Novel antimalarial chloroquine- and primaquine-quinoxaline 1,4-di-N-oxide hybrids: Design, synthesis, Plasmodium life cycle stage profile, and preliminary toxicity studies

Name: Work Video:
Duration: 3 min 30 s
Leonardo Bonilla-Ramírez; Alexandra Ríos; Miguel Quiliano; Gustavo Ramirez-Calderon; Iván Beltran-Hortelano; Jean‐François Franetich; Luís J. Corcuera; Mallaury Bordessoulles; Ariane Vettorazzi; Adela López de Ceráin; Ignacio Aldana; Dominique Mazier; Adriana Pabón; Silvia Galiano
{'id': 'https://openalex.org/W2889377009', 'doi': 'https://doi.org/10.1016/j.ejmech.2018.08.063', 'title': 'Novel antimalarial chloroquine- and primaquine-quinoxaline 1,4-di-N-oxide hybrids: Design, synthesis, Plasmodium life cycle stage profile, and preliminary toxicity studies', 'display_name': 'Novel antimalarial chloroquine- and primaquine-quinoxaline 1,4-di-N-oxide hybrids: Design, synthesis, Plasmodium life cycle stage profile, and preliminary toxicity studies', 'publication_year': 2018, 'publication_date': '2018-08-30', 'ids': {'openalex': 'https://openalex.org/W2889377009', 'doi': 'https://doi.org/10.1016/j.ejmech.2018.08.063', 'mag': '2889377009', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30199706'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.ejmech.2018.08.063', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210169613', 'display_name': 'European Journal of Medicinal Chemistry', 'issn_l': '0223-5234', 'issn': ['0223-5234', '1768-3254'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5086863676', 'display_name': 'Leonardo Bonilla-Ramírez', 'orcid': 'https://orcid.org/0000-0002-3203-9896'}, 'institutions': [{'id': 'https://openalex.org/I35961687', 'display_name': 'Universidad de Antioquia', 'ror': 'https://ror.org/03bp5hc83', 'country_code': 'CO', 'type': 'education', 'lineage': ['https://openalex.org/I35961687']}], 'countries': ['CO'], 'is_corresponding': False, 'raw_author_name': 'Leonardo Bonilla-Ramirez', 'raw_affiliation_strings': ['Grupo Malaria, Facultad de Medicina, Universidad de Antioquía (UdeA), Sede de Investigación Universitaria (SIU), Medellín, Colombia'], 'affiliations': [{'raw_affiliation_string': 'Grupo Malaria, Facultad de Medicina, Universidad de Antioquía (UdeA), Sede de Investigación Universitaria (SIU), Medellín, Colombia', 'institution_ids': ['https://openalex.org/I35961687']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036006245', 'display_name': 'Alexandra Ríos', 'orcid': 'https://orcid.org/0000-0002-4833-8698'}, 'institutions': [{'id': 'https://openalex.org/I35961687', 'display_name': 'Universidad de Antioquia', 'ror': 'https://ror.org/03bp5hc83', 'country_code': 'CO', 'type': 'education', 'lineage': ['https://openalex.org/I35961687']}], 'countries': ['CO'], 'is_corresponding': False, 'raw_author_name': 'Alexandra Rios', 'raw_affiliation_strings': ['Grupo Malaria, Facultad de Medicina, Universidad de Antioquía (UdeA), Sede de Investigación Universitaria (SIU), Medellín, Colombia'], 'affiliations': [{'raw_affiliation_string': 'Grupo Malaria, Facultad de Medicina, Universidad de Antioquía (UdeA), Sede de Investigación Universitaria (SIU), Medellín, Colombia', 'institution_ids': ['https://openalex.org/I35961687']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016657499', 'display_name': 'Miguel Quiliano', 'orcid': 'https://orcid.org/0000-0002-6777-2529'}, 'institutions': [{'id': 'https://openalex.org/I88155538', 'display_name': 'Universidad de Navarra', 'ror': 'https://ror.org/02rxc7m23', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I88155538']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Miguel Quiliano', 'raw_affiliation_strings': ['Universidad de Navarra, Facultad de Farmacia y Nutrición, Department of Organic and Pharmaceutical Chemistry, Campus Universitario, 31008, Pamplona, Spain', 'Universidad de Navarra, Institute of Tropical Health (ISTUN), Campus Universitario, 31008, Pamplona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Universidad de Navarra, Institute of Tropical Health (ISTUN), Campus Universitario, 31008, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}, {'raw_affiliation_string': 'Universidad de Navarra, Facultad de Farmacia y Nutrición, Department of Organic and Pharmaceutical Chemistry, Campus Universitario, 31008, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060823666', 'display_name': 'Gustavo Ramirez-Calderon', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I35961687', 'display_name': 'Universidad de Antioquia', 'ror': 'https://ror.org/03bp5hc83', 'country_code': 'CO', 'type': 'education', 'lineage': ['https://openalex.org/I35961687']}], 'countries': ['CO'], 'is_corresponding': False, 