Publication Information

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806, 823, 930, 980], 'al1': [254, 434, 498, 807, 824, 931, 981], 'sought': [255], 'find': [257, 1149], 'trauma': [261], 'maximum': [267, 388], 'lysis': [268], '(ML),': [269], 'below': [270], 'less': [276], 'survive': [279], '48': [280, 345, 484], 'hours.': [281, 346, 485], 'They': [282, 315], 'logistic': [284], 'regression,': [285], 'with': [286, 372, 426, 727, 803, 864, 923, 998, 1161, 1423, 1675, 1778, 1801], 'mortality': [287, 307, 482], 'ML': [292, 302, 334, 440, 449], '(although': [308], 'reported).': [314], "Youden's": [318, 347, 384, 405, 443, 505, 630, 743, 765, 828, 878, 988, 1023, 1043, 1307, 1334, 1365, 1409, 1435, 1491], 'index,': [319, 444, 744], 'maximizes': [321, 620, 746], 'sum': [323, 748], 'specificity,': [327, 752, 838, 890, 1176], 'choose': [329, 701, 909], 'discriminating': [336], 'expected': [341], 'die': [343], 'within': [344, 483], 'index': [348, 385, 406, 506, 766, 829, 879, 989, 1024, 1044, 1335, 1366, 1410, 1436, 1471, 1492], '(J)': [349, 1336], 'calculated': [351], 'J': [353, 375, 1355, 1411], '=': [354, 1356, 1362], '+': [356, 1358, 1413], '−': [358, 1360, 1415], 'predictor.': [366, 1122], 'The': [367, 898], 'largest': [374, 1489], 'chosen': [378, 613, 763, 1085], 'cut-point.2': [382], 'Thus,': [383], 'minimum': [394], '0.': [397], 'As': [398], 'pointed': [399], 'out': [400, 934], 'Zhou': [402], 'al,3': [404], 'also': [408, 768], 'equal': [409, 652, 1375], 'rate,': [415], 'reflects': [417], 'likelihood': [419], 'positive': [422], 'result': [423], 'among': [424], 'without': [428, 1063], 'condition.': [430, 1328, 1393], 'found': [435], '<3.2%': [441, 450], 'maximized': [442, 1251], 'they,': [446], 'therefore,': [447], 'chose': [448], '"fibrinolysis': [453], 'shutdown"': [454], 'patient.': [457], 'Using': [458], 'cut-point,': [460, 1072, 1817], '42%': [466], '(95%': [467, 477], 'confidence': [468], 'interval': [469], '[CI],': [470], '27%–57%)': [471], '76%': [476], 'CI,': [478], '51%–88%)': [479], 'predicting': [481, 1324, 1389], 'However,': [486, 913, 1142], 'striking': [488], 'gap': [489], 'prompt': [500], 'ask': [503], 'method': [510, 678, 775, 1286], 'define': [512, 1170], 'cutoff—at': [515], 'least': [516, 1181, 1205, 1210, 1763], 'situation—and': [519], 'question': [521], 'other': [525, 1052, 1451, 1544, 1780], 'available': [526, 1061], 'methods.': [527], 'For': [528, 718, 1608], 'example,': [529, 1198, 1609], 'if': [530, 551, 681, 687, 914, 1092, 1878], 'equally': [535, 555, 670, 1021, 1283], 'important,': [536, 556, 671, 1015, 1022, 1284], 'similar?3': [549], 'And': [550, 585], 'reflected': [561], 'choice': [564, 1029], 'cut-point?': [568], 'Finally,': [569, 742, 1767], 'times': [572], 'when': [573, 781, 843, 857, 1017, 1042, 1618, 1742], 'no': [574], 'worthy': [577], 'being': [579, 949, 1179, 1519], 'published': [580], 'practice?': [584], 'tell?': [589], 'FORK': [590], 'IN': [591], 'THE': [592], 'ROAD': [593], 'There': [594], 'are,': [595], 'fact,': [597], 'several': [598], 'methods': [599, 1053], 'cutoff.4': [608], 'Perhaps': [609], 'most': [610], 'commonly,': [611], 'both': [621, 660, 1252, 1547], '(not': [625], 'sum,': [627], 'index).': [631], 'This': [632, 853, 1904, 1917], 'point': [636, 703, 933, 1399, 1462], 'curve': [640, 1262, 1291], 'equal,': [647], 'close': [650, 731], 'possible': [654, 1147], 'given': [657, 995, 1050, 