Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2890683537', 'doi': 'https://doi.org/10.2217/epi-2018-0116', 'title': 'Does DNA methylation provide a link between folate and neural tube closure?', 'display_name': 'Does DNA methylation provide a link between folate and neural tube closure?', 'publication_year': 2018, 'publication_date': '2018-09-14', 'ids': {'openalex': 'https://openalex.org/W2890683537', 'doi': 'https://doi.org/10.2217/epi-2018-0116', 'mag': '2890683537', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30215549'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.2217/epi-2018-0116', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S42283280', 'display_name': 'Epigenomics', 'issn_l': '1750-192X', 'issn': ['1750-192X', '1750-1911'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310321119', 'host_organization_name': 'Future Medicine', 'host_organization_lineage': ['https://openalex.org/P4310321119'], 'host_organization_lineage_names': ['Future Medicine'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'editorial', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100786250', 'display_name': 'Huili Li', 'orcid': 'https://orcid.org/0000-0002-9248-0720'}, 'institutions': [{'id': 'https://openalex.org/I188538660', 'display_name': 'University of Colorado Boulder', 'ror': 'https://ror.org/02ttsq026', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I188538660']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Huili Li', 'raw_affiliation_strings': ['Department of Molecular, Cellular&Development Biology, University of Colorado Boulder, Boulder, CO 80309, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular, Cellular&Development Biology, University of Colorado Boulder, Boulder, CO 80309, USA', 'institution_ids': ['https://openalex.org/I188538660']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5056393947', 'display_name': 'Lee Niswander', 'orcid': 'https://orcid.org/0000-0002-9959-0594'}, 'institutions': [{'id': 'https://openalex.org/I188538660', 'display_name': 'University of Colorado Boulder', 'ror': 'https://ror.org/02ttsq026', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I188538660']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lee Niswander', 'raw_affiliation_strings': ['Department of Molecular, Cellular&Development Biology, University of Colorado Boulder, Boulder, CO 80309, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular, Cellular&Development Biology, University of Colorado Boulder, Boulder, CO 80309, USA', 'institution_ids': ['https://openalex.org/I188538660']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 8, 'citation_normalized_percentile': {'value': 0.646667, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 83, 'max': 84}, 'biblio': {'volume': '10', 'issue': '10', 'first_page': '1263', 'last_page': '1265'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10499', 'display_name': 'Folate and B Vitamins Research', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10499', 'display_name': 'Folate and B Vitamins Research', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11633', 'display_name': 'Prenatal Substance Exposure Effects', 'score': 0.9838, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2780594696', 'wikidata': 'https://www.wikidata.org/wiki/Q1127402', 'display_name': 'Neural tube', 'level': 3, 'score': 0.56021225}, {'id': 'https://openalex.org/C2779473830', 'wikidata': 'https://www.wikidata.org/wiki/Q1540899', 'display_name': 'MEDLINE', 'level': 2, 'score': 0.50517446}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.46879634}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.42575586}, {'id': 'https://openalex.org/C161191863', 'wikidata': 'https://www.wikidata.org/wiki/Q199655', 'display_name': 'Library science', 'level': 1, 'score': 