'raw_author_name': 'Gustavo Ramirez-Calderon', 'raw_affiliation_strings': ['Grupo Malaria, Facultad de Medicina, Universidad de Antioquía (UdeA), Sede de Investigación Universitaria (SIU), Medellín, Colombia'], 'affiliations': [{'raw_affiliation_string': 'Grupo Malaria, Facultad de Medicina, Universidad de Antioquía (UdeA), Sede de Investigación Universitaria (SIU), Medellín, Colombia', 'institution_ids': ['https://openalex.org/I35961687']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068817287', 'display_name': 'Iván Beltran-Hortelano', 'orcid': 'https://orcid.org/0000-0002-4734-1166'}, 'institutions': [{'id': 'https://openalex.org/I88155538', 'display_name': 'Universidad de Navarra', 'ror': 'https://ror.org/02rxc7m23', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I88155538']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Iván Beltrán-Hortelano', 'raw_affiliation_strings': ['Universidad de Navarra, Facultad de Farmacia y Nutrición, Department of Organic and Pharmaceutical Chemistry, Campus Universitario, 31008, Pamplona, Spain', 'Universidad de Navarra, Institute of Tropical Health (ISTUN), Campus Universitario, 31008, Pamplona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Universidad de Navarra, Institute of Tropical Health (ISTUN), Campus Universitario, 31008, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}, {'raw_affiliation_string': 'Universidad de Navarra, Facultad de Farmacia y Nutrición, Department of Organic and Pharmaceutical Chemistry, Campus Universitario, 31008, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020848386', 'display_name': 'Jean‐François Franetich', 'orcid': 'https://orcid.org/0000-0002-3308-8550'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}, {'id': 'https://openalex.org/I4210128915', 'display_name': "Centre d'Immunologie et des Maladies Infectieuses", 'ror': 'https://ror.org/0375b8f90', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I39804081', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210128915']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Jean François Franetich', 'raw_affiliation_strings': ["Sorbonne Universités, UPMC Univ Paris 06, INSERM U1135, CNRS ERL, 8255, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France"], 'affiliations': [{'raw_affiliation_string': "Sorbonne Universités, UPMC Univ Paris 06, INSERM U1135, CNRS ERL, 8255, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France", 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I39804081', 'https://openalex.org/I4210128915', 'https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026276621', 'display_name': 'Luís J. Corcuera', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I88155538', 'display_name': 'Universidad de Navarra', 'ror': 'https://ror.org/02rxc7m23', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I88155538']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Luis Corcuera', 'raw_affiliation_strings': ['Universidad de Navarra, Facultad de Farmacia y Nutrición, Department of Organic and Pharmaceutical Chemistry, Campus Universitario, 31008, Pamplona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Universidad de Navarra, Facultad de Farmacia y Nutrición, Department of Organic and Pharmaceutical Chemistry, Campus Universitario, 31008, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033515746', 'display_name': 'Mallaury Bordessoulles', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}, {'id': 'https://openalex.org/I4210128915', 'display_name': "Centre d'Immunologie et des Maladies Infectieuses", 'ror': 'https://ror.org/0375b8f90', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I39804081', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210128915']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Mallaury Bordessoulles', 'raw_affiliation_strings': ["Sorbonne Universités, UPMC Univ Paris 06, INSERM U1135, CNRS ERL, 8255, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France"], 'affiliations': [{'raw_affiliation_string': "Sorbonne Universités, UPMC Univ Paris 06, INSERM U1135, CNRS ERL, 8255, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France", 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I39804081', 'https://openalex.org/I4210128915', 'https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088724637', 'display_name': 'Ariane Vettorazzi', 'orcid': 'https://orcid.org/0000-0001-9182-8417'}, 'institutions': [{'id': 'https://openalex.org/I88155538', 'display_name': 'Universidad de Navarra', 'ror': 'https://ror.org/02rxc7m23', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I88155538']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Ariane Vettorazzi', 