Publication Information

{'id': 'https://openalex.org/W2895892541', 'doi': 'https://doi.org/10.1021/acs.biochem.8b00892', 'title': 'Identification of Myricetin as an Ebola Virus VP35–Double-Stranded RNA Interaction Inhibitor through a Novel Fluorescence-Based Assay', 'display_name': 'Identification of Myricetin as an Ebola Virus VP35–Double-Stranded RNA Interaction Inhibitor through a Novel Fluorescence-Based Assay', 'publication_year': 2018, 'publication_date': '2018-10-09', 'ids': {'openalex': 'https://openalex.org/W2895892541', 'doi': 'https://doi.org/10.1021/acs.biochem.8b00892', 'mag': '2895892541', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30298725'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/acs.biochem.8b00892', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104038378', 'display_name': 'Biochemistry', 'issn_l': '0006-2960', 'issn': ['0006-2960', '1520-4995', '1943-295X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://iris.unica.it/bitstream/11584/251997/2/acs.biochem.8b00892.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5079536497', 'display_name': 'Gian Luca Daino', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Gian Luca Daino', 'raw_affiliation_strings': ['Department of Life and Environmental Sciences, University of Cagliari, Cagliari 09042, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Life and Environmental Sciences, University of Cagliari, Cagliari 09042, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063748153', 'display_name': 'Aldo Frau', 'orcid': 'https://orcid.org/0000-0002-0749-263X'}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Aldo Frau', 'raw_affiliation_strings': ['Department of Life and Environmental Sciences, University of Cagliari, Cagliari 09042, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Life and Environmental Sciences, University of Cagliari, Cagliari 09042, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076064456', 'display_name': 'Cinzia Sanna', 'orcid': 'https://orcid.org/0000-0001-9797-2460'}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Cinzia Sanna', 'raw_affiliation_strings': ['Department of Life and Environmental Sciences, University of Cagliari, Cagliari 09042, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Life and Environmental Sciences, University of Cagliari, Cagliari 09042, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025344108', 'display_name': 'Daniela Rigano', 'orcid': 'https://orcid.org/0000-0002-9176-8044'}, 'institutions': [{'id': 'https://openalex.org/I71267560', 'display_name': 'University of Naples Federico II', 'ror': 'https://ror.org/05290cv24', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I71267560']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Daniela Rigano', 'raw_affiliation_strings': ['Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples 80131, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples 80131, Italy', 'institution_ids': ['https://openalex.org/I71267560']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002260688', 'display_name': 'Simona Distinto', 'orcid': 'https://orcid.org/0000-0003-1620-6225'}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Simona Distinto', 'raw_affiliation_strings': ['Department of Life and Environmental Sciences, University of Cagliari, Cagliari 09042, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Life and Environmental Sciences, University of Cagliari, Cagliari 09042, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024432515', 'display_name': 'Veronica Madau', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Veronica Madau', 'raw_affiliation_strings': ['Department of Life and Environmental Sciences, University of Cagliari, Cagliari 09042, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Life and Environmental Sciences, University of Cagliari, Cagliari 09042, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101683201', 'display_name': 'Francesca Esposito', 'orcid': 'https://orcid.org/0000-0001-9725-7977'}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesca Esposito', 'raw_affiliation_strings': ['Department of Life and Environmental Sciences, University of Cagliari, Cagliari 09042, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Life and Environmental Sciences, University of Cagliari, Cagliari 09042, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036810939', 'display_name': 'Elisa Fanunza', 'orcid': 'https://orcid.org/0000-0002-2044-8473'}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Elisa Fanunza', 