Abstract: ABO blood group system was firstly recognized by Landsteiner in 1900. Since then, the antigens of the ABO system (A, B and H determinants, respectively) have been shown to encompass complex carbohydrate structures. A and B antigen were synthesized by the sequential action of glycosyltransferases, with A and B glycosyltransferases catalyzing the addition of N-acetylgalactosamine and D-galactose to precursor H antigen, respectively. Group O individuals lack such transferase enzymes and consequently continue to express the basic H structure only. It is determined that approximate 2 million ABH glycan antigen sites are presented on each red blood cell. Additionally, the ABH antigens are widely expressed in other human cells and tissues, including the sensory neurons, epithelium, the vascular endothelium and platelets.
Publication Year: 2018
Publication Date: 2018-10-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 1
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