'raw_affiliation_strings': ['Universidad de Navarra, Facultad de Farmacia y Nutrición, Department of Pharmacology and Toxicology, 31008, Pamplona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Universidad de Navarra, Facultad de Farmacia y Nutrición, Department of Pharmacology and Toxicology, 31008, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067575111', 'display_name': 'Adela López de Ceráin', 'orcid': 'https://orcid.org/0000-0002-2085-1289'}, 'institutions': [{'id': 'https://openalex.org/I88155538', 'display_name': 'Universidad de Navarra', 'ror': 'https://ror.org/02rxc7m23', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I88155538']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Adela López de Cerain', 'raw_affiliation_strings': ['Universidad de Navarra, Facultad de Farmacia y Nutrición, Department of Pharmacology and Toxicology, 31008, Pamplona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Universidad de Navarra, Facultad de Farmacia y Nutrición, Department of Pharmacology and Toxicology, 31008, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082647428', 'display_name': 'Ignacio Aldana', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I88155538', 'display_name': 'Universidad de Navarra', 'ror': 'https://ror.org/02rxc7m23', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I88155538']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Ignacio Aldana', 'raw_affiliation_strings': ['Universidad de Navarra, Facultad de Farmacia y Nutrición, Department of Organic and Pharmaceutical Chemistry, Campus Universitario, 31008, Pamplona, Spain', 'Universidad de Navarra, Institute of Tropical Health (ISTUN), Campus Universitario, 31008, Pamplona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Universidad de Navarra, Facultad de Farmacia y Nutrición, Department of Organic and Pharmaceutical Chemistry, Campus Universitario, 31008, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}, {'raw_affiliation_string': 'Universidad de Navarra, Institute of Tropical Health (ISTUN), Campus Universitario, 31008, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077020153', 'display_name': 'Dominique Mazier', 'orcid': 'https://orcid.org/0000-0002-8059-1810'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}, {'id': 'https://openalex.org/I4210128915', 'display_name': "Centre d'Immunologie et des Maladies Infectieuses", 'ror': 'https://ror.org/0375b8f90', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I39804081', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210128915']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Dominique Mazier', 'raw_affiliation_strings': ["Sorbonne Universités, UPMC Univ Paris 06, INSERM U1135, CNRS ERL, 8255, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France"], 'affiliations': [{'raw_affiliation_string': "Sorbonne Universités, UPMC Univ Paris 06, INSERM U1135, CNRS ERL, 8255, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France", 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I39804081', 'https://openalex.org/I4210128915', 'https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090449535', 'display_name': 'Adriana Pabón', 'orcid': 'https://orcid.org/0000-0002-5535-0708'}, 'institutions': [{'id': 'https://openalex.org/I35961687', 'display_name': 'Universidad de Antioquia', 'ror': 'https://ror.org/03bp5hc83', 'country_code': 'CO', 'type': 'education', 'lineage': ['https://openalex.org/I35961687']}], 'countries': ['CO'], 'is_corresponding': False, 'raw_author_name': 'Adriana Pabón', 'raw_affiliation_strings': ['Grupo Malaria, Facultad de Medicina, Universidad de Antioquía (UdeA), Sede de Investigación Universitaria (SIU), Medellín, Colombia'], 'affiliations': [{'raw_affiliation_string': 'Grupo Malaria, Facultad de Medicina, Universidad de Antioquía (UdeA), Sede de Investigación Universitaria (SIU), Medellín, Colombia', 'institution_ids': ['https://openalex.org/I35961687']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5026800849', 'display_name': 'Silvia Galiano', 'orcid': 'https://orcid.org/0000-0002-1362-8628'}, 'institutions': [{'id': 'https://openalex.org/I88155538', 'display_name': 'Universidad de Navarra', 'ror': 'https://ror.org/02rxc7m23', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I88155538']}], 'countries': ['ES'], 'is_corresponding': True, 'raw_author_name': 'Silvia Galiano', 'raw_affiliation_strings': ['Universidad de Navarra, Facultad de Farmacia y Nutrición, Department of Organic and Pharmaceutical Chemistry, Campus Universitario, 31008, Pamplona, Spain', 'Universidad de Navarra, Institute of Tropical Health (ISTUN), Campus Universitario, 31008, Pamplona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Universidad