Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2889884729', 'doi': 'https://doi.org/10.1186/s12885-018-4764-0', 'title': '‘DURVIT’: a phase-I trial of single low-dose durvalumab (Medi4736) IntraTumourally injected in cervical cancer: safety, toxicity and effect on the primary tumour- and lymph node microenvironment', 'display_name': '‘DURVIT’: a phase-I trial of single low-dose durvalumab (Medi4736) IntraTumourally injected in cervical cancer: safety, toxicity and effect on the primary tumour- and lymph node microenvironment', 'publication_year': 2018, 'publication_date': '2018-09-12', 'ids': {'openalex': 'https://openalex.org/W2889884729', 'doi': 'https://doi.org/10.1186/s12885-018-4764-0', 'mag': '2889884729', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30208866', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6134598'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s12885-018-4764-0', 'pdf_url': 'https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-018-4764-0', 'source': {'id': 'https://openalex.org/S192926780', 'display_name': 'BMC Cancer', 'issn_l': '1471-2407', 'issn': ['1471-2407'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-018-4764-0', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5041181183', 'display_name': 'Jossie Rotman', 'orcid': 'https://orcid.org/0000-0002-3771-247X'}, 'institutions': [{'id': 'https://openalex.org/I4210151833', 'display_name': 'Amsterdam University Medical Centers', 'ror': 'https://ror.org/05grdyy37', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210151833']}, {'id': 'https://openalex.org/I865915315', 'display_name': 'Vrije Universiteit Amsterdam', 'ror': 'https://ror.org/008xxew50', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I865915315']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'J. Rotman', 'raw_affiliation_strings': ['Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Obstetrics and Gynaecology, Cancer Center Amsterdam, Center for Gynaecologic Oncology Amsterdam (CGOA), CCA 2.48, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Obstetrics and Gynaecology, Cancer Center Amsterdam, Center for Gynaecologic Oncology Amsterdam (CGOA), CCA 2.48, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands', 'institution_ids': ['https://openalex.org/I4210151833', 'https://openalex.org/I865915315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068372434', 'display_name': 'Constantijne H. Mom', 'orcid': 'https://orcid.org/0000-0003-2838-2031'}, 'institutions': [{'id': 'https://openalex.org/I4210151833', 'display_name': 'Amsterdam University Medical Centers', 'ror': 'https://ror.org/05grdyy37', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210151833']}, {'id': 'https://openalex.org/I865915315', 'display_name': 'Vrije Universiteit Amsterdam', 'ror': 'https://ror.org/008xxew50', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I865915315']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'C. H. Mom', 'raw_affiliation_strings': ['Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Obstetrics and Gynaecology, Cancer Center Amsterdam, Center for Gynaecologic Oncology Amsterdam (CGOA), CCA 2.48, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Obstetrics and Gynaecology, Cancer Center Amsterdam, Center for Gynaecologic Oncology Amsterdam (CGOA), CCA 2.48, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands', 'institution_ids': ['https://openalex.org/I4210151833', 'https://openalex.org/I865915315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022121778', 'display_name': 'Ekaterina S. Jordanova', 'orcid': 'https://orcid.org/0000-0002-8121-1322'}, 'institutions': [{'id': 'https://openalex.org/I4210151833', 'display_name': 'Amsterdam University Medical Centers', 'ror': 'https://ror.org/05grdyy37', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210151833']}, {'id': 'https://openalex.org/I865915315', 'display_name': 'Vrije Universiteit Amsterdam', 'ror': 'https://ror.org/008xxew50', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I865915315']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'E. S. Jordanova', 'raw_affiliation_strings': ['Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Obstetrics and Gynaecology, Cancer Center Amsterdam, Center for Gynaecologic Oncology Amsterdam (CGOA), CCA 2.48, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Obstetrics and Gynaecology, Cancer Center Amsterdam, Center for Gynaecologic Oncology Amsterdam (CGOA), CCA 2.48, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands', 'institution_ids': ['https://openalex.org/I4210151833', 