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[577], 'management': [579, 3323, 3657], 'required.We': [584], 'used': [585, 1499, 1512], 'VigiBase': [586], '(http://www.vigiaccess.org/),': [587], 'World': [589, 1463], 'Health': [590, 1464, 1485], 'Organization': [591], 'database': [592], 'individual': [594, 679], 'safety': [595, 680, 1869], 'case': [596, 681, 1682, 1849, 2610], 'reports': [597], 'maintained': [598], 'Uppsala': [601], 'Monitoring': [602], 'Sweden.': [605], 'Through': [606, 2283], 'March': [607, 827], '25,': [608], '2018,': [609, 825], 'we': [610, 1102, 1191, 1240], 'identified': [611], '180': [612], 'using': [617, 671], 'High': [619], 'Level': [620], 'Term': [621], '"Muscle': [622], 'infections': [623], 'inflammations"': [625], 'Dictionary': [629, 673], 'for': [630, 674, 722, 1288, 1407, 1419, 1482, 1596, 2084, 2391, 2480, 2560, 2941, 3071, 3319, 3431, 3655], 'Regulatory': [631, 675], 'Activities': [632, 676], 'terms': [633, 1519], 'then': [635], 'refined': [636], 'search': [638], '"Myositis"': [640], 'Preferred': [642], 'Term.': [643], 'We': [644], 'included': [645, 1031], '7': [646], 'approved': [647], 'ICIs': [648], 'search:': [651], 'nivolumab,': [652], 'pembrolizumab,': [653], 'ipilimumab,': [654], 'tremelimumab,': [655], 'avelumab,': [656], 'durvalumab,': [657], 'atezolizumab.': [659], 'Myocarditis': [660, 1762, 1984], 'was': [661, 687, 969, 983, 1145, 1160, 1469], 'defined': [662], 'selection': [664], 'preferred': [668, 1518], 'term': [669], 'level': [670, 3433], 'reports.': [682, 1453], 'Institutional': [683], 'review': [684, 1633, 2382, 3252, 3485], 'board': [685], 'approval': [686], 'not': [688, 1321, 1448, 1457], 'required': [689], '(no': [690], 'intervention': [691], 'human': [693], 'subjects': [694], 'access': [696], 'identifiable': [698], 'information).Affected': [699], 'had': [701, 717, 1128, 1248], 'median': [703, 747, 978], 'age': [704], '71': [706], 'years': [707, 1055], '(range,': [708, 986], '29–90': [709], 'years,': [710], 'data': [711, 1319, 1335, 1373, 1434, 1498], 'available': [712, 849, 970, 1322, 1505], '134/180': [714], 'reports)': [715], 'often': [719], 'treated': [721, 732, 2490, 3398], 'melanoma': [723, 1734], 'lung': [725, 1602], 'cancer.': [726], 'Eighty-five': [727], 'percent': [728], 'were': [731, 1086, 1320], 'monotherapy': [735, 1154], '(Table).Table.': [736], 'Description': [737], 'Patients': [739, 3014, 3690], 'Immune': [741, 1624, 1799, 1839, 1940, 2080, 2116, 2206, 2255, 2353, 2410, 2566, 2597, 2735, 2765, 2853, 3016, 3067, 3118, 3194], 'Inhibitor-Associated': [743], 'MyositisCharacteristicsn/N': [744], '(%)Age,': [745], 'y,': [746], '(IQR)71': [748], '(62.3–76)Male': [749], 'sex110/166': [750], '(62.3)Region': [751], 'reporting': [752, 1048, 1653, 2889], 'myositis/total': [754, 945, 957], 'number': [755, 841, 846, 946, 958], 'America70/19': [760], '867': [761], '(0.35)': [762], 'Europe58/10': [763], '771': [764], '(0.54)': [765], 'Asia47/3469': [766], '(1.4)': [767], 'Oceania5/972': [768], '(5.1)Indication': [769], 'Melanoma56/180': [770], '(31.1)': [771], 'Pulmonary': [772], 'cancer55/180': [773], '(30.6)': [774], 'Renal': [775], 'cancer20/180': [776], '(11.1)': [777], 'Other': [778, 1028], 'cancers*25/180': [779], '(13.9)': [780], 'Unknown24/180': [781], '(13.3)Treatment': [782], 'Monotherapy': [783, 791, 1768], 'anti-PD1/PD-L1149/180': [784], '(83)': [785], 'Nivolumab92': [786], 'Pembrolizumab34': [787], 'Durvalumab20': [788], 'Atezolizumab1': [789], 'Avelumab2': [790], 'anti-CTLA44/180': [792], '(2)': [793], 'Ipilimumab4': [794], 'Tremelimumab0': [795], 'Combination27/180': [796], '(15)': [797], 'Nivolumab+ipilimumab26': [798], 'Durvalumab+tremelimumab1': [799], 'Time': [800], 'onsetN=61': [802], 'Median': [803], '(IQR)': [804], 'days26': [805], '(18–39)': [806], 'Statin': [807], 'exposure25/180': [808], '(13.9)Associated': [809], 'Myasthenia-like': [811], 'disorder28/180': [812], '(15.6)': [813], 'Myocarditis29/180': [814], '(16.1)': [815], 'Other25/180': [816], '(13.9)Fatal': [817], 'outcome‡36/170': [818], '(21.2)Year': [819], 'reportingN=180': [821], '2012–201517': [822], '201643': [823], '2017§87': [824], 'through': [826], '2533ICI': [828], 'indicates': [829], 'inhibitor;': [832], 'IQR,': [833], 'interquartile': [834], 'range;': [835], 'irAE,': [836], 'event;': [839], 'n,': [840], 'cases;': [843], 'N,': [845, 2055, 2061, 2221, 2523, 2907, 2997, 3003, 3510, 3616], 'total': [848], 'data.