Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2891796239', 'doi': 'https://doi.org/10.1007/s00401-018-1914-z', 'title': 'Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold', 'display_name': 'Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold', 'publication_year': 2018, 'publication_date': '2018-10-01', 'ids': {'openalex': 'https://openalex.org/W2891796239', 'doi': 'https://doi.org/10.1007/s00401-018-1914-z', 'mag': '2891796239', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30276465', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6208733'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s00401-018-1914-z', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007/s00401-018-1914-z.pdf', 'source': {'id': 'https://openalex.org/S198620474', 'display_name': 'Acta Neuropathologica', 'issn_l': '0001-6322', 'issn': ['0001-6322', '1432-0533'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://link.springer.com/content/pdf/10.1007/s00401-018-1914-z.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5091551842', 'display_name': 'Benjamin Falcon', 'orcid': 'https://orcid.org/0000-0002-8176-2618'}, 'institutions': [{'id': 'https://openalex.org/I170203145', 'display_name': 'MRC Laboratory of Molecular Biology', 'ror': 'https://ror.org/00tw3jy02', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I170203145', 'https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Benjamin Falcon', 'raw_affiliation_strings': ['MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK'], 'affiliations': [{'raw_affiliation_string': 'MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK', 'institution_ids': ['https://openalex.org/I170203145']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100454486', 'display_name': 'Wenjuan Zhang', 'orcid': 'https://orcid.org/0000-0002-3011-9956'}, 'institutions': [{'id': 'https://openalex.org/I170203145', 'display_name': 'MRC Laboratory of Molecular Biology', 'ror': 'https://ror.org/00tw3jy02', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I170203145', 'https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Wenjuan Zhang', 'raw_affiliation_strings': ['MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK'], 'affiliations': [{'raw_affiliation_string': 'MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK', 'institution_ids': ['https://openalex.org/I170203145']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083679122', 'display_name': 'Manuel Schweighauser', 'orcid': 'https://orcid.org/0000-0002-1848-1610'}, 'institutions': [{'id': 'https://openalex.org/I170203145', 'display_name': 'MRC Laboratory of Molecular Biology', 'ror': 'https://ror.org/00tw3jy02', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I170203145', 'https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Manuel Schweighauser', 'raw_affiliation_strings': ['MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK'], 'affiliations': [{'raw_affiliation_string': 'MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK', 'institution_ids': ['https://openalex.org/I170203145']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025834882', 'display_name': 'Alexey G. Murzin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I170203145', 'display_name': 'MRC Laboratory of Molecular Biology', 'ror': 'https://ror.org/00tw3jy02', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I170203145', 'https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Alexey G. Murzin', 'raw_affiliation_strings': ['MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK'], 'affiliations': [{'raw_affiliation_string': 'MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK', 'institution_ids': ['https://openalex.org/I170203145']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054119993', 'display_name': 'Rubén Vidal', 'orcid': 'https://orcid.org/0000-0002-5803-3871'}, 'institutions': [{'id': 'https://openalex.org/I55769427', 'display_name': 'Indiana University – Purdue University Indianapolis', 'ror': 'https://ror.org/05gxnyn08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55769427', 'https://openalex.org/I592451']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ruben Vidal', 'raw_affiliation_strings': ['Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA', 'institution_ids': ['https://openalex.org/I55769427']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050959761', 'display_name': 'Holly J. Garringer', 'orcid': 'https://orcid.org/0000-0002-1899-7676'}, 'institutions': [{'id': 'https://openalex.org/I55769427', 'display_name': 'Indiana University – Purdue University Indianapolis', 'ror': 'https://ror.org/05gxnyn08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55769427', 'https://openalex.org/I592451']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Holly J. Garringer', 'raw_affiliation_strings': ['Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA', 'institution_ids': ['https://openalex.org/I55769427']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047929315', 'display_name': 'Bernardino Ghetti', 'orcid': 