1232, 1885], 'data.': [658, 1916], 'Maximizing': [659], 'assumes': [664], 'so': [673], 'use': [680, 1089, 1572, 1874], 'prerequisite,': [685], 'it': [688, 839, 918, 1037, 1093, 1143, 1301, 1522, 1668, 1782], 'known': [691, 846], 'important.': [695, 852], 'Another': [696], 'option': [697], 'smallest': [707], 'distance': [708], 'upper': [711], 'left': [712], 'corner': [713], 'curve.': [717, 1607], 'strong': [720, 1480, 1568, 1729], 'predictor,': [721], 'will': [724, 1082, 1687], 'often': [725, 1476], 'coincide': [726], 'very': [730, 785, 886], 'first': [734, 1099], 'method:': [735], 'equalizing': [738, 777], 'specificity.': [741, 820, 927, 1003, 1255, 1403, 1641], 'used,': [755], 'al.1': [761], 'Cut-points': [762], 'tend': [769], 'closer': [772], 'strong,': [786], 'corresponding': [787], 'high': [793, 965], '(eg,': [794, 875], '>0.80).': [795], 'But': [796, 1364], 'was': [798, 812, 1919], 'apparently': [799], 'situation': [802, 904], 'because': [808, 827, 856, 967, 987], '<0.50,': [813], 'enormous': [816], '0.34': [817], 'lower': [818, 1163], 'than': [819, 1002, 1888], 'claim': [825], 'does': [830], 'definition,': [833], 'favor': [834], 'either': [835, 1009, 1235, 1693, 1820], 'useful': [842, 1539], 'neither': [844, 1526], 'assumed': [848], 'spurious': [855], 'strongly': [862], 'associated': [863], 'outcome,': [866], 'moderate': [872], '<0.80),': [877], 'produce': [881], '"best"': [882], 'cut-points': [883, 1872], 'different': [887], 'their': [894, 1582], 'own': [895], 'data': [896, 1808], 'set.': [897], 'approach': [900], 'any': [910, 1673, 1733, 1779], 'cut-point.': [912], 'chosen,': [917], 'optimally': [920], 'similar': [924], 'correctly': [932], 'situations': [937, 1006], 'theirs,': [940], 'new': [944], 'clinical': [945, 1227, 1274, 1681], 'tool': [947], 'introduced': [950], 'into': [951], 'practice': [952, 1091, 1876], 'severe': [956], 'higher': [959, 1000], 'generally': [962, 1500], 'preferred': [963], 'over': [964], 'interested': [970], 'reducing': [972], 'findings.': [974], 'It': [975], 'appears': [976], 'were': [982, 1514], 'fortunate': [983], 'regard': [986], 'could': [990], 'just': [992], 'easily': [994], 'cutoff': [997, 1270], 'considerably': [999], 'Therefore,': [1004], 'deemed': [1020, 1282], 'probably': [1032], 'used.': [1035], 'Actually,': [1036], 'difficult': [1039, 1670], 'see': [1041], 'option,': [1049], 'achieve': [1054], 'goal': [1056], 'providing': [1058], 'limitations.': [1065], 'STUDY': [1066], 'DESIGN': [1067], 'seeking': [1069], 'specify': [1075], 'design': [1078], 'phase': [1079], 'only': [1083, 1632, 1853, 1877], 'recommended': [1087, 1190], 'meets': [1094, 1153], 'criteria.': [1096], 'A': [1097, 1320, 1385, 1405, 1706, 1789], 'reasonable': [1098], 'step': [1100], 'state': [1104], 'minimally': [1106, 1520], 'acceptable': [1107], 'AUC,': [1110], '0.75,': [1113], 'before': [1114, 1185], 'searching': [1115, 1288], 'Note': [1123], '0.75': [1128, 1469, 1557], '50%': [1130], 'way': [1133], '(random': [1136], 'guessing)': [1137], '(perfect': [1140], 'discrimination).': [1141], 'still': [1144], 'study': [1155, 1849], 'criterion': [1156], 'AUC.': [1164], 'Next,': [1165], 'authors': [1166, 1194], 'priori': [1169, 1517], 'minimal': [1171], 'criteria': [1172], 'like': [1177], '70%': [1182], '75%,': [1184], 'practice.': [1192, 1541, 1574, 1682, 1737], 'Alternatively,': [1193], 'specify,': [1196], 'needs': [1201], '90%': [1206], '65%,': [1211], 