Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2891571918', 'doi': 'https://doi.org/10.2174/1381612824666180913151059', 'title': 'Mesenchymal Stem Cell Therapy for Ischemic Heart Disease: Advances and Challenges', 'display_name': 'Mesenchymal Stem Cell Therapy for Ischemic Heart Disease: Advances and Challenges', 'publication_year': 2018, 'publication_date': '2018-09-13', 'ids': {'openalex': 'https://openalex.org/W2891571918', 'doi': 'https://doi.org/10.2174/1381612824666180913151059', 'mag': '2891571918', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30209995'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/1381612824666180913151059', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S55674637', 'display_name': 'Current Pharmaceutical Design', 'issn_l': '1381-6128', 'issn': ['1381-6128', '1873-4286'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5091905139', 'display_name': 'Mikhail Konoplyannikov', 'orcid': 'https://orcid.org/0000-0003-1180-2343'}, 'institutions': [{'id': 'https://openalex.org/I64264942', 'display_name': 'Federal Medical-Biological Agency', 'ror': 'https://ror.org/052ay8m85', 'country_code': 'RU', 'type': 'government', 'lineage': ['https://openalex.org/I64264942']}, {'id': 'https://openalex.org/I4210125717', 'display_name': 'State Research Institute of Highly Pure Biopreparations', 'ror': 'https://ror.org/03ad6jw85', 'country_code': 'RU', 'type': 'facility', 'lineage': ['https://openalex.org/I4210125717']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Mikhail Konoplyannikov', 'raw_affiliation_strings': ['Federal Research Clinical Center of Specialized Medical Care and Medical Technologies of the FMBA of Russia, Moscow, Russian Federation'], 'affiliations': [{'raw_affiliation_string': 'Federal Research Clinical Center of Specialized Medical Care and Medical Technologies of the FMBA of Russia, Moscow, Russian Federation', 'institution_ids': ['https://openalex.org/I64264942', 'https://openalex.org/I4210125717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084472936', 'display_name': 'Svetlana Kotova', 'orcid': 'https://orcid.org/0000-0001-7011-4503'}, 'institutions': [{'id': 'https://openalex.org/I64264942', 'display_name': 'Federal Medical-Biological Agency', 'ror': 'https://ror.org/052ay8m85', 'country_code': 'RU', 'type': 'government', 'lineage': ['https://openalex.org/I64264942']}, {'id': 'https://openalex.org/I4210125717', 'display_name': 'State Research Institute of Highly Pure Biopreparations', 'ror': 'https://ror.org/03ad6jw85', 'country_code': 'RU', 'type': 'facility', 'lineage': ['https://openalex.org/I4210125717']}], 'countries': ['RU'], 'is_corresponding': True, 'raw_author_name': 'Svetlana Kotova', 'raw_affiliation_strings': ['Federal Research Clinical Center of Specialized Medical Care and Medical Technologies of the FMBA of Russia, Moscow, Russian Federation'], 'affiliations': [{'raw_affiliation_string': 'Federal Research Clinical Center of Specialized Medical Care and Medical Technologies of the FMBA of Russia, Moscow, Russian Federation', 'institution_ids': ['https://openalex.org/I64264942', 'https://openalex.org/I4210125717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057327086', 'display_name': 'Владимир П. Баклаушев', 'orcid': 'https://orcid.org/0000-0003-1039-4245'}, 'institutions': [{'id': 'https://openalex.org/I64264942', 'display_name': 'Federal Medical-Biological Agency', 'ror': 'https://ror.org/052ay8m85', 'country_code': 'RU', 'type': 'government', 'lineage': ['https://openalex.org/I64264942']}, {'id': 'https://openalex.org/I4210125717', 'display_name': 'State Research Institute of Highly Pure Biopreparations', 'ror': 'https://ror.org/03ad6jw85', 'country_code': 'RU', 'type': 'facility', 'lineage': ['https://openalex.org/I4210125717']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Vladimir Baklaushev', 'raw_affiliation_strings': ['Federal Research Clinical Center of Specialized Medical Care and Medical Technologies of the FMBA of Russia, Moscow, Russian Federation'], 'affiliations': [{'raw_affiliation_string': 'Federal Research Clinical Center of Specialized Medical Care and Medical Technologies of the FMBA of Russia, Moscow, Russian Federation', 'institution_ids': ['https://openalex.org/I64264942', 'https://openalex.org/I4210125717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5106623218', 'display_name': 'Anatoly Konoplyannikov', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210117327', 'display_name': 'Medical Radiological Research Center', 'ror': 'https://ror.org/02dr19631', 'country_code': 'RU', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117327']}, {'id': 'https://openalex.org/I4210117042', 'display_name': 'Ministry of Health of the Russian Federation', 'ror': 'https://ror.org/01p8ehb87', 'country_code': 'RU', 'type': 'government', 'lineage': ['https://openalex.org/I4210117042']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Anatoly