Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2889394978', 'doi': 'https://doi.org/10.2147/copd.s171707', 'title': 'A randomized study using functional respiratory imaging to characterize bronchodilator effects of glycopyrrolate/formoterol fumarate delivered by a metered dose inhaler using co-suspension delivery technology in patients with COPD', 'display_name': 'A randomized study using functional respiratory imaging to characterize bronchodilator effects of glycopyrrolate/formoterol fumarate delivered by a metered dose inhaler using co-suspension delivery technology in patients with COPD', 'publication_year': 2018, 'publication_date': '2018-08-01', 'ids': {'openalex': 'https://openalex.org/W2889394978', 'doi': 'https://doi.org/10.2147/copd.s171707', 'mag': '2889394978', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30214185', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6124470'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2147/copd.s171707', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=44028', 'source': {'id': 'https://openalex.org/S105319247', 'display_name': 'International Journal of COPD', 'issn_l': '1176-9106', 'issn': ['1176-9106', '1178-2005'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.dovepress.com/getfile.php?fileID=44028', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5060082670', 'display_name': 'Wilfried De Backer', 'orcid': 'https://orcid.org/0000-0002-6599-8276'}, 'institutions': [{'id': 'https://openalex.org/I149213910', 'display_name': 'University of Antwerp', 'ror': 'https://ror.org/008x57b05', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I149213910']}], 'countries': ['BE'], 'is_corresponding': True, 'raw_author_name': 'Wilfried De Backer', 'raw_affiliation_strings': ['Department of respiratory Medicine, University of antwerp, antwerp, Belgium;'], 'affiliations': [{'raw_affiliation_string': 'Department of respiratory Medicine, University of antwerp, antwerp, Belgium;', 'institution_ids': ['https://openalex.org/I149213910']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5106134306', 'display_name': 'Jan De Backer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210104298', 'display_name': 'Fluidda (United States)', 'ror': 'https://ror.org/01a70q325', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210104298', 'https://openalex.org/I4210142475']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jan De Backer', 'raw_affiliation_strings': ['FlUIDDa, los angeles, Ca, Usa;'], 'affiliations': [{'raw_affiliation_string': 'FlUIDDa, los angeles, Ca, Usa;', 'institution_ids': ['https://openalex.org/I4210104298']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007303067', 'display_name': 'Wim Vos', 'orcid': 'https://orcid.org/0000-0003-0827-421X'}, 'institutions': [{'id': 'https://openalex.org/I4210142475', 'display_name': 'Fluidda (Belgium)', 'ror': 'https://ror.org/03wj3v998', 'country_code': 'BE', 'type': 'company', 'lineage': ['https://openalex.org/I4210142475']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Wim Vos', 'raw_affiliation_strings': ['FlUIDDa, Kontich, Belgium;'], 'affiliations': [{'raw_affiliation_string': 'FlUIDDa, Kontich, Belgium;', 'institution_ids': ['https://openalex.org/I4210142475']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019088855', 'display_name': 'Ilse Verlinden', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210142475', 'display_name': 'Fluidda (Belgium)', 'ror': 'https://ror.org/03wj3v998', 'country_code': 'BE', 'type': 'company', 'lineage': ['https://openalex.org/I4210142475']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Ilse Verlinden', 'raw_affiliation_strings': ['FlUIDDa, Kontich, Belgium;'], 'affiliations': [{'raw_affiliation_string': 'FlUIDDa, Kontich, Belgium;', 'institution_ids': ['https://openalex.org/I4210142475']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019899932', 'display_name': 'Cedric Van Holsbeke', 'orcid': 'https://orcid.org/0000-0003-0248-841X'}, 'institutions': [{'id': 'https://openalex.org/I4210142475', 'display_name': 'Fluidda (Belgium)', 'ror': 'https://ror.org/03wj3v998', 'country_code': 'BE', 'type': 'company', 'lineage': ['https://openalex.org/I4210142475']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Cedric Van Holsbeke', 'raw_affiliation_strings': ['FlUIDDa, Kontich, Belgium;'], 'affiliations': [{'raw_affiliation_string': 'FlUIDDa, Kontich, Belgium;', 