'vice': [1213], 'versa,': [1214], 'depending': [1215], 'errors': [1221], 'problematic': [1224], 'application.3': [1228], 'If,': [1229, 1276], 'study,': [1233, 1776], 'making': [1234], 'decisions': [1239], 'clinically': [1241], 'worse,': [1242], 'Given': [1256], 'particular': [1258, 1638, 1734], 'specifications,': [1259], 'searched': [1265], 'maximize': [1267, 1293], 'potential': [1269], 'while': [1271], 'fulfilling': [1272], 'requirements.': [1275], 'indeed,': [1277], 'them': [1296], 'seems': [1297], 'extremely': [1298], 'useful,': [1299], 'avoid': [1303, 1717], 'pitfalls': [1305], 'index.': [1308], 'Figure,': [1311], '2': [1314], 'exemplary': [1315], 'curves': [1317, 1382], 'representing': [1318], 'biomarkers': [1319, 1384], 'B,': [1322, 1387], 'binary': [1326, 1391], 'disease': [1327, 1392], 'Notice': [1329], 'A,': [1333], 'highest': [1338, 1408], '0.55': [1348, 1357, 1427], '0.85,': [1353, 1432], '0.85': [1359], '0.40.': [1363], '0.30': [1368, 1438], '0.65.Figure.:': [1380], 'Data': [1394], 'parentheses': [1396], 'Biomarker': [1404], 'its': [1407], '(sensitivity': [1412], '1)': [1416], '0.40': [1418], 'equalizes': [1443, 1464], '0.65.': [1448], 'On': [1449, 1542], 'hand,': [1452, 1545], 'B': [1458, 1553], 'clearly': [1460], "(Youden's": [1470], '0.50),': [1473], 'considered': [1478, 1566], 'sufficiently': [1479, 1538, 1567], 'diagnostic': [1481, 1569, 1585, 1743, 1847, 1879], 'accuracy': [1482, 1570, 1586, 1744, 1848, 1880], 'practical': [1484], 'use.': [1485], 'Simply': [1486], 'recommended.': [1501], 'indicates': [1503], 'characteristic.Depending': [1506], 'what': [1508], 'values': [1509], 'specific': [1513], 'identified': [1515], 'sufficient,': [1521], 'adequate': [1530, 1676], 'combination': [1531], 'maximizing': [1546], 'yields': [1554], 'estimates': [1555], 'each,': [1559], 'which,': [1560], 'many': [1562, 1809], 'applications,': [1563], 'some': [1576], 'situations,': [1577, 1685], 'investigators': [1578], 'want': [1579, 1612, 1630], 'restrict': [1581], 'estimate': [1583, 1614, 1633], 'range': [1592, 1600], 'specificities,': [1594], 'consider': [1597], 'entire': [1599], '"partial"': [1616], 'limited': [1621, 1653], '0.70': [1624], '0.90,': [1626], 'scenarios,': [1644], 'desired': [1656], 'area': [1657], 'inference.3': [1659], 'Not': [1660], 'uncommonly,': [1661], 'low,': [1666], 'obtain': [1672], 'certainly': [1688], 'regions': [1690], 'may': [1697, 1752], 'adequate,': [1699], 'but': [1700], 'both—such': [1702], 'Figure.': [1709], 'Researchers': [1710, 1869], 'shy': [1713], 'away': [1714], 'concluding': [1718], 'relationship': [1721], 'enough': [1730], 'recommend': [1732, 1871], 'To': [1738], 'make': [1739], 'recommendation': [1741], 'measured': [1745], 'weak': [1751], 'put': [1753], 'risk,': [1756], 'lead': [1757], 'unnecessary': [1759], 'testing,': [1760], 'poor': [1765], 'decision-making.': [1766], 'whenever': [1768], 'estimate,': [1781], 'accompanied': [1785], 'CI.': [1788], 'CI': [1790, 1826], 'bootstrap': [1799], 'resampling': [1800, 1806], 'replacement,': [1802], 'involves': [1804], 'times,': [1810], 'time': [1813], 'estimating': [1814], 'obtaining': [1819], 'standard': [1822], 'error': [1823], 'distribution': [1829], 'cut-points.5': [1833], 'conclusion,': 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'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-12-17T02:51:34.253729', 'created_date': '2018-10-12'}