de Navarra, Facultad de Farmacia y Nutrición, Department of Organic and Pharmaceutical Chemistry, Campus Universitario, 31008, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}, {'raw_affiliation_string': 'Universidad de Navarra, Institute of Tropical Health (ISTUN), Campus Universitario, 31008, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 6, 'corresponding_author_ids': ['https://openalex.org/A5026800849'], 'corresponding_institution_ids': ['https://openalex.org/I88155538'], 'apc_list': {'value': 4710, 'currency': 'USD', 'value_usd': 4710, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.625, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 47, 'citation_normalized_percentile': {'value': 0.765382, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '158', 'issue': None, 'first_page': '68', 'last_page': '81'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13160', 'display_name': 'Synthesis and Biological Evaluation', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13160', 'display_name': 'Synthesis and Biological Evaluation', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10091', 'display_name': 'Malaria Research and Control', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13454', 'display_name': 'Phenothiazines and Benzothiazines Synthesis and Activities', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/primaquine', 'display_name': 'Primaquine', 'score': 0.93530285}, {'id': 'https://openalex.org/keywords/plasmodium-berghei', 'display_name': 'Plasmodium berghei', 'score': 0.65796864}, {'id': 'https://openalex.org/keywords/plasmodium-yoelii', 'display_name': 'Plasmodium yoelii', 'score': 0.6295447}, {'id': 'https://openalex.org/keywords/quinoxaline', 'display_name': 'Quinoxaline', 'score': 0.55343175}], 'concepts': [{'id': 'https://openalex.org/C2776793103', 'wikidata': 'https://www.wikidata.org/wiki/Q419834', 'display_name': 'Primaquine', 'level': 4, 'score': 0.93530285}, {'id': 'https://openalex.org/C2777425658', 'wikidata': 'https://www.wikidata.org/wiki/Q422438', 'display_name': 'Chloroquine', 'level': 3, 'score': 0.71373665}, {'id': 'https://openalex.org/C2777237215', 'wikidata': 'https://www.wikidata.org/wiki/Q65021', 'display_name': 'Plasmodium berghei', 'level': 3, 'score': 0.65796864}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.6516223}, {'id': 'https://openalex.org/C2776486806', 'wikidata': 'https://www.wikidata.org/wiki/Q12065970', 'display_name': 'Plasmodium yoelii', 'level': 5, 'score': 0.6295447}, {'id': 'https://openalex.org/C2778371730', 'wikidata': 'https://www.wikidata.org/wiki/Q311383', 'display_name': 'Plasmodium falciparum', 'level': 3, 'score': 0.62072533}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.562939}, {'id': 'https://openalex.org/C2780362310', 'wikidata': 'https://www.wikidata.org/wiki/Q419930', 'display_name': 'Quinoxaline', 'level': 2, 'score': 0.55343175}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.44305253}, {'id': 'https://openalex.org/C2778048844', 'wikidata': 'https://www.wikidata.org/wiki/Q12156', 'display_name': 'Malaria', 'level': 2, 'score': 0.40289608}, {'id': 'https://openalex.org/C2775867548', 'wikidata': 'https://www.wikidata.org/wiki/Q1897162', 'display_name': 'Parasitemia', 'level': 4, 'score': 0.3453021}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.28527063}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.13536665}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D002738', 'descriptor_name': 'Chloroquine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D002738', 'descriptor_name': 'Chloroquine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D010961', 'descriptor_name': 'Plasmodium', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D011319', 'descriptor_name': 'Primaquine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D011319', 'descriptor_name': 'Primaquine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002738', 'descriptor_name': 'Chloroquine', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D002738', 'descriptor_name': 'Chloroquine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056945', 'descriptor_name': 'Hep G2 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008018', 'descriptor_name': 'Life Cycle Stages', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008018', 'descriptor_name': 'Life Cycle Stages', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008288', 'descriptor_name': 'Malaria', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D008288', 'descriptor_name': 'Malaria', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': False}, {'descriptor_ui': 'D008288', 'descriptor_name': 