Management of anaemia and iron deficiency in patients with cancer: ESMO Clinical Practice Guidelines

Name: Work Video:
Duration: 3 min 30 s
Matti Aapro; Yves Béguin; Carsten Bokemeyer; Mario Dicato; Pere Gascón; John A. Glaspy; Axel Hofmann; Hartmut Link; T. Littlewood; Heinz Ludwig; Anders Österborg; P. Pronzato; Valeria Santini; D. Schrijvers; R. Stauder; Kim Jordan; Jørn Herrstedt
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'relation': [117], 'to': [118, 298, 381, 396, 577, 602, 1128, 1302, 1552, 1660, 1744, 1807, 1826, 1983, 1990, 2048, 2062, 2070, 2258, 2414, 2419, 2458, 2678, 2688, 2809, 2837, 2883, 2918, 2985, 2992, 3071, 3120, 3125, 3141, 3201, 3351, 3365, 3374, 3390, 3416, 3463, 3491, 3504, 3639, 3866, 3999], 'prognosis': [119], 'elderly': [121], 'aggressive': [124], 'lymphoma': [125], 'receiving': [126, 252, 1534, 1619, 1750, 2429, 2525, 2565, 2787, 3731, 3768, 3926, 4077], 'first': [127], 'line': [128], 'immunochemotherapy:': [129], 'an': [130, 327, 562, 1332, 1384, 1403, 1419, 1442, 1539, 1573, 1656, 1704, 1967, 2024, 2139, 3131, 3835], 'analysis': [131], 'Lysa': [134], 'LNH': [135], '03-6B': [136], 'Study.Blood.': [137], '122': [139], '(Abstr': [140], '2202)Google': [141], 'Scholar].': [142, 290, 372, 544, 778, 842, 1068, 1209, 2610, 3821, 3938, 4035], 'Frequently,': [143], 'is': [145, 1364, 1422, 1434, 1446, 1478, 1607, 1666, 1877, 1931, 2042, 2210, 3039, 3080, 3096, 3104, 3180, 3388, 3403, 3441, 3502, 3517, 3831], 'associated': [146, 3015, 3575], 'fatigue,': [148, 560], 'impaired': [149, 296, 585], 'physical': [150], 'function': [151], 'reduced': [153, 302, 647], 'quality': [154, 202, 243, 2453, 2519], 'life': [156, 204, 245, 2455, 2521], '(QoL)': [157], '[4.Anker': [158], 'S.D.': [159], 'Comin': [160], 'Colet': [161], 'J.': [162, 190, 230, 355, 2475, 2546, 2715, 3597], 'Filippatos': [163], 'al.Ferric': [166], 'carboxymaltose': [167], 'heart': [171], 'failure': [172], 'deficiency.N': [175], 'Engl': [176], 'Med.': [178], '2009;': [179, 2603, 3618], '361:': [180], '2436-2448http://dx.doi.org/10.1056/NEJMoa0908355Crossref': [181], '(1102)': [184], '5.Cella': [187], 'D.': [188, 232, 684, 866, 1154, 1181, 2319, 3005], 'Kallich': [189], 'McDermott': [191], 'A.': [192, 322, 427, 742, 927, 1006, 2651, 4017], 'Xu': [193], 'X.': [194], 'longitudinal': [196], 'relationship': [197, 311], 'hemoglobin,': [199], 'fatigue': [200, 720], 'anemic': [206, 249, 3919], 'patients:': [208, 273, 881, 2448, 2732], 'results': [209, 2528, 2620, 3772], 'from': [210, 696, 763, 1166, 1549, 1636, 2315, 3122, 3689], 'five': [211], 'randomized': [212, 2554, 3691], 'clinical': [213, 363, 521, 813, 844, 987, 3209, 3471], 'trials.Ann': [214], '15:': [217], '979-986http://dx.doi.org/10.1093/annonc/mdh235Abstract': [218], '(174)': [226], '6.Crawford': [229], 'Cella': [231], 'Cleeland': [233, 2433], 'C.S.': [234, 2434], 'al.Relationship': [236], 'between': [237, 2630], 'changes': [238, 1548], 'hemoglobin': [240, 2451, 3718, 4064], 'level': [241, 641, 1386, 1405, 1449, 1639, 3678], 'during': [246, 1678], 'chemotherapy': [247, 2430, 2447, 3769], 'epoetin': [253, 529, 1513, 1535, 1585, 2444, 2513, 2975, 3066, 3721, 3907, 4067], 'alfa': [254, 2445, 2482, 2514, 2560, 3722, 3908, 4068], 'therapy.Cancer.': [255], '2002;': [256, 2570], '95:': [257], '888-895http://dx.doi.org/10.1002/cncr.10763Crossref': [258], '(366)': [261], '7.Demetri': [264], 'G.D.': [265], 'functional': [269, 648, 1605, 1685, 1718, 1789, 2800], 'consequences': [270, 594], 'current': [274], 'challenges': [275], 'management': [277, 433, 550, 975, 1012, 1130, 1259, 1278, 2595], 'prospects': [279], 'for': [280, 331, 408, 493, 790, 801, 819, 886, 910, 931, 1106, 1147, 1191, 1232, 1257, 1276, 1439, 1484, 1503, 1512, 1532, 1843, 1864, 1923, 1936, 2136, 2155, 2202, 2215, 2273, 2329, 2423, 2579, 2658, 2756, 2813, 2922, 3065, 3182, 3443, 3582, 3606, 3757, 3828, 3883, 3985, 4004, 4024], 'improving': [281], 'therapy.Br': [282], '2001;': [285, 341, 1244, 2463, 2537], '84:': [286], '31-37Crossref': [287], 'Consequences': [291], 'may': [294, 1588, 1711, 2270, 3261, 3558], 'include': [295, 392, 1125], 'response': [297, 1576, 2804, 2836, 2984, 3079], 'overall': [303], 'survival': [304, 332, 2870, 3735, 3885, 4081], '(OS),': [305], 'even': [306], 'though': [307], 'causal': [309], 'direct': [310], 'has': [312, 808, 1596, 3269], 'not': [313, 782, 1412, 1423, 1429, 1527, 1556, 1562, 1567, 1597, 1734, 1920, 2060, 2068, 2199, 2680, 2842, 2978, 3040, 3056, 3062, 3146, 3270, 3767, 3878, 3984], 'yet': [314, 2843], 'been': [315, 809, 1079, 2412, 3199, 