3184, 3226, 3360, 3452], 'omega-O-acylceramides.J.': [2151, 3056, 3186], '394-402Abstract': [2156, 3061, 3191], '(67)': [2164, 3069, 3199], '25.Hirabayashi': [2167], 'T.': [2168, 2170, 2184, 2223, 4213, 4219], 'Anjo': [2169], 'Kaneko': [2171], 'Senoo': [2173], 'Shibata': [2175], 'Takama': [2177], 'Yokoyama': [2179], 'Nishito': [2181], 'Ono': [2183], 'Taya': [2185], 'has': [2189, 2294, 2372, 3812], 'directing': [2198], 'biosynthesis.Nat.': [2200], 'Commun.': [2201, 2335], '8:': [2203, 2337], '14609Crossref': [2204], '(89)': [2207], '26.Pichery': [2210], 'Huchenq': [2212], 'Sandhoff': [2214], 'Severino-Freire': [2216], 'Zaafouri': [2218], 'Opálka': [2220], 'L.': [2221, 2438, 4175], 'Levade': [2222], 'Soldan': [2224], 'Bertrand-Michel': [2226], 'Lhuillier': [2228], 'defects': [2232], 'patients': [2234], 'KO': [2241], 'sustain': [2243], 'irreplaceable': [2245], 'omega-O-acylceramide': [2249], 'barrier.Hum.': [2254], 'Mol.': [2255], '26:': [2258], '1787-1800Crossref': [2259], '(37)': [2262], 'epidermis': [2267, 2409, 3135], 'lacked': [2268], 'dysfunction': [2279], 'individuals.': [2287], 'line': [2289], 'observations,': [2292], 'recently': [2295], 'been': [2296, 2373, 3813], 'suggested': [2297], 'transacylase,': [2301], 'utilizing': [2302], 'TAG': [2303], 'acyl': [2306], 'donor': [2307, 3215, 3387], '(27.Ohno': [2313], 'Kamiyama': [2315], 'N.': [2316, 4215], 'Nakamichi': [2317], 'Kihara': [2319], 'transacylase': [2324, 2347], 'generation': [2328], 'ω-O-acylceramide.Nat.': [2334], '14610Crossref': [2338], '(78)': [2341], 'However,': [2344], 'measured': [2346], 'relatively': [2352], 'low': [2353], 'vitro': [2356, 2417, 3224, 3358], 'assays,': [2357, 3227], 'additional': [2362], 'reach': [2365], 'full': [2366], 'enzymatic': [2367], 'similar': [2369, 3809], 'what': [2371, 3811], 'homologous': [2377], 'ABHD5.': [2384, 3932], 'Here,': [2385], 'Human': [2397, 2570], 'murine': [2399, 2408, 2501, 2572, 3617, 3624, 3878, 3882, 4047], 'cDNAs': [2400], 'prepared': [2402], 'total': [2404, 3391], 'RNA': [2405], 'obtained': [2406, 2939, 3439], 'white': [2411], 'tissue': [2413], 'human': [2419, 2482], 'primary': [2420, 3734], 'described': [2423, 2582, 2709, 3019, 3149, 3249, 3461, 3483, 3631], 'previously': [2424, 2583, 2710, 3020, 3150, 3814], '(28.Radner': [2425], 'Marrakchi': [2427], 'Kirchmeier': [2429], 'G-J.': [2432], 'Ribierre': [2433], 'Kamoun': [2435], 'Abid': [2437], 'Leipoldt': [2439], 'Turki': [2441], 'Schempp': [2443], 'W.': [2444], 'CERS3': [2448, 3242], 'humans.PLoS': [2455], '9:': [2458], 'e1003536Crossref': [2459], '(122)': [2462], 'Scholar)': [2464, 3201, 4252], 'using': [2465, 2513, 2821, 2994, 3343, 3480, 3592, 3628, 3671, 3718, 3753], 'SuperScript': [2466], 'Reverse': [2467], 'Transcriptase': [2468], 'protocol': [2469], '(Invitrogen': [2470, 