Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2891797518', 'doi': 'https://doi.org/10.1093/hmg/ddy335', 'title': 'Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity', 'display_name': 'Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity', 'publication_year': 2018, 'publication_date': '2018-09-19', 'ids': {'openalex': 'https://openalex.org/W2891797518', 'doi': 'https://doi.org/10.1093/hmg/ddy335', 'mag': '2891797518', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30239719', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6322070'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/hmg/ddy335', 'pdf_url': 'https://academic.oup.com/hmg/article-pdf/28/2/177/27215304/ddy335.pdf', 'source': {'id': 'https://openalex.org/S166515463', 'display_name': 'Human Molecular Genetics', 'issn_l': '0964-6906', 'issn': ['0964-6906', '1460-2083'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://academic.oup.com/hmg/article-pdf/28/2/177/27215304/ddy335.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5039583864', 'display_name': 'Maria Mańczak', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I12315562', 'display_name': 'Texas Tech University', 'ror': 'https://ror.org/0405mnx93', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I12315562']}, {'id': 'https://openalex.org/I926076166', 'display_name': 'Texas Tech University Health Sciences Center', 'ror': 'https://ror.org/033ztpr93', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I926076166']}, {'id': 'https://openalex.org/I4210136305', 'display_name': 'Institute on Aging', 'ror': 'https://ror.org/0390vdb22', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210136305']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Maria Manczak', 'raw_affiliation_strings': ['Garrison Institute on Aging, Texas Tech University Health Sciences Center, MS, Lubbock, TX, USA', 'Neurology Department, Texas Tech University Health Sciences Center, MS, Lubbock, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Garrison Institute on Aging, Texas Tech University Health Sciences Center, MS, Lubbock, TX, USA', 'institution_ids': ['https://openalex.org/I12315562', 'https://openalex.org/I4210136305', 'https://openalex.org/I926076166']}, {'raw_affiliation_string': 'Neurology Department, Texas Tech University Health Sciences Center, MS, Lubbock, TX, USA', 'institution_ids': ['https://openalex.org/I926076166', 'https://openalex.org/I12315562']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037442385', 'display_name': 'Ramesh Kandimalla', 'orcid': 'https://orcid.org/0000-0002-3313-4393'}, 'institutions': [{'id': 'https://openalex.org/I926076166', 'display_name': 'Texas Tech University Health Sciences Center', 'ror': 'https://ror.org/033ztpr93', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I926076166']}, {'id': 'https://openalex.org/I4210136305', 'display_name': 'Institute on Aging', 'ror': 'https://ror.org/0390vdb22', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210136305']}, {'id': 'https://openalex.org/I12315562', 'display_name': 'Texas Tech University', 'ror': 'https://ror.org/0405mnx93', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I12315562']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ramesh Kandimalla', 'raw_affiliation_strings': ['Garrison Institute on Aging, Texas Tech University Health Sciences Center, MS, Lubbock, TX, USA', 'Pharmacology & Neuroscience Department, Texas Tech University Health Sciences Center, MS, Lubbock, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Garrison Institute on Aging, Texas Tech University Health Sciences Center, MS, Lubbock, TX, USA', 'institution_ids': ['https://openalex.org/I926076166', 'https://openalex.org/I4210136305', 'https://openalex.org/I12315562']}, {'raw_affiliation_string': 'Pharmacology & Neuroscience Department, Texas Tech University Health Sciences Center, MS, Lubbock, TX, USA', 'institution_ids': ['https://openalex.org/I926076166', 'https://openalex.org/I12315562']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091297684', 'display_name': 'Xiangling Yin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I926076166', 'display_name': 'Texas Tech University Health Sciences Center', 'ror': 'https://ror.org/033ztpr93', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I926076166']}, {'id': 'https://openalex.org/I4210136305', 'display_name': 'Institute on Aging', 'ror': 'https://ror.org/0390vdb22', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210136305']}, {'id': 