*Other': [850], 'cancers:': [851], 'colorectal': [852], 'cancer': [853, 861, 864, 869, 881, 884, 887, 899, 933, 940, 1603, 3331, 3427], '(n=4),': [854], 'urothelial': [855], 'carcinoma': [856, 872, 878, 891, 895], '(n=3),': [857, 859, 906, 908, 910, 929, 935, 1035, 1037, 1039], 'thymoma': [858], 'bladder': [860], '(n=2),': [862, 865, 870, 876], 'endometrial': [863], 'head': [866], 'neck': [868], 'neuroendocrine': [871], 'skin': [875], 'hepatocellular': [877], '(n=1),': [879, 882, 885, 888, 892, 896], 'mediastinal': [880], 'pancreas': [883], 'ovarian': [886], 'squamous': [889], 'Merkel': [893], 'prostate': [898], '(n=1).†Other': [900], 'associated': [901, 1147, 1312, 1351, 1628, 1902, 2158, 2385, 2874, 3092, 3239, 3479], 'irAEs:': [902], 'hepatitis': [903, 928, 1032], '(n=14),': [904, 1033], 'colitis': [905, 931, 1034], 'thyroiditis': [907, 1036], 'nephritis': [909, 1038], 'hypophysitis': [912, 1041], '(n=2).‡Fatal': [913], 'outcome:': [914], '(n=10),': [916], 'other': [919], '(n=21': [921], 'including': [922, 1516], 'cardiac': [923, 1431, 2308, 2502], 'mostly': [925], '(n=17),': [927], '(n=1)),': [932], 'progression': [934, 941], 'combined': [937], '(n=2).§In': [942], '2017,': [943], 'reported': [948, 961], '87/15': [952], '334': [953], '(0.57%),': [954], 'drug-induced': [960], '87/405': [963], '(21.5%).Precise': [964], 'timing': [965], 'onset': [968, 982], '61': [972], 'patients.': [973], 'In': [974, 1065, 1227], 'these': [975, 1318], 'patients,': [976], 'time': [979], '26': [984], 'days': [985], '18–39': [987], 'days)': [988], 'after': [989, 1224], 'exposure': [992], 'ICIs.': [994], 'Among': [995], 'all': [996, 1452], '16.1%': [1000], '(n=29)': [1001], 'presented': [1003, 1009], '15.6%': [1007], '(n=28)': [1008], 'myasthenia': [1011, 1017, 1308, 1357, 1844, 2602, 2768], 'gravis–like': [1012, 1018], 'symptoms.': [1013], 'Both': [1014], 'symptoms': [1019, 1250, 1280, 1390], 'occurred': [1020], '3.3%': [1022], '(n=6)': [1023], 'myositis.': [1027, 1266], 'concurrent': [1029], '(n=2).We': [1042], 'noted': [1043, 1241], 'dramatic': [1045], 'increase': [1046], 'past': [1054], 'parallel': [1057], 'use.': [1064], '2011,': [1066], 'ipilimumab': [1067], 'obtained': [1068], 'Food': [1070], 'Drug': [1072], 'Administration': [1073], 'approval,': [1074], '300': [1076], 'immunotherapies': [1077], 'currently': [1079], 'development.': [1081], 'Before': [1082], '2016,': [1083, 1094], '0.5': [1084], 'cases/mo': [1085, 1092, 1097], 'reported,': [1087], 'comparison': [1089, 1152], '3.6': [1091], '7.3': [1096], '2017.In': [1099], 'this': [1100], 'analysis,': [1101], 'found': [1103], 'caused': [1107], 'significant': [1108, 2477], 'morbidity': [1109], 'mortality,': [1111], 'fatalities': [1113], 'occurring': [1114, 1384], '21.2%': [1116], '(detailed': [1119], 'Table).': [1121], 'Moreover,': [1122], '49.4%': [1123], 'severe': [1129, 1342], 'complications': [1130, 3853], 'such': [1131, 1251], 'prolonged': [1133], 'hospitalization,': [1134], 'life-threatening': [1136], 'event,': [1137], 'disabling': [1140], 'effect.': [1141], 'The': [1142, 1371, 1423, 1441, 1454, 1472, 1494, 1510, 2775, 3151], 'significantly': [1146], 'combination': [1149, 1369], 'therapy': [1150, 1364], '(38.5%': [1155], 'versus': [1156, 1168, 1594], '18.1%,': [1157], 'P=0.02)': [1158], 'higher': [1161, 1237], '(51.7%': [1167], '14.9%': [1169], 'without': [1172], 'myocarditis,': [1173, 1842], 'P<0.0001).Although': [1174], 'systematic,': [1176], 'comprehensive': [1177, 2881], 'clinical': [1178, 2478, 3087, 3559, 3563, 3594, 3598, 