Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2890680313', 'doi': 'https://doi.org/10.1515/cclm-2018-0782', 'title': 'MS-based proteomics: a metrological sound and robust alternative for apolipoprotein E phenotyping in a multiplexed test', 'display_name': 'MS-based proteomics: a metrological sound and robust alternative for apolipoprotein E phenotyping in a multiplexed test', 'publication_year': 2018, 'publication_date': '2018-09-21', 'ids': {'openalex': 'https://openalex.org/W2890680313', 'doi': 'https://doi.org/10.1515/cclm-2018-0782', 'mag': '2890680313', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30240356'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1515/cclm-2018-0782', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S124948411', 'display_name': 'Clinical Chemistry and Laboratory Medicine (CCLM)', 'issn_l': '1434-6621', 'issn': ['1434-6621', '1437-4331'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310313990', 'host_organization_name': 'De Gruyter', 'host_organization_lineage': ['https://openalex.org/P4310313990'], 'host_organization_lineage_names': ['De Gruyter'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'letter', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.degruyter.com/document/doi/10.1515/cclm-2024-frontmatter6/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5080379557', 'display_name': 'L. Renee Ruhaak', 'orcid': 'https://orcid.org/0000-0003-3737-3807'}, 'institutions': [{'id': 'https://openalex.org/I2800006345', 'display_name': 'Leiden University Medical Center', 'ror': 'https://ror.org/05xvt9f17', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800006345']}], 'countries': ['NL'], 'is_corresponding': True, 'raw_author_name': 'L. Renee Ruhaak', 'raw_affiliation_strings': ['Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I2800006345']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007218876', 'display_name': 'Nico P.M. Smit', 'orcid': 'https://orcid.org/0000-0002-8166-5332'}, 'institutions': [{'id': 'https://openalex.org/I2800006345', 'display_name': 'Leiden University Medical Center', 'ror': 'https://ror.org/05xvt9f17', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800006345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Nico P.M. Smit', 'raw_affiliation_strings': ['Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I2800006345']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044232630', 'display_name': 'H. Eka D. Suchiman', 'orcid': 'https://orcid.org/0000-0002-7168-5516'}, 'institutions': [{'id': 'https://openalex.org/I2800006345', 'display_name': 'Leiden University Medical Center', 'ror': 'https://ror.org/05xvt9f17', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800006345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'H. Eka D. Suchiman', 'raw_affiliation_strings': ['Section of Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Section of Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I2800006345']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013283177', 'display_name': 'Mervin Pieterse', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2800006345', 'display_name': 'Leiden University Medical Center', 'ror': 'https://ror.org/05xvt9f17', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800006345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Mervin M. Pieterse', 'raw_affiliation_strings': ['Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I2800006345']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036582402', 'display_name': 'Fred P.H.T.M. Romijn', 'orcid': 'https://orcid.org/0000-0003-4470-7959'}, 'institutions': [{'id': 'https://openalex.org/I2800006345', 'display_name': 'Leiden University Medical Center', 'ror': 'https://ror.org/05xvt9f17', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800006345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Fred P.H.T.M. Romijn', 'raw_affiliation_strings': ['Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I2800006345']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064751516', 'display_name': 'Marian Beekman', 'orcid': 'https://orcid.org/0000-0003-0585-6206'}, 'institutions': [{'id': 'https://openalex.org/I2800006345', 'display_name': 'Leiden University Medical Center', 'ror': 'https://ror.org/05xvt9f17', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800006345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Marian Beekman', 'raw_affiliation_strings': ['Section of Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Section of Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I2800006345']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5010614061', 'display_name': 'Christa M. Cobbaert', 'orcid': 'https://orcid.org/0000-0003-3565-1404'}, 'institutions': [{'id': 'https://openalex.org/I2800006345', 'display_name': 'Leiden University Medical Center', 'ror': 'https://ror.org/05xvt9f17', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800006345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Christa M. Cobbaert', 'raw_affiliation_strings': ['Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I2800006345']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5080379557'], 'corresponding_institution_ids': ['https://openalex.org/I2800006345'], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 10, 'citation_normalized_percentile': {'value': 0.75, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 85, 'max': 86}, 'biblio': {'volume': '57', 'issue': '5', 'first_page': 'e102', 'last_page': 'e104'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10519', 'display_name': 'Mass Spectrometry Techniques with Proteins', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/1607', 'display_name': 'Spectroscopy'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10519', 'display_name': 'Mass Spectrometry Techniques with Proteins', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/1607', 'display_name': 'Spectroscopy'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10836', 'display_name': 'Advances in Metabolomics Research', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12867', 'display_name': 'Protein Microarray Technology and