3461], 'established': [316], '[8.Caro': [317], 'J.J.': [318], 'Salas': [319], 'M.': [320, 425, 485, 509, 713, 925, 1004, 1040, 2470, 2472, 2587, 3003, 3632, 3672, 3714, 4060], 'Ward': [321], 'Goss': [323], 'Anemia': [325, 472], 'as': [326, 1390, 1392, 1800, 2018, 2097, 2645, 3405, 3519], 'independent': [328, 2269, 3253], 'prognostic': [329, 751], 'factor': [330], 'cancer:': [336, 941], 'systemic,': [338], 'quantitative': [339], 'review.Cancer.': [340], '91:': [342], '2214-2221Crossref': [343], '(718)': [346], '9.Hudis': [349], 'C.A.': [350, 1227], 'Chang': [354], 'Muenstedt': [356], 'K.': [357, 3599], 'rHuEPO': [358], 'outcomes:': [361], 'experience.Oncologist.': [364], '9:': [366], '55-69Crossref': [367], '(0)': [370, 457, 1036, 1249, 3706, 3936], 'These': [373, 1281], 'new': [374, 1103, 1905, 2247, 2943, 3526], 'ESMO': [375, 882, 1104, 1140, 1187, 2325], 'Clinical': [376, 519, 664, 828, 860, 883, 1188, 2326], 'Practice': [377, 465, 861, 884, 1189, 2327], 'Guidelines': [378, 466, 862, 885, 1190, 2328], 'provide': [379], 'tools': [380], 'evaluate': [382], 'anaemia,': [383, 436, 583, 1015, 1977], 'also': [384, 627], 'myelodysplastic': [388, 671, 691, 726, 759, 835, 1161, 2191, 2302, 2404, 3437, 3540], 'syndromes': [389, 692, 1162], '(MDS),': [390], 'recommendations': [393, 492, 695, 1165, 1217, 1225, 1282, 1299], 'on': [394, 525, 970, 1054, 1091, 1430, 1735, 1746, 1763, 2515, 2590, 2725, 3044, 3345, 3611], 'how': [395], 'safely': [397], 'manage': [398], 'chemotherapy-induced': [399], '(CIA)': [401], 'erythropoiesis-stimulating': [403, 977, 1052, 1883, 2171, 2280, 2359, 2384, 2597, 2723, 2888, 2949, 3430, 3533], '(ESAs),': [405], 'preparations': [407, 993, 1523], 'intravenous': [409, 444, 1023], '(i.v.)': [410], 'oral': [412], 'administration,': [413], 'red': [414, 1893, 2194, 2305, 2369, 2407, 2899, 2903, 2960, 2964], 'blood': [415, 1095, 1894, 2195, 2306, 2370, 2408, 2904, 2965], 'cell': [416, 1239, 2900, 2961], '(RBC)': [417], 'transfusions': [418, 661, 1096, 1456, 1874, 1998, 2089, 2130, 2147, 2425], 'combinations': [420], 'these': [422, 657, 1123, 1213], 'treatments': [423, 2755], '[10.Aapro': [424, 1003], 'Österborg': [426, 1005], 'Gascón': [428, 1007], 'al.Prevalence': [431, 1010], 'cancer-related': [435, 1014], 'specific': [441, 1020, 1070, 1295], 'role': [442, 1021], 'iron.Ann': [445, 1024], '2012;': [447, 1026, 1061, 2665, 4031], '23:': [448, 1027, 3740, 4086], '1954-1962Abstract': [449, 1028], '11.National': [460], 'Comprehensive': [461], 'Network.': [463], 'NCCN': [464], 'Oncology;': [468], 'Chemotherapy-Induced': [471], '–': [473], 'v.1.2018,': [474], '2017;': [475], 'http://www.nccn.org/professionals/physician_gls/PDF/anemia.pdf': [476], '(18': [477], 'October': [478], '2017,': [479], 'date': [480], 'last': [481, 904], 'accessed).Google': [482], '12.Aapro': [484], 'Chernov': [486], 'V.M.': [487], 'Gladkov': [488], 'O.A.': [489], 'al.Practical': [491], 'anemia': [497, 974, 2594, 3014, 3761], 'patients.Malignant': [500], 'Tumors.': [501], '2016;': [502, 3931], '4:': [503], '368-377Google': [504], '13.Rizzo': [506], 'J.D.': [507], 'Brouwers': [508], 'Hurley': [510], 'al.American': [513], 'Society': [514, 517, 854], 'Hematology/American': [516], 'Oncology': [520, 857], 'practice': [522], 'guideline': [523], 'update': [524, 960, 969, 1136, 2589], 'use': [527, 665, 791, 829, 933, 1093, 1924, 2203], 'darbepoetin': [531, 1504, 2051, 2481, 2559, 2657, 3580, 3605, 4023], 'adult': [533], 'cancer.Blood.': [536], '2010;': [537, 889], '116:': [538], '4045-4059http://dx.doi.org/10.1182/blood-2010-08-300541Crossref': [539], '(168)': [542], 'major': [546], 'aims': [547], 'reduction': [553], 'resolution': [555], 'symptoms,': [558], 'improved': [563], 'QoL': [564, 2619, 2639], 'minimum': [567], 'invasive': [568], 'that': [570, 2617, 3143, 3555, 3861, 3997], 'corrects': [571], 'underlying': [573, 604, 1297, 1347], 'causes': [574, 581, 620, 1348], 'proves': [576], 'be': [578, 593, 1327, 1335, 1416, 1463, 1519, 1589, 1671, 1712, 1742, 1757, 1785, 1841, 1917, 1970, 2013, 2016, 2065, 2078, 2095, 2122, 2134, 2271, 2679, 2810, 2919, 3072, 3088, 3118, 3147, 3262, 3847, 3951], 'safe.': [579], 'Underlying': [580], 'mainly': [584, 3724, 4070], 'erythropoietic': [586, 667, 831, 935], 'activity': [587, 807], 'disturbed': [589], 'homeostasis,': [591], 'can': [592, 3117, 3949], 'increased': [596, 1002, 1520, 1598, 3271], 'release': [597], 'inflammatory': [599], 'cytokines': [600], 'due': [601, 2882], 'and/or': [606, 1677, 1852, 2001], 'toxicity': [607], 'therapy.': [610, 1583], 'Furthermore,': [611, 