3652], 'description': [1179], '(cardiac': [1182], 'skeletal': [1184, 1420, 3394], 'tissues)': [1185], 'remains': [1187, 1217], 'an': [1188, 1907, 2696], 'urgent': [1189], 'need,': [1190], 'they': [1194], 'unique': [1197], 'entities': [1198], 'different': [1199, 1380], 'from': [1200, 1382, 1436, 1706, 3556, 3591, 3665], 'spontaneous': [1201, 1214, 1289, 1386], 'following': [1207], 'ways.': [1208], 'First,': [1209], 'myopathies': [1216, 3395], '<10%': [1218], '(n=66/716)': [1219], 'within': [1220], 'first': [1222], 'year': [1223], 'diagnosis.5': [1226], 'contrast,': [1228], 'has': [1231], 'poor': [1233], 'prognosis': [1234], 'rate.Next,': [1239], 'frequently': [1247, 1367], 'myasthenia-like': [1249], 'ptosis': [1253], 'oculomotor': [1255], 'addition': [1258], 'classical': [1261], 'phenotype': [1262], 'This': [1267], 'observation': [1268], 'line': [1271], 'previous': [1273], 'reports4': [1274], 'describing': [1275], 'occurrence': [1277], 'quite': [1286], 'unusual': [1287], 'be': [1293, 1394], 'related': [1294, 1625], 'either': [1296], 'disorder.': [1302], 'Most': [1303], 'gravis': [1309, 1845, 2603], 'antiacetylcholine': [1314], 'receptor': [1315, 3857], 'autoantibodies,4': [1316], 'VigiBase.In': [1325], 'summary,': [1326], 'largest': [1329], 'study': [1330], 'its': [1332], 'kind,': [1333], 'our': [1334, 1402], 'show': [1336], 'coexisting': [1356], 'gravis–type': [1358], 'features.': [1359], 'occurs': [1361], 'early': [1362], 'more': [1366], 'regimens.': [1370], 'preliminary': [1372], 'on': [1374, 1506, 2814], 'nature': [1376], 'presentation': [1378], 'suggest': [1379, 1404], 'mechanisms': [1381], 'myopathies.': [1388], 'Because': [1389], 'can': [1393], 'overlooked,': [1395], 'especially': [1396], 'who': [1399], 'ill,': [1401], 'observations': [1403], 'need': [1406], 'index': [1410], 'suspicion': [1412], 'among': [1413], 'oncologists': [1414], 'low': [1417], 'threshold': [1418], 'biopsy.': [1422], 'presence': [1425], 'require': [1429], 'systematic': [1430, 1632, 2315, 2482], 'screening.AcknowledgmentsThe': [1432], 'supplied': [1433], 'come': [1435], 'variety': [1438], 'sources.': [1440], 'likelihood': [1442], 'causal': [1445], 'relationship': [1446], 'same': [1450], 'information': [1455], 'does': [1456], 'represent': [1458], 'opinion': [1460], 'Organization.Sources': [1465], 'FundingThis': [1467], 'work': [1468], 'supported': [1470], 'Cancer': [1473, 1489, 1911, 2085, 2203, 2946, 3013, 3041, 3454, 3649, 3689], 'Multi-Organisation': [1474], 'Thematic': [1475], 'French': [1479], 'Alliance': [1481], 'Life': [1483], 'Sciences': [1486], '(AVIESAN):': [1487], 'Plan': [1488], '2014': [1490], '2019.DisclosuresNone.Footnoteshttps://www.ahajournals.org/journal/circData': [1492], 'sharing:': [1493], 'sources': [1495], 'produce': [1501], 'results': [1503, 1705], 'Vigibase': [1507], 'website': [1508], '(http://www.vigiaccess.org/).': [1509], 'methods': [1511], 'article,': [1515], 'drug': [1521, 2172], 'names': [1522], 'outlined': [1524], 'research': [1527], 'letter.Yves': [1528], 'yves.[email': [1552], 'protected]frReferences1.': [1553], 'Herbst': [1554], 'RS,': [1555], 'Baas': [1556], 'P,': [1557, 1832, 2135, 2145, 2448, 2454, 2724, 2726, 3181, 3361, 3634, 3710, 3790], 'Kim': [1558, 1568], 'DW,': [1559], 'Felip': [1560], 'E,': [1561, 1588, 1951, 1953, 2580, 2586, 2756, 2758, 2954, 3280, 3542, 3548, 3577, 3583, 3794], 'Pérez-Gracia': [1562], 'JL,': [1563], 'Han': [1564], 'JY,': [1565], 'Molina': [1566], 'J,': [1567, 1695, 1783, 1820, 1828, 1963, 2002, 2039, 2100, 2298, 2328, 2334, 2521, 2531, 2720, 2797, 2909, 2991, 3107, 3179, 3185, 3276, 3290, 3304, 3306, 3357, 3466, 3504, 3630, 3734, 3754, 3758, 3780], 'JH,': [1569], 'Arvis': [1570], 'CD,': [1571], 'Ahn': [1572, 2959], 'MJ,': [1573, 1577], 'Majem': [1574], 'M,': [1575, 1582, 1590, 1617, 1752, 1826, 1893, 1957, 1967, 2049, 2057, 2374, 2444, 2537, 2543, 2547, 2582, 2624, 2722, 3001, 3030, 3183, 3228, 3268, 3294, 3377, 3414, 3416, 3502, 3506, 3512, 3540, 3546, 3575, 3581, 3612, 