2547, 2691], 'Life': [2471, 2548, 2692], 'Technologies,': [2472], 'Carlsbad,': [2473], 'CA).': [2474], 'Sequences': [2475], 'containing': [2476, 2962, 3084, 3211, 3380, 3435, 4073], 'complete': [2478], 'open-reading': [2479], 'frame': [2480], 'PNPLA1,': [2483], 'elongase-4': [2485], '(ELOVL4),': [2486], 'cytochrome': [2487], 'P450': [2488], 'family': [2489], '4': [2490], 'subfamily': [2491], 'F': [2492], 'member': [2493], '22': [2494], '(CYP4F22),': [2495], 'ceramide': [2496, 3219], 'synthase': [2497], '3': [2498], '(CERS3),': [2499], 'Pnpla1,': [2502], 'Abhd5,': [2503, 2573], 'Atgl': [2505], 'amplified': [2507], 'PCR': [2509, 2531], 'respective': [2511, 3370], 'cDNA': [2512], 'Phusion': [2514], 'High-Fidelity': [2515], 'DNA': [2516, 2820], 'Polymerase': [2517], '(Finnzymes,': [2518], 'Espoo,': [2519], 'Finland)': [2520], 'gene-specific': [2523], 'primer': [2524], 'pairs': [2525], 'listed': [2526], 'supplemental': [2528], 'Table': [2529], 'S1.': [2530], 'amplification': [2532], 'products': [2533], 'ligated': [2535], 'compatible': [2537], 'restriction': [2538], 'sites': [2539], 'following': [2542], 'eukaryotic': [2543], 'vectors:': [2545], 'pcDNA4/HisMax': [2546, 2579, 2681], 'Technologies),': [2549], 'pFLAG-CMV-5.1': [2550], '(Sigma-Aldrich,': [2551], 'St': [2552], 'Louis,': [2553, 2888], 'MO),': [2554], 'pEYFP-C1': [2555], '(Takara': [2556, 2563], 'Bio': [2557, 2564], 'USA,': [2558], 'Mountain': [2559], 'View,': [2560], 'CA),': [2561], 'pECFP-C1': [2562], 'USA),': [2565, 3742], 'pLVX-ultra-IRES-Puro': [2567], '(see': [2568], 'below).': [2569], 'ABHD5,': [2571, 2698, 3365, 3974, 4040], 'Pnpla1': [2575], 'cloned': [2577], 'vector': [2580, 2682], '23.Grall': [2635], 'A': [2679, 3289, 4184], 'control': [2680, 3919], 'expressing': [2683, 3478, 3626], 'β-galactosidase': [2684], '(β-gal)': [2685], 'provided': [2687], 'manufacturer': [2690], 'Technologies).': [2693], 'c.389A>C': [2699], '(p.Gln130Pro),': [2700], 'c.778G>A': [2701], '(p.Glu260Lys),': [2702], 'c.568C>T': [2704], '(p.Gln190Ter),': [2705], 'generated': [2707], 'Sequence': [2762], 'performed': [2765, 3713, 3870], 'Microsynth': [2767], 'AG': [2768], '(Balgach,': [2769], 'Switzerland).': [2770], 'HEK': [2771, 2832, 3228, 3463, 3874], '293T': [2772, 2833, 3229, 3464, 3875], 'cells': [2773, 2778, 2834, 2859, 2921, 3230, 3253, 3274, 3324, 3465, 3489, 3599, 3668, 3876, 4095], '(ATCC': [2774, 2779], 'CRL-3216)': [2775], 'COS-7': [2777, 3598, 4094], 'CRL-1651)': [2780], 'cultivated': [2782, 2861], 'DMEM': [2784, 2850, 2863], '(Thermo': [2785, 2998], 'Fisher': [2786, 2999], 'Scientific,': [2787], 'Waltham,': [2788], 'MA)': [2789], 'supplemented': [2790, 2864, 3641], '10%': [2792, 3406, 3772, 3794], 'FBS': [2793, 2852], '(Sigma-Aldrich)': [2794, 2803, 2911, 3556, 3652], 'cell': [2796, 