1069, 2611], 'vitamin': [612], 'B12': [613], 'folate': [615], 'relatively': [618], 'rare': [619, 2775], 'patients.': [625], 'Notably,': [626, 3960], 'more': [628, 820, 2128, 3399, 3513], 'than': [629, 821, 1350, 1995, 3400, 3514], 'half': [630], 'MDS': [634, 768, 793, 800, 824, 1134, 1148, 1956, 1973, 2056, 2120, 2235, 3187, 3448], 'characterised': [636], 'by': [637, 784, 1081, 1212, 1599, 1933, 2212, 2877, 3195, 3272, 3457, 3953], 'haemoglobin': [639, 3677], '(Hb)': [640], '<': [642, 1387, 1406, 1648, 1688, 1721, 1849, 1979, 2004, 2820, 2827, 2929, 2936, 3081, 3989], '10': [643, 1388, 1946, 1980, 2225, 2701, 2988, 3990], 'g/dL,': [644, 1389, 1603, 1981, 3833], 'resulting': [645], 'capacities': [649], 'health-related': [651], 'QoL,': [652], '>': [654, 1693, 1726, 3839, 3874, 3980], '80%': [655], 'require': [659, 2125], 'RBC': [660, 1455, 1844, 1873, 1997, 2088, 2129, 2146, 2424, 2766, 2834], '[14.Santini': [662, 826], 'V.': [663, 827, 3007, 3712, 4058], 'stimulating': [668, 832], 'syndromes.Oncologist.': [672, 836], '2011;': [673, 837, 3696], '16:': [674, 838], '35-42Crossref': [675, 839], '15.Malcovati': [679], 'L.': [680, 740, 1150], 'Hellström-Lindberg': [681, 1151], 'Bowen': [683, 1153], 'al.Diagnosis': [686, 1156], 'primary': [690, 1160, 1955, 2234], 'adults:': [694, 1164], 'LeukemiaNet.Blood.': [699, 1169], '122:': [701, 1171, 2497], '2943-2964Crossref': [702, 1172], '(404)': [705, 1175], '16.Efficace': [708], 'F.': [709, 871], 'Gaidano': [710], 'Breccia': [712], 'al.Prevalence,': [715], 'severity': [716], 'correlates': [718], 'newly': [722], 'diagnosed': [723], 'syndromes.Br': [727], 'Haematol.': [729, 772, 2495], '2015;': [730, 773], '168:': [731], '361-370http://dx.doi.org/10.1111/bjh.13138Crossref': [732], '(35)': [735], '17.de': [738], 'Swart': [739], 'Smith': [741], 'Johnston': [743], 'T.W.': [744], 'al.Validation': [746], 'revised': [749, 2185, 2294, 2398], 'international': [750], 'scoring': [752], 'system': [753], '(IPSS-R)': [754], 'lower-risk': [758], 'syndromes:': [760, 1186, 2324], 'report': [762], 'LeukaemiaNet': [767], '(EUMDS)': [769], 'registry.Br': [770], '170:': [774], '372-383http://dx.doi.org/10.1111/bjh.13450Crossref': [775], 'However,': [779, 2672, 3939], 'ESAs': [780, 990, 1462, 2012, 2197, 2410, 2634, 3111, 3162, 3549], 'were': [781, 1118], 'approved': [783, 1468, 1828, 2578, 3169, 3194, 3456, 4002], 'Medicines': [787, 2166, 2379, 3427, 3530], 'Agency': [788], '(EMA)': [789], 'despite': [795], 'being': [796], 'used': [797, 3148], 'effectively': [798], 'at': [802, 1538, 1571, 1577, 1600, 1771, 1857, 2023, 2080, 3090, 3273], 'least': [803, 1572, 1601, 3274], '20': [804, 1507, 2043, 3360, 3411], 'years;': [805], 'their': [806, 3168], 'demonstrated': [810], 'numerous': [812], 'trials,': [814], 'published': [816, 2693, 2738], 'evidence': [817, 1221, 1569, 3106], 'existing': [818], '2500': [822], 'ESA-treated': [823], 'Randomised': [843], 'trials': [845, 2699], 'ongoing.': [847], 'Since': [848, 2969], 'publication': [850], 'Medical': [856], '(ESMO)': [858], '2010': [864], '[18.Schrijvers': [865], 'De': [867], 'Samblanx': [868], 'Roila': [870], 'Erythropoiesis-stimulating': [872], 'use.Ann': [887], '21:': [890], 'v244-v247Abstract': [891], '(108)': [899], 'Scholar]': [901, 958, 1251, 2575, 2669], 'review': [905, 2734, 3965], 'Organisation': [909], 'Research': [911], 'Treatment': [913], '(EORTC)': [916], 'guidelines': [919, 930, 972, 1105, 1124, 1146, 1214, 1231], '2006': [921, 942], '[19.Bokemeyer': [922], 'C.': [923, 3601, 3636], 'Aapro': [924, 3750], 'Courdi': [926], 'al.EORTC': [929], 'proteins': [936], 'anaemic': [938, 2119, 2484, 3854], 'update.Eur': [943], '2007;': [946, 3814], '43:': [947], '258-270http://dx.doi.org/10.1016/j.ejca.2006.10.014Abstract': [948], '(337)': [956], '(last': [959], '2007': [962, 968], '[20.Aapro': [963], 'M.S.': [964, 3751], 'Link': [965], 'September': [967], 'EORTC': [971], 'agents.Oncologist.': [978], '2008;': [979, 3588, 3784], '13:': [980], '33-36Crossref': [981], '(156)': [984], 'Scholar]),': [986, 4092], 'experience': [988, 2684], 'understanding': [996], 'homeostasis': [999], 'have': [1000, 1078, 1958, 2150, 2159, 2237, 2411, 3198, 3202, 3460, 3464], 'markedly': [1001], '21.Aapro': [1039], 'Jelkmann': [1041], 'Constantinescu': [1043], 'S.N.': [1044], 'Leyland-Jones': [1045], 'B.': [1046, 2550, 3569, 3710, 3893, 4056], 'Effects': [1047], 'erythropoietin': [1049, 3011, 3578, 3804, 3864], 'receptors': [1050], 'progression': [1056], 'cancer.Br': [1058], '106:': [1062], '1249-1258Crossref': [1063], '(83)': [1066], 