3632, 3636, 3708, 3712, 3718, 3730, 3736, 3744, 3746, 3748, 3752, 3766], 'Fidler': [1576], 'Castro': [1579], 'G,': [1580, 1789, 1926, 1928, 1955, 2141, 2962, 3468, 3724, 3845], 'Garrido': [1581], 'Lubiniecki': [1583], 'GM,': [1584], 'Shentu': [1585], 'Y,': [1586, 2330, 2338, 2529, 2675, 2960, 3292, 3772], 'Im': [1587], 'Dolled-Filhart': [1589], 'Garon': [1591], 'EB.': [1592], 'Pembrolizumab': [1593], 'docetaxel': [1595], 'previously': [1597], 'treated,': [1598], 'PD-L1-positive,': [1599], 'advanced': [1600], 'non-small-cell': [1601], '(KEYNOTE-010):': [1604], 'randomised': [1606], 'controlled': [1607], 'trial.Lancet.': [1608], '2016;': [1609], '387:1540–1550.': [1610], 'doi:': [1611, 1639, 1662, 1689, 1717], '10.1016/S0140-6736(15)01281-7CrossrefMedlineGoogle': [1612], 'Scholar2.': [1613], 'Bertrand': [1614], 'A,': [1615, 1668, 1670, 1969, 2037, 2047, 2106, 2131, 2190, 2192, 2270, 2442, 2452, 2456, 2466, 2525, 2539, 2541, 2673, 2828, 2834, 2901, 2956, 3032, 3034, 3076, 3109, 3111, 3144, 3270, 3286, 3302, 3373, 3379, 3508, 3628, 3764, 3768, 3776, 3788, 3800, 3806], 'Kostine': [1616, 3267], 'Barnetche': [1618], 'T,': [1619, 1824, 1924, 2129, 2336, 2533, 3284, 3624, 3740], 'Truchetet': [1620], 'ME,': [1621], 'Schaeverbeke': [1622, 3312], 'T.': [1623], 'anti-CTLA-4': [1630], 'antibodies:': [1631], 'meta-analysis.BMC': [1635], 'Med.': [1636], '2015;': [1637], '13:211.': [1638], '10.1186/s12916-015-0455-8CrossrefMedlineGoogle': [1640], 'Scholar3.': [1641], 'JJ,': [1643], 'JE,': [1645], 'Sosman': [1646], 'JA,': [1647], 'B,': [1649, 1750, 1996, 2460, 2791, 2864, 3770], 'DB.': [1651], 'Increased': [1652], 'fatal': [1655], 'inhibitor-associated': [1658, 2767], 'myocarditis.Lancet.': [1659], '2018;': [1660, 1715], '391:933.': [1661], '10.1016/S0140-6736(18)30533-6CrossrefMedlineGoogle': [1663], 'Scholar4.': [1664], 'Gonzalez': [1665], 'NL,': [1666], 'Puwanant': [1667], 'Lu': [1669], 'Marks': [1671], 'SM,': [1672], 'Živković': [1673], 'SA.': [1674], 'Myasthenia': [1675], 'triggered': [1676], 'inhibitors:': [1680, 1876, 1906, 2162, 2812, 2878, 3424, 3483, 3862], 'New': [1681], 'literature': [1684], 'review.Neuromuscul': [1685], 'Disord.': [1686], '2017;': [1687], '27:266–268.': [1688], '10.1016/j.nmd.2017.01.002CrossrefMedlineGoogle': [1690], 'Scholar5.': [1691], 'Dobloug': [1692], 'GC,': [1693], 'Svensson': [1694], 'Lundberg': [1696], 'IE,': [1697], 'Holmqvist': [1698], 'M.': [1699], 'Mortality': [1700], 'idiopathic': [1702, 2311], 'myopathy:': [1704], 'Swedish': [1708], 'nationwide': [1709], 'population-based': [1710], 'cohort': [1711], 'study.Ann': [1712], 'Rheum': [1713], 'Dis.': [1714], '77:40–47.': [1716], '10.1136/annrheumdis-2017-211402CrossrefMedlineGoogle': [1718], 'Scholar': [1719], 'Previous': [1720], 'Back': [1721], 'top': [1723], 'Next': [1724], 'FiguresReferencesRelatedDetailsCited': [1725], 'By': [1726], 'Rassaf': [1727, 2532], 'Schadendorf': [1730], 'D': [1731, 2275, 3080, 3850], '(2023)': [1732], 'Cutaneous': [1733], 'Practice': [1736], 'Manual': [1737], ':': [1738, 2020], 'Companion': [1740], 'Braunwald': [1742], "'s": [1743], 'Heart': [1744], 'Disease,': [1745, 3259], '10.1016/B978-0-323-68135-3.00053-2,': [1746], '(370-375),': [1747], '.': [1748, 2296, 3443, 3458], 'Zhou': [1749, 2337, 3223], 'Li': [1751, 3227], 'Chen': [1753, 2333, 2861], 'She': [1756, 1782], 'J': [1757, 1975, 2066, 2154, 2197, 2305, 2347, 2473, 2553, 2556, 2914, 3063, 3189, 3470, 3810], '(2022)': [1758, 1795, 1838, 1866, 1936, 1979, 2008, 2067, 2112, 2198, 2229, 2254, 2276], 'Case': [1759, 2349], 'Report:': [1760], 'Acute': [1761, 1983], 'Due': [1763], 'PD-L1': [1765], 'Inhibitor': [1766, 2082, 2355, 2855, 3069, 3196], 'Durvalumab': [1767], 'Patient': [1771, 2635, 2698], 'Lung': [1773, 2945], 'Squamous': [1774], 'Cell': [1775, 2742], 'Carcinoma,': [1776], 'Frontiers': [1777, 1806, 1945, 1988, 2123, 2366, 2747, 2948], '10.3389/fmed.2022.866068,': [1780], '9': [1781, 1811, 1992], 'Liu': [1784, 2335], 'H,': [1785, 1787, 3278, 3365, 3462, 