3339, 3371], 'culture': [2797, 2845, 3278, 3638], 'dishes': [2798], 'precoated': [2799], '0.1%': [2801, 2984], 'gelatin': [2802], 'standard': [2806, 3716], 'humidified': [2807], '7%': [2808], 'CO2': [2809], 'atmosphere': [2810], '37°C.': [2812], 'Cells': [2813], 'transfected': [2815, 2836, 3232, 3255, 3467, 3611], '2.5': [2817], 'µg': [2818, 3367], 'plasmid': [2819, 3237, 3262], 'Metafectene': [2822, 3481, 3629], '(Biontex': [2823], 'GmbH,': [2824, 3090], 'Munich,': [2825], 'Germany)': [2826, 3609], 'according': [2827, 3714], "manufacturer's": [2830], 'instructions.': [2831], 'plasmids': [2838], 'indicated.': [2840], 'Twenty-four': [2841, 3485], 'hours': [2842, 3486, 3634], 'transfection,': [2844, 3488, 3636], 'medium': [2846, 3639], 'changed': [2848], 'without': [2851], 'supplementation.': [2853], 'After': [2854, 2919, 3271, 3317, 3408, 3665], '30': [2855, 3522], 'min': [2856, 3523], 'incubation,': [2858], '20': [2866, 3299, 3510, 3551], 'µM': [2867, 2871, 2875, 2879, 3644], 'nervonic': [2868], 'acid,': [2869, 2873, 3775], '10': [2870, 2878, 3581], '2': [2874, 3302, 3513], 'sphingosine,': [2876], '[1-14C]linoleic': [2880, 3146, 3246], '(ARC': [2882], '0294;': [2883], 'American': [2884, 2896], 'Radiolabeled': [2885, 2897, 3072], 'Chemicals,': [2886], 'St.': [2887], 'MO)': [2889], '25': [2891], 'nM': [2892], '[3-3H]sphingosine': [2893], '(ART': [2894], '0490;': [2895], 'Chemicals)': [2898], '37°C': [2900, 3415], '6': [2902], 'h.': [2903, 3116], 'complexed': [2906, 3647], 'essentially': [2908, 3649], 'FA-free': [2909, 3650], 'BSA': [2910, 3002, 3350, 3651], 'molar': [2914, 3655], 'FA-BSA': [2915, 3656], 'ratio': [2916, 3657], '3:1.': [2918], 'washing': [2920], 'twice': [2922], 'PBS,': [2924, 3284], 'extracted': [2927], 'times': [2929, 3282], 'chloroform-methanol-glacial': [2931, 3427], 'acetic': [2932, 3428, 3774, 3796], '(66/33/1;': [2934, 3430], 'v/v/v).': [2935, 3431], 'Phase': [2936], 'separation': [2937], 'addition': [2942], '1/5': [2944], 'vol.': [2945], 'centrifugation': [2948, 3326, 3441], '1,400': [2950, 3443], 'g': [2951, 3329, 3444, 3535], 'room': [2953, 3446], 'temperature': [2954, 3447], 'min.': [2957, 3450, 3540, 3582], 'lower': [2959], 'organic': [2960, 3433], 'phase': [2961, 3434], 'collected': [2966], 'dried': [2968], 'under': [2969], 'stream': [2971], 'nitrogen.': [2973], 'Remaining': [2974], 'solubilized': [2978], '0.3': [2980], 'N': [2981], 'NaOH': [2982], 'SDS': [2985], '65°C': [2987], 'overnight,': [2988], 'content': [2991], 'determined': [2993, 3342], 'Pierce': [2995], 'BCA': [2996], 'reagent': [2997, 3083, 3345], 'Scientific)': [3000], 'standard.': [3005, 3353], 'Lipids': [3006], 'corresponding': [3007, 3124], 'equal': [3009, 3376], 'amounts': [3010, 3377, 3542], 'separated': [3014], 'normal-phase': [3016], 