'safety': [1071, 2479, 2839, 3137, 3204, 3466, 3547], 'aspects': [1072, 1126, 1296], 'options': [1077, 1306], 'addressed': [1080, 1211], 'several': [1082], 'analyses': [1083, 3968], 'reviews': [1085], 'recent': [1087, 1139, 3963], 'years,': [1088], 'although': [1089], 'data': [1090], 'sparse.': [1101], 'Therefore,': [1102], 'diagnosis': [1108], 'ID': [1114, 1263, 1315, 1344, 1606, 1645, 1686, 1719, 1790, 1819, 1836, 2759, 2801, 2818, 2831, 2927], 'deemed': [1119], 'necessary.': [1120], 'In': [1121, 1748, 3542, 3849], 'addition,': [1122], 'related': [1127, 1301], 'most': [1138, 3962], 'LeukemiaNet': [1143], '(ELN)': [1144], '[15.Malcovati': [1149], '22.Fenaux': [1178], 'Haase': [1180, 2318], 'Sanz': [1182, 2320], 'G.F.': [1183, 2321], 'al.Myelodysplastic': [1185, 2323], 'diagnosis,': [1192, 2330], 'follow-up.Ann': [1195, 2333], '2014;': [1197, 2335, 2744], '25:': [1198, 2336, 3815], 'iii57-iii69Abstract': [1199, 2337], '(54)': [1207, 2345], 'Questions': [1210], 'respective': [1216], 'including': [1218], 'levels': [1219, 2417, 2852, 3627, 3719, 4065], 'grades': [1223], '[23.Dykewicz': [1226], 'Summary': [1228], 'preventing': [1233], 'opportunistic': [1234], 'infections': [1235, 2881], 'among': [1236, 3110], 'haematopoietic': [1237], 'stem': [1238], 'transplant': [1240], 'recipients.Clin': [1241], 'Infect': [1242], 'Dis.': [1243], '33:': [1245], '139-144http://dx.doi.org/10.1086/321805Crossref': [1246], 'summarised': [1253, 1308], 'Table': [1255, 1274, 1907], '1': [1256, 1290, 1602, 3082, 3275], 'malignancies': [1271], '2': [1275, 1634, 2126, 3840], 'MDS.': [1280, 1928, 2207, 2260], 'further': [1284], 'illustrated': [1285], 'algorithms': [1288], '(Figures': [1289], '2).': [1292], 'Discussions': [1293], 'this': [1310, 1578, 2676, 3091], 'article.Table': [1311], '1Managing': [1312], 'malignanciesWhen': [1323], 'should': [1324, 1334, 1359, 1461, 1465, 1580, 1615, 1651, 1670, 1741, 1755, 1782, 1791, 1820, 1840, 1914, 1969, 2011, 2015, 2055, 2077, 2094, 2117, 2133, 3087, 3145, 3846], 'ESA': [1325, 1333, 1361, 1517, 1522, 1544, 1551, 1582, 1664, 1679, 1915, 1968, 2063, 2071, 3085, 3556, 3829, 4012], 'considered?Treatment': [1328], 'considered': [1336, 1713, 1842, 1971, 2096, 2135, 2272, 2675, 2811, 2920], 'under': [1339], 'ChT': [1340, 1373, 1399, 1414, 1431, 1621, 1736, 1769], 'after': [1341, 1591, 1761, 2073, 3074, 3264], 'correction': [1342, 1834], 'other': [1346, 1349], '[I,': [1356, 1374, 1432, 1457, 1515, 1612, 1696, 1837, 2007, 2053, 2115, 2163], 'A].Which': [1357, 1613, 1838], 'receive': [1360, 1372, 1398, 1413, 1616, 1652, 1699, 1737, 1792, 1821], 'therapy?ESA': [1362], 'therapy': [1363, 1680, 1702, 1710, 2689, 2790, 4013], 'recommended': [1365, 1424, 1476, 3063, 3824], 'symptomatic': [1369, 1940, 1976, 2219], 'who': [1371, 1397, 1410, 1427, 1565, 1622, 1732, 1957, 2058, 2110, 2124, 2236, 2263, 3054], 'A]': [1375], 'combined': [1377], 'RT-ChT': [1378], '[II,': [1379, 1879], 'B]': [1380], 'present': [1382, 1401, 1623], 'Hb': [1385, 1404, 1436, 1444, 1575, 1595, 1631, 1848, 1859, 1866, 1978, 2416, 2849, 2983, 3078, 3101, 3268, 3626, 3825, 3836, 3873, 3979, 3986, 3988, 3993, 4009, 4043, 4051], 'well': [1391, 2644], 'asymptomatic': [1395], '8': [1407], 'g/dL.Should': [1408], 'do': [1411, 1566, 3055], 'ESA?ESA': [1420], 'A].What': [1433], 'target': [1437, 1445, 3625, 3826, 3872, 4008, 4042, 4050], 'range': [1438, 2029, 3827, 4010, 4044], 'ESA?The': [1443], 'stable': [1448], '∼': [1451, 2081, 3229], '12': [1452, 1641, 3629, 3875, 3981], 'g/dL': [1453, 1629, 1635, 1851, 3630, 3841, 3876, 3982, 3991, 3996, 4054], 'without': [1454, 1703, 1707, 1875, 2102, 3150, 3154], 'A].At': [1458, 2008], 'what': [1459, 1780, 2009], 'doses': [1460, 1518, 1781, 1805, 1824, 2010], 'given?Dosing': [1464], 'follow': [1466], 'labels': [1469, 1829, 3379, 3496], 'individual': [1472, 1715, 3612], 'products;': [1473], 'currently': [1475, 4001], 'dosage': [1477], 'approximately': [1479], '450': [1480, 3230], 'IU/week/kg': [1481], 'body': [1482, 1492, 1500, 3232, 3255, 3294, 3305, 3362, 3413], 'weight': [1483, 1493, 1501, 3233, 3256, 3306, 3339, 3363, 3414, 3482], 'epoetins': [1485], 'alpha,': [1486], 'beta': [1487, 2976], 'zeta;': [1489], '6.75': [1490], 'µg/kg': [1491, 1499], 'every': [1494, 3299], '3': [1495, 3220, 3286, 3300], 'weeks': [1496, 1560, 1593, 3060, 3076, 3266, 3301, 3956], '2.25': [1498, 3303], 'weekly': [1502, 1511, 3215, 3241], 'alpha;': [1505], '000': [1508, 2033, 2044, 2989, 3225, 3250], 'IU': [1509, 2034, 3226, 3251], 'once': [1510, 3214, 3240, 3258, 3280, 3298, 3308], 'theta': [1514, 1536, 