'raw_affiliation_strings': ['Department of Life and Environmental Sciences, University of Cagliari, Cagliari 09042, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Life and Environmental Sciences, University of Cagliari, Cagliari 09042, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079794076', 'display_name': 'Giulia Bianco', 'orcid': 'https://orcid.org/0000-0001-9558-6339'}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giulia Bianco', 'raw_affiliation_strings': ['Department of Life and Environmental Sciences, University of Cagliari, Cagliari 09042, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Life and Environmental Sciences, University of Cagliari, Cagliari 09042, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080001817', 'display_name': 'Orazio Taglialatela‐Scafati', 'orcid': 'https://orcid.org/0000-0001-8010-0180'}, 'institutions': [{'id': 'https://openalex.org/I71267560', 'display_name': 'University of Naples Federico II', 'ror': 'https://ror.org/05290cv24', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I71267560']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Orazio Taglialatela-Scafati', 'raw_affiliation_strings': ['Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples 80131, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples 80131, Italy', 'institution_ids': ['https://openalex.org/I71267560']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084818615', 'display_name': 'Luca Zinzula', 'orcid': 'https://orcid.org/0000-0001-6489-7070'}, 'institutions': [{'id': 'https://openalex.org/I4210150093', 'display_name': 'Max Planck Institute of Biochemistry', 'ror': 'https://ror.org/04py35477', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210150093']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Luca Zinzula', 'raw_affiliation_strings': ['The Max-Planck Institute of Biochemistry, Department of Molecular Structural Biology, Martinsried 82152, Germany'], 'affiliations': [{'raw_affiliation_string': 'The Max-Planck Institute of Biochemistry, Department of Molecular Structural Biology, Martinsried 82152, Germany', 'institution_ids': ['https://openalex.org/I4210150093']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033239989', 'display_name': 'Elias Maccioni', 'orcid': 'https://orcid.org/0000-0003-2175-2802'}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Elias Maccioni', 'raw_affiliation_strings': ['Department of Life and Environmental Sciences, University of Cagliari, Cagliari 09042, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Life and Environmental Sciences, University of Cagliari, Cagliari 09042, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056464448', 'display_name': 'Angela Corona', 'orcid': 'https://orcid.org/0000-0002-6630-8636'}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Angela Corona', 'raw_affiliation_strings': ['Department of Life and Environmental Sciences, University of Cagliari, Cagliari 09042, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Life and Environmental Sciences, University of Cagliari, Cagliari 09042, Italy', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5037425032', 'display_name': 'Enzo Tramontano', 'orcid': 'https://orcid.org/0000-0002-4849-0980'}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}, {'id': 'https://openalex.org/I4210116388', 'display_name': 'Institute of Genetic and Biomedical Research', 'ror': 'https://ror.org/02dr63s31', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210116388', 'https://openalex.org/I4210155236']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'Enzo Tramontano', 'raw_affiliation_strings': ['Department of Life and Environmental Sciences, University of Cagliari, Cagliari 09042, Italy', 'Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato 09042, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Life and Environmental Sciences, University of Cagliari, Cagliari 09042, Italy', 'institution_ids': ['https://openalex.org/I172446870']}, {'raw_affiliation_string': 'Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato 09042, Italy', 'institution_ids': ['https://openalex.org/I4210116388']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5037425032'], 'corresponding_institution_ids': ['https://openalex.org/I172446870', 'https://openalex.org/I4210116388'], 'apc_list': None, 'apc_paid': None, 'fwci': 2.796, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 38, 'citation_normalized_percentile': {'value': 0.999918, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '57', 'issue': '44', 'first_page': '6367', 