Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2895861302', 'doi': 'https://doi.org/10.1073/pnas.1811345115', 'title': 'The mechanism of resistance to favipiravir in influenza', 'display_name': 'The mechanism of resistance to favipiravir in influenza', 'publication_year': 2018, 'publication_date': '2018-10-23', 'ids': {'openalex': 'https://openalex.org/W2895861302', 'doi': 'https://doi.org/10.1073/pnas.1811345115', 'mag': '2895861302', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30352857', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6233120'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1811345115', 'pdf_url': 'https://www.pnas.org/content/pnas/115/45/11613.full.pdf', 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://www.pnas.org/content/pnas/115/45/11613.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5018615613', 'display_name': 'Daniel H. Goldhill', 'orcid': 'https://orcid.org/0000-0003-4597-5963'}, 'institutions': [{'id': 'https://openalex.org/I348769827', 'display_name': 'Public Health England', 'ror': 'https://ror.org/00vbvha87', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I1311074006', 'https://openalex.org/I348769827']}, {'id': 'https://openalex.org/I47508984', 'display_name': 'Imperial College London', 'ror': 'https://ror.org/041kmwe10', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I47508984']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Daniel H. Goldhill', 'raw_affiliation_strings': ['National Infection Service, Public Health England, London NW9 5EQ, United Kingdom;', 'Section of Molecular Virology, Imperial College London, London W2 1PG, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': 'National Infection Service, Public Health England, London NW9 5EQ, United Kingdom;', 'institution_ids': ['https://openalex.org/I348769827']}, {'raw_affiliation_string': 'Section of Molecular Virology, Imperial College London, London W2 1PG, United Kingdom;', 'institution_ids': ['https://openalex.org/I47508984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055741592', 'display_name': 'Aartjan J. W. te Velthuis', 'orcid': 'https://orcid.org/0000-0002-5129-3953'}, 'institutions': [{'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}, {'id': 'https://openalex.org/I4210156194', 'display_name': "Addenbrooke's Hospital", 'ror': 'https://ror.org/055vbxf86', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802466933', 'https://openalex.org/I4210156194']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Aartjan J. W. te Velthuis', 'raw_affiliation_strings': ["Division of Virology, Department of Pathology, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 2QQ, United Kingdom"], 'affiliations': [{'raw_affiliation_string': "Division of Virology, Department of Pathology, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 2QQ, United Kingdom", 'institution_ids': ['https://openalex.org/I241749', 'https://openalex.org/I4210156194']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017801776', 'display_name': 'Robert A. Fletcher', 'orcid': 'https://orcid.org/0000-0002-0885-1788'}, 'institutions': [{'id': 'https://openalex.org/I47508984', 'display_name': 'Imperial College London', 'ror': 'https://ror.org/041kmwe10', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I47508984']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Robert A. Fletcher', 'raw_affiliation_strings': ['Section of Molecular Virology, Imperial College London, London W2 1PG, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': 'Section of Molecular Virology, Imperial College London, London W2 1PG, United Kingdom;', 'institution_ids': ['https://openalex.org/I47508984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072986293', 'display_name': 'Pinky Langat', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I47508984', 'display_name': 'Imperial College London', 'ror': 'https://ror.org/041kmwe10', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I47508984']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Pinky Langat', 'raw_affiliation_strings': ['Section of Molecular Virology, Imperial College London, London W2 1PG, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': 'Section of Molecular Virology, Imperial College London, London W2 1PG, United Kingdom;', 'institution_ids': ['https://openalex.org/I47508984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055194670', 'display_name': 'Maria Zambon', 'orcid': 'https://orcid.org/0000-0002-8897-7881'}, 'institutions': [{'id': 'https://openalex.org/I348769827', 'display_name': 'Public Health England', 'ror': 'https://ror.org/00vbvha87', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I1311074006', 'https://openalex.org/I348769827']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Maria Zambon', 'raw_affiliation_strings': ['National Infection Service, Public Health England, London NW9 5EQ, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': 'National Infection Service, Public