'https://openalex.org/I865915315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053105927', 'display_name': 'Tanja D. de Gruijl', 'orcid': 'https://orcid.org/0000-0003-1464-8978'}, 'institutions': [{'id': 'https://openalex.org/I865915315', 'display_name': 'Vrije Universiteit Amsterdam', 'ror': 'https://ror.org/008xxew50', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I865915315']}, {'id': 'https://openalex.org/I4210151833', 'display_name': 'Amsterdam University Medical Centers', 'ror': 'https://ror.org/05grdyy37', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210151833']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'T. D. de Gruijl', 'raw_affiliation_strings': ['Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Medical Oncology, Cancer Center Amsterdam, CCA 2.44, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Medical Oncology, Cancer Center Amsterdam, CCA 2.44, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands', 'institution_ids': ['https://openalex.org/I865915315', 'https://openalex.org/I4210151833']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5085925712', 'display_name': 'Gemma G. Kenter', 'orcid': 'https://orcid.org/0000-0002-7284-3918'}, 'institutions': [{'id': 'https://openalex.org/I4210138709', 'display_name': 'Centrum voor Gynaecologische Oncologie Amsterdam', 'ror': 'https://ror.org/03sxzz606', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210138709']}, {'id': 'https://openalex.org/I4210151833', 'display_name': 'Amsterdam University Medical Centers', 'ror': 'https://ror.org/05grdyy37', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210151833']}, {'id': 'https://openalex.org/I887064364', 'display_name': 'University of Amsterdam', 'ror': 'https://ror.org/04dkp9463', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I887064364']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'G. G. Kenter', 'raw_affiliation_strings': ['Amsterdam UMC, Univ(ersity) of Amsterdam, Department of Obstetrics and Gynaecology, Center for Gynaecologic Oncology Amsterdam (CGOA), H4-222, Postbus 22660, 1100 DD, Amsterdam, the Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Amsterdam UMC, Univ(ersity) of Amsterdam, Department of Obstetrics and Gynaecology, Center for Gynaecologic Oncology Amsterdam (CGOA), H4-222, Postbus 22660, 1100 DD, Amsterdam, the Netherlands', 'institution_ids': ['https://openalex.org/I4210138709', 'https://openalex.org/I4210151833', 'https://openalex.org/I887064364']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1790, 'currency': 'GBP', 'value_usd': 2195, 'provenance': 'doaj'}, 'apc_paid': {'value': 1790, 'currency': 'GBP', 'value_usd': 2195, 'provenance': 'doaj'}, 'fwci': 1.785, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 27, 'citation_normalized_percentile': {'value': 0.861407, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '18', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10668', 'display_name': 'Gynecologic Oncology', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2729', 'display_name': 'Obstetrics and Gynecology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13110', 'display_name': 'Treatment and Management of Anal Cancer', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/durvalumab', 'display_name': 'Durvalumab', 'score': 0.9352567}, {'id': 'https://openalex.org/keywords/pd-1-and-pd-l1', 'display_name': 'PD-1 and PD-L1', 'score': 0.553913}, {'id': 'https://openalex.org/keywords/tumor-microenvironment', 'display_name': 'Tumor Microenvironment', 'score': 0.530901}, {'id': 'https://openalex.org/keywords/cervical-cancer', 'display_name': 'Cervical Cancer', 'score': 0.518934}, {'id': 'https://openalex.org/keywords/clinical-endpoint', 'display_name': 'Clinical endpoint', 'score': 0.4432123}, {'id': 'https://openalex.org/keywords/immune-checkpoint', 'display_name': 'Immune checkpoint', 'score': 0.43334275}], 'concepts': [{'id': 'https://openalex.org/C2777742743', 'wikidata': 'https://www.wikidata.org/wiki/Q19904005', 'display_name': 'Durvalumab', 'level': 5, 'score': 0.9352567}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.86025}, {'id': 'https://openalex.org/C2780849966', 'wikidata': 'https://www.wikidata.org/wiki/Q170758', 'display_name': 'Lymph node', 'level': 2, 'score': 0.6351928}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.50131416}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.49658352}, {'id': 'https://openalex.org/C2778220009', 'wikidata': 'https://www.wikidata.org/wiki/Q160105', 'display_name': 'Cervical cancer', 'level': 3, 'score': 0.48783377}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.45989162}, {'id': 'https://openalex.org/C203092338', 