'last_page': '6378'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11581', 'display_name': 'Viral Infections and Outbreaks Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11581', 'display_name': 'Viral Infections and Outbreaks Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12047', 'display_name': 'Viral Infections and Vectors', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11668', 'display_name': 'interferon and immune responses', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/rna-silencing', 'display_name': 'RNA Silencing', 'score': 0.5278492}, {'id': 'https://openalex.org/keywords/arenavirus', 'display_name': 'Arenavirus', 'score': 0.459623}], 'concepts': [{'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.6565372}, {'id': 'https://openalex.org/C2777469322', 'wikidata': 'https://www.wikidata.org/wiki/Q8064876', 'display_name': 'Ebola virus', 'level': 3, 'score': 0.6337353}, {'id': 'https://openalex.org/C136449434', 'wikidata': 'https://www.wikidata.org/wiki/Q428253', 'display_name': 'Innate immune system', 'level': 3, 'score': 0.560575}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5448042}, {'id': 'https://openalex.org/C2191507', 'wikidata': 'https://www.wikidata.org/wiki/Q7277185', 'display_name': 'RNA silencing', 'level': 5, 'score': 0.5278492}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.5006826}, {'id': 'https://openalex.org/C2779574689', 'wikidata': 'https://www.wikidata.org/wiki/Q2368907', 'display_name': 'Arenavirus', 'level': 5, 'score': 0.459623}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.4021892}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.2944281}, {'id': 'https://openalex.org/C166703698', 'wikidata': 'https://www.wikidata.org/wiki/Q201993', 'display_name': 'RNA interference', 'level': 4, 'score': 0.18895134}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.13248265}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.111272514}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.10588497}, {'id': 'https://openalex.org/C2780190958', 'wikidata': 'https://www.wikidata.org/wiki/Q1878776', 'display_name': 'Lymphocytic choriomeningitis', 'level': 4, 'score': 0.0758796}, {'id': 'https://openalex.org/C167672396', 'wikidata': 'https://www.wikidata.org/wiki/Q417800', 'display_name': 'CD8', 'level': 3, 'score': 0.074145675}], 'mesh': [{'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D005419', 'descriptor_name': 'Flavonoids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D005453', 'descriptor_name': 'Fluorescence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D010936', 'descriptor_name': 'Plant Extracts', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D012330', 'descriptor_name': 'RNA, Double-Stranded', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D012367', 'descriptor_name': 'RNA, Viral', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D054334', 'descriptor_name': 'Viral Regulatory and Accessory Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029043', 'descriptor_name': 'Ebolavirus', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D029043', 'descriptor_name': 'Ebolavirus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005419', 'descriptor_name': 'Flavonoids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019142', 'descriptor_name': 'Hemorrhagic Fever, Ebola', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D019142', 'descriptor_name': 'Hemorrhagic Fever, Ebola', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019142', 'descriptor_name': 'Hemorrhagic Fever, Ebola', 'qualifier_ui': 'Q000821', 'qualifier_name': 'virology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D062105', 'descriptor_name': 'Molecular Docking Simulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010936', 'descriptor_name': 'Plant Extracts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029606', 'descriptor_name': 'Plumbaginaceae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029606', 'descriptor_name': 'Plumbaginaceae', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012330', 'descriptor_name': 'RNA, Double-Stranded', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012330', 'descriptor_name': 'RNA, Double-Stranded', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012330', 'descriptor_name': 'RNA, Double-Stranded', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012367', 'descriptor_name': 'RNA, Viral', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012367', 'descriptor_name': 'RNA, Viral', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012367', 