Noninvasive Molecular Monitoring in Multiple Myeloma Patients Using Cell-Free Tumor DNA

Name: Work Video:
Duration: 3 min 30 s
Giulia Biancon; Silvia Gimondi; Antonio Vendramin; Cristiana Carniti; Paolo Corradini
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270, 275, 311, 335, 354, 419, 449, 519, 612, 647, 690, 751, 851, 893, 908, 971, 1071, 1090, 1121, 1295, 1564, 1653, 1696, 1796, 1843, 1919, 1945, 2009, 2118, 2128, 2157, 2168, 2178, 2269, 2340, 2346, 2370, 2372, 2388, 2441, 2748, 2823, 2864, 2878, 2890, 2982, 3017, 3054, 3112, 3188, 3247, 3269, 3341, 3422, 3528, 3609, 3625, 3694, 3732, 3821, 3890, 3917, 3921, 4068, 4173], 'more': [15, 197, 466], 'accurate': [16, 198, 467], 'methods': [17, 41, 199, 223, 468, 791], 'to': [18, 34, 58, 138, 200, 216, 240, 320, 525, 641, 772, 1101, 1407, 1434, 1442, 1573, 1689, 1780, 1784, 1981, 1987, 1998, 2045, 2051, 2103, 2133, 2145, 2183, 2195, 2263, 2479, 2515, 2703, 2800, 2850, 2871, 3077, 3386, 3454, 3461, 3621, 4011, 4164], 'evaluate': [19, 201], 'residual': [20, 143, 202, 325, 470, 491, 517, 609, 624, 748, 891, 1087, 3525, 3691, 3729], 'disease.': [21, 203], 'Cell-free': [22, 204], 'tumor': [23, 65, 89, 107, 151, 170, 205, 247, 271, 289, 333, 352, 492, 802, 881, 906, 976, 1088, 3048, 3056, 3467, 3833, 4158], 'DNA': [24, 206, 803, 847, 907, 1670, 2221, 3058, 3583, 4235], '(cfDNA)': [25, 207], 'analysis': [26, 208, 1041, 2736], 'may': [27, 209, 780], 'represent': [28, 210], 'a': [29, 211, 666, 768, 859, 884, 1057, 1079, 1102, 1110, 1115, 1309, 1320, 1400, 1419, 1530, 1654, 1703, 1720, 1771, 1790, 1800, 1808, 2090, 2119, 2158, 2169, 2287, 2343, 2356, 2442, 2712, 2760, 3018, 3243, 3375, 3435, 3447, 3457, 3463, 3466, 3606, 3618, 3855, 3946, 3979, 4064, 4094, 4256], 'minimally': [30, 212], 'invasive': [31, 213], 'approach': [32, 48, 214, 230, 4182], 'complementary': [33, 215, 3076, 4010], 'multiparameter': [35, 217, 476], 'flow': [36, 218, 477, 1505, 2924], 'cytometry': [37, 219, 478], '(MFC)': [38, 220, 479], 'and': [39, 69, 97, 105, 155, 221, 251, 279, 287, 337, 422, 643, 675, 848, 895, 966, 1025, 1085, 1132, 1137, 1237, 1257, 1263, 1278, 1283, 1319, 1379, 1428, 1511, 1547, 1694, 1756, 1795, 1902, 1907, 1914, 1985, 1996, 2049, 2060, 2089, 2112, 2143, 2162, 2193, 2211, 2227, 2237, 2284, 2309, 2350, 2412, 2431, 2457, 2470, 2496, 2502, 2521, 2567, 2577, 2657, 2663, 2734, 2762, 2774, 2834, 3080, 3171, 3176, 3183, 3389, 3412, 3434, 3840, 3854, 3869, 3880, 3913, 3959, 3984, 4013, 4093, 4122, 4127, 4131, 4152], 'molecular': [40, 222], 'on': [42, 224, 545, 1529, 1578, 1719, 2213, 2294, 2355, 2538, 2649, 2914, 3370], 'bone': [43, 225, 546, 2993, 3022], 'marrow': [44, 226, 547], 'aspirates.': [45, 227], 'A': [46, 228, 1831, 3100, 3394], 'sequencing': [47, 229, 542, 605, 678, 744, 1017, 2329, 2419, 2453, 3301, 3326, 3521, 3602, 3687, 3726, 3999, 4170, 4254], 'using': [49, 110, 231, 292, 475, 658, 1522, 1540, 1674, 1702, 1765, 2218, 2231, 2255, 2316, 2331, 2375, 2436, 2530, 2589, 2788, 3071, 3327, 4004, 4103], 'the': [50, 120, 130, 162, 166, 232, 302, 312, 344, 348, 373, 377, 423, 463, 488, 523, 526, 631, 663, 682, 784, 797, 807, 810, 1046, 1074, 1127, 1443, 1579, 1735, 1785, 1797, 1836, 1924, 1949, 2013, 2129, 2179, 2219, 2248, 2264, 2270, 2327, 2332, 