'https://orcid.org/0000-0002-1842-8019'}, 'institutions': [{'id': 'https://openalex.org/I55769427', 'display_name': 'Indiana University – Purdue University Indianapolis', 'ror': 'https://ror.org/05gxnyn08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55769427', 'https://openalex.org/I592451']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bernardino Ghetti', 'raw_affiliation_strings': ['Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA', 'institution_ids': ['https://openalex.org/I55769427']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061952716', 'display_name': 'Sjors H. W. Scheres', 'orcid': 'https://orcid.org/0000-0002-0462-6540'}, 'institutions': [{'id': 'https://openalex.org/I170203145', 'display_name': 'MRC Laboratory of Molecular Biology', 'ror': 'https://ror.org/00tw3jy02', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I170203145', 'https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Sjors H. W. Scheres', 'raw_affiliation_strings': ['MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK'], 'affiliations': [{'raw_affiliation_string': 'MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK', 'institution_ids': ['https://openalex.org/I170203145']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5037379608', 'display_name': 'Michel Goedert', 'orcid': 'https://orcid.org/0000-0002-5214-7886'}, 'institutions': [{'id': 'https://openalex.org/I170203145', 'display_name': 'MRC Laboratory of Molecular Biology', 'ror': 'https://ror.org/00tw3jy02', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I170203145', 'https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Michel Goedert', 'raw_affiliation_strings': ['MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK'], 'affiliations': [{'raw_affiliation_string': 'MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK', 'institution_ids': ['https://openalex.org/I170203145']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3690, 'currency': 'EUR', 'value_usd': 4790, 'provenance': 'doaj'}, 'apc_paid': {'value': 3690, 'currency': 'EUR', 'value_usd': 4790, 'provenance': 'doaj'}, 'fwci': 21.896, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 278, 'citation_normalized_percentile': {'value': 0.999954, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '136', 'issue': '5', 'first_page': '699', 'last_page': '708'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10086', 'display_name': "Mechanisms of Alzheimer's Disease", 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10086', 'display_name': "Mechanisms of Alzheimer's Disease", 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11335', 'display_name': 'Prion Diseases: Causes and Molecular Basis', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13481', 'display_name': 'Neurodegeneration with Brain Iron Accumulation', 'score': 0.9933, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tau-pathology', 'display_name': 'Tau Pathology', 'score': 0.539425}, {'id': 'https://openalex.org/keywords/negative-stain', 'display_name': 'Negative stain', 'score': 0.47599924}, {'id': 'https://openalex.org/keywords/posterior-cortical-atrophy', 'display_name': 'Posterior cortical atrophy', 'score': 0.47311068}], 'concepts': [{'id': 'https://openalex.org/C14228908', 'wikidata': 'https://www.wikidata.org/wiki/Q2920483', 'display_name': 'Protein filament', 'level': 2, 'score': 0.5213174}, {'id': 'https://openalex.org/C502032728', 'wikidata': 'https://www.wikidata.org/wiki/Q11081', 'display_name': "Alzheimer's disease", 'level': 3, 'score': 0.5145128}, {'id': 'https://openalex.org/C2777348757', 'wikidata': 'https://www.wikidata.org/wiki/Q2346577', 'display_name': 'Cortex (anatomy)', 'level': 2, 'score': 0.5004277}, {'id': 'https://openalex.org/C93877712', 'wikidata': 'https://www.wikidata.org/wiki/Q132560', 'display_name': 'Electron microscope', 'level': 2, 'score': 0.49959874}, {'id': 'https://openalex.org/C166029249', 'wikidata': 'https://www.wikidata.org/wiki/Q3772564', 'display_name': 'Negative stain', 'level': 3, 'score': 0.47599924}, {'id': 'https://openalex.org/C2776228812', 'wikidata': 'https://www.wikidata.org/wiki/Q2869816', 'display_name': 'Posterior cortical atrophy', 'level': 4, 'score': 0.47311068}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.46484488}, {'id': 'https://openalex.org/C2781172350', 'wikidata': 'https://www.wikidata.org/wiki/Q194520', 'display_name': 'Atrophy', 'level': 2, 'score': 0.44685677}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.42518073}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.42329156}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.39717028}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.3365246}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.23950511}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.20649996}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.1670765}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.1454812}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.11257926}, {'id': 'https://openalex.org/C2779483572', 'wikidata': 'https://www.wikidata.org/wiki/Q83030', 