Konoplyannikov', 'raw_affiliation_strings': ['A. Tsyb Medical Radiological Research Center of the Ministry of Health of Russia, Obninsk, Russian Federation'], 'affiliations': [{'raw_affiliation_string': 'A. Tsyb Medical Radiological Research Center of the Ministry of Health of Russia, Obninsk, Russian Federation', 'institution_ids': ['https://openalex.org/I4210117327', 'https://openalex.org/I4210117042']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072296148', 'display_name': 'Vladimir A. Kalsin', 'orcid': 'https://orcid.org/0000-0003-2705-3578'}, 'institutions': [{'id': 'https://openalex.org/I64264942', 'display_name': 'Federal Medical-Biological Agency', 'ror': 'https://ror.org/052ay8m85', 'country_code': 'RU', 'type': 'government', 'lineage': ['https://openalex.org/I64264942']}, {'id': 'https://openalex.org/I4210125717', 'display_name': 'State Research Institute of Highly Pure Biopreparations', 'ror': 'https://ror.org/03ad6jw85', 'country_code': 'RU', 'type': 'facility', 'lineage': ['https://openalex.org/I4210125717']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Vladimir Kalsin', 'raw_affiliation_strings': ['Federal Research Clinical Center of Specialized Medical Care and Medical Technologies of the FMBA of Russia, Moscow, Russian Federation'], 'affiliations': [{'raw_affiliation_string': 'Federal Research Clinical Center of Specialized Medical Care and Medical Technologies of the FMBA of Russia, Moscow, Russian Federation', 'institution_ids': ['https://openalex.org/I64264942', 'https://openalex.org/I4210125717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086299939', 'display_name': 'Peter Timashev', 'orcid': 'https://orcid.org/0000-0001-7773-2435'}, 'institutions': [{'id': 'https://openalex.org/I17877952', 'display_name': 'Sechenov University', 'ror': 'https://ror.org/02yqqv993', 'country_code': 'RU', 'type': 'education', 'lineage': ['https://openalex.org/I17877952']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Peter Timashev', 'raw_affiliation_strings': ['Institute for Regenerative Medicine, Sechenov University, Moscow, Russian Federation'], 'affiliations': [{'raw_affiliation_string': 'Institute for Regenerative Medicine, Sechenov University, Moscow, Russian Federation', 'institution_ids': ['https://openalex.org/I17877952']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5024686410', 'display_name': 'A. V. Troitskiy', 'orcid': 'https://orcid.org/0000-0003-2411-6043'}, 'institutions': [{'id': 'https://openalex.org/I64264942', 'display_name': 'Federal Medical-Biological Agency', 'ror': 'https://ror.org/052ay8m85', 'country_code': 'RU', 'type': 'government', 'lineage': ['https://openalex.org/I64264942']}, {'id': 'https://openalex.org/I4210125717', 'display_name': 'State Research Institute of Highly Pure Biopreparations', 'ror': 'https://ror.org/03ad6jw85', 'country_code': 'RU', 'type': 'facility', 'lineage': ['https://openalex.org/I4210125717']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Alexander Troitskiy', 'raw_affiliation_strings': ['Federal Research Clinical Center of Specialized Medical Care and Medical Technologies of the FMBA of Russia, Moscow, Russian Federation'], 'affiliations': [{'raw_affiliation_string': 'Federal Research Clinical Center of Specialized Medical Care and Medical Technologies of the FMBA of Russia, Moscow, Russian Federation', 'institution_ids': ['https://openalex.org/I64264942', 'https://openalex.org/I4210125717']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': ['https://openalex.org/A5084472936'], 'corresponding_institution_ids': ['https://openalex.org/I64264942', 'https://openalex.org/I4210125717'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.146, 'has_fulltext': False, 'cited_by_count': 12, 'citation_normalized_percentile': {'value': 0.325112, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 86, 'max': 87}, 'biblio': {'volume': '24', 'issue': '26', 'first_page': '3132', 'last_page': '3142'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10729', 'display_name': 'Electrospun Nanofibers in Biomedical Applications', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/2502', 'display_name': 'Biomaterials'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10729', 'display_name': 'Electrospun Nanofibers in Biomedical Applications', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/2502', 'display_name': 'Biomaterials'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T12264', 'display_name': 'Tissue Engineering and Regenerative Medicine', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10176', 'display_name': 'Mesenchymal stem cell research', 'score': 0.9949, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cell-therapy', 'display_name': 'Cell therapy', 'score': 0.78418994}, {'id': 'https://openalex.org/keywords/stem-cell-therapy', 'display_name': 'Stem Cell Therapy', 'score': 0.6521629}, {'id': 'https://openalex.org/keywords/regenerative-medicine', 