0.4039381}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.37371957}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.3196892}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.29222533}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.21402025}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.10279429}, {'id': 'https://openalex.org/C196843134', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryo', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005492', 'descriptor_name': 'Folic Acid', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D054259', 'descriptor_name': 'Neural Tube', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': True}, {'descriptor_ui': 'D009436', 'descriptor_name': 'Neural Tube Defects', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044127', 'descriptor_name': 'Epigenesis, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005492', 'descriptor_name': 'Folic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054259', 'descriptor_name': 'Neural Tube', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D054259', 'descriptor_name': 'Neural Tube', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009436', 'descriptor_name': 'Neural Tube Defects', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009436', 'descriptor_name': 'Neural Tube Defects', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.2217/epi-2018-0116', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S42283280', 'display_name': 'Epigenomics', 'issn_l': '1750-192X', 'issn': ['1750-192X', '1750-1911'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310321119', 'host_organization_name': 'Future Medicine', 'host_organization_lineage': ['https://openalex.org/P4310321119'], 'host_organization_lineage_names': ['Future Medicine'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30215549', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320337611', 'funder_display_name': 'Eunice Kennedy Shriver National Institute of Child Health and Human Development', 'award_id': 'R01HD081562-S1'}], 'datasets': [], 'versions': [], 'referenced_works_count': 20, 'referenced_works': ['https://openalex.org/W1560239518', 'https://openalex.org/W1575442658', 'https://openalex.org/W1975131136', 'https://openalex.org/W1997427906', 'https://openalex.org/W2008982730', 'https://openalex.org/W2051826739', 'https://openalex.org/W2074559252', 'https://openalex.org/W2090898106', 'https://openalex.org/W2112903461', 'https://openalex.org/W2132760127', 'https://openalex.org/W2335949919', 'https://openalex.org/W2357037093', 'https://openalex.org/W2520894026', 'https://openalex.org/W2531631157', 'https://openalex.org/W2575440932', 'https://openalex.org/W2606189516', 'https://openalex.org/W2610368603', 'https://openalex.org/W2743507983', 'https://openalex.org/W2770089211', 'https://openalex.org/W2794907452'], 'related_works': ['https://openalex.org/W4377238114', 'https://openalex.org/W4315785934', 'https://openalex.org/W4242868585', 'https://openalex.org/W4210534638', 'https://openalex.org/W3142740859', 'https://openalex.org/W2372981175', 'https://openalex.org/W2096156362', 'https://openalex.org/W2057129148', 'https://openalex.org/W1981543043', 'https://openalex.org/W1981240410'], 'abstract_inverted_index': {'EpigenomicsVol.': [0], '10,': [1, 769, 820], 'No.': [2, 709, 728, 744, 770, 784, 817, 821], '10': [3, 822], 'EditorialDoes': [4], 'DNA': [5, 427, 648, 756], 'methylation': [6, 428, 544, 583, 649, 671, 711, 757], 'provide': [7], 'a': [8, 362, 396, 402, 443, 585, 698, 899], 'link': [9, 699], 'between': [10, 574], 'folate': [11, 245, 302, 549, 611], 'and': [12, 77, 89, 114, 164, 221, 246, 282, 304, 335, 580, 616, 693, 704, 712, 731, 755, 796, 862, 880], 'neural': [13, 94, 118, 196, 252, 306, 329, 332, 408, 447, 486, 514, 677, 735, 746], 'tube': [14, 80, 82, 95, 119, 160, 197, 253, 307, 333, 409, 448, 487, 515, 678, 736, 747, 865, 867], 