'institution_ids': ['https://openalex.org/I4210142475']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055399198', 'display_name': 'Johan Clukers', 'orcid': 'https://orcid.org/0000-0003-0021-8870'}, 'institutions': [{'id': 'https://openalex.org/I149213910', 'display_name': 'University of Antwerp', 'ror': 'https://ror.org/008x57b05', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I149213910']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Johan Clukers', 'raw_affiliation_strings': ['Department of respiratory Medicine, University of antwerp, antwerp, Belgium;'], 'affiliations': [{'raw_affiliation_string': 'Department of respiratory Medicine, University of antwerp, antwerp, Belgium;', 'institution_ids': ['https://openalex.org/I149213910']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032403798', 'display_name': 'Bita Hajian', 'orcid': 'https://orcid.org/0000-0003-0453-968X'}, 'institutions': [{'id': 'https://openalex.org/I149213910', 'display_name': 'University of Antwerp', 'ror': 'https://ror.org/008x57b05', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I149213910']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Bita Hajian', 'raw_affiliation_strings': ['Department of respiratory Medicine, University of antwerp, antwerp, Belgium;'], 'affiliations': [{'raw_affiliation_string': 'Department of respiratory Medicine, University of antwerp, antwerp, Belgium;', 'institution_ids': ['https://openalex.org/I149213910']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011502862', 'display_name': 'Shahid Siddiqui', 'orcid': 'https://orcid.org/0000-0001-9726-9003'}, 'institutions': [{'id': 'https://openalex.org/I4210150756', 'display_name': 'AstraZeneca (United States)', 'ror': 'https://ror.org/043cec594', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I105036370', 'https://openalex.org/I4210150756']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shahid Siddiqui', 'raw_affiliation_strings': ['astraZeneca, gaithersburg, MD, Usa;'], 'affiliations': [{'raw_affiliation_string': 'astraZeneca, gaithersburg, MD, Usa;', 'institution_ids': ['https://openalex.org/I4210150756']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110921458', 'display_name': 'Martin Jenkins', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I105036370', 'display_name': 'AstraZeneca (United Kingdom)', 'ror': 'https://ror.org/04r9x1a08', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I105036370']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Martin Jenkins', 'raw_affiliation_strings': ['astraZeneca, Cambridge, UK;'], 'affiliations': [{'raw_affiliation_string': 'astraZeneca, Cambridge, UK;', 'institution_ids': ['https://openalex.org/I105036370']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077419098', 'display_name': 'Colin Reisner', 'orcid': 'https://orcid.org/0000-0003-1856-9863'}, 'institutions': [{'id': 'https://openalex.org/I4210150756', 'display_name': 'AstraZeneca (United States)', 'ror': 'https://ror.org/043cec594', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I105036370', 'https://openalex.org/I4210150756']}, {'id': 'https://openalex.org/I4210136823', 'display_name': 'AstraZeneca (Poland)', 'ror': 'https://ror.org/04gdybn86', 'country_code': 'PL', 'type': 'company', 'lineage': ['https://openalex.org/I105036370', 'https://openalex.org/I4210136823']}], 'countries': ['PL', 'US'], 'is_corresponding': False, 'raw_author_name': 'Colin Reisner', 'raw_affiliation_strings': ['Pearl -a member of the astraZeneca group, Morristown, nJ, Usa', 'astraZeneca, gaithersburg, MD, Usa;'], 'affiliations': [{'raw_affiliation_string': 'astraZeneca, gaithersburg, MD, Usa;', 'institution_ids': ['https://openalex.org/I4210150756']}, {'raw_affiliation_string': 'Pearl -a member of the astraZeneca group, Morristown, nJ, Usa', 'institution_ids': ['https://openalex.org/I4210136823']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5077936927', 'display_name': 'Ubaldo J. Martin', 'orcid': 'https://orcid.org/0000-0002-0089-7677'}, 'institutions': [{'id': 'https://openalex.org/I4210150756', 'display_name': 'AstraZeneca (United States)', 'ror': 'https://ror.org/043cec594', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I105036370', 'https://openalex.org/I4210150756']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ubaldo J Martin', 'raw_affiliation_strings': ['astraZeneca, gaithersburg, MD, Usa;'], 'affiliations': [{'raw_affiliation_string': 'astraZeneca, gaithersburg, MD, Usa;', 'institution_ids': ['https://openalex.org/I4210150756']}]}], 