Health England, London NW9 5EQ, United Kingdom;', 'institution_ids': ['https://openalex.org/I348769827']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066628426', 'display_name': 'Angie Lackenby', 'orcid': 'https://orcid.org/0000-0002-1557-0415'}, 'institutions': [{'id': 'https://openalex.org/I348769827', 'display_name': 'Public Health England', 'ror': 'https://ror.org/00vbvha87', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I1311074006', 'https://openalex.org/I348769827']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Angie Lackenby', 'raw_affiliation_strings': ['National Infection Service, Public Health England, London NW9 5EQ, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': 'National Infection Service, Public Health England, London NW9 5EQ, United Kingdom;', 'institution_ids': ['https://openalex.org/I348769827']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5038353299', 'display_name': 'William Barclay', 'orcid': 'https://orcid.org/0000-0002-3948-0895'}, 'institutions': [{'id': 'https://openalex.org/I47508984', 'display_name': 'Imperial College London', 'ror': 'https://ror.org/041kmwe10', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I47508984']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'Wendy S. Barclay', 'raw_affiliation_strings': ['Section of Molecular Virology, Imperial College London, London W2 1PG, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': 'Section of Molecular Virology, Imperial College London, London W2 1PG, United Kingdom;', 'institution_ids': ['https://openalex.org/I47508984']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5038353299'], 'corresponding_institution_ids': ['https://openalex.org/I47508984'], 'apc_list': None, 'apc_paid': None, 'fwci': 32.308, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 273, 'citation_normalized_percentile': {'value': 0.88002, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '115', 'issue': '45', 'first_page': '11613', 'last_page': '11618'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10167', 'display_name': 'Influenza Virus Research and Epidemiology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10167', 'display_name': 'Influenza Virus Research and Epidemiology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11243', 'display_name': 'Epidemiology and Pathogenesis of Respiratory Viral Infections', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11668', 'display_name': 'Innate Immunity to Viral Infection', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/favipiravir', 'display_name': 'Favipiravir', 'score': 0.98944986}, {'id': 'https://openalex.org/keywords/resistance-mutation', 'display_name': 'Resistance mutation', 'score': 0.68299675}, {'id': 'https://openalex.org/keywords/antiviral-response', 'display_name': 'Antiviral Response', 'score': 0.466556}, {'id': 'https://openalex.org/keywords/rna-virus', 'display_name': 'RNA virus', 'score': 0.44427702}], 'concepts': [{'id': 'https://openalex.org/C2779772310', 'wikidata': 'https://www.wikidata.org/wiki/Q16934561', 'display_name': 'Favipiravir', 'level': 5, 'score': 0.98944986}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.818748}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.7324683}, {'id': 'https://openalex.org/C182707283', 'wikidata': 'https://www.wikidata.org/wiki/Q7315622', 'display_name': 'Resistance mutation', 'level': 5, 'score': 0.68299675}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6367319}, {'id': 'https://openalex.org/C2776449523', 'wikidata': 'https://www.wikidata.org/wiki/Q272631', 'display_name': 'RNA polymerase', 'level': 4, 'score': 0.61037225}, {'id': 'https://openalex.org/C2777546802', 'wikidata': 'https://www.wikidata.org/wiki/Q834390', 'display_name': 'Influenza A virus', 'level': 3, 'score': 0.58447874}, {'id': 'https://openalex.org/C82381507', 'wikidata': 'https://www.wikidata.org/wiki/Q416878', 'display_name': 'Polymerase', 'level': 3, 'score': 0.5170353}, {'id': 'https://openalex.org/C41258723', 'wikidata': 'https://www.wikidata.org/wiki/Q2919111', 'display_name': 'RNA-dependent RNA polymerase', 'level': 4, 'score': 0.45201856}, {'id': 'https://openalex.org/C2779174946', 'wikidata': 'https://www.wikidata.org/wiki/Q751911', 'display_name': 'RNA virus', 'level': 4, 'score': 0.44427702}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.37235963}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.290501}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.22955242}, {'id': 'https://openalex.org/C156719811', 'wikidata': 'https://www.wikidata.org/wiki/Q28774', 'display_name': 'Reverse transcriptase', 'level': 4, 'score': 0.17021388}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.10953617}, {'id': 'https://openalex.org/C3008058167', 'wikidata': 'https://www.wikidata.org/wiki/Q84263196', 'display_name': 'Coronavirus disease 2019 (COVID-19)', 'level': 4, 'score': 0.07962912}, {'id': 'https://openalex.org/C524204448', 'wikidata': 