1586, 2039], 'A].Should': [1516, 1697], 'changed': [1524], 'responding': [1528, 1557, 2061, 2069, 2687], 'within': [1529, 1558, 3058], '4–8': [1530, 1559, 3059], 'weeks?Except': [1531], '(given': [1537], 'intentionally': [1540], 'low': [1541, 1951, 1959, 1982, 1989, 2230, 2238, 2257, 3068, 3183, 3444], 'starting': [1542, 2040, 3069], 'dose),': [1543], 'dose': [1545, 1587, 1794, 1802, 2026, 2041, 2971, 3022, 3045, 3050, 3070, 3260, 3372, 3387, 3394, 3489, 3501, 3508], 'escalations': [1546, 3046, 3051], 'one': [1550, 3123, 4038], 'another': [1553, 3126], 'recommended.': [1563], 'Patients': [1564, 1815], 'show': [1568, 2979], 'initial': [1574, 2025], 'time': [1579, 3092], 'stop': [1581], 'doubled': [1590, 3073, 3263], '4': [1592, 3075, 3265], 'if': [1594, 2148, 2157, 3077, 3094, 3267, 3393, 3507, 3624], 'unless': [1604], 'detected': [1608], '(see': [1609, 3188, 3449], 'next': [1610], 'recommendation)': [1611], 'therapy?Patients': [1618], 'ongoing': [1620], '(Hb': [1626], '≤': [1627, 1640, 1945, 2224], '11': [1628], 'decrease': [1632], '≥': [1633], 'baseline': [1638, 3978], 'g/dL)': [1642, 1947, 2226], 'absolute': [1644, 1818, 2817, 2926], '(serum': [1646], 'ferritin': [1647, 1692, 1725], '100': [1649, 1694, 1727, 2821, 2930], 'ng/mL)': [1650, 1695, 1728, 2822, 2931], 'i.v.': [1657, 1700, 1753, 1783, 1812, 1822, 2274, 3164], 'preparation': [1659], 'correct': [1661], 'ID.': [1662], 'If': [1663, 3500], 'considered,': [1667], 'given': [1672, 1758, 1799, 2017, 2084, 3239, 3257, 3297], 'before': [1673, 1759], 'initiation': [1675, 4005], 'case': [1683, 3129], '(TSAT': [1687, 1720], '20%': [1689, 1722], 'serum': [1691, 1724, 1960, 2002, 2239, 2309], 'ESA?i.v.': [1705], 'additional': [1708], '[III,': [1729, 1778], 'C].Should': [1730], 'therapy?Iron': [1739], 'limited': [1743], 'ChT.': [1747], 'cardiotoxic': [1751], 'ChT,': [1752, 2356], 'either': [1756], '(not': [1762], 'same': [1765], 'day)': [1766], 'administration': [1767, 1871, 3581], 'end': [1773], 'cycle': [1777], 'C].At': [1779], 'given?Patients': [1786], 'confirmed': [1788, 1817], '1000': [1796, 2995, 3366, 3375, 3391, 3396, 3417, 3492, 3505, 3510], 'mg': [1797, 3321, 3331, 3367, 3397, 3418, 3511], 'single': [1801, 3042], 'multiple': [1804, 3017], 'according': [1806, 1825], 'label': [1809, 3312, 3475], 'available': [1811, 1831], 'formulations.': [1814], 'products': [1832, 2093, 3144, 3191, 3453], 'until': [1833], 'transfusions?In': [1845], '7–8': [1850], 'severe': [1853], 'anaemia-related': [1854, 2646, 2712, 2728, 2769, 2857], 'symptoms': [1855, 2643, 2647, 2713, 2729], '(even': [1856], 'higher': [1858], 'levels)': [1860], 'need': [1863, 2422], 'immediate': [1865], 'symptom': [1868], 'improvement,': [1869], 'delay': [1876], 'justified': [1878], 'B].ChT,': [1880], 'chemotherapy;': [1881, 2357], 'ESA,': [1882, 2170, 2279, 2358, 2383, 2887, 2948, 3429, 3532], 'agent;': [1884, 2172, 2281, 2360, 2385, 2889, 2950, 3431, 3534], 'Hb,': [1885, 2177, 2286, 2361, 2390, 2890, 2951, 3432, 3535], 'haemoglobin;': [1886, 2178, 2287, 2362, 2391, 2891, 2952, 3433, 3536], 'ID,': [1887, 2363, 2892, 2953], 'deficiency;': [1889, 2365, 2894, 2955], 'i.v.,': [1890, 2299, 2366, 2895, 2956, 3434, 3537], 'intravenous;': [1891, 2300, 2367, 2896, 2957, 3435, 3538], 'RBC,': [1892, 2193, 2304, 2368, 2406, 2902, 2963], 'cell;': [1895, 2307, 2371, 2905, 2966], 'RT,': [1896, 2372, 2906, 2967], 'radiotherapy;': [1897, 2373], 'TSAT,': [1898, 2311, 2374], 'transferrin': [1899, 2312, 2375], 'saturation.': [1900, 2313, 2376], 'Open': [1901, 2243, 2939, 3522], 'table': [1902, 2244, 2940, 3523], 'tab': [1906, 2248, 2944, 3527], '2Managing': [1908], 'MDSWhen': [1913], 'considered?aESAs': [1918], 'all': [1921, 2200], 'EMA-approved': [1922, 2201, 3181, 3442], 'Epoetin': [1929, 2208, 3439], 'alpha': [1930, 2052, 2209, 3179, 3440, 3756], 'indicated': [1932, 2211], 'EMA': [1935, 2214, 3197, 3459], '(haemoglobin': [1942, 2221], 'concentration': [1943, 2222], 'adults': [1949, 2228], 'intermediate-1': [1953, 1984, 2232, 3185, 3446], 'risk': [1954, 1985, 1992, 2233, 2879, 3186, 3447], 'EPO': [1961, 2003, 2037, 2240, 3958], '(<200': [1962, 2241], 'IU/mL).Treatment': [1963], '(IPSS)': [1986], 'very': [1988, 2256], 'intermediate': [1991], '(IPSS-R),': [1993], 'less': [1994], 'two': [1996], 'per': [1999, 2131, 3222, 3247, 3288, 3406, 3420, 3520], 'month': [2000, 2132], '500': [2005, 2993], 'IU/L': [2006], 'given?ESAs': [2014], 'fixed-dose,': [2019], 'weekly,': [2020, 3259, 3281], 'subcutaneous': [2021], '30': [2031, 3401, 3515], '000–80': [2032], 'recombinant': [2035, 3577], 