'display_name': 'Dementia', 'level': 3, 'score': 0.09511843}, {'id': 'https://openalex.org/C120665830', 'wikidata': 'https://www.wikidata.org/wiki/Q14620', 'display_name': 'Optics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016874', 'descriptor_name': 'Neurofibrillary Tangles', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D016875', 'descriptor_name': 'tau Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016564', 'descriptor_name': 'Amyloid beta-Protein Precursor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016564', 'descriptor_name': 'Amyloid beta-Protein Precursor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D001057', 'descriptor_name': 'Apolipoproteins E', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001057', 'descriptor_name': 'Apolipoproteins E', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D020285', 'descriptor_name': 'Cryoelectron Microscopy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016253', 'descriptor_name': 'Microscopy, Immunoelectron', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008953', 'descriptor_name': 'Models, Anatomic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016874', 'descriptor_name': 'Neurofibrillary Tangles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016874', 'descriptor_name': 'Neurofibrillary Tangles', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D000073359', 'descriptor_name': 'Whole Exome Sequencing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016875', 'descriptor_name': 'tau Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016875', 'descriptor_name': 'tau Proteins', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}], 'locations_count': 7, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s00401-018-1914-z', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007/s00401-018-1914-z.pdf', 'source': {'id': 'https://openalex.org/S198620474', 'display_name': 'Acta Neuropathologica', 'issn_l': '0001-6322', 'issn': ['0001-6322', '1432-0533'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6208733', 'pdf_url': 'https://europepmc.org/articles/pmc6208733?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/1805/19557', 'pdf_url': 'https://scholarworks.iupui.edu/bitstreams/cba09305-6d11-4a69-88c4-8284be835cf7/download', 'source': {'id': 'https://openalex.org/S4306402593', 'display_name': 'Purdue University Indianapolis (Indiana University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I592451', 'host_organization_name': 'Indiana University', 'host_organization_lineage': ['https://openalex.org/I592451'], 'host_organization_lineage_names': ['Indiana University'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.repository.cam.ac.uk/handle/1810/286006', 'pdf_url': 'https://www.repository.cam.ac.uk/bitstreams/f7208b2e-312d-4b32-9d9f-359ff3f63b08/download', 'source': {'id': 'https://openalex.org/S4306401777', 'display_name': 'Apollo (University of Cambridge)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I241749', 'host_organization_name': 'University of Cambridge', 'host_organization_lineage': ['https://openalex.org/I241749'], 'host_organization_lineage_names': ['University of Cambridge'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208733', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/411215', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30276465', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s00401-018-1914-z', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007/s00401-018-1914-z.pdf', 'source': {'id': 'https://openalex.org/S198620474', 'display_name': 'Acta Neuropathologica', 'issn_l': '0001-6322', 'issn': ['0001-6322', '1432-0533'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320306219', 'funder_display_name': "Alzheimer's Association", 'award_id': 'Zenith Award'}, {'funder': 'https://openalex.org/F4320307758', 'funder_display_name': 'Eli Lilly and Company', 'award_id': None}, {'funder': 'https://openalex.org/F4320314158', 'funder_display_name': 'EU Joint Programme – Neurodegenerative Disease Research', 'award_id': None}, {'funder': 'https://openalex.org/F4320326631', 'funder_display_name': 'Innovative Medicines Initiative', 'award_id': None}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'P30-AG010133'}, {'funder': 'https://openalex.org/F4320334626', 'funder_display_name': 'Medical Research Council', 'award_id': 'MC_U105184291'}, {'funder': 'https://openalex.org/F4320334626', 'funder_display_name': 'Medical Research Council', 'award_id': 'MC_UP_A025_1013'}], 'datasets': [], 'versions': [], 'referenced_works_count': 45, 'referenced_works': ['https://openalex.org/W1528511554', 'https://openalex.org/W1621042331', 'https://openalex.org/W1967285029', 'https://openalex.org/W1994282166', 'https://openalex.org/W1994514180', 'https://openalex.org/W2018908557', 'https://openalex.org/W2021181758', 'https://openalex.org/W2021267750', 'https://openalex.org/W2024363942', 'https://openalex.org/W2028605133', 'https://openalex.org/W2032920422', 'https://openalex.org/W2038840577', 'https://openalex.org/W2046209489', 