'https://openalex.org/I12315562', 'display_name': 'Texas Tech University', 'ror': 'https://ror.org/0405mnx93', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I12315562']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xiangling Yin', 'raw_affiliation_strings': ['Garrison Institute on Aging, Texas Tech University Health Sciences Center, MS, Lubbock, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Garrison Institute on Aging, Texas Tech University Health Sciences Center, MS, Lubbock, TX, USA', 'institution_ids': ['https://openalex.org/I926076166', 'https://openalex.org/I4210136305', 'https://openalex.org/I12315562']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5084673116', 'display_name': 'P. Hemachandra Reddy', 'orcid': 'https://orcid.org/0000-0002-9560-9948'}, 'institutions': [{'id': 'https://openalex.org/I4210136305', 'display_name': 'Institute on Aging', 'ror': 'https://ror.org/0390vdb22', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210136305']}, {'id': 'https://openalex.org/I12315562', 'display_name': 'Texas Tech University', 'ror': 'https://ror.org/0405mnx93', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I12315562']}, {'id': 'https://openalex.org/I926076166', 'display_name': 'Texas Tech University Health Sciences Center', 'ror': 'https://ror.org/033ztpr93', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I926076166']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'P Hemachandra Reddy', 'raw_affiliation_strings': ['Cell Biology & Biochemistry Department, Texas Tech University Health Sciences Center, MS, Lubbock, TX, USA', 'Department of Public Health, Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center, MS, Lubbock, TX, USA', 'Garrison Institute on Aging, South West Campus, Texas Tech University Health Sciences Center, S. Quaker Suite E, MS, Lubbock, TX, USA', 'Neurology Department, Texas Tech University Health Sciences Center, MS, Lubbock, TX, USA', 'Pharmacology & Neuroscience Department, Texas Tech University Health Sciences Center, MS, Lubbock, TX, USA', 'Speech, Language and Hearing Sciences Department, Texas Tech University Health Sciences Center, MS, Lubbock, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Garrison Institute on Aging, South West Campus, Texas Tech University Health Sciences Center, S. Quaker Suite E, MS, Lubbock, TX, USA', 'institution_ids': ['https://openalex.org/I4210136305', 'https://openalex.org/I12315562', 'https://openalex.org/I12315562', 'https://openalex.org/I926076166', 'https://openalex.org/I926076166', 'https://openalex.org/I4210136305']}, {'raw_affiliation_string': 'Pharmacology & Neuroscience Department, Texas Tech University Health Sciences Center, MS, Lubbock, TX, USA', 'institution_ids': ['https://openalex.org/I12315562', 'https://openalex.org/I926076166']}, {'raw_affiliation_string': 'Neurology Department, Texas Tech University Health Sciences Center, MS, Lubbock, TX, USA', 'institution_ids': ['https://openalex.org/I12315562', 'https://openalex.org/I926076166']}, {'raw_affiliation_string': 'Department of Public Health, Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center, MS, Lubbock, TX, USA', 'institution_ids': ['https://openalex.org/I12315562', 'https://openalex.org/I926076166']}, {'raw_affiliation_string': 'Speech, Language and Hearing Sciences Department, Texas Tech University Health Sciences Center, MS, Lubbock, TX, USA', 'institution_ids': ['https://openalex.org/I12315562', 'https://openalex.org/I926076166']}, {'raw_affiliation_string': 'Cell Biology & Biochemistry Department, Texas Tech University Health Sciences Center, MS, Lubbock, TX, USA', 'institution_ids': ['https://openalex.org/I12315562', 'https://openalex.org/I926076166']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5084673116'], 'corresponding_institution_ids': ['https://openalex.org/I4210136305', 'https://openalex.org/I12315562', 'https://openalex.org/I926076166'], 'apc_list': {'value': 4181, 'currency': 'USD', 'value_usd': 4181, 'provenance': 'doaj'}, 'apc_paid': {'value': 4181, 'currency': 'USD', 'value_usd': 4181, 'provenance': 'doaj'}, 'fwci': 5.671, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 135, 'citation_normalized_percentile': {'value': 0.787198, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '28', 'issue': '2', 'first_page': '177', 'last_page': '199'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Dynamics and