'closure?Huili': [15], 'Li': [16, 633], '&': [17, 30, 41, 48, 870], 'Lee': [18, 42], 'NiswanderHuili': [19], 'Li*Author': [20], 'for': [21, 192, 251, 389, 401, 446, 697, 828], 'correspondence:': [22], 'E-mail': [23], 'Address:': [24], '[email protected]': [25], 'Department': [26, 44], 'of': [27, 34, 45, 52, 93, 195, 241, 278, 327, 433, 439, 477, 485, 647, 672, 695, 714, 718, 761, 775, 787, 927], 'Molecular,': [28, 46], 'Cellular': [29, 47], 'Development': [31, 49], 'Biology,': [32, 50], 'University': [33, 51], 'Colorado': [35, 53], 'Boulder,': [36, 37, 54, 55], 'CO': [38, 56], '80309,': [39, 57], 'USA': [40, 289, 555], 'Niswander': [43, 110], 'USAPublished': [58], 'Online:14': [59], 'Sep': [60], '2018https://doi.org/10.2217/epi-2018-0116AboutSectionsView': [61], 'ArticleView': [62], 'Full': [63], 'TextPDF/EPUB': [64], 'ToolsAdd': [65], 'to': [66, 117, 142, 406], 'favoritesDownload': [67], 'CitationsTrack': [68], 'CitationsPermissionsReprints': [69], 'ShareShare': [70], 'onFacebookTwitterLinkedInReddit': [71], 'View': [72], 'articleKeywords:': [73], 'developmental': [74], 'epigeneticsDNA': [75, 860], 'methylationepigenetics': [76, 861], 'diseasefolatefolic': [78, 863], 'acidneural': [79, 864], 'closureneural': [81, 866], 'defectone-carbon': [83, 868], 'metabolismReferences1': [84], 'Obladen': [85], 'M.': [86], 'Cats,': [87], 'frogs,': [88], 'snakes:': [90], 'early': [91], 'concepts': [92], 'defects.': [96, 308, 449, 488, 516], 'J.': [97, 167, 652, 681], 'Child.': [98], 'Neurol.': [99], '26(11),': [100], '1452–1461': [101], '(2011).Crossref,': [102], 'Medline,': [103, 127, 150, 175, 210, 228, 260, 293, 313, 342, 375, 416, 460, 522, 559, 597, 625, 658, 685], 'Google': [104, 129, 151, 176, 211, 230, 262, 295, 315, 344, 377, 417, 462, 494, 523, 561, 599, 627, 660, 687], 'Scholar2': [105], 'Wilde': [106], 'JJ,': [107], 'Petersen': [108], 'JR,': [109], 'L.': [111], 'Genetic,': [112], 'epigenetic,': [113], 'environmental': [115], 'contributions': [116], 'closure.': [120, 254, 679], 'Annu.': [121], 'Rev.': [122], 'Genet.': [123, 654], '48,': [124], '583–611': [125], '(2014).Crossref,': [126, 521], 'CAS,': [128, 229, 261, 294, 314, 343, 376, 461, 493, 560, 598, 626, 659, 686], 'Scholar3': [130], 'Jacob': [131], 'JA.': [132], 'Twenty': [133], 'years': [134], 'after': [135], 'folic': [136, 162], 'acid': [137, 163, 190], 'fortification,': [138], 'FDA': [139], 'ponders': [140], 'expansion': [141], 'corn': [143], 'masa': [144], 'flour.': [145], 'JAMA': [146, 206], '315(17),': [147], '1821–1822': [148], '(2016).Crossref,': [149, 415, 596], 'Scholar4': [152], 'Imbard': [153], 'A,': [154, 298, 380], 'Benoist': [155], 'JF,': [156], 'Blom': [157], 'HJ.': [158], 'Neural': [159, 777, 788], 'defects,': [161], 'methylation.': [165], 'Int.': [166], 'Environ.': [168], 'Res.': [169, 367, 452, 589], 'Public': [170], 'Health': [171], '10(9),': [172], '4352–4389': [173], '(2013).Crossref,': [174, 624], 'Scholar5': [177], 'US': [178, 199], 'Preventive': [179], 'Services': [180], 'Task': [181], 'Force,': [182], 'Bibbins-domingo': [183], 'K,': [184], 'Grossman': [185], 'DC': [186], 'et': [187, 238, 323, 352, 385, 425, 502, 531, 569, 607, 635], 'al.': [188, 239, 324, 353, 386, 426, 503, 532, 570, 608, 636], 'Folic': [189], 'supplementation': [191], 'the': [193, 437, 483, 537, 572, 829, 907, 914, 925], 'prevention': [194], 'defects:': [198], 'preventive': [200], 'services': [201], 'task': [202], 'force': [203], 'recommendation': [204], 'statement.': [205], '317(2),': [207], '183–189': [208], '(2017).Crossref,': [209, 227, 259, 292, 341, 684], 'Scholar6': [212], 'Ducker': [213], 'GS,': [214], 'Rabinowitz': [215], 'JD.': [216], 'One-carbon': [217], 'metabolism': [218, 248, 303, 612], 'in': [219, 244, 442, 513, 536, 610, 639, 650, 734, 749, 772, 780, 851, 902, 913, 924], 'health': [220], 'disease.': [222], 'Cell': [223, 255, 337, 