'human': [2036, 3010], '(epoetin': [2038], 'IU)': [2045], 'up': [2047, 3373, 3389, 3490, 3503], '300': [2049, 2082], 'µg': [2050], 'A].How': [2054, 2116], 'treated?In': [2066], '8–12': [2074], 'weeks,': [2075], 'G-CSF': [2076], 'added': [2079], 'µg/week,': [2083], '2–3': [2086], 'doses.': [2087], 'investigational': [2091, 2140], 'medicinal': [2092], 'second-line': [2098], '5q': [2104, 2113, 2152, 2161], 'deletion,': [2105, 2153], 'lenalidomide': [2107, 2156], 'acquired': [2111], 'deletion': [2114, 2162], 'transfusion-dependent,': [2118], 'treated?Patients': [2123], 'agent': [2141], 'supportive': [2143, 3912, 3916], 'care': [2144, 3869, 3890, 3913, 3917], 'they': [2149, 2158], 'no': [2151, 2788, 3097, 3105, 3115], 'A].EMA,': [2164], 'Agency;': [2167, 2380, 3428, 3531], 'EPO,': [2168, 2277, 2381], 'erythropoietin;': [2169, 2278, 2382], 'G-CSF,': [2173, 2282, 2386], 'granulocyte': [2174, 2283, 2387], 'colony-stimulating': [2175, 2284, 2388], 'factor;': [2176, 2285, 2389], 'IPSS,': [2179, 2288, 2392], 'International': [2180, 2186, 2289, 2295, 2393, 2399], 'Prognostic': [2181, 2187, 2290, 2296, 2394, 2400], 'Scoring': [2182, 2188, 2291, 2297, 2395, 2401], 'System;': [2183, 2189, 2292, 2298, 2396, 2402], 'IPSS-R,': [2184, 2293, 2397], 'MDS,': [2190, 2301, 2403, 3436, 3539], 'syndrome;': [2192, 2303, 2405], 'cell.a': [2196], 'IU/mL).': [2242], 'Figure': [2249, 2350], '2Management': [2250], 'intermediate-risk': [2259], 'aESA-treated': [2261], 'deficient': [2266], 'transfusion': [2268, 3682], 'treatment.': [2276], 'SF,': [2308], 'ferritin;': [2310], 'Adapted': [2314], '[22.Fenaux': [2316], 'Scholar].View': [2347], 'Large': [2348], 'Image': [2349], 'ViewerDownload': [2351], 'Hi-res': [2352], 'image': [2353], 'Download': [2354], '(PPT)': [2355], 'EMA,': [2377, 3528], 'cell.': [2409], 'shown': [2413, 3200, 3462], 'increase': [2415, 2847], 'reduce': [2420], '[24.Gabrilove': [2431], 'J.L.': [2432], 'Livingston': [2435], 'R.B.': [2436], 'al.Clinical': [2438], 'evaluation': [2439], 'once-weekly': [2441], 'dosing': [2442, 3170], 'improvements': [2449], 'similar': [2457, 3203, 3465], 'three-times-weekly': [2459], 'dosing.J': [2460], 'Clin': [2461, 2535, 3737, 3782, 3812, 3929, 4083], '19:': [2464, 2538], '2875-2882http://dx.doi.org/10.1200/JCO.2001.19.11.2875Crossref': [2465], '25.Hedenus': [2469], 'Adriansson': [2471], 'San': [2473], 'Miguel': [2474], 'al.Efficacy': [2477], 'lymphoproliferative': [2487], 'malignancies:': [2488], 'randomized,': [2490, 2531, 3778, 3900], 'double-blind,': [2491, 2532, 3651, 3779, 3800], 'placebo-controlled': [2492, 2533, 3652, 3780, 3801], 'study.Br': [2493], '2003;': [2496, 3654], '394-403http://dx.doi.org/10.1046/j.1365-2141.2003.04448.xCrossref': [2498], '(287)': [2501], '26.Littlewood': [2504], 'T.J.': [2505], 'Bajetta': [2506], 'Nortier': [2508], 'J.W.': [2509], 'al.Effects': [2511, 2721], 'hematologic': [2516], 'nonplatinum': [2526], 'chemotherapy:': [2527, 3733, 4079], 'trial.J': [2534], '2865-2874http://dx.doi.org/10.1200/JCO.2001.19.11.2865Crossref': [2539], '(918)': [2542], '27.Vansteenkiste': [2545], 'Pirker': [2547], 'Massuti': [2549], 'al.Double-blind,': [2552], 'placebo-controlled,': [2553], 'phase': [2555, 3775, 3903], 'III': [2556, 3904], 'trial': [2557, 3802], 'lung': [2562, 3807], 'chemotherapy.J': [2566, 3928], 'Natl': [2567], 'Inst.': [2569], '94:': [2571], '1211-1220http://dx.doi.org/10.1093/jnci/94.16.1211Crossref': [2572], 'CIA': [2583], 'since': [2584, 3037], '1993': [2585], '[28.Aapro': [2586], 'An': [2588], 'twenty': [2591], 'years': [2592], 'nephrology': [2600], 'oncology/hematology.Oncologist.': [2602], '14:': [2604], '1-5Crossref': [2605], '(14)': [2608], 'meta-analysis': [2613, 2694], '23': [2615], 'studies': [2616, 2973], 'reported': [2618], 'included': [2622, 3966], '5584': [2623], 'showed': [2625, 3970], 'statistically': [2627, 3971], 'significant': [2628, 3972], 'difference': [2629, 2981], 'controls': [2636], 'when': [2637, 3552], 'combining': [2638], 'fatigue-related': [2642], '[29.Tonia': [2648, 4014], 'T.': [2649, 2717, 4015], 'Mettler': [2650, 4016], 'Robert': [2652, 4018], 'N.': [2653, 4019], 'al.Erythropoietin': [2655, 3603, 3638, 4021], 'cancer.Cochrane': [2661, 4027], 'Database': [2662, 3615, 4028], 'Syst': [2663, 3616, 4029], 'Rev.': [2664, 3617, 4030], '12:': [2666, 4032], 'CD003407.PubMed': [2667, 4033], '(Table': [2670, 3112], '3).': [2671], 'authors': [2674, 3369, 3486], 'finding': [2677, 2972, 3023], 'clinically': [2681, 2708], 'important.': [2682], 'Conversely,': [2683], 'recently': [2692], '37': [2696], 'randomised,': [2697, 