'institution_assertions': [], 'countries_distinct_count': 4, 'institutions_distinct_count': 6, 'corresponding_author_ids': ['https://openalex.org/A5060082670'], 'corresponding_institution_ids': ['https://openalex.org/I149213910'], 'apc_list': {'value': 2836, 'currency': 'USD', 'value_usd': 2836, 'provenance': 'doaj'}, 'apc_paid': {'value': 2836, 'currency': 'USD', 'value_usd': 2836, 'provenance': 'doaj'}, 'fwci': 3.609, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 23, 'citation_normalized_percentile': {'value': 0.890108, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': 'Volume 13', 'issue': None, 'first_page': '2673', 'last_page': '2684'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10143', 'display_name': 'Chronic Obstructive Pulmonary Disease (COPD) Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10143', 'display_name': 'Chronic Obstructive Pulmonary Disease (COPD) Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11651', 'display_name': 'Inhalation and Respiratory Drug Delivery', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10051', 'display_name': 'Asthma and respiratory diseases', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/metered-dose-inhaler', 'display_name': 'Metered-dose inhaler', 'score': 0.7533735}, {'id': 'https://openalex.org/keywords/crossover-study', 'display_name': 'Crossover study', 'score': 0.5237313}, {'id': 'https://openalex.org/keywords/dry-powder-inhaler', 'display_name': 'Dry-powder inhaler', 'score': 0.47018114}, {'id': 'https://openalex.org/keywords/plethysmograph', 'display_name': 'Plethysmograph', 'score': 0.42795905}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.89268523}, {'id': 'https://openalex.org/C2780667556', 'wikidata': 'https://www.wikidata.org/wiki/Q16897784', 'display_name': 'Metered-dose inhaler', 'level': 4, 'score': 0.7533735}, {'id': 'https://openalex.org/C2781018748', 'wikidata': 'https://www.wikidata.org/wiki/Q927234', 'display_name': 'Bronchodilator', 'level': 3, 'score': 0.6781517}, {'id': 'https://openalex.org/C2776780178', 'wikidata': 'https://www.wikidata.org/wiki/Q199804', 'display_name': 'COPD', 'level': 2, 'score': 0.6153172}, {'id': 'https://openalex.org/C2780333948', 'wikidata': 'https://www.wikidata.org/wiki/Q653305', 'display_name': 'Spirometry', 'level': 3, 'score': 0.6060573}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.56628346}, {'id': 'https://openalex.org/C87813604', 'wikidata': 'https://www.wikidata.org/wiki/Q1242899', 'display_name': 'Crossover study', 'level': 4, 'score': 0.5237313}, {'id': 'https://openalex.org/C33362165', 'wikidata': 'https://www.wikidata.org/wiki/Q754455', 'display_name': 'Airway resistance', 'level': 3, 'score': 0.5221394}, {'id': 'https://openalex.org/C56283660', 'wikidata': 'https://www.wikidata.org/wiki/Q1073808', 'display_name': 'Functional residual capacity', 'level': 4, 'score': 0.5116227}, {'id': 'https://openalex.org/C27081682', 'wikidata': 'https://www.wikidata.org/wiki/Q269829', 'display_name': 'Placebo', 'level': 3, 'score': 0.4907895}, {'id': 'https://openalex.org/C2777419714', 'wikidata': 'https://www.wikidata.org/wiki/Q1334805', 'display_name': 'Dry-powder inhaler', 'level': 4, 'score': 0.47018114}, {'id': 'https://openalex.org/C2779871671', 'wikidata': 'https://www.wikidata.org/wiki/Q637247', 'display_name': 'Formoterol', 'level': 4, 'score': 0.4695148}, {'id': 'https://openalex.org/C27101514', 'wikidata': 'https://www.wikidata.org/wiki/Q206120', 'display_name': 'Lung volumes', 'level': 3, 'score': 0.4595716}, {'id': 'https://openalex.org/C73362275', 'wikidata': 'https://www.wikidata.org/wiki/Q181277', 'display_name': 'Plethysmograph', 'level': 2, 'score': 0.42795905}, {'id': 'https://openalex.org/C2780261241', 'wikidata': 'https://www.wikidata.org/wiki/Q1394363', 'display_name': 'Inhaler', 'level': 3, 'score': 0.38609865}, {'id': 'https://openalex.org/C2776042228', 'wikidata': 'https://www.wikidata.org/wiki/Q35869', 'display_name': 'Asthma', 'level': 2, 'score': 0.38048536}, {'id': 'https://openalex.org/C126894567', 'wikidata': 'https://www.wikidata.org/wiki/Q105650', 'display_name': 'Urology', 'level': 1, 'score': 0.32128924}, {'id': 'https://openalex.org/C105922876', 'wikidata': 'https://www.wikidata.org/wiki/Q1423981', 'display_name': 'Airway', 'level': 2, 'score': 0.2873874}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.25645536}, {'id': 'https://openalex.org/C2776954882', 'wikidata': 'https://www.wikidata.org/wiki/Q840343', 