'https://www.wikidata.org/wiki/Q788926', 'display_name': 'Infectious disease (medical specialty)', 'level': 3, 'score': 0.058357954}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000577', 'descriptor_name': 'Amides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D024882', 'descriptor_name': 'Drug Resistance, Viral', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D053118', 'descriptor_name': 'Influenza A Virus, H1N1 Subtype', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011719', 'descriptor_name': 'Pyrazines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D012324', 'descriptor_name': 'RNA-Dependent RNA Polymerase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D014764', 'descriptor_name': 'Viral Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000577', 'descriptor_name': 'Amides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001120', 'descriptor_name': 'Arginine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001120', 'descriptor_name': 'Arginine', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D001120', 'descriptor_name': 'Arginine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004285', 'descriptor_name': 'Dogs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024882', 'descriptor_name': 'Drug Resistance, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053118', 'descriptor_name': 'Influenza A Virus, H1N1 Subtype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053118', 'descriptor_name': 'Influenza A Virus, H1N1 Subtype', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D053118', 'descriptor_name': 'Influenza A Virus, H1N1 Subtype', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D053118', 'descriptor_name': 'Influenza A Virus, H1N1 Subtype', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': False}, {'descriptor_ui': 'D008239', 'descriptor_name': 'Lysine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008239', 'descriptor_name': 'Lysine', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008239', 'descriptor_name': 'Lysine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D061985', 'descriptor_name': 'Madin Darby Canine Kidney Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008826', 'descriptor_name': 'Microbial Sensitivity Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011719', 'descriptor_name': 'Pyrazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012324', 'descriptor_name': 'RNA-Dependent RNA Polymerase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012324', 'descriptor_name': 'RNA-Dependent RNA Polymerase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012324', 'descriptor_name': 'RNA-Dependent RNA Polymerase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014764', 'descriptor_name': 'Viral Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014764', 'descriptor_name': 'Viral Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014764', 'descriptor_name': 'Viral Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014779', 'descriptor_name': 'Virus Replication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1811345115', 'pdf_url': 'https://www.pnas.org/content/pnas/115/45/11613.full.pdf', 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6233120', 'pdf_url': 'https://europepmc.org/articles/pmc6233120?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/10044/1/65134', 'pdf_url': 'http://spiral.imperial.ac.uk/bitstream/10044/1/65134/2/The%20mechanism%20of%20resistance%20to%20favipiravir%20in%20influenza.pdf', 'source': {'id': 'https://openalex.org/S4306401396', 'display_name': 'Spiral (Imperial College London)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I47508984', 'host_organization_name': 'Imperial College London', 'host_organization_lineage': ['https://openalex.org/I47508984'], 'host_organization_lineage_names': ['Imperial College London'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.repository.cam.ac.uk/handle/1810/286306', 'pdf_url': 'https://www.repository.cam.ac.uk/bitstreams/0cc118db-7151-42fc-8b5f-3ce858f40c74/download', 'source': {'id': 'https://openalex.org/S4306401776', 'display_name': 'Apollo (University of Cambridge)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I241749', 'host_organization_name': 'University of Cambridge', 'host_organization_lineage': ['https://openalex.org/I241749'], 'host_organization_lineage_names': ['University of Cambridge'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233120', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30352857', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1811345115', 'pdf_url': 'https://www.pnas.org/content/pnas/115/45/11613.full.pdf', 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.86}], 'grants': [{'funder': 'https://openalex.org/F4320311904', 'funder_display_name': 'Wellcome Trust', 'award_id': '206579/Z/17/Z'}, {'funder': 'https://openalex.org/F4320319994', 'funder_display_name': 'Department of Health and Social Care', 'award_id': '10064'}, {'funder': 'https://openalex.org/F4320322909', 