Reactive Oxygen Species Regulation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Dynamics and Reactive Oxygen Species Regulation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12763', 'display_name': 'ATP Synthase Function and Regulation', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11027', 'display_name': 'Metabolic Disorders and Biochemical Genetics', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/fis1', 'display_name': 'FIS1', 'score': 0.87034845}, {'id': 'https://openalex.org/keywords/mfn2', 'display_name': 'MFN2', 'score': 0.8265592}, {'id': 'https://openalex.org/keywords/dnm1l', 'display_name': 'DNM1L', 'score': 0.6281916}, {'id': 'https://openalex.org/keywords/mitochondrial-apoptosis-induced-channel', 'display_name': 'Mitochondrial apoptosis-induced channel', 'score': 0.5861206}, {'id': 'https://openalex.org/keywords/dnaja3', 'display_name': 'DNAJA3', 'score': 0.5684792}, {'id': 'https://openalex.org/keywords/mitochondrial-fission', 'display_name': 'Mitochondrial Fission', 'score': 0.543823}, {'id': 'https://openalex.org/keywords/mitochondrial-function', 'display_name': 'Mitochondrial Function', 'score': 0.539498}, {'id': 'https://openalex.org/keywords/mitochondrial-fusion', 'display_name': 'Mitochondrial Fusion', 'score': 0.507308}, {'id': 'https://openalex.org/keywords/mfn1', 'display_name': 'MFN1', 'score': 0.48536122}, {'id': 'https://openalex.org/keywords/tfam', 'display_name': 'TFAM', 'score': 0.41304243}], 'concepts': [{'id': 'https://openalex.org/C17619807', 'wikidata': 'https://www.wikidata.org/wiki/Q6881852', 'display_name': 'Mitochondrial fission', 'level': 3, 'score': 0.9325389}, {'id': 'https://openalex.org/C2777755479', 'wikidata': 'https://www.wikidata.org/wiki/Q18039927', 'display_name': 'FIS1', 'level': 5, 'score': 0.87034845}, {'id': 'https://openalex.org/C2777092462', 'wikidata': 'https://www.wikidata.org/wiki/Q15334407', 'display_name': 'MFN2', 'level': 5, 'score': 0.8265592}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7812501}, {'id': 'https://openalex.org/C163950672', 'wikidata': 'https://www.wikidata.org/wiki/Q14905375', 'display_name': 'mitochondrial fusion', 'level': 4, 'score': 0.7664896}, {'id': 'https://openalex.org/C2777229759', 'wikidata': 'https://www.wikidata.org/wiki/Q6881848', 'display_name': 'Mitochondrial biogenesis', 'level': 3, 'score': 0.6653056}, {'id': 'https://openalex.org/C2777324860', 'wikidata': 'https://www.wikidata.org/wiki/Q18034992', 'display_name': 'DNM1L', 'level': 4, 'score': 0.6281916}, {'id': 'https://openalex.org/C28859421', 'wikidata': 'https://www.wikidata.org/wiki/Q39572', 'display_name': 'Mitochondrion', 'level': 2, 'score': 0.59812355}, {'id': 'https://openalex.org/C173358068', 'wikidata': 'https://www.wikidata.org/wiki/Q6881847', 'display_name': 'Mitochondrial apoptosis-induced channel', 'level': 4, 'score': 0.5861206}, {'id': 'https://openalex.org/C111491248', 'wikidata': 'https://www.wikidata.org/wiki/Q18033821', 'display_name': 'DNAJA3', 'level': 5, 'score': 0.5684792}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.550635}, {'id': 'https://openalex.org/C2777591492', 'wikidata': 'https://www.wikidata.org/wiki/Q18041951', 'display_name': 'MFN1', 'level': 5, 'score': 0.48536122}, {'id': 'https://openalex.org/C169415338', 'wikidata': 'https://www.wikidata.org/wiki/Q18031951', 'display_name': 'TFAM', 'level': 4, 'score': 0.41304243}, {'id': 'https://openalex.org/C24586158', 'wikidata': 'https://www.wikidata.org/wiki/Q27075', 'display_name': 'Mitochondrial DNA', 'level': 3, 'score': 0.37692076}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3420069}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.23299697}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.16622457}, {'id': 'https://openalex.org/C29311851', 'wikidata': 'https://www.wikidata.org/wiki/Q408223', 'display_name': 'Cytochrome c', 'level': 3, 'score': 0.1535388}], 'mesh': [{'descriptor_ui': 'D020558', 'descriptor_name': 'GTP Phosphohydrolases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008869', 'descriptor_name': 'Microtubule-Associated Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D063154', 'descriptor_name': 'Mitochondrial Dynamics', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D024101', 'descriptor_name': 'Mitochondrial Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D052999', 'descriptor_name': 'Quinazolinones', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034281', 