'display_name': 'Inhalation', 'level': 2, 'score': 0.24160472}, {'id': 'https://openalex.org/C2777714996', 'wikidata': 'https://www.wikidata.org/wiki/Q7886', 'display_name': 'Lung', 'level': 2, 'score': 0.20007566}, {'id': 'https://openalex.org/C2776136866', 'wikidata': 'https://www.wikidata.org/wiki/Q422212', 'display_name': 'Budesonide', 'level': 3, 'score': 0.09488797}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001993', 'descriptor_name': 'Bronchodilator Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000068759', 'descriptor_name': 'Formoterol Fumarate', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D006024', 'descriptor_name': 'Glycopyrrolate', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D029424', 'descriptor_name': 'Pulmonary Disease, Chronic Obstructive', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D012119', 'descriptor_name': 'Respiration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000280', 'descriptor_name': 'Administration, Inhalation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001530', 'descriptor_name': 'Belgium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001993', 'descriptor_name': 'Bronchodilator Agents', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D001993', 'descriptor_name': 'Bronchodilator Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004311', 'descriptor_name': 'Double-Blind Method', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005541', 'descriptor_name': 'Forced Expiratory Volume', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000068759', 'descriptor_name': 'Formoterol Fumarate', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D000068759', 'descriptor_name': 'Formoterol Fumarate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005858', 'descriptor_name': 'Germany', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006024', 'descriptor_name': 'Glycopyrrolate', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D006024', 'descriptor_name': 'Glycopyrrolate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008131', 'descriptor_name': 'London', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D036501', 'descriptor_name': 'Metered Dose Inhalers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029424', 'descriptor_name': 'Pulmonary Disease, Chronic Obstructive', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029424', 'descriptor_name': 'Pulmonary Disease, Chronic Obstructive', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D029424', 'descriptor_name': 'Pulmonary Disease, Chronic Obstructive', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.2147/copd.s171707', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=44028', 'source': {'id': 'https://openalex.org/S105319247', 'display_name': 'International Journal of COPD', 'issn_l': '1176-9106', 'issn': ['1176-9106', '1178-2005'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6124470', 'pdf_url': 'https://europepmc.org/articles/pmc6124470?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/10067/1537930151162165141', 'pdf_url': 'https://repository.uantwerpen.be/docman/irua/ebe71e/153793.pdf', 'source': {'id': 'https://openalex.org/S4306401849', 'display_name': 'Institutional Repository University of Antwerp (University of Antwerp)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I149213910', 'host_organization_name': 'University of Antwerp', 'host_organization_lineage': ['https://openalex.org/I149213910'], 'host_organization_lineage_names': ['University of Antwerp'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124470', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30214185', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2147/copd.s171707', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=44028', 'source': {'id': 'https://openalex.org/S105319247', 'display_name': 'International Journal of COPD', 'issn_l': '1176-9106', 'issn': ['1176-9106', '1178-2005'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 27, 'referenced_works': ['https://openalex.org/W1548173965', 'https://openalex.org/W1890874870', 'https://openalex.org/W1963710622', 'https://openalex.org/W2000935460', 'https://openalex.org/W2030135903', 'https://openalex.org/W2050877844', 'https://openalex.org/W2092334358', 'https://openalex.org/W2108084885', 'https://openalex.org/W2108290557', 'https://openalex.org/W2121914298', 'https://openalex.org/W2125078269', 'https://openalex.org/W2136581092', 'https://openalex.org/W2154466524', 