'TLC': [3017, 3075, 3459], 'plates': [3076], 'detected': [3078, 3704, 3752], 'spraying': [3080], 'fluorographic': [3082], 'scintillation': [3085], 'cocktail': [3086], '(Rotiszint;': [3087], 'Carl': [3088], 'Roth': [3089], 'Karlsruhe,': [3091], 'Germany),': [3092], 'methanol,': [3093], '(4/1/1;': [3096], 'v/v/v),': [3097], 'followed': [3098, 3782], 'exposure': [3100], 'light-sensitive': [3103], 'film': [3104], '(Amersham': [3105], 'Hyperfilm': [3106], 'ECL;': [3107], 'GE': [3108, 3727], 'Healthcare,': [3109], 'Chicago,': [3110], 'IL)': [3111], '−80°C': [3113], '24–48': [3115], 'spots': [3123], 'AcylCer,': [3126], 'radiolabeled': [3128, 3212, 3268, 3384, 3454], 'extracts': [3130], 'wild-type': [3132], 'PNPLA1-deficient': [3134], '(the': [3136], 'latter': [3137], 'AcylCer)': [3144], 'used': [3203, 3915], 'them': [3204], 'standards.': [3207], 'obtain': [3209], 'homogenates': [3210, 3340, 3372, 3379], 'acceptor': [3220, 3382], 'ELOVL4,': [3239], 'CYP4F22,': [3240], 'labeled': [3244], 'above.': [3250, 3462, 3484, 3632], 'not': [3265, 3935], 'incubated': [3266, 3549], 'acid.': [3270, 3797], '24': [3272], 'h,': [3273, 3667], 'scraped': [3276], 'off': [3277], 'dishes,': [3279], 'washed': [3280, 3568], 'disrupted': [3286], 'buffer': [3288, 3393, 3496, 3571, 3577], '(0.25': [3290], 'M': [3291], 'sucrose,': [3292], 'mM': [3294, 3297, 3399, 3404, 3498, 3503, 3506], 'EDTA,': [3295, 3507], 'dithiothreitol,': [3298], 'mg/ml': [3300, 3303, 3306], 'leupetine,': [3301], 'antipain,': [3304, 3515], 'pepstatin,': [3307], 'pH': [3308, 3401, 3500], '7.0)': [3309], 'sonication': [3311], '(Virsonic': [3312], '475;': [3313], 'Virtis,': [3314], 'Gardiner,': [3315], 'NJ).': [3316], 'removal': [3319], 'nuclei': [3321], 'unbroken': [3323], '1,000': [3328, 3534], '4°C': [3331, 3525, 3537, 3559], 'min,': [3334, 3418], 'concentration': [3337], 'Bradford': [3344], '(Bio-Rad,': [3346], 'Hercules,': [3347], 'CA)': [3348], 'determine': [3355], '100': [3366], 'mixed': [3374], 'assay': [3392], 'volume': [3394], '240': [3396], 'µl': [3397], '(50': [3398, 3497], 'HEPES/NaOH': [3400], '7.4,': [3402, 3501], '150': [3403, 3502], 'NaCl,': [3405, 3504], 'glycerol).': [3407], 'incubation': [3409, 3520], 'bath': [3413], '60': [3417], 'reaction': [3420], 'stopped': [3422], 'adding': [3424], '1.2': [3425], 'ml': [3426], 'analyzed': [3457, 4042], 'FLAG-PNPLA1': [3469], 'FLAG-ATGL': [3471], 'together': [3472], 'histidine': [3474], '(His)-ABHD5': [3475], 'His-β-Gal': [3477], 'vectors': [3479, 3627], 'harvested': [3491], 'lysed': [3493], 'lysis': [3495, 3570], 'Tris/HCl': [3499], '1%': [3508], 'NP-40,': [3509], 'μg/ml': [3511, 3514, 3517], 'leupeptine,': [3512], 'pepstatin)': [3518], 'rotating': [3528, 3562], 'wheel.': [3529, 3563], 'Lysates': [3530], 'centrifuged': [3532], 'Equal': [3541], 