'descriptor_name': 'RNA, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054334', 'descriptor_name': 'Viral Regulatory and Accessory Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D054334', 'descriptor_name': 'Viral Regulatory and Accessory Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D054334', 'descriptor_name': 'Viral Regulatory and Accessory Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/acs.biochem.8b00892', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104038378', 'display_name': 'Biochemistry', 'issn_l': '0006-2960', 'issn': ['0006-2960', '1520-4995', '1943-295X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/11584/251997', 'pdf_url': 'https://iris.unica.it/bitstream/11584/251997/2/acs.biochem.8b00892.pdf', 'source': {'id': 'https://openalex.org/S4377196293', 'display_name': 'UNICA IRIS Institutional Research Information System (University of Cagliari)', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I172446870', 'host_organization_name': 'University of Cagliari', 'host_organization_lineage': ['https://openalex.org/I172446870'], 'host_organization_lineage_names': ['University of Cagliari'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30298725', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/11584/251997', 'pdf_url': 'https://iris.unica.it/bitstream/11584/251997/2/acs.biochem.8b00892.pdf', 'source': {'id': 'https://openalex.org/S4377196293', 'display_name': 'UNICA IRIS Institutional Research Information System (University of Cagliari)', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I172446870', 'host_organization_name': 'University of Cagliari', 'host_organization_lineage': ['https://openalex.org/I172446870'], 'host_organization_lineage_names': ['University of Cagliari'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.87}], 'grants': [{'funder': 'https://openalex.org/F4320326069', 'funder_display_name': 'Regione Autonoma della Sardegna', 'award_id': 'CRP2_682'}, {'funder': 'https://openalex.org/F4320326069', 'funder_display_name': 'Regione Autonoma della Sardegna', 'award_id': 'CRP-78711/F72I15000900002'}], 'datasets': [], 'versions': [], 'referenced_works_count': 95, 'referenced_works': ['https://openalex.org/W1487878063', 'https://openalex.org/W1620505964', 'https://openalex.org/W1964046231', 'https://openalex.org/W1965694039', 'https://openalex.org/W1968507863', 'https://openalex.org/W1968906564', 'https://openalex.org/W1975375203', 'https://openalex.org/W1976140850', 'https://openalex.org/W1978168286', 'https://openalex.org/W1982074178', 'https://openalex.org/W1982583962', 'https://openalex.org/W1984936484', 'https://openalex.org/W1988006693', 'https://openalex.org/W1991001144', 'https://openalex.org/W1996840082', 'https://openalex.org/W1999969892', 'https://openalex.org/W2007178775', 'https://openalex.org/W2010072146', 'https://openalex.org/W2013913832', 'https://openalex.org/W2017700325', 'https://openalex.org/W2025384456', 'https://openalex.org/W2026660010', 'https://openalex.org/W2029136400', 'https://openalex.org/W2031320723', 'https://openalex.org/W2034487380', 'https://openalex.org/W2036436901', 'https://openalex.org/W2038033854', 'https://openalex.org/W2040446474', 'https://openalex.org/W2041039254', 'https://openalex.org/W2041086925', 'https://openalex.org/W2042164521', 'https://openalex.org/W2045782233', 'https://openalex.org/W2056266529', 'https://openalex.org/W2057559854', 'https://openalex.org/W2061482476', 'https://openalex.org/W2068198382', 'https://openalex.org/W2071229331', 'https://openalex.org/W2077361112', 'https://openalex.org/W2081524511', 'https://openalex.org/W2086844537', 'https://openalex.org/W2086882580', 'https://openalex.org/W2088166099', 'https://openalex.org/W2099467602', 'https://openalex.org/W2099533608', 'https://openalex.org/W2100575506', 'https://openalex.org/W2100827617', 'https://openalex.org/W2102377211', 'https://openalex.org/W2105746066', 'https://openalex.org/W2106587802', 'https://openalex.org/W2108945732', 'https://openalex.org/W2115250531', 'https://openalex.org/W2126952890', 'https://openalex.org/W2129111190', 'https://openalex.org/W2131124255', 'https://openalex.org/W2131583337', 'https://openalex.org/W2134667443', 'https://openalex.org/W2134967712', 'https://openalex.org/W2137587180', 'https://openalex.org/W2143320796', 'https://openalex.org/W2149549646', 'https://openalex.org/W2150892779', 'https://openalex.org/W2155409207', 'https://openalex.org/W2158534713', 'https://openalex.org/W2162395676', 'https://openalex.org/W2170639014', 