3798], 'Wu': [1786, 2863, 3186], 'Tuerhongjiang': [1788], 'Zheng': [1790, 2931], 'Bai': [1793], 'L': [1794, 2344, 2964, 3113], 'Cardiotoxicity': [1796, 2230], 'Related': [1797], 'Inhibitors:': [1801, 2118], 'A': [1802, 1978, 2007, 2108, 2119, 2272, 2281, 2358, 2376, 2381, 2592, 2760, 2802, 2842, 2845, 3005, 3445, 3484, 3518, 3550, 3585, 3847], 'Real-World': [1803], 'Retrospective': [1804], 'Analysis,': [1805], '10.3389/fcvm.2022.838488,': [1810], 'Wai': [1812], 'Siu': [1813], 'D,': [1814, 2102, 2147, 2248, 2332, 2754, 2838, 2905, 3175, 3375, 3618, 3620, 3722, 3782], "O'Neill": [1815], 'R,': [1816, 1922, 2590, 2718, 2840, 3058, 3177, 3353, 3359, 3371, 3626, 3760, 3796], 'Harris': [1817], 'C,': [1818, 1961, 1971, 2000, 2104, 2133, 2139, 2326, 2446, 2450, 2458, 2462, 2464, 2468, 2588, 2647, 2795, 2862, 2958, 2999, 3272, 3296, 3355, 3716, 3728, 3738, 3756, 3778, 3784, 3786, 3802], 'Wang': [1819, 2038, 2325, 2329, 3225, 3469], 'Ardolino': [1821], 'L,': [1822, 1973, 1994, 2041, 2043, 2051, 2053, 2188, 2372, 2519, 2789, 3140, 3226, 3298, 3308, 3367, 3464, 3704, 3726, 3774], 'Downton': [1823], 'Tong': [1825], 'Hong': [1827], 'Chin': [1829], 'V,': [1830, 2098, 2836, 3369, 3750, 3808], 'Clingan': [1831], 'Aghmesheh': [1833], 'M': [1834, 1862, 2228, 2626, 3008, 3036, 3083, 3383, 3418, 3421, 3521, 3680, 3683], 'Soudy': [1836], 'H': [1837, 2653, 2935, 3060, 3192, 3473], 'inhibitor-induced': [1841], 'transaminitis:': [1847], 'series': [1850], 'review,': [1852, 2316], 'Immunotherapy,': [1853, 1913, 2982, 3455], '10.2217/imt-2021-0225,': [1854], '14:7,': [1855], '(511-520),': [1856], 'Online': [1857, 1888, 1917, 2032, 2093, 2183, 2216, 2243, 2321, 2398, 2429, 2514, 2575, 2619, 2642, 2668, 2713, 2784, 2823, 2896, 2927, 2986, 3025, 3102, 3131, 3135, 3168, 3217, 3263, 3344, 3407, 3497, 3535, 3570, 3607, 3675, 3828, 3832, 3836, 3840], 'publication': [1858, 1889, 1918, 2033, 2094, 2184, 2217, 2244, 2322, 2399, 2430, 2515, 2576, 2620, 2643, 2669, 2714, 2785, 2824, 2897, 2928, 2987, 3026, 3103, 3132, 3136, 3169, 3218, 3264, 3345, 3408, 3498, 3536, 3571, 3608, 3676, 3829, 3833, 3837, 3841], 'date:': [1859, 1890, 1919, 2034, 2095, 2185, 2218, 2245, 2323, 2400, 2431, 2516, 2577, 2621, 2644, 2670, 2715, 2786, 2825, 2898, 2929, 2988, 3027, 3104, 3133, 3137, 3170, 3219, 3265, 3346, 3409, 3499, 3537, 3572, 3609, 3677, 3830, 3834, 3838, 3842], '1-May-2022.': [1860], 'Villagrán-García': [1861], 'Velasco': [1864], 'R': [1865, 2733, 3116, 3813], 'Neurotoxicity': [1867], 'rechallenge': [1872], 'growing': [1878], 'issue': [1879], 'neuro-oncology': [1881], 'practice,': [1882, 3564, 3599, 3867], 'Neurological': [1883, 1900, 3475, 3852], 'Sciences,': [1884], '10.1007/s10072-022-05920-4,': [1885], '43:4,': [1886], '(2339-2361),': [1887], '1-Apr-2022.': [1891, 1920], 'Seki': [1892], 'Kitano': [1894], 'S': [1895, 1898, 2302, 2629, 2687, 2690, 2763, 2967], 'Suzuki': [1897, 2686], '(2021)': [1899, 2306, 2348, 2380, 2409, 2474, 2557, 2630, 2654, 2691, 2734, 2764, 2803, 2846, 2870, 2915, 2936, 2968, 3009, 3040, 3084, 3117, 3150, 3193, 3234, 3387, 3422, 3446], 'association': [1908], 'autoantibodies,': [1910], '10.1007/s00262-021-03053-9,': [1914], '71:4,': [1915], '(769-775),': [1916], 'Poto': [1921], 'Troiani': [1923], 'Criscuolo': [1925], 'Marone': [1927], 'Ciardiello': [1929], 'F,': [1930, 2440, 2545, 2683, 2830, 3544, 3579, 3804], 'Tocchetti': [1931], 'C': [1932, 2866], 'Varricchi': [1934], 'G': [1935], 'Holistic': [1937], 'Approach': [1938, 3687], 'Inhibitor-Related': [1942], 'Adverse': [1943, 2072, 2200, 2849, 2939, 3693], 'Events,': [1944], '10.3389/fimmu.2022.804597,': [1948], '13': [1949, 2127], 'Ammirati': [1950], 'Bizzi': [1952], 'Veronese': [1954], 'Groh': [1956], 'Van': [1958], 'Heyning': [1960], 'Lehtonen': [1962], 'Pineton': [1964], 'Chambrun': [1966], 'Cereda': [1968], 'Picchi': [1970], 'Trotta': [1972], 'Brucato': [1977], 'Immunomodulating': [1980], 'Therapies': [1981], 'Recurrent/Acute': [1986], 'Pericarditis,': [1987], '10.3389/fmed.2022.838564,': [1991], 