'wikidata': 'https://www.wikidata.org/wiki/Q1340863', 'display_name': 'Clinical endpoint', 'level': 3, 'score': 0.4432123}, {'id': 'https://openalex.org/C2777863537', 'wikidata': 'https://www.wikidata.org/wiki/Q357896', 'display_name': 'Adjuvant', 'level': 2, 'score': 0.4407727}, {'id': 'https://openalex.org/C2780851360', 'wikidata': 'https://www.wikidata.org/wiki/Q21686041', 'display_name': 'Immune checkpoint', 'level': 4, 'score': 0.43334275}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.42744574}, {'id': 'https://openalex.org/C2777701055', 'wikidata': 'https://www.wikidata.org/wiki/Q1427096', 'display_name': 'Immunotherapy', 'level': 3, 'score': 0.3556324}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.35442454}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.31356654}, {'id': 'https://openalex.org/C2780057760', 'wikidata': 'https://www.wikidata.org/wiki/Q13896859', 'display_name': 'Pembrolizumab', 'level': 4, 'score': 0.10484001}], 'mesh': [{'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D000074322', 'descriptor_name': 'Antineoplastic Agents, Immunological', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D002985', 'descriptor_name': 'Clinical Protocols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D058990', 'descriptor_name': 'Molecular Targeted Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D002583', 'descriptor_name': 'Uterine Cervical Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000074322', 'descriptor_name': 'Antineoplastic Agents, Immunological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000074322', 'descriptor_name': 'Antineoplastic Agents, Immunological', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D060890', 'descriptor_name': 'B7-H1 Antigen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D060890', 'descriptor_name': 'B7-H1 Antigen', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015552', 'descriptor_name': 'Injections, Intralesional', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008207', 'descriptor_name': 'Lymphatic Metastasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009367', 'descriptor_name': 'Neoplasm Staging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059016', 'descriptor_name': 'Tumor Microenvironment', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059016', 'descriptor_name': 'Tumor Microenvironment', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002583', 'descriptor_name': 'Uterine Cervical Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D002583', 'descriptor_name': 'Uterine Cervical Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002583', 'descriptor_name': 'Uterine Cervical Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s12885-018-4764-0', 'pdf_url': 'https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-018-4764-0', 'source': {'id': 'https://openalex.org/S192926780', 'display_name': 'BMC Cancer', 'issn_l': '1471-2407', 'issn': ['1471-2407'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/f453dab7a0e14f039a836ef640ef8daa', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134598', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30208866', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s12885-018-4764-0', 'pdf_url': 'https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-018-4764-0', 'source': {'id': 'https://openalex.org/S192926780', 'display_name': 'BMC Cancer', 'issn_l': '1471-2407', 'issn': ['1471-2407'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.89, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320307770', 'funder_display_name': 'AstraZeneca', 'award_id': 'PO 260459655'}], 'datasets': [], 'versions': [], 'referenced_works_count': 44, 'referenced_works': ['https://openalex.org/W1757407923', 'https://openalex.org/W1809117905', 'https://openalex.org/W1902699342', 'https://openalex.org/W1978857579', 'https://openalex.org/W1999428377', 'https://openalex.org/W2002495158', 'https://openalex.org/W2011764275', 'https://openalex.org/W2019936110', 'https://openalex.org/W2020586896', 'https://openalex.org/W2034943935', 'https://openalex.org/W2045600910', 'https://openalex.org/W2049078823', 'https://openalex.org/W2050302729', 'https://openalex.org/W2054373401', 'https://openalex.org/W2060071366', 'https://openalex.org/W2068081619', 'https://openalex.org/W2075154637', 'https://openalex.org/W2094845970', 'https://openalex.org/W2101653483', 'https://openalex.org/W2106199155', 'https://openalex.org/W2106777015', 'https://openalex.org/W2115091768', 'https://openalex.org/W2128940859', 'https://openalex.org/W2136313650', 'https://openalex.org/W2149134183', 'https://openalex.org/W2157025016', 