'display_name': 'Regenerative Medicine', 'score': 0.5924787}], 'concepts': [{'id': 'https://openalex.org/C198826908', 'wikidata': 'https://www.wikidata.org/wiki/Q1922379', 'display_name': 'Mesenchymal stem cell', 'level': 2, 'score': 0.87828934}, {'id': 'https://openalex.org/C10882517', 'wikidata': 'https://www.wikidata.org/wiki/Q15268054', 'display_name': 'Cell therapy', 'level': 3, 'score': 0.78418994}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.7353555}, {'id': 'https://openalex.org/C2779389132', 'wikidata': 'https://www.wikidata.org/wiki/Q1533033', 'display_name': 'Stem-cell therapy', 'level': 3, 'score': 0.6521629}, {'id': 'https://openalex.org/C10854531', 'wikidata': 'https://www.wikidata.org/wiki/Q1061415', 'display_name': 'Regenerative medicine', 'level': 3, 'score': 0.5924787}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.58027214}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.5726586}, {'id': 'https://openalex.org/C7876069', 'wikidata': 'https://www.wikidata.org/wiki/Q14873666', 'display_name': 'Paracrine signalling', 'level': 3, 'score': 0.57236147}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.54400754}, {'id': 'https://openalex.org/C177713679', 'wikidata': 'https://www.wikidata.org/wiki/Q679690', 'display_name': 'Intensive care medicine', 'level': 1, 'score': 0.4789127}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.39178538}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.27293313}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.25557148}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.13148761}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.084408164}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D045164', 'descriptor_name': 'Mesenchymal Stem Cell Transplantation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D059630', 'descriptor_name': 'Mesenchymal Stem Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D017202', 'descriptor_name': 'Myocardial Ischemia', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059630', 'descriptor_name': 'Mesenchymal Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017202', 'descriptor_name': 'Myocardial Ischemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/1381612824666180913151059', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S55674637', 'display_name': 'Current Pharmaceutical Design', 'issn_l': '1381-6128', 'issn': ['1381-6128', '1873-4286'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30209995', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.85}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4323348290', 'https://openalex.org/W4211057124', 'https://openalex.org/W3160733534', 'https://openalex.org/W3037954421', 'https://openalex.org/W3037705713', 'https://openalex.org/W3006696679', 'https://openalex.org/W2163059752', 'https://openalex.org/W2104113751', 'https://openalex.org/W2078065913', 'https://openalex.org/W1970368333'], 'abstract_inverted_index': {'Ischemic': [0], 'Heart': [1], 'Disease': [2], '(IHD)': [3], 'has': [4, 26], 'been': [5, 27], 'recognized': [6], 'as': [7, 99], 'the': [8, 14, 23, 31, 40, 48, 55, 73, 88, 95, 108, 114, 126, 129], 'main': [9], 'cause': [10], 'of': [11, 18, 33, 42, 50, 54, 62, 87, 97, 107], 'mortality': [12], 'in': [13, 47, 58, 125], 'modern': [15], 'world.': [16], 'Application': [17], 'cell': [19, 74, 100], 'therapy': [20, 49, 117], 'technologies': [21], 'for': [22, 60], 'IHD': [24, 116], 'treatment': [25], 'actively': [28], 'studied': [29], 'from': [30], 'beginning': [32], '2000s.': [34], 'The': [35, 52, 85, 105], 'review': [36], 'is': [37], 'dedicated': [38], 'to': [39, 71, 94], 'use': [41, 96], 'mesenchymal': [43], 'stem': [44], 'cells': [45], '(MSC)': [46], 'IHD.': [51], 'strategies': [53], 'MSC': [56, 89], 'modification': [57], 'vitro': [59], 'improvement': [61], 'their': [63, 77, 82], 'regenerative': [64], 'potential': [65], 'are': [66, 102, 118], 'extensively': [67], 'discussed,': [68], 'including': [69, 120], 'preconditioning': [70], 'enhance': [72], 'survival,': [75], 'boosting': [76], 'paracrine': [78], 'effect': [79], 'and': [80, 91, 123, 128], 'manipulating': [81], 'cardiomyogenic': [83], 'differentiation.': [84], 'optimization': [86], 'delivery': [90], 'opportunities': [92], 'related': [93], 'biomaterials': [98], 'carriers': [101], 'also': [103], 'discussed.': [104], 'results': [106], 'most': [109], 'important': [110], 'clinical': [111, 131], 'studies': [112], 'on': [113], 'MSC-based': [115], 'presented,': [119], 'those': [121], 'completed': [122], 'published': [124], 'literature': [127], 'ongoing': [130], 'trials': [132], 'registered': [133], 'at': [134], 'clinicaltrials.gov': [135], 'by': [136], 'June': [137], '2018.': [138]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2891571918', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}], 'updated_date': '2024-12-09T02:19:32.419424', 'created_date': '2018-09-27'}