'Adda': [1993, 2788], 'Batteux': [1995, 2790], 'Saidak': [1997, 2792], 'Z,': [1998, 2340, 2342, 2793, 3224, 3349], 'Poulet': [1999, 2794], 'Arnault': [2001, 2796], 'Chauffert': [2003, 2798], 'B': [2004, 2225, 2799, 3641], 'Séjourné': [2006, 2801], 'Effets': [2009], 'indésirables': [2010], 'rhumatologiques': [2011], 'associés': [2012], 'aux': [2013], 'inhibiteurs': [2014], 'points': [2016, 3316], 'contrôle': [2018], 'immunitaire': [2019], 'impact': [2021], 'sur': [2022], 'survie': [2024], 'globale,': [2025], 'Revue': [2026, 2660], 'du': [2027], 'Rhumatisme,': [2028], '10.1016/j.rhum.2021.10.564,': [2029], '89:2,': [2030], '(168-175),': [2031], '1-Mar-2022.': [2035, 2096], 'Cunningham‐Bussel': [2036], 'Prisco': [2040], 'Martin': [2042], 'Vanni': [2044], 'K,': [2045, 2584, 2677, 2679, 2681, 3078, 3142, 3274, 3282, 3381], 'Zaccardelli': [2046], 'Nasrallah': [2048], 'Gedmintas': [2050], 'MacFarlane': [2052], 'Shadick': [2054], 'Awad': [2056], 'Rahma': [2058], 'O,': [2059, 2149, 2535, 2903, 3288, 3514], 'LeBoeuf': [2060], 'Gravallese': [2062], 'E': [2063, 2194, 3039, 3553, 3588], 'Sparks': [2065], 'Predictors': [2068], 'Rheumatic': [2070, 2156, 2178, 2804, 2847, 3235, 3339, 3448], 'Immune‐Related': [2071], 'Events': [2073, 2201, 2940, 3694], 'De': [2075], 'Novo': [2076], 'Inflammatory': [2077, 2631, 3010], 'After': [2079], 'Treatment': [2083, 2236, 2564], '&': [2088, 3020], 'Rheumatology,': [2089, 2263, 2317, 3021], '10.1002/art.41949,': [2090], '74:3,': [2091], '(527-540),': [2092], 'Albarrán': [2097], 'Chamorro': [2099], 'Rosero': [2101], 'Saavedra': [2103], 'Soria': [2105], 'Carrato': [2107], 'Gajate': [2110], 'P': [2111, 2151, 2253], 'Neurologic': [2113], 'Toxicity': [2114], 'Review': [2120, 2422, 3209], 'Literature,': [2122], '10.3389/fphar.2022.774170,': [2126], 'Nguyễn': [2128], 'Maria': [2130], 'Ladhari': [2132], 'Palassin': [2134], 'Quantin': [2136], 'X,': [2137, 2143, 2993, 3516, 3614], 'Lesage': [2138], 'Taïeb': [2140], 'Ayrignac': [2142], 'Rullier': [2144], 'Hillaire-Buys': [2146], 'Lambotte': [2148, 2469, 3287, 3513], 'Guilpain': [2150], 'Faillie': [2153], '(2020)': [2155, 2596, 3314, 3474, 3522, 3554, 3589, 3642, 3684, 3851], 'what': [2163], 'about': [2164], 'myositis?': [2165], 'An': [2166, 2879], 'analysis': [2167, 2883], "WHO's": [2170], 'reactions': [2173], 'database,': [2174], 'Annals': [2175, 3336], '10.1136/annrheumdis-2020-217018,': [2180], '81:2,': [2181], '(e32-e32),': [2182], '1-Feb-2022.': [2186, 2219, 2246], 'Cano-Cruz': [2187], 'Barrera-Vargas': [2189], 'Mateos-Soria': [2191], 'Soto-Perez-de-Celis': [2193], 'Merayo-Chalico': [2196], 'Rheumatological': [2199], 'Therapy': [2204, 3070], 'Inhibitors,': [2208, 3018, 3698], 'Archives': [2209], 'Research,': [2212, 2924], '10.1016/j.arcmed.2021.09.004,': [2213], '53:2,': [2214], '(113-121),': [2215], 'Mukunda': [2220], 'Vallabhaneni': [2222], 'S,': [2223, 2403, 2434, 2436, 2438, 2549, 2551, 2995, 3173, 3187, 3222, 3300, 3351, 3363, 3412, 3460, 3714, 3720, 3732, 3742], 'Lefebvre': [2224], 'Fradley': [2227], 'Systemic': [2232], 'Melanoma': [2233], 'Treatments,': [2234], 'Current': [2235, 3048, 3868], 'Options': [2237], '10.1007/s11864-021-00924-2,': [2240], '23:2,': [2241], '(240-253),': [2242], 'Saygin': [2247], 'Ghosh': [2249], 'N': [2250, 2405, 2408, 3146], 'Reid': [2252], 'Myositis,': [2258], 'JCR:': [2259], 'Journal': [2260, 2508, 2613, 2777, 2980, 3050, 3125, 3490], '10.1097/RHU.0000000000001874,': [2264], 'Publish': [2265], 'Ahead': [2266], 'Print': [2268], 'Solimando': [2269], 'Vacca': [2271], 'Ribatti': [2274], 'Inborn': [2277], 'Error': [2278], 'Immunity:': [2280], 'Journey': [2282], 'Novel': [2284], 'Genes': [2285], 'Presentation': [2288], 'Encyclopedia': [2289], 'Infection': [2291], 'Immunity,': [2293], '10.1016/B978-0-12-818731-9.00124-5,': [2294], '(798-818),': [2295], 'Fairley': [2297], 'Wicks': [2299], 'I,': [2300, 2685, 2832, 3622, 3706, 3762], 'Peters': [2301], 'Day': [2304], 'Defining': [2307], 'involvement': [2309], 