621], 'Metab.': [224], '25(1),': [225], '27–42': [226], 'Scholar7': [231], 'Leung': [232], 'KY,': [233], 'Pai': [234], 'YJ,': [235], 'Chen': [236, 346], 'Q': [237], 'Partitioning': [240], 'one-carbon': [242], 'units': [243], 'methionine': [247], 'is': [249, 357, 480, 641, 875], 'essential': [250], 'Rep.': [256, 338], '21(7),': [257], '1795–1808': [258], 'Scholar8': [263], 'Palmer': [264], 'AM,': [265], 'Kamynina': [266], 'E,': [267], 'Field': [268], 'MS,': [269], 'Stover': [270], 'PJ.': [271], 'Folate': [272], 'rescues': [273], 'vitamin': [274], 'b12': [275], 'depletion-induced': [276], 'inhibition': [277], 'nuclear': [279], 'thymidylate': [280], 'biosynthesis': [281], 'genome': [283], 'instability.': [284], 'Proc.': [285, 551], 'Natl': [286, 552], 'Acad.': [287, 553], 'Sci.': [288, 554], '114(20),': [290], 'e4095–e4102': [291], 'Scholar9': [296], 'Fleming': [297], 'Copp': [299], 'AJ.': [300], 'Embryonic': [301], 'mouse': [305], 'Science': [309], '280(5372),': [310], '2107–2109': [311], '(1998).Crossref,': [312], 'Scholar10': [316], 'Valensisi': [317], 'C,': [318, 320], 'Andrus': [319], 'Buckberry': [321], 'S': [322, 424, 568], 'Epigenomic': [325], 'landscapes': [326], 'hesc-derived': [328], 'rosettes:': [330], 'modeling': [331], 'formation': [334], 'diseases.': [336], '20(6),': [339], '1448–1462': [340], 'Scholar11': [345], 'X,': [347, 630], 'Guo': [348], 'J,': [349], 'Lei': [350], 'Y': [351], 'Global': [354], 'dna': [355, 543, 582], 'hypomethylation': [356, 394], 'associated': [358, 481, 508, 642, 758], 'with': [359, 399, 482, 509, 548, 643, 700, 804, 893, 898, 906], 'ntd-affected': [360], 'pregnancy:': [361], 'case–control': [363], 'study.': [364], 'Birth': [365, 450, 587], 'Defects': [366, 451, 588], 'A.': [368, 453, 475, 590], 'Clin.': [369, 411, 454, 591], 'Mol.': [370, 455, 592], 'Teratol.': [371, 456, 593], '88(7),': [372], '575–581': [373], '(2010).Crossref,': [374], 'Scholar12': [378], 'Rochtus': [379], 'Winand': [381], 'R,': [382], 'Laenen': [383], 'G': [384], 'Methylome': [387], 'analysis': [388], 'spina': [390, 440], 'bifida': [391, 441, 638], 'shows': [392], 'Sox18': [393], 'as': [395], 'risk': [397, 438], 'factor': [398], 'evidence': [400, 696], 'complex': [403], '(epi)genetic': [404], 'interplay': [405], 'affect': [407], 'development.': [410, 620], 'Epigenetics': [412], '8,': [413], '108': [414], 'Scholar13': [418], 'Shangguan': [419, 565], 'S,': [420, 526, 566], 'Wang': [421, 466, 563], 'L,': [422, 467, 564, 632], 'Chang': [423, 567], 'aberrations': [429], 'rather': [430], 'than': [431], 'polymorphisms': [432, 579], 'FZD3': [434], 'gene': [435, 479, 540, 578, 715], 'increase': [436], 'high-risk': [444], 'region': [445], '103(1),': [457], '37–44': [458], '(2015).Crossref,': [459, 657], 'Scholar14': [463], 'Tian': [464], 'T,': [465], 'Shen': [468], 'Y,': [469], 'Zhang': [470, 498, 629], 'B,': [471, 497], 'Finnell': [472, 668], 'RH,': [473], 'Ren': [474], 'Hypomethylation': [476], 'GRHL3': [478], 'occurrence': [484], 'Epigenomics': [489], '10(7),': [490], '891–901': [491], '(2018).Link,': [492], 'Scholar15': [495], 'Bai': [496], 'Q,': [499], 'Liu': [500], 'X': [501], 'Different': [504], 'epigenetic': [505, 614], 'alterations': [506], 'are': [507], 'abnormal': [510], 'IGF2/Igf2': [511], 'upregulation': [512], 'PLoS': [517], 'ONE': [518], '9(11),': [519], 'e113308': [520], 'Scholar16': [524], 'Friso': [525], 'Choi': [527], 'SW,': [528], 'Girelli': [529], 'D': [530], 'A': [533], 'common': [534, 732], 'mutation': [535], '5,10-methylenetetrahydrofolate': [538], 'reductase': [539, 576], 'affects': [541], 'genomic': [542, 581], 'through': [545], 'an': [546, 644], 'interaction': [547], 'status.': [550], '99(8),': [556], '5606–5611': [557], '(2002).Crossref,': [558], 'Scholar17': [562], 'Determining': [571], 'association': [573], 'methylenetetrahydrofolate': [575], '(MTHFR)': [577], 