'https://openalex.org/W2157357637', 'https://openalex.org/W2157719711', 'https://openalex.org/W2161558877', 'https://openalex.org/W2171896038', 'https://openalex.org/W2177405394', 'https://openalex.org/W2265285917', 'https://openalex.org/W2280266688', 'https://openalex.org/W2318880831', 'https://openalex.org/W2342029300', 'https://openalex.org/W2467885539', 'https://openalex.org/W2521929712', 'https://openalex.org/W2626715571', 'https://openalex.org/W2672184770', 'https://openalex.org/W2738732123', 'https://openalex.org/W2745624257', 'https://openalex.org/W2749372123', 'https://openalex.org/W2761796554', 'https://openalex.org/W3203488151'], 'related_works': ['https://openalex.org/W4360600080', 'https://openalex.org/W3215427184', 'https://openalex.org/W3137861895', 'https://openalex.org/W3136285682', 'https://openalex.org/W3112273539', 'https://openalex.org/W3026834933', 'https://openalex.org/W2990790803', 'https://openalex.org/W2921840556', 'https://openalex.org/W2736039453', 'https://openalex.org/W2188594974'], 'abstract_inverted_index': {'Treatment': [0], 'with': [1, 149], 'programmed': [2, 8], 'cell': [3, 9, 41, 178], 'death': [4, 10], 'receptor': [5], '(PD-1)': [6], 'and': [7, 52, 59, 141, 175, 195, 230, 232], 'ligand': [11], '1': [12], '(PD-L1)': [13], 'inhibitors': [14], 'is': [15, 46, 118, 165], 'a': [16, 110, 119], 'promising': [17], 'strategy': [18], 'to': [19, 78], 'lift': [20], 'tumour-induced': [21], 'immune': [22, 104], 'response': [23], 'suppression.': [24], 'However,': [25], 'the': [26, 154, 225, 238], 'current': [27], 'systemic': [28], 'treatment': [29], 'often': [30], 'causes': [31], 'autoimmune': [32], 'side': [33, 116], 'effects.': [34], 'In': [35], 'more': [36], 'than': [37], '50%': [38], 'of': [39, 55, 67, 84, 130, 161, 171, 193, 198, 216, 240], 'squamous': [40], 'cervical': [42, 68, 72, 210, 217], 'cancer,': [43], 'PD-L1': [44, 56, 87], 'expression': [45], 'detected.': [47], 'Moreover,': [48], 'we': [49], 'observed': [50], 'high': [51], 'interrelated': [53], 'rates': [54], 'positive': [57], 'macrophages': [58], 'regulatory': [60], 'T': [61, 177], 'cells': [62, 219], 'in': [63, 74, 109, 187, 190, 224], 'metastatic': [64, 214], 'lymph': [65, 80, 227], 'nodes': [66], 'cancer': [69, 73, 211, 218], 'patients.': [70, 212], 'As': [71], 'general': [75], 'initially': [76], 'metastasizes': [77], 'regional': [79], 'nodes,': [81], 'local': [82], 'administration': [83], 'durvalumab': [85, 134], '(a': [86], 'checkpoint': [88, 202], 'inhibitor)': [89], 'at': [90, 153], 'an': [91, 150], 'early': [92], 'stage': [93], 'will': [94, 135, 169], 'deliver': [95], 'these': [96], 'antibodies': [97], 'exactly': [98], 'where': [99], 'they': [100], 'are': [101], 'needed,': [102], 'facilitating': [103], 'protection.': [105], 'This': [106], 'may': [107, 204, 220], 'result': [108], 'clinical': [111], 'benefit': [112], 'while': [113], 'reducing': [114], 'undesirable': [115], 'effects.DURVIT': [117], 'non-randomized,': [120], 'single-arm,': [121], 'open-label,': [122], 'phase': [123], 'I': [124], 'study.': [125], 'Three': [126], 'escalating': [127], 'dose': [128, 147], 'levels': [129], 'intratumourally': [131], '(i.t.)': [132], 'injected': [133], 'be': [136, 222], 'tested,': [137], 'i.e.': [138], '5,': [139], '10': [140], '20': [142], 'mg': [143], '(three': [144], 'patients': [145], 'per': [146], 'level,': [148], 'additional': [151], 'three': [152], 'highest': [155], 'tolerated': [156], 'dose).': [157], 'The': [158, 181], 'primary': [159], 'endpoint': [160], 'this': [162, 188, 199], 'phase-I': [163], 'study': [164], 'safety.': [166], 'Immune': [167], 'monitoring': [168], 'consist': [170], 'flow': [172], 'cytometric,': [173], 'immunohistochemical': [174], 'functional': [176], 'reactivity': [179], 'testing.': [180], 'first': [182], 'patient': [183], 'has': [184], 'been': [185], 'included': [186], 'trial': [189], 'November': [191], '2017.Evidence': [192], 'safety': [194], 'biological': [196], 'efficacy': [197], 'locally': [200], 'administered': [201], 'blockade': [203], 'expand': [205], 'adjuvant': [206], 'therapy': [207], 'options': [208], 'for': [209], 'Early': [213], 'spread': [215], 'thus': [221], 'controlled': [223], 'draining': [226], 'node': [228], 'basin,': [229], 'beyond,': [231], 'hopefully': [233], 'delay': [234], 'or': [235], 'even': [236], 'prevent': [237], 'onset': [239], 'disease': [241], 'recurrence.NTR6119': [242], ',': [243], '1-nov-2016.': [244]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2889884729', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 5}], 'updated_date': '2024-09-01T07:22:59.834956', 'created_date': '2018-09-27'}