Title: Plasma neutrophil gelatinase-associated lipocalin (NGAL) for timing of initiation of renal replacement therapy for acute kidney injury?
Abstract: Renal replacement therapy (RRT) for acute kidney injury (AKI) has been in use in critically ill patient since the first successful treatments done by William Kolff during the mid-1940-ties (1). Similar to many other invasive treatments used in the intensive care unit (ICU) such as mechanical ventilation, decompressive craniotomy, or intra-aortic balloon pump and despite over 6 decades of experience, the optimal timing of initiation of RRT for AKI is still a matter of debate (2).