3650], 'controlled': [2698], '581': [2702], 'suggest': [2704, 3370, 3487], 'small': [2706], 'but': [2707, 3983], 'important': [2709], 'improvement': [2710, 2855], '[30.Bohlius': [2714], 'Tonia': [2716], 'Nüesch': [2718], 'fatigue-': [2726], 'systematic': [2733], 'meta-analyses': [2736, 3553], 'unpublished': [2740], 'data.Br': [2741], '111:': [2745], '33-45Crossref': [2746], '(37)': [2749], 'Scholar].Table': [2751], '3Benefit-risk': [2752], 'profiles': [2753], 'patientsBenefitsRisks': [2762], 'limitationsESAs•Reduction': [2764], 'transfusions•Improvement': [2767], 'symptoms•Increase': [2770, 2858], 'thrombotic': [2772, 2860], 'events•PRCA': [2773], 'casesaDocumented': [2776], 'only': [2777, 2792, 2812, 2909, 2921], 'non-cancer': [2779, 2911], 'chronic': [2780, 2912], 'kidney': [2781, 2913], 'patients.•Increased': [2783], 'mortality': [2784, 3560, 3574, 3974], 'RT•Only': [2793], 'effective': [2794], '60%': [2796], 'patients•Induction': [2798], 'decreasing': [2803], 'over': [2805, 3244, 3842], 'timei.v.': [2806], 'ironbOral': [2807], 'both': [2816, 2925], '(ferritin': [2819, 2928], 'non-inflammatory': [2824, 2933], 'conditions': [2825, 2934], '(CRP': [2826, 2935], '5': [2828, 2937, 3693], 'mg/L).•Correction': [2829], 'anaemia•Reduction': [2832], 'transfusions•Increase': [2835], 'ESAs•Long-term': [2838], 'oncology': [2841], 'fully': [2844], 'establishedRBC': [2845], 'transfusions•Immediate': [2846], 'haematocrit': [2851], '100%•Rapid': [2854], 'events•Transfusion': [2861], 'reactions': [2862], 'circulatory': [2864], 'overload•Transmission': [2865], 'known/unknown': [2867], 'pathogens•Possibly': [2868], 'decreased': [2869], 'certain': [2872], 'types': [2873], 'surgery•Increased': [2878], 'immunosuppressionCRP,': [2884], 'C-reactive': [2885, 2946], 'protein;': [2886, 2947], 'PRCA,': [2897, 2958], 'pure': [2898, 2959], 'aplasia;': [2901, 2962], 'radiotherapy.a': [2907], 'Documented': [2908], 'patients.b': [2915], 'Oral': [2916], 'mg/L).': [2938], 'CRP,': [2945], 'radiotherapy.': [2968], 'early': [2970], 'did': [2977, 3877], '5000': [2986], 'IU/day': [2990], '(corresponding': [2991], 'IU/kg/week': [2996], '70': [2999, 3236], 'kg': [3000, 3237], 'individual)': [3001], '[31.Cazzola': [3002], 'Messinger': [3004], 'Battistel': [3006], 'al.Recombinant': [3009], 'myeloma': [3018], 'non-Hodgkin’s': [3020], 'lymphoma:': [3021], 'identification': [3025], 'predictors': [3027], 'response.Blood.': [3029], '1995;': [3030], '86:': [3031], '4446-4453Crossref': [3032], 'Scholar],': [3035, 3622], 'there': [3038, 3095], 'study': [3043, 3852, 3905, 4039], 'showing': [3047], 'benefit,': [3049], 'respond': [3057], '(except': [3064], 'theta’s': [3067], 'g/dL).': [3083], 'Instead,': [3084], 'stopped': [3089], 'point': [3093], 'emerging': [3098], 'sign': [3099], 'response.': [3102, 3133], 'There': [3103], 'differing': [3108], 'efficacy': [3109], '4)': [3113], 'recommendation': [3116], 'made': [3119], 'change': [3121], 'product': [3124], 'insufficient': [3132], 'Because': [3134], 'possible': [3136], 'issues,': [3138], 'we': [3139], 'continue': [3140], 'recommend': [3142], 'interchangeably': [3149], 'adequate': [3151], 'traceability': [3152], 'notifying': [3155], 'treating': [3157], 'physician': [3158], '[V,': [3159], 'C].Table': [3160], '4Approved': [3161], 'compounds': [3166], 'malignanciesaEpoetin': [3178], 'text).,bBoth': [3189], 'originator': [3190, 3452], 'biosimilars': [3193, 3455], 'therapeutic': [3206, 3468], 'equivalence': [3207, 3469], 'practice.ESAsEpoetin': [3210], 'alpha450': [3211], 'IU/kg': [3212, 3218, 3231, 3278, 3284], 'subcutaneously': [3213, 3219, 3227, 3252, 3279, 3285, 3296, 3307], '150': [3217, 3283], 'times': [3221, 3246, 3287], 'weekEpoetin': [3223, 3248], 'beta30': [3224], '(i.e.': [3228], 'patient)': [3238], 'divided': [3243], '3–7': [3245], 'theta20': [3249], 'g/dLEpoetin': [3276], 'zeta450': [3277], 'weekDarbepoetin': [3289], 'alpha500': [3290], 'μg': [3291], '(6.75': [3292], 'μg/kg': [3293, 3304], 'weight)': [3295], 'weeklyi.v.': [3309], 'ironcFollow': [3310], 'indications': [3313, 3476], 'your': [3315, 3478], 'country.Ferric': [3316], 'gluconateMaximum': [3317], 'infusion': [3318, 3323, 3328, 3333, 3342, 3353, 3358, 3383, 3409, 3422], 'dose:': [3319, 3329, 3343, 3359, 3410], '125': [3320], 'ironMinimum': [3322, 3332], 'time:': [3324, 3334, 3354, 3384, 3423], '60': [3325], 'minIron': [3326, 3336, 3356], 'sucroseMaximum': [3327], '200–500': [3330], '30–210': [3335], 'dextrandLow': [3337], 'molecular': [3338, 3481], 'dextran.Maximum': [3341], 'depends': [3344], 'exact': [3346], 