'https://openalex.org/W2159798284', 'https://openalex.org/W2161527110', 'https://openalex.org/W2166432084', 'https://openalex.org/W2167941825', 'https://openalex.org/W2230075589', 'https://openalex.org/W2270582105', 'https://openalex.org/W2395417159', 'https://openalex.org/W243325842', 'https://openalex.org/W2558903543', 'https://openalex.org/W2591678263', 'https://openalex.org/W2746644590', 'https://openalex.org/W2750520206', 'https://openalex.org/W2761239349', 'https://openalex.org/W2765538469'], 'related_works': ['https://openalex.org/W4236612133', 'https://openalex.org/W2727492120', 'https://openalex.org/W2145884593', 'https://openalex.org/W2140730458', 'https://openalex.org/W2095082128', 'https://openalex.org/W2062078911', 'https://openalex.org/W2027923985', 'https://openalex.org/W2001268547', 'https://openalex.org/W1994848648', 'https://openalex.org/W1968394560'], 'abstract_inverted_index': {'A': [0, 80], 'randomized': [1, 217], 'study': [2], 'using': [3, 20, 142, 167], 'functional': [4, 199], 'respiratory': [5, 91], 'imaging': [6, 92], 'to': [7, 100, 195], 'characterize': [8], 'bronchodilator': [9], 'effects': [10], 'of': [11, 55, 59, 82, 214, 220], 'glycopyrrolate/formoterol': [12, 126], 'fumarate': [13, 127], 'delivered': [14, 128], 'by': [15, 129, 231, 236], 'a': [16, 130], 'metered': [17, 131], 'dose': [18, 132], 'inhaler': [19, 133], 'co-suspension': [21, 144], 'delivery': [22, 145], 'technology': [23], 'in': [24, 103, 179, 184, 197], 'patients': [25, 120, 211], 'with': [26, 121], 'COPD': [27, 123], 'Wilfried': [28], 'De': [29, 32], 'Backer,1': [30], 'Jan': [31], 'Backer,2': [33], 'Wim': [34], 'Vos,3': [35], 'Ilse': [36], 'Verlinden,3': [37], 'Cedric': [38], 'Van': [39], 'Holsbeke,3': [40], 'Johan': [41], 'Clukers,1': [42], 'Bita': [43], 'Hajian,1': [44], 'Shahid': [45], 'Siddiqui,4': [46], 'Martin': [47], 'Jenkins,5': [48], 'Colin': [49], 'Reisner,4,6': [50], 'Ubaldo': [51], 'J': [52], 'Martin4': [53], '1Department': [54], 'Respiratory': [56], 'Medicine,': [57], 'University': [58], 'Antwerp,': [60, 61], 'Belgium;': [62, 70], '2FLUIDDA,': [63], 'Los': [64], 'Angeles,': [65], 'CA,': [66], 'USA;': [67, 74], '3FLUIDDA,': [68], 'Kontich,': [69], '4AstraZeneca,': [71], 'Gaithersburg,': [72], 'MD,': [73], '5AstraZeneca,': [75], 'Cambridge,': [76], 'UK;': [77], '6Pearl': [78], '–': [79], 'member': [81], 'the': [83, 150, 174, 224], 'AstraZeneca': [84], 'Group,': [85], 'Morristown,': [86], 'NJ,': [87], 'USA': [88], 'Background:': [89], 'Functional': [90], '(FRI)': [93], 'uses': [94], 'high-resolution': [95], 'computed': [96], 'tomography': [97], '(HRCT)': [98], 'scans': [99], 'assess': [101], 'changes': [102], 'airway': [104, 154, 160], 'volume': [105, 155, 183, 205], 'and': [106, 109, 138, 157, 170, 188, 193, 203, 218, 233], 'resistance.': [107], 'Patients': [108], 'methods:': [110], 'In': [111], 'this': [112], 'randomized,': [113], 'double-blind,': [114], '2-week,': [115], 'crossover,': [116], 'Phase': [117], 'IIIB': [118], 'study,': [119], 'moderate-to-severe': [122], 'received': [124], 'twice-daily': [125], '(GFF': [134], 'MDI,': [135, 140], '18/9.6': [136], 'µg)': [137], 'placebo': [139, 239], 'formulated': [141], 'innovative': [143], 'technology.': [146], 'Co-primary': [147], 'endpoints': [148, 172], 'included': [149, 173], 'following:': [151, 175], 'specific': [152, 158], 'image-based': [153, 159], '(siVaw)': [156], 'resistance': [161], '(siRaw)': [162], 'at': [163], 'Day': [164], '15,': [165], 'measured': [166], 'FRI.': [168], 'Secondary': [169], 'other': [171], 'change': [176], 'from': [177], 'baseline': [178, 196], 'post-dose': [180, 198], 'forced': [181], 'expiratory': [182], '1': [185], 'second': [186], '(FEV1)': [187], 'inspiratory': [189], 'capacity': [190, 201], '(IC;': [191], 'spirometry)': [192], 'ratio': [194], 'residual': [200, 204], '(FRC)': [202], '(RV;': [206], 'body': [207], 'plethysmography).': [208], 'Results:': [209], 'Twenty': [210], '(46–78': [212], 'years': [213], 'age)': [215], 'were': [216], 'treated;': [219], 'whom': [221], '19': [222], 'completed': [223], 'study.': [225], 'GFF': [226], 'MDI': [227, 240], 'treatment': [228], 'increased': [229], 'siVaw': [230], '75%': [232], 'reduced': [234], 'siRaw': [235], '71%': [237], 'vs': [238], '(both': [241], 'P': [242]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2889394978', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 4}], 'updated_date': '2025-01-06T06:45:47.657438', 'created_date': '2018-09-07'}