'myopathies:': [2313], '10.1093/rheumatology/keab573,': [2318], '61:1,': [2319, 3215], '(103-120),': [2320], '24-Dec-2021.': [2324], 'Lin': [2327], 'Hsi': [2331], 'Ren': [2339, 3461], 'Zeng': [2341, 3232], 'Cheng': [2343], 'Ge': [2346], 'Series': [2350], 'Steroid-Resistant': [2352], 'Associated': [2356, 2920], 'Myocarditis:': [2357, 2743], 'Comparative': [2359], 'Analysis': [2360], 'Corticosteroid': [2362], 'Tofacitinib': [2364], 'Treatment,': [2365, 2947], '10.3389/fphar.2021.770631,': [2369], '12': [2370], 'Burton': [2371], 'Eskian': [2373], 'Guidon': [2375, 3378], 'Reynolds': [2378, 3141, 3380], 'K': [2379, 2911], 'neurotoxicities': [2384], 'immunotherapy': [2387, 3332], 'framework': [2390], 'evaluation,': [2392], 'Neuro-Oncology': [2393], 'Advances,': [2394, 3404], '10.1093/noajnl/vdab107,': [2395], '3:Supplement_5,': [2396], '(v108-v120),': [2397], '27-Nov-2021.': [2401], 'Eftekhar': [2402], 'Yazdanpanah': [2404], 'Rezaei': [2407], 'cardiotoxicity:': [2414], 'possible': [2415], 'mechanisms,': [2416, 3124], 'manifestations,': [2417], 'diagnosis': [2418, 3321], 'management,': [2420], 'Expert': [2421], 'Anticancer': [2424], 'Therapy,': [2425, 2856], '10.1080/14737140.2021.1979396,': [2426], '21:11,': [2427], '(1211-1228),': [2428], '2-Nov-2021.': [2432], 'Hajem': [2433], 'Ederhy': [2435, 2550], 'Champiat': [2437], 'Troalen': [2439], 'Nolin-Lapalme': [2441], 'Berhoune': [2443], 'Cauquil': [2445], 'Martin-Romano': [2447], 'Baldini': [2449], 'Laparra': [2451], 'Vuagnat': [2453], 'Hollebecque': [2455], 'Mateus': [2457], 'Besse': [2459], 'Naltet': [2461], 'Robert': [2463], 'Marabelle': [2465, 3301], 'Massard': [2467], 'O': [2470], 'Michot': [2472], 'Absence': [2475], 'benefit': [2479], 'routine': [2483], 'phosphokinase': [2485], 'measurement': [2486], 'asymptomatic': [2488], 'anti-programmed': [2492], 'death': [2493], 'protein': [2494], '(ligand)': [2495], 'inhibitor': [2499], 'screen': [2501], 'toxicities,': [2506], 'European': [2507], 'Cancer,': [2510, 3671], '10.1016/j.ejca.2021.08.045,': [2511], '157,': [2512], '(383-390),': [2513], '1-Nov-2021.': [2517, 2578], 'Lehmann': [2518], 'Cautela': [2520], 'Palaskas': [2522, 2996, 3145], 'Baik': [2524, 2900, 3075], 'Meijers': [2526], 'W,': [2527, 2728, 3792], 'Alexandre': [2530], 'Müller': [2534], 'Aras': [2536, 3082], 'Asnani': [2538], 'Deswal': [2540, 3004], 'Laufer-Perl': [2542], 'Thuny': [2544], 'Kerneis': [2546], 'Hayek': [2548], 'Strategy': [2559], 'Diagnosis': [2562], 'Myocarditis,': [2569, 2979], 'JAMA': [2570], 'Cardiology,': [2571], '10.1001/jamacardio.2021.2241,': [2572], '6:11,': [2573], '(1329),': [2574], 'Wong': [2579], 'Yong': [2581, 2583], 'Tan': [2585], 'Toh': [2587], 'Kanesvaran': [2589], 'Takano': [2591], 'Ng': [2594], 'Q': [2595], 'inhibitor‐associated': [2599], 'overlap:': [2604], 'Understanding': [2605, 3198], 'diversity': [2607], 'series,': [2611], 'Asia-Pacific': [2612, 3489], '10.1111/ajco.13442,': [2617], '17:5,': [2618], '1-Oct-2021.': [2622], 'Maheswaranathan': [2623], 'Khouri': [2625], 'Weinmann': [2628], 'Melanoma,': [2637, 3072], 'JAMA,': [2638], '10.1001/jama.2021.9025,': [2639], '326:9,': [2640], '(865),': [2641], '7-Sep-2021.': [2645], 'Ricordel': [2646], 'Le': [2648], 'Guen': [2649], 'Y': [2650], 'Léna': [2652], 'Gestion': [2655], 'des': [2656, 2661], 'toxicités': [2657], "l'immunothérapie,": [2659], 'Maladies': [2662], 'Respiratoires': [2663], 'Actualités,': [2664], '10.1016/S1877-1203(21)00118-X,': [2665], '13:2,': [2666], '(2S258-2S265),': [2667], '1-Sep-2021.': [2671], 'Sugiyama': [2672], 'Onishi': [2674], 'Ito': [2676], 'Shibuya': [2678], 'Nakamura': [2680], 'Oda': [2682], 'Nishino': [2684], 'Kuwabara': [2689], 'Marked': [2692], 'Respiratory': [2693], 'Failure': [2694], 'Ambulant': [2697], 'Immune-mediated': [2700], 'Necrotizing': [2701], 'Myopathy': [2702], 'Anti-Kv1.4': [2704], 'Anti-titin': [2706], 'Antibodies,': [2707], '10.2169/internalmedicine.6834-20,': [2710], '60:16,': [2711], '(2671-2675),': [2712], '15-Aug-2021.': [2716], 