'descriptor_name': 'Dynamins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004579', 'descriptor_name': 'Electron Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004579', 'descriptor_name': 'Electron Transport', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004579', 'descriptor_name': 'Electron Transport', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D020558', 'descriptor_name': 'GTP Phosphohydrolases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015151', 'descriptor_name': 'Immunoblotting', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008869', 'descriptor_name': 'Microtubule-Associated Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D063154', 'descriptor_name': 'Mitochondrial Dynamics', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D063154', 'descriptor_name': 'Mitochondrial Dynamics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024101', 'descriptor_name': 'Mitochondrial Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001678', 'descriptor_name': 'Organelle Biogenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052999', 'descriptor_name': 'Quinazolinones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/hmg/ddy335', 'pdf_url': 'https://academic.oup.com/hmg/article-pdf/28/2/177/27215304/ddy335.pdf', 'source': {'id': 'https://openalex.org/S166515463', 'display_name': 'Human Molecular Genetics', 'issn_l': '0964-6906', 'issn': ['0964-6906', '1460-2083'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6322070', 'pdf_url': 'https://europepmc.org/articles/pmc6322070?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322070', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30239719', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/hmg/ddy335', 'pdf_url': 'https://academic.oup.com/hmg/article-pdf/28/2/177/27215304/ddy335.pdf', 'source': {'id': 'https://openalex.org/S166515463', 'display_name': 'Human Molecular Genetics', 'issn_l': '0964-6906', 'issn': ['0964-6906', '1460-2083'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320306276', 'funder_display_name': 'CH Foundation', 'award_id': None}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'NS105473'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'AG042178'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'AG047812'}], 'datasets': [], 'versions': [], 'referenced_works_count': 50, 'referenced_works': ['https://openalex.org/W1564001101', 'https://openalex.org/W179761311', 'https://openalex.org/W1966762854', 'https://openalex.org/W1969548568', 'https://openalex.org/W1996981671', 'https://openalex.org/W2000742321', 'https://openalex.org/W2008584420', 'https://openalex.org/W2009271779', 'https://openalex.org/W2017115444', 'https://openalex.org/W2026308971', 'https://openalex.org/W2042515284', 'https://openalex.org/W2044494908', 'https://openalex.org/W2055976032', 'https://openalex.org/W2059009119', 'https://openalex.org/W2065018825', 'https://openalex.org/W2072595318', 'https://openalex.org/W2074905627', 'https://openalex.org/W2085367705', 'https://openalex.org/W2089141103', 'https://openalex.org/W2098548022', 'https://openalex.org/W2105442740', 'https://openalex.org/W2105754268', 'https://openalex.org/W2112032807', 'https://openalex.org/W2113917457', 'https://openalex.org/W2119278281', 'https://openalex.org/W2130434635', 'https://openalex.org/W2136045787', 'https://openalex.org/W2147551208', 'https://openalex.org/W2152165298', 'https://openalex.org/W2168681379', 'https://openalex.org/W2171577843', 'https://openalex.org/W2172204522', 'https://openalex.org/W2200046622', 'https://openalex.org/W2200332082', 'https://openalex.org/W2519570594', 'https://openalex.org/W2527422074', 'https://openalex.org/W2602846991', 'https://openalex.org/W2606718169', 'https://openalex.org/W2607143731', 'https://openalex.org/W2737962827', 'https://openalex.org/W2761011647', 'https://openalex.org/W2785798903', 'https://openalex.org/W2789405288', 'https://openalex.org/W2796036472', 'https://openalex.org/W2802911313', 'https://openalex.org/W2988265459', 'https://openalex.org/W2990413290', 'https://openalex.org/W3009518051', 'https://openalex.org/W3015038300', 'https://openalex.org/W3022060020'], 'related_works': ['https://openalex.org/W4206968673', 'https://openalex.org/W2999800867', 'https://openalex.org/W2891797518', 'https://openalex.org/W2792079871', 'https://openalex.org/W2572344066', 'https://openalex.org/W246142158', 'https://openalex.org/W2355990987', 