'funder_display_name': 'Isaac Newton Trust', 'award_id': '17.37(r)'}], 'datasets': [], 'versions': [], 'referenced_works_count': 51, 'referenced_works': ['https://openalex.org/W1563454002', 'https://openalex.org/W1967819126', 'https://openalex.org/W1971292277', 'https://openalex.org/W1994278598', 'https://openalex.org/W1998875841', 'https://openalex.org/W2000266617', 'https://openalex.org/W2013539008', 'https://openalex.org/W2018928802', 'https://openalex.org/W2024386730', 'https://openalex.org/W2027847351', 'https://openalex.org/W2046094044', 'https://openalex.org/W2058203122', 'https://openalex.org/W2060514161', 'https://openalex.org/W2068672631', 'https://openalex.org/W2072316294', 'https://openalex.org/W2073010926', 'https://openalex.org/W2075261488', 'https://openalex.org/W2075704126', 'https://openalex.org/W2088164673', 'https://openalex.org/W2088778118', 'https://openalex.org/W2102368840', 'https://openalex.org/W2108367829', 'https://openalex.org/W2112481771', 'https://openalex.org/W2125529503', 'https://openalex.org/W2138274210', 'https://openalex.org/W2153568159', 'https://openalex.org/W2154270538', 'https://openalex.org/W2155229144', 'https://openalex.org/W2156788262', 'https://openalex.org/W2163576465', 'https://openalex.org/W2166097176', 'https://openalex.org/W2166280456', 'https://openalex.org/W2206845419', 'https://openalex.org/W2405362382', 'https://openalex.org/W2463475606', 'https://openalex.org/W2474251565', 'https://openalex.org/W2508973728', 'https://openalex.org/W2512126238', 'https://openalex.org/W2605190880', 'https://openalex.org/W2611397933', 'https://openalex.org/W2622319469', 'https://openalex.org/W2738654971', 'https://openalex.org/W2739679816', 'https://openalex.org/W2762731179', 'https://openalex.org/W2765684836', 'https://openalex.org/W2766051069', 'https://openalex.org/W2791347300', 'https://openalex.org/W2883693064', 'https://openalex.org/W2949985558', 'https://openalex.org/W2952184608', 'https://openalex.org/W2952745536'], 'related_works': ['https://openalex.org/W4210961822', 'https://openalex.org/W3164225409', 'https://openalex.org/W3157609033', 'https://openalex.org/W3096742390', 'https://openalex.org/W3081957818', 'https://openalex.org/W2895861302', 'https://openalex.org/W2080725002', 'https://openalex.org/W1997573290', 'https://openalex.org/W1971212384', 'https://openalex.org/W116843981'], 'abstract_inverted_index': {'Favipiravir': [0], 'is': [1], 'a': [2, 56, 74, 105, 116, 144], 'broad-spectrum': [3], 'antiviral': [4], 'that': [5, 61, 73, 153], 'has': [6, 19, 104], 'shown': [7], 'promise': [8], 'in': [9, 48, 55, 77, 96, 99, 119, 163], 'treatment': [10], 'of': [11, 17, 33, 44, 80, 84, 123, 134, 149, 184], 'influenza': [12, 52, 86, 136, 175], 'virus': [13, 54, 87, 138], 'infections.': [14], 'While': [15], 'emergence': [16, 183], 'resistance': [18, 45, 68, 93, 130, 160], 'been': [20], 'observed': [21], 'for': [22, 66, 181], 'many': [23], 'antiinfluenza': [24], 'drugs,': [25], 'to': [26, 46, 69, 94, 107, 131, 173], 'date,': [27], 'clinical': [28], 'trials': [29], 'and': [30, 98, 140], 'laboratory': [31, 57], 'studies': [32], 'favipiravir': [34, 47, 95, 129, 180], 'have': [35], 'not': [36], 'yielded': [37], 'resistant': [38], 'viruses.': [39], 'Here': [40], 'we': [41], 'show': [42], 'evolution': [43], 'the': [49, 81, 85, 120, 124, 150, 182], 'pandemic': [50], 'H1N1': [51], 'A': [53, 137], 'setting.': [58], 'We': [59, 71], 'found': [60], 'two': [62], 'mutations': [63, 162, 167], 'were': [64], 'required': [65], 'robust': [67], 'favipiravir.': [70], 'demonstrate': [72], 'K229R': [75, 126], 'mutation': [76, 103, 118], 'motif': [78, 164], 'F': [79], 'PB1': [82], 'subunit': [83, 122], 'RNA-dependent': [88], 'RNA': [89, 132, 155], 'polymerase': [90], '(RdRP)': [91], 'confers': [92], 'vitro': [97], 'cell': [100], 'culture.': [101], 'This': [102], 'cost': [106], 'viral': [108], 'fitness,': [109], 'but': [110], 'fitness': [111], 'can': [112], 'be': [113, 171], 'restored': [114], 'by': [115], 'P653L': [117], 'PA': [121], 'polymerase.': [125], 'also': [127, 158], 'conferred': [128], 'polymerases': [133], 'other': [135, 154], 'strains,': [139], 'its': [141], 'location': [142], 'within': [143], 'highly': [145], 'conserved': [146], 'structural': [147], 'feature': [148], 'RdRP': [151], 'suggests': [152], 'viruses': [156], 'might': [157], 'acquire': [159], 'through': [161], 'F.': [165], 'The': [166], 'identified': [168], 'here': [169], 'could': [170], 'used': [172], 'screen': [174], 'virus-infected': [176], 'patients': [177], 'treated': [178], 'with': [179], 'resistance.': [185]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2895861302', 'counts_by_year': [{'year': 2024, 'cited_by_count': 14}, {'year': 2023, 'cited_by_count': 41}, {'year': 2022, 'cited_by_count': 44}, {'year': 2021, 'cited_by_count': 75}, {'year': 2020, 'cited_by_count': 80}, {'year': 2019, 'cited_by_count': 18}], 'updated_date': '2024-09-17T20:04:59.622754', 'created_date': '2018-10-26'}