'Rikhi': [2717], 'Karnuta': [2719], 'Hussain': [2721], 'Collier': [2723], 'Funchain': [2725], 'Tang': [2727], 'Chan': [2729], 'Moudgil': [2732], 'Inhibitors': [2737], 'Mediated': [2738], 'Lymphocytic': [2739], 'Giant': [2741], 'Uncovering': [2744], 'Etiological': [2745], 'Mechanisms,': [2746], '10.3389/fcvm.2021.721333,': [2751], '8': [2752], 'Lipe': [2753], 'Galvis-Carvajal': [2755], 'Rajha': [2757], 'Wechsler': [2759], 'Gaeta': [2762], 'gravis,': [2769], 'overlap': [2773], 'syndrome,': [2774], 'American': [2776], 'Emergency': [2779], '10.1016/j.ajem.2021.03.005,': [2781], '46,': [2782], '(51-55),': [2783], '1-Aug-2021.': [2787], 'musculoskeletal': [2806], 'induced': [2808], 'Consequences': [2813], 'survival,': [2816], 'Joint': [2817], 'Bone': [2818], 'Spine,': [2819], '10.1016/j.jbspin.2021.105168,': [2820], '88:4,': [2821], '(105168),': [2822], '1-Jul-2021.': [2826], 'Bobircă': [2827, 2829], 'Ancuta': [2831], 'Florescu': [2833, 2837, 2841], 'Pădureanu': [2835, 2839], 'Mușetescu': [2844], 'Immune-Related': [2848, 2938, 3692], 'Events—A': [2850], 'Consequence': [2851], 'Biology,': [2857], '10.3390/biology10060561,': [2858], '10:6,': [2859], '(561)': [2860], 'Zhang': [2865, 3139, 3221, 3229], 'Xu': [2868], 'Immune-related': [2871, 3523], 'updated': [2880], 'disproportionality': [2882], 'FDA': [2886], 'event': [2888], 'system,': [2890], 'International': [2891], 'Immunopharmacology,': [2892], '10.1016/j.intimp.2021.107498,': [2893], '95,': [2894], '(107498),': [2895], '1-Jun-2021.': [2899], 'Oluwole': [2902], 'Shah': [2906], 'Tsai': [2910, 3077], 'Mechanisms': [2916, 3085, 3200], 'Toxicities': [2919, 3555, 3590], 'Immunotherapies,': [2922], 'Circulation': [2923], '128:11,': [2925], '(1780-1801),': [2926], '28-May-2021.': [2930], 'X': [2932, 3233, 3310], 'Wei': [2934], 'Organ-Specific': [2937], 'PD-1': [2942], 'Antibodies': [2943], '10.3389/fonc.2021.628243,': [2951], '11': [2952], 'Ang': [2953], 'Mweempwa': [2955], 'Heron': [2957], 'Rivalland': [2961], 'Ha': [2963], 'Deva': [2966], 'Troponin': [2970], 'I': [2971], 'Inhibitor–associated': [2976], '10.1097/CJI.0000000000000356,': [2983], '44:4,': [2984], '(162-163),': [2985], '1-May-2021.': [2989, 3028], 'Aldrich': [2990], 'Pundole': [2992, 3613], 'Tummala': [2994], 'Andersen': [2998], 'Shoukier': [3000], 'Abdel‐Wahab': [3002], 'Suarez‐Almazor': [3007], 'Receiving': [3015], '10.1002/art.41604,': [3022], '73:5,': [3023], '(866-874),': [3024], 'Bohdan': [3029], 'Kowalczys': [3031], 'Mickiewicz': [3033], 'Gruchała': [3035], 'Lewicka': [3038], 'Therapy-Related': [3042], 'Practice:': [3047], 'Perspectives,': [3049], '10.3390/jcm10081647,': [3054], '10:8,': [3055], '(1647)': [3056], 'Thomas': [3057], 'Patel': [3059], 'Scott': [3062], 'Dermatomyositis': [3064], 'Flare': [3065], 'Cureus,': [3073], '10.7759/cureus.14387': [3074], 'Oh': [3079], 'manifestations': [3088, 3122], 'cardiovascular': [3090], 'toxicities': [3091, 3664], 'inhibitors,': [3096, 3335, 3402, 3528, 3667], 'Science,': [3098], '10.1042/CS20200331,': [3099], '135:5,': [3100], '(703-724),': [3101], '12-Mar-2021.': [3105], 'Lichtman': [3108], 'Sharpe': [3110], 'Galluzzi': [3112], 'Kitsis': [3115], 'inhibitor–associated': [3120], 'myocarditis:': [3121], 'Investigation,': [3128], '10.1172/JCI145186,': [3129], '131:5,': [3130], '1-Mar-2021.,': [3134], '1-Mar-2021.': [3138, 3171], 'Lyon': [3143], 'Neilan': [3148, 3385], 'Evolving': [3152], 'Landscape': [3154], 'Epidemiology,': [3157], 'Diagnosis,': [3158], 'Management': [3160], 'Cardiotoxicity,': [3162], 'JACC:': [3163], 'CardioOncology,': [3164], '10.1016/j.jaccao.2020.11.012,': [3165], '3:1,': [3166], '(35-47),': [3167], 'Waliany': [3172], 'Lee': [3174, 3354], 'Witteles': [3176], 'Neal': [3178], 'Nguyen': [3180], 'Davis': [3182], 'Zhu': [3191], 'Cardiotoxicity:': [3197], 'Basic': [3199], 'Characteristics': [3203], 'Finding': [3205], 'Cure,': [3207], 'Annual': [3208], 'Pharmacology': [3211], 'Toxicology,': [3213], 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