'dextran': [3348], 'type;': [3349], 'refer': [3350], 'label.Minimum': [3352], '240–360': [3355], 'isomaltosideMaximum': [3357], 'mg/kg': [3361, 3412], '(up': [3364, 3415], 'ironeThe': [3368], 'mg,': [3376, 3493], 'while': [3377, 3494], 'drug': [3378, 3495], 'might': [3380, 3497], 'allow': [3381, 3498], 'more.)Minimum': [3382], '15': [3385, 3424], 'minfIf': [3386], 'mg;': [3392, 3506], 'exceeds': [3395, 3509], 'iron,': [3398, 3512], 'min': [3402, 3516], 'recommended,': [3404, 3518], 'label.Ferric': [3407], 'carboxymaltoseMaximum': [3408], 'week)Minimum': [3421], 'minEMA,': [3425], 'syndrome.a': [3438], 'text).b': [3450], 'Both': [3451], 'practice.c': [3472], 'Follow': [3473], 'country.d': [3479], 'Low': [3480], 'dextran.e': [3484], 'more.f': [3499], 'label.': [3521], 'syndrome.': [3541], 'late': [3544, 3941], '2000s,': [3545], 'was': [3550], 'discussed': [3551], 'suggested': [3554, 3860], 'affect': [3559], '[32.Bennett': [3564], 'C.L.': [3565], 'Silver': [3566], 'S.M.': [3567], 'Djulbegovic': [3568], 'al.Venous': [3571], 'thromboembolism': [3572], 'cancer-associated': [3586], 'anemia.JAMA.': [3587], '299:': [3589], '914-924http://dx.doi.org/10.1001/jama.299.8.914Crossref': [3590], '(603)': [3593], '33.Bohlius': [3596], 'Schmidlin': [3598], 'Brillant': [3600], 'cancer–meta-analysis': [3609], 'based': [3610], 'patient': [3613], 'data.Cochrane': [3614], '3:': [3619], 'CD007303PubMed': [3620], 'exceeded': [3628], '[34.Henke': [3631], 'Laszig': [3633], 'Rübe': [3635], 'treat': [3640], 'head': [3641], 'neck': [3643], 'undergoing': [3648], 'radiotherapy:': [3649, 3771], 'trial.Lancet.': [3653], '362:': [3655], '1255-1260Abstract': [3656], '(1123)': [3664], '35.Hoff': [3667], 'C.M.': [3668], 'Hansen': [3669], 'H.S.': [3670], 'Overgaard': [3671], 'al.The': [3674], 'importance': [3675], 'effect': [3680, 4094], 'HNSCC': [3684], 'radiotherapy—results': [3688], 'DAHANCA': [3692], 'study.Radiother': [3694], '98:': [3697], '28-33Abstract': [3698], '36.Leyland-Jones': [3709], 'Semiglazov': [3711, 4057], 'Pawlicki': [3713, 4059], 'al.Maintaining': [3716, 4062], 'normal': [3717, 4063], 'nonanemic': [3725, 4071], 'metastatic': [3728, 3857, 3922, 4074], 'breast': [3729, 3858, 3923, 4075], 'first-line': [3732, 4078], 'study.J': [3736, 3781, 4082], '2005;': [3739, 4085], '5960-5972http://dx.doi.org/10.1200/JCO.2005.06.150Crossref': [3741, 4087], '(581)': [3744, 4090], '37.Smith': [3747], 'Jr,': [3748], 'R.E.': [3749], 'Ludwig': [3752], 'al.Darbepoetin': [3755], 'active': [3765], 'III,': [3776], 'multicenter,': [3777, 3902], '26:': [3785], '1040-1050http://dx.doi.org/10.1200/JCO.2007.14.2885Crossref': [3786], '(179)': [3789], '38.Wright': [3792], 'J.R.': [3793], 'Ung': [3794], 'Y.C.': [3795], 'Julian': [3796], 'J.A.': [3797], 'al.Randomized,': [3799], 'non-small-cell': [3806], 'disease-related': [3810], 'anemia.J': [3811], '1027-1032http://dx.doi.org/10.1200/JCO.2006.07.1514Crossref': [3816], '(355)': [3819], 'Consequently,': [3822], '10–12': [3832, 3995], 'rise': [3837], '4-week': [3844], 'period': [3845], 'avoided.': [3848], '2014,': [3850], 'addition': [3862], '(EPO)': [3865, 3909], 'standard': [3867, 3888, 3911, 3915, 3927], 'meet': [3879], 'non-inferiority': [3881], 'criteria': [3882], 'progression-free': [3884], '(PFS)': [3886], 'versus': [3887, 3914], 'alone': [3891], '[39.Leyland-Jones': [3892], 'Bondarenko': [3894], 'I.': [3895], 'Nemsadze': [3896], 'al.A': [3899], 'open-label,': [3901], 'plus': [3910], '(MBC)': [3925], '34:': [3932], '1197-1207http://dx.doi.org/10.1200/JCO.2015.63.5649Crossref': [3933], 'separation': [3942], 'PFS': [3945], 'OS': [3947], 'curves': [3948], 'hardly': [3950], 'explained': [3952], 'few': [3955], 'exposure.': [3959], 'Cochrane': [3964], 'subgroup': [3967], 'on-study': [3973], 'categories': [3987], '=': [3994, 4052], 'correspond': [3998], 'cut-off': [4003], 'When': [4036], 'excluding': [4037], 'above': [4045], 'labelled': [4047], 'guidance': [4048], '(BEST,': [4049], '12–14': [4053], '[36.Leyland-Jones': [4055], 'lost': [4095], 'statistical': [4096], 'significance': [4097], '[od': [4098]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2894700795', 'counts_by_year': [{'year': 2024, 'cited_by_count': 35}, {'year': 2023, 'cited_by_count': 34}, {'year': 2022, 'cited_by_count': 38}, {'year': 2021, 'cited_by_count': 38}, {'year': 2020, 'cited_by_count': 38}, {'year': 2019, 'cited_by_count': 23}, {'year': 2018, 'cited_by_count': 11}], 'updated_date': '2024-12-28T03:12:38.509107', 'created_date': '2018-10-12'}
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