'lysate': [3544], '(1': [3546], 'mg)': [3547], 'μl': [3552], 'anti-FLAG': [3553, 3719], 'M2-agarose': [3554], 'beads': [3555, 3565, 3963], 'overnight': [3557], 'Thereafter,': [3564], 'extensively': [3567], 'heated': [3573], '2×': [3575], 'Laemmli': [3576], '95°C': [3579], 'Input': [3583], 'immunoprecipitation': [3585], 'fractions': [3586], 'subjected': [3588], 'immunoblot': [3590], 'appropriate': [3593, 3745], 'antibodies.': [3594], 'localization': [3596, 4045, 4106], 'studies,': [3597], 'seeded': [3601], 'chambers': [3603], 'mounted': [3604], 'coverslips': [3606], '(Sarstedt,': [3607], 'Nümbrecht,': [3608], 'yellow': [3613], 'fluorescent': [3614, 3621, 4090], '(YFP)-tagged': [3616], 'cyan': [3620], '(CFP)-tagged': [3623], 'Four': [3633], '400': [3643], 'oleic': [3645], '3:1': [3659], 'promote': [3661], 'droplet': [3663], 'formation.': [3664], '18': [3666], 'imaged': [3670], 'Leica': [3673, 3680], 'SP5': [3674], 'confocal': [3675], 'microscope': [3676], 'equipped': [3677], 'HCX': [3681], '63×': [3682], '1.4': [3683], 'numerical': [3684], 'aperture': [3685], 'oil': [3686], 'immersion': [3687], 'objective.': [3688], 'CFP': [3689], 'YFP': [3691, 4100], 'fluorescence': [3692], 'excited': [3694], '458': [3696], '514': [3698], 'nm,': [3699], 'respectively,': [3700], 'emission': [3702], '477': [3706], '535': [3708], 'nm.': [3709], 'Immunoblot': [3710], 'protocols': [3717], 'M2-HRP': [3720], '(A8592;': [3721], 'Sigma-Aldrich)': [3722], 'antibody': [3723, 3735], 'anti-His': [3725], '(27-4710-01;': [3726], 'Healthcare),': [3728], 'anti-Xpress': [3729], '(R910-25;': [3730], 'Invitrogen)': [3731], 'anti-GAPDH': [3733], '(2118S;': [3736], 'Cell': [3737], 'Signaling': [3738], 'Technology,': [3739], 'Danvers,': [3740], 'MA,': [3741], 'HRP-conjugated': [3746, 3749], 'secondary': [3747], 'antibody.': [3748], 'IgG': [3750], 'Clarity': [3754], 'Western': [3755], 'ECL': [3756], 'Substrate': [3757], '(Bio-Rad).': [3758], 'Finally,': [3759], 'membrane-bound': [3760], 'stained': [3763], 'Coomassie': [3765, 3778], 'blue': [3766], 'staining': [3767], 'solution': [3768, 3787], '[45%': [3769], '(v/v)': [3770, 3773, 3791, 3795], 'ethanol,': [3771], '0.25%': [3776], '(v/w)': [3777], 'Brilliant': [3779], 'Blue': [3780], 'R250]': [3781], 'destaining': [3784], '30%': [3790], 'ethanol': [3792], 'evaluate': [3799], 'whether': [3800], 'potential': [3804], 'interaction': [3805, 3928, 4036], 'partner': [3806], 'reported': [3815], 'coimmunoprecipitation': [3871], 'experiments': [3872], 'coexpressing': [3877], 'FLAG-tagged': [3879, 3898, 3911], 'His-tagged': [3883, 3907, 3956], '1C,': [3886], 'D).': [3887], 'Using': [3888], 'experimental': [3890], 'setup,': [3891], 'observed': [3893, 4121], 'coimmunoprecipitated': [3896, 3909], 'anti-FLAG-tagged': [3902, 3960], 