'https://openalex.org/W2171288645', 'https://openalex.org/W2238727653', 'https://openalex.org/W2273520902', 'https://openalex.org/W2276422964', 'https://openalex.org/W2287735258', 'https://openalex.org/W2360497488', 'https://openalex.org/W2481228070', 'https://openalex.org/W2516082120', 'https://openalex.org/W2523092345', 'https://openalex.org/W2540706713', 'https://openalex.org/W2551961464', 'https://openalex.org/W2562654073', 'https://openalex.org/W2584575235', 'https://openalex.org/W2586511141', 'https://openalex.org/W2588124836', 'https://openalex.org/W2591829777', 'https://openalex.org/W2600989122', 'https://openalex.org/W2609060004', 'https://openalex.org/W2652825108', 'https://openalex.org/W2700656906', 'https://openalex.org/W2725760085', 'https://openalex.org/W2729564205', 'https://openalex.org/W2789805379', 'https://openalex.org/W2790441311', 'https://openalex.org/W2793241190', 'https://openalex.org/W2795192137', 'https://openalex.org/W2802589745', 'https://openalex.org/W2888770709', 'https://openalex.org/W4236092730', 'https://openalex.org/W628847457'], 'related_works': ['https://openalex.org/W4242764090', 'https://openalex.org/W4205520475', 'https://openalex.org/W2815188593', 'https://openalex.org/W2785673800', 'https://openalex.org/W25642773', 'https://openalex.org/W2370455357', 'https://openalex.org/W2237091872', 'https://openalex.org/W2160331787', 'https://openalex.org/W1966243747', 'https://openalex.org/W1949143643'], 'abstract_inverted_index': {'Ebola': [0, 35], 'virus': [1], '(EBOV)': [2], 'is': [3], 'a': [4, 8, 15, 65, 113, 125, 146], 'filovirus': [5], 'that': [6, 174, 190], 'causes': [7], 'severe': [9], 'and': [10, 81, 122, 124, 127], 'rapidly': [11], 'progressing': [12], 'hemorrhagic': [13], 'syndrome;': [14], 'recent': [16], 'epidemic': [17], 'illustrated': [18], 'the': [19, 41, 53, 76, 86, 96, 101, 105, 157, 167, 172, 194, 199, 205], 'urgent': [20], 'need': [21], 'for': [22, 32, 116, 207], 'novel': [23, 126], 'therapeutic': [24], 'agents': [25], 'because': [26], 'no': [27], 'drugs': [28], 'have': [29], 'been': [30], 'approved': [31], 'treatment': [33], 'of': [34, 52, 95, 98, 135, 139, 149, 169, 183, 198, 211, 214], 'virus.': [36], 'A': [37, 162], 'key': [38], 'contribution': [39], 'to': [40, 92, 166], 'high': [42], 'lethality': [43], 'observed': [44], 'during': [45], 'EBOV': [46], 'outbreaks': [47], 'comes': [48], 'from': [49], 'viral': [50, 61, 77, 102, 107], 'evasion': [51], 'host': [54], 'antiviral': [55], 'innate': [56, 108], 'immune': [57, 109], 'response': [58], 'in': [59], 'which': [60], 'protein': [62], 'VP35': [63, 99, 106, 119, 200], 'plays': [64], 'crucial': [66], 'role,': [67], 'blocking': [68], 'interferon': [69], 'type': [70], 'I': [71], 'production,': [72], 'first': [73], 'by': [74, 85], 'masking': [75], 'double-stranded': [78], 'RNA': [79, 201], '(dsRNA)': [80], 'preventing': [82], 'its': [83], 'detection': [84], 'pattern': [87], 'recognition': [88], 'receptor': [89], 'RIG-I.': [90], 'Aiming': [91], 'identify': [93], 'inhibitors': [94, 213], 'interaction': [97, 131, 178], 'with': [100, 179, 193], 'dsRNA,': [103], 'counteracting': [104], 'evasion,': [110], 'we': [111, 144], 'established': [112, 142], 'new': [114], 'methodology': [115], 'high-yield': [117], 'recombinant': [118], '(rVP35)': [120], 'expression': [121], 'purification': [123], 'robust': [128], 'fluorescence-based': [129], 'rVP35–RNA': [130], 'assay': [132], '(Z′': [133], 'factor': [134], '0.69).': [136], 'Taking': [137], 'advantage': [138], 'such': [140], 'newly': [141], 'methods,': [143], 'screened': [145], 'small': [147], 'library': [148], 'Sardinian': [150], 'natural': [151], 'extracts,': [152], 'identifying': [153], 'Limonium': [154], 'morisianum': [155], 'as': [156, 171], 'most': [158], 'potent': [159, 212], 'inhibitor': [160], 'extract.': [161], 'bioguided': [163], 'fractionation': [164], 'led': [165], 'identification': [168], 'myricetin': [170, 191], 'component': [173], 'can': [175], 'inhibit': [176], 'rVP35–dsRNA': [177], 'an': [180], 'IC50': [181], 'value': [182], '2.7': [184], 'μM.': [185], 'Molecular': [186], 'docking': [187], 'studies': [188], 'showed': [189], 'interacts': [192], 'highly': [195], 'conserved': [196], 'region': [197], 'binding': [202], 'domain,': [203], 'laying': [204], 'basis': [206], 'further': [208], 'structural': [209], 'optimization': [210], 'VP35–dsRNA': [215], 'interaction.': [216]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2895892541', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2025-01-14T20:41:30.703079', 'created_date': '2018-10-26'}