'https://openalex.org/W2046847750', 'https://openalex.org/W2051896853', 'https://openalex.org/W2052742260', 'https://openalex.org/W2054770020', 'https://openalex.org/W2057682957', 'https://openalex.org/W2058723245', 'https://openalex.org/W2083633251', 'https://openalex.org/W2104234755', 'https://openalex.org/W2124019813', 'https://openalex.org/W2124026197', 'https://openalex.org/W2141839336', 'https://openalex.org/W2142287887', 'https://openalex.org/W2146008734', 'https://openalex.org/W2153323361', 'https://openalex.org/W2154714625', 'https://openalex.org/W2159377066', 'https://openalex.org/W2169033080', 'https://openalex.org/W2178497502', 'https://openalex.org/W2185034389', 'https://openalex.org/W2192012340', 'https://openalex.org/W2317760348', 'https://openalex.org/W2549098625', 'https://openalex.org/W2593511418', 'https://openalex.org/W2618553145', 'https://openalex.org/W2727929522', 'https://openalex.org/W2771052591', 'https://openalex.org/W2779322228', 'https://openalex.org/W2796637563', 'https://openalex.org/W2950967305', 'https://openalex.org/W2951384153', 'https://openalex.org/W4211213171', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W4389445088', 'https://openalex.org/W2739421931', 'https://openalex.org/W2570451634', 'https://openalex.org/W2537747254', 'https://openalex.org/W2391068494', 'https://openalex.org/W2077674754', 'https://openalex.org/W2002497916', 'https://openalex.org/W1986471226', 'https://openalex.org/W1965583259', 'https://openalex.org/W1878317980'], 'abstract_inverted_index': {'The': [0, 91, 166, 183], 'ordered': [1], 'assembly': [2], 'of': [3, 13, 28, 37, 45, 59, 72, 75, 85, 94, 102, 105, 129, 149, 164, 180, 190, 197, 201, 206, 212], 'tau': [4, 29, 207, 232, 250], 'protein': [5], 'into': [6], 'abnormal': [7], 'filaments': [8, 30, 62, 66], 'is': [9, 22, 227], 'a': [10, 43, 127, 154], 'defining': [11], 'characteristic': [12], 'Alzheimer’s': [14], 'disease': [15], '(AD)': [16], 'and': [17, 49, 64, 79, 82, 96, 109, 124, 131, 145, 193, 204, 253, 258], 'other': [18], 'neurodegenerative': [19], 'disorders.': [20], 'It': [21], 'not': [23, 196], 'known': [24], 'if': [25], 'the': [26, 35, 57, 69, 99, 122, 181, 188, 198, 209, 219, 246], 'structures': [27, 58, 93, 169, 234], 'vary': [31], 'within,': [32], 'or': [33], 'between,': [34], 'brains': [36], 'individuals': [38, 236], 'with': [39, 153, 218, 237], 'AD.': [40, 165, 238], 'We': [41, 116], 'used': [42, 118], 'combination': [44], 'electron': [46, 52], 'cryo-microscopy': [47], '(cryo-EM)': [48], 'immuno-gold': [50], 'negative-stain': [51], 'microscopy': [53], '(immuno-EM)': [54], 'to': [55, 120], 'determine': [56], 'paired': [60], 'helical': [61], '(PHFs)': [63], 'straight': [65], '(SFs)': [67], 'from': [68, 98, 126], 'frontal': [70, 100], 'cortex': [71, 101], '17': [73], 'cases': [74, 84, 104], 'AD': [76, 87, 140, 214], '(15': [77], 'sporadic': [78, 108], '2': [80, 83, 107], 'inherited)': [81], 'atypical': [86], '(posterior': [88], 'cortical': [89, 130], 'atrophy).': [90], 'high-resolution': [92], 'PHFs': [95, 123, 135, 144], 'SFs': [97, 125, 137, 146], '3': [103, 192], 'AD,': [106], '1': [110, 203], 'inherited,': [111], 'were': [112, 147, 216], 'determined': [113], 'by': [114], 'cryo-EM.': [115], 'also': [117], 'immuno-EM': [119, 184], 'study': [121], 'number': [128], 'subcortical': [132], 'brain': [133], 'regions.': [134], 'outnumbered': [136], 'in': [138, 208, 231], 'all': [139, 213], 'cases.': [141], 'By': [142], 'cryo-EM,': [143], 'made': [148], 'two': [150, 173], 'C-shaped': [151], 'protofilaments': [152], 'combined': [155], 'cross-β/β-helix': [156], 'structure,': [157], 'as': [158], 'described': [159], 'previously': [160], 'for': [161, 244, 254], 'one': [162], 'case': [163], 'higher': [167], 'resolution': [168], 'obtained': [170], 'here': [171], 'showed': [172], 'additional': [174], 'amino': [175], 'acids': [176], 'at': [177], 'each': [178], 'end': [179], 'protofilament.': [182], 'findings,': [185], 'which': [186], 'indicated': [187], 'presence': [189], 'repeats': [191, 202], '4,': [194], 'but': [195], 'N-terminal': [199], 'regions': [200], '2,': [205], 'filament': [210, 233, 251], 'cores': [211], 'cases,': [215], 'consistent': [217], 'cryo-EM': [220], 'results.': [221], 'These': [222], 'findings': [223], 'show': [224], 'that': [225, 248], 'there': [226], 'no': [228], 'significant': [229], 'variation': [230], 'between': [235], 'This': [239], 'knowledge': [240], 'will': [241], 'be': [242], 'crucial': [243], 'understanding': [245], 'mechanisms': [247], 'underlie': [249], 'formation': [252], 'developing': [255], 'novel': [256], 'diagnostics': [257], 'therapies.': [259]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2891796239', 'counts_by_year': [{'year': 2024, 'cited_by_count': 35}, {'year': 2023, 'cited_by_count': 56}, {'year': 2022, 'cited_by_count': 52}, {'year': 2021, 'cited_by_count': 51}, {'year': 2020, 'cited_by_count': 49}, {'year': 2019, 'cited_by_count': 30}, {'year': 2018, 'cited_by_count': 4}], 'updated_date': '2024-09-13T14:00:46.239453', 'created_date': '2018-09-27'}