Applications', 'score': 0.9627, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/multiplexed-assays', 'display_name': 'Multiplexed Assays', 'score': 0.574423}, {'id': 'https://openalex.org/keywords/phosphoproteomics', 'display_name': 'Phosphoproteomics', 'score': 0.574124}, {'id': 'https://openalex.org/keywords/functional-proteomics', 'display_name': 'Functional Proteomics', 'score': 0.570464}, {'id': 'https://openalex.org/keywords/proteomics', 'display_name': 'Proteomics', 'score': 0.55707}, {'id': 'https://openalex.org/keywords/mass-spectrometry', 'display_name': 'Mass Spectrometry', 'score': 0.545905}], 'concepts': [{'id': 'https://openalex.org/C46111723', 'wikidata': 'https://www.wikidata.org/wiki/Q471857', 'display_name': 'Proteomics', 'level': 3, 'score': 0.596701}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.5507534}, {'id': 'https://openalex.org/C195766429', 'wikidata': 'https://www.wikidata.org/wiki/Q394', 'display_name': 'Metrology', 'level': 2, 'score': 0.467922}, {'id': 'https://openalex.org/C203718221', 'wikidata': 'https://www.wikidata.org/wiki/Q491713', 'display_name': 'Sound (geography)', 'level': 2, 'score': 0.45051378}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.42376307}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.32104433}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2898752}, {'id': 'https://openalex.org/C33923547', 'wikidata': 'https://www.wikidata.org/wiki/Q395', 'display_name': 'Mathematics', 'level': 0, 'score': 0.14752385}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.119708896}, {'id': 'https://openalex.org/C24890656', 'wikidata': 'https://www.wikidata.org/wiki/Q82811', 'display_name': 'Acoustics', 'level': 1, 'score': 0.11376709}, {'id': 'https://openalex.org/C105795698', 'wikidata': 'https://www.wikidata.org/wiki/Q12483', 'display_name': 'Statistics', 'level': 1, 'score': 0.09628391}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.09145242}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D053329', 'descriptor_name': 'Apolipoprotein E2', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D053318', 'descriptor_name': 'Apolipoprotein E3', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D053327', 'descriptor_name': 'Apolipoprotein E4', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D053329', 'descriptor_name': 'Apolipoprotein E2', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D053329', 'descriptor_name': 'Apolipoprotein E2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053318', 'descriptor_name': 'Apolipoprotein E3', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D053318', 'descriptor_name': 'Apolipoprotein E3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053327', 'descriptor_name': 'Apolipoprotein E4', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D053327', 'descriptor_name': 'Apolipoprotein E4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002853', 'descriptor_name': 'Chromatography, Liquid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013058', 'descriptor_name': 'Mass Spectrometry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D040901', 'descriptor_name': 'Proteomics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D040901', 'descriptor_name': 'Proteomics', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1515/cclm-2018-0782', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S124948411', 'display_name': 'Clinical Chemistry and Laboratory Medicine (CCLM)', 'issn_l': '1434-6621', 'issn': ['1434-6621', '1437-4331'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310313990', 'host_organization_name': 'De Gruyter', 'host_organization_lineage': ['https://openalex.org/P4310313990'], 'host_organization_lineage_names': ['De Gruyter'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.degruyter.com/view/j/cclm.ahead-of-print/cclm-2018-0782/cclm-2018-0782.xml', 'pdf_url': 'https://www.degruyter.com/document/doi/10.1515/cclm-2024-frontmatter6/pdf', 'source': {'id': 'https://openalex.org/S4306400850', 'display_name': 'Leiden Repository (Leiden University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I121797337', 'host_organization_name': 'Leiden University', 'host_organization_lineage': ['https://openalex.org/I121797337'], 'host_organization_lineage_names': ['Leiden University'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30240356', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://www.degruyter.com/view/j/cclm.ahead-of-print/cclm-2018-0782/cclm-2018-0782.xml', 'pdf_url': 'https://www.degruyter.com/document/doi/10.1515/cclm-2024-frontmatter6/pdf', 'source': {'id': 'https://openalex.org/S4306400850', 'display_name': 'Leiden Repository (Leiden University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I121797337', 'host_organization_name': 'Leiden University', 'host_organization_lineage': ['https://openalex.org/I121797337'], 'host_organization_lineage_names': ['Leiden University'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Zero hunger', 'id': 'https://metadata.un.org/sdg/2', 'score': 0.65}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 13, 'referenced_works': ['https://openalex.org/W1983258394', 'https://openalex.org/W1987030556', 'https://openalex.org/W2006534012', 'https://openalex.org/W2020737544', 'https://openalex.org/W2045393960', 'https://openalex.org/W2075064977', 'https://openalex.org/W2117655698', 'https://openalex.org/W2145622300', 'https://openalex.org/W2176161796', 'https://openalex.org/W2214950733', 'https://openalex.org/W2416854880', 'https://openalex.org/W2800713945', 'https://openalex.org/W2804991438'], 'related_works': ['https://openalex.org/W4248659496', 'https://openalex.org/W3021604969', 'https://openalex.org/W2899084033', 'https://openalex.org/W2748952813', 'https://openalex.org/W2161712355', 'https://openalex.org/W2153167812', 'https://openalex.org/W2088324202', 'https://openalex.org/W2080856312', 'https://openalex.org/W1892840179', 'https://openalex.org/W1614434693'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2890680313', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 2}], 'updated_date': '2024-09-17T20:02:31.077760', 'created_date': '2018-09-27'}