'https://openalex.org/W2333552486', 'https://openalex.org/W2009271779', 'https://openalex.org/W1884222370'], 'abstract_inverted_index': {'The': [0], 'purpose': [1], 'of': [2, 11, 43, 95, 100, 111, 121, 134, 183, 193, 230, 250, 255, 291, 305, 311, 327], 'our': [3], 'study': [4, 86], 'was': [5, 59, 63, 287, 315, 321], 'to': [6, 65, 352], 'better': [7], 'understand': [8], 'the': [9, 96, 103, 108, 115, 142, 184, 194, 202], 'effects': [10, 99, 110], 'mitochondrial-division': [12], 'inhibitor': [13, 339], '1': [14, 69], '(Mdivi-1)': [15], 'on': [16], 'mitochondrial': [17, 19, 34, 46, 53, 74, 77, 127, 143, 145, 154, 285, 343], 'fission,': [18, 75], 'biogenesis,': [20], 'electron': [21, 122, 244], 'transport': [22, 123], 'activities': [23, 133, 298], 'and': [24, 36, 62, 72, 80, 118, 129, 140, 153, 172, 188, 199, 201, 214, 222, 234, 252, 274, 295, 317, 340, 345, 361], 'cellular': [25], 'protection.': [26], 'In': [27, 102], 'recent': [28, 85], 'years,': [29], 'researchers': [30], 'have': [31, 51], 'found': [32, 64, 180, 226, 300], 'excessive': [33, 73], 'fragmentation': [35, 344], 'reduced': [37, 181, 248], 'fusion': [38, 78, 195], 'in': [39, 157, 227, 258, 301, 323], 'a': [40, 84, 337, 349], 'large': [41], 'number': [42], 'diseases': [44, 355], 'with': [45, 161, 165, 240, 262, 267, 308, 356], 'dysfunction.': [47], 'Therefore,': [48], 'several': [49], 'groups': [50, 304, 326], 'developed': [52], 'division': [54], 'inhibitors.': [55], 'Among': [56], 'these,': [57], 'Mdivi-1': [58, 112, 335, 347], 'extensively': [60], 'studied': [61, 107], 'reduce': [66], 'dynamin-related': [67], 'protein': [68, 119, 223], '(Drp1)': [70], 'levels': [71, 120, 182, 192, 220, 224, 290], 'enhance': [76], 'activity': [79, 152, 320], 'protect': [81], 'cells.': [82, 178, 280, 329], 'However,': [83], 'by': [87, 113], 'Bordt': [88], 'et': [89], 'al.': [90], '(1)': [91, 156, 257], 'questioned': [92], 'earlier': [93], 'findings': [94], 'beneficial,': [97], 'inhibiting': [98], 'Mdivi-1.': [101, 312], 'current': [104], 'study,': [105], 'we': [106], 'protective': [109], 'studying': [114], 'following:': [116], 'mRNA': [117, 221, 241], 'chain': [124], '(ETC)': [125], 'genes;': [126, 131], 'dynamics': [128], 'biogenesis': [130, 203], 'enzymatic': [132, 151, 297], 'ETC': [135, 228, 357], 'complexes': [136, 231], 'I,': [137, 232, 293, 359], 'II,': [138], 'III': [139], 'IV;': [141], 'network;': [144], 'size': [146], '&': [147], 'number;': [148], 'Drp1': [149, 167, 174, 187, 269, 276, 319, 338], 'GTPase': [150, 318], 'respiration': [155, 207], 'N2a': [158, 170, 177, 259, 272, 279, 328], 'cells': [159, 171, 260, 265, 273, 306], 'treated': [160, 261, 307], 'Mdivi-1,': [162, 263], '(2)': [163, 264], 'overexpressed': [164, 266], 'full-length': [166, 268], '+': [168, 270], 'Mdivi-1-treated': [169, 271], '(3)': [173, 275], 'RNA': [175, 277], 'silenced+Mdivi-1-treated': [176, 278], 'We': [179], 'fission': [185], 'genes': [186, 196, 204, 229], 'Fis1': [189], 'levels;': [190], 'increased': [191, 253, 316], 'Mfn1,': [197], 'Mfn2': [198], 'Opa1;': [200], 'PGC1α,': [205], 'nuclear': [206, 210], 'factor': [208, 212, 216], '1,': [209], 'respiratory': [211], '2': [213], 'transcription': [215], 'A,': [217], 'mitochondrial.': [218], 'Increased': [219, 289], 'were': [225, 299], 'II': [233, 294, 360], 'IV': [235, 296], 'genes.': [236], 'Immunoblotting': [237], 'data': [238], 'agreed': [239], 'changes.': [242], 'Transmission': [243], 'microscopy': [245], 'analysis': [246, 282], 'revealed': [247, 283], 'numbers': [249], 'mitochondria': [251, 256], 'length': [254], 'Immunofluorescence': [281], 'that': [284, 334], 'network': [286], 'increased.': [288], 'complex': [292], 'all': [302, 324], 'three': [303, 325], 'low': [309], 'concentration': [310], 'Mitochondrial': [313], 'function': [314], 'decreased': [322], 'These': [330], 'observations': [331], 'strongly': [332], 'suggest': [333], 'is': [336, 348], 'directly': [341], 'reduces': [342], 'further,': [346], 'promising': [350], 'molecule': [351], 'treat': [353], 'human': [354], 'complexes,': [358], 'IV.': [362]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2891797518', 'counts_by_year': [{'year': 2024, 'cited_by_count': 19}, {'year': 2023, 'cited_by_count': 30}, {'year': 2022, 'cited_by_count': 22}, {'year': 2021, 'cited_by_count': 23}, {'year': 2020, 'cited_by_count': 19}, {'year': 2019, 'cited_by_count': 21}], 'updated_date': '2024-09-11T22:30:59.677076', 'created_date': '2018-09-27'}