'antibody-coated': [3903], 'agarose': [3904, 3962], 'beads.': [3905], 'Similarly,': [3906], 'ATGL,': [3912], 'positive': [3918], 'assay.': [3922], 'Experimental': [3923], 'controls': [3924], 'confirmed': [3925], 'We': [3933], 'did': [3934], 'observe': [3936], 'unspecific': [3938], 'binding': [3939, 3954, 4188], 'FLAG-': [3942], 'His-tag': [3945], '(controls:': [3946], 'PNPLA1-FLAG,': [3947], 'His-β-Gal;': [3948], 'His-ABHD5,': [3949], 'empty': [3950], 'FLAG': [3951], 'vector)': [3952], 'antibody-coupled': [3961], '(control:': [3964], 'His-ABHD5': [3965], 'alone).': [3966], 'finding': [3968, 4257], 'demonstrates': [3969, 4258], 'direct': [3977], 'investigate': [4033], 'intracellular': [4044], 'YFP-tagged': [4048], 'CFP-tagged': [4051], 'live-cell': [4054], 'imaging.': [4055], 'Consistent': [4056], 'previous': [4058], 'reports': [4059], '(29.Chang': [4060], 'P.A.': [4061], 'Han': [4062], 'L.P.': [4063], 'Sun': [4064], 'L.X.': [4065], 'Huang': [4066], 'F.F.': [4067], 'Identification': [4068], 'mouse': [4069], 'domain': [4072], 'skin-specific': [4078], 'membrane-associated': [4080], 'protein.Gene.': [4081], '2016;': [4082], '591:': [4083], '344-350Crossref': [4084], '(4)': [4087], 'microscopy': [4091, 4143], 'YFP-PNPLA1-transfected': [4093], 'evenly': [4098], 'distributed': [4099], 'signal,': [4101], 'consistent': [4102], 'YFP-PNPLA1': [4109, 4117], 'fusion': [4110], '2A).': [4113], 'Upon': [4114], 'coexpression': [4115], 'CFP-ABHD5,': [4119], 'both': [4123], 'colocalized': [4125], 'droplets': [4128, 4193], '2B,': [4130, 4145], 'merge': [4131], 'image': [4132, 4149], 'inset),': [4134], 'appearing': [4135], 'vesicular': [4137], 'structures': [4138], 'differential': [4140, 4146], 'interference': [4141, 4147], 'contrast': [4142, 4148], 'inset).': [4151], 'Given': [4152], 'bona': [4157], 'fide': [4158], 'droplet-associated': [4160], '(30.Subramanian': [4162], 'Rothenberg': [4164], 'Gomez': [4166], 'Cohen': [4168], 'A.W.': [4169], 'Garcia': [4170], 'Bhattacharyya': [4172], 'Shapiro': [4174], 'Dolios': [4176], 'Wang': [4178], 'Lisanti': [4180], 'M.P.': [4181], 'al.Perilipin': [4183], 'reversible': [4187], '3T3–L1': [4195], 'adipocytes.J.': [4196], '2004;': [4199, 4240], '279:': [4200, 4241], '42062-42071Abstract': [4201], '(253)': [4209], '31.Yamaguchi': [4212], 'Omatsu': [4214], 'Matsushita': [4216], 'Osumi': [4218], 'perilipin': [4223], 'localized': [4226], 'Possible': [4230], 'involvement': [4231], 'mislocalization': [4234], '30490-30497Abstract': [4242], '(210)': [4250], '(supplemental': [4253], 'Fig.': [4254], 'S1),': [4255], 'our': [4256], 'inter': [4262]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2898143895', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 3}], 'updated_date': '2025-01-12T19:07:04.990784', 'created_date': '2018-11-02'}