'level:': [584], 'meta-analysis.': [586], '106(8),': [594], '667–674': [595], 'Scholar18': [600], 'Padmanabhan': [601], 'N,': [602], 'Jia': [603], 'D,': [604], 'Geary-Joo': [605], 'C': [606], 'Mutation': [609], 'causes': [613], 'instability': [615], 'transgenerational': [617], 'effects': [618], 'on': [619, 773, 801, 825], '155(1),': [622], '81–93': [623], 'Scholar19': [628], 'Pei': [631], 'R': [634], 'Spina': [637], 'fetus': [640], 'altered': [645], 'pattern': [646], 'placenta.': [651], 'Hum.': [653], '60(10),': [655], '605–611': [656], 'Scholar20': [661], 'Toriyama': [662, 664], 'M,': [663, 665], 'Wallingford': [666], 'JB,': [667], 'RH.': [669], 'Folate-dependent': [670], 'Septins': [673], 'governs': [674], 'ciliogenesis': [675], 'during': [676], 'Faseb': [680], '31(8),': [682], '3622–3635': [683], 'ScholarFiguresReferencesRelatedDetailsCited': [688], 'ByMaternal': [689], 'effect': [690], 'genes:': [691], 'Update': [692], 'review': [694], 'birth': [701], 'defectsHuman': [702], 'Genetics': [703], 'Genomics': [705], 'Advances,': [706], 'Vol.': [707, 726, 742, 768, 782, 808, 815, 819], '3,': [708], '1DNA': [710], 'regulation': [713], 'expression:': [716], 'Guardian': [717], 'our': [719], 'health16': [720], 'August': [721, 843], '2021': [722, 739, 764], '|': [723, 740, 765, 813], 'The': [724, 883], 'Nucleus,': [725], '64,': [727], '3Micronutrient': [729], 'imbalance': [730], 'phenotypes': [733], 'defects19': [737], 'October': [738, 811, 853], 'genesis,': [741], '59,': [743], '11Homocysteine-induced': [745], 'defects': [748], 'chick': [750], 'embryos': [751], 'via': [752], 'oxidative': [753], 'stress': [754], 'transcriptional': [759], 'down-regulation': [760], 'miR-12426': [762], 'April': [763, 791], 'Toxicology': [766], 'Research,': [767], '3Closing': [771], 'Mechanisms': [774], 'Open': [776], 'Tube': [778, 789], 'DefectsTrends': [779], 'Neurosciences,': [781], '43,': [783], '7Mouse': [785], 'Models': [786], 'Defects18': [790], '2020Bioactive': [792], 'food': [793], 'compounds,': [794], 'epigenetics': [795], 'chronic': [797], 'disease': [798], 'prevention:': [799], 'Focus': [800], 'early-life': [802], 'interventions': [803], 'polyphenolsFood': [805], 'Research': [806], 'International,': [807], '125Microtia': [809], 'epigenetics1': [810], '2019': [812], 'Medicine,': [814], '98,': [816], '41': [818], 'Follow': [823], 'us': [824], 'social': [826], 'media': [827], 'latest': [830], 'updates': [831], 'Metrics': [832], 'Downloaded': [833], '212': [834], 'times': [835], 'History': [836], 'Received': [837], '19': [838], 'July': [839], '2018': [840, 844, 849, 854, 856], 'Accepted': [841], '2': [842], 'Published': [845, 850], 'online': [846], '14': [847], 'September': [848], 'print': [852], 'Information©': [855], 'Future': [857], 'Medicine': [858], 'LtdKeywordsdevelopmental': [859], 'metabolismFinancial': [869], 'competing': [871], 'interests': [872], 'disclosureThis': [873], 'work': [874], 'supported': [876], 'by': [877], 'NIH/NICHD': [878], 'R01HD081562-S1': [879], 'NIH/NIDCR': [881], 'R01DE024034.': [882], 'authors': [884], 'have': [885], 'no': [886], 'other': [887], 'relevant': [888], 'affiliations': [889], 'or': [890, 896, 903, 910], 'financial': [891, 900, 904], 'involvement': [892], 'any': [894], 'organization': [895], 'entity': [897], 'interest': [901], 'conflict': [905], 'subject': [908], 'matter': [909], 'materials': [911], 'discussed': [912], 'manuscript': [915], 'apart': [916], 'from': [917], 'those': [918], 'disclosed.No': [919], 'writing': [920], 'assistance': [921], 'was': [922], 'utilized': [923], 'production': [926], 'this': [928], 'manuscript.PDF': [929], 'download': [930]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2890683537', 'counts_by_year': [{'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}], 'updated_date': '2024-12-07T07:43:18.102078', 'created_date': '2018-09-27'}