'Malaria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010961', 'descriptor_name': 'Plasmodium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010961', 'descriptor_name': 'Plasmodium', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D011319', 'descriptor_name': 'Primaquine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011319', 'descriptor_name': 'Primaquine', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D011810', 'descriptor_name': 'Quinoxalines', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D011810', 'descriptor_name': 'Quinoxalines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011810', 'descriptor_name': 'Quinoxalines', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011810', 'descriptor_name': 'Quinoxalines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.ejmech.2018.08.063', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210169613', 'display_name': 'European Journal of Medicinal Chemistry', 'issn_l': '0223-5234', 'issn': ['0223-5234', '1768-3254'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://hal.science/hal-03994334', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30199706', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/12', 'display_name': 'Responsible consumption and production', 'score': 0.59}], 'grants': [{'funder': 'https://openalex.org/F4320309955', 'funder_display_name': 'Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS)', 'award_id': '528-2011'}, {'funder': 'https://openalex.org/F4320322649', 'funder_display_name': 'Universidad de Navarra', 'award_id': None}, {'funder': 'https://openalex.org/F4320326618', 'funder_display_name': 'Innóvate Perú', 'award_id': '065-FINCYT-BDE-2014'}], 'datasets': [], 'versions': [], 'referenced_works_count': 63, 'referenced_works': ['https://openalex.org/W1503382362', 'https://openalex.org/W1516448966', 'https://openalex.org/W1968807810', 'https://openalex.org/W1971887114', 'https://openalex.org/W1973451419', 'https://openalex.org/W1973828942', 'https://openalex.org/W1986303437', 'https://openalex.org/W1992402289', 'https://openalex.org/W1993528208', 'https://openalex.org/W1994443543', 'https://openalex.org/W2001190858', 'https://openalex.org/W2016759257', 'https://openalex.org/W2017080914', 'https://openalex.org/W2017114273', 'https://openalex.org/W2023970272', 'https://openalex.org/W2028540820', 'https://openalex.org/W2029017772', 'https://openalex.org/W2033495141', 'https://openalex.org/W2035826427', 'https://openalex.org/W2038819383', 'https://openalex.org/W2053342497', 'https://openalex.org/W2055949419', 'https://openalex.org/W2070778360', 'https://openalex.org/W2071551353', 'https://openalex.org/W2092358442', 'https://openalex.org/W2095778094', 'https://openalex.org/W2099606128', 'https://openalex.org/W2105649494', 'https://openalex.org/W2105668259', 'https://openalex.org/W2111179758', 'https://openalex.org/W2113020765', 'https://openalex.org/W2114918609', 'https://openalex.org/W2124634096', 'https://openalex.org/W2127474550', 'https://openalex.org/W2127733438', 'https://openalex.org/W2134845482', 'https://openalex.org/W2135732933', 'https://openalex.org/W2137089838', 'https://openalex.org/W2138637931', 'https://openalex.org/W2143085703', 'https://openalex.org/W2143552714', 'https://openalex.org/W2154882650', 'https://openalex.org/W2164460325', 'https://openalex.org/W2171102256', 'https://openalex.org/W2172062656', 'https://openalex.org/W2175743794', 'https://openalex.org/W2316733185', 'https://openalex.org/W2320865713', 'https://openalex.org/W2328036388', 'https://openalex.org/W2329668034', 'https://openalex.org/W2590050812', 'https://openalex.org/W2590767446', 'https://openalex.org/W2593436234', 'https://openalex.org/W2593845381', 'https://openalex.org/W2597115859', 'https://openalex.org/W2616943224', 'https://openalex.org/W2804191972', 'https://openalex.org/W2949662243', 'https://openalex.org/W3081548864', 'https://openalex.org/W4230014471', 'https://openalex.org/W4248107770', 'https://openalex.org/W607527786', 'https://openalex.org/W791158601'], 'related_works': ['https://openalex.org/W4323926257', 'https://openalex.org/W2413650653', 'https://openalex.org/W2399698722', 'https://openalex.org/W2313559587', 'https://openalex.org/W2088572442', 'https://openalex.org/W2064005572', 'https://openalex.org/W1987571326', 'https://openalex.org/W1942269991', 'https://openalex.org/W1931794862', 'https://openalex.org/W1506789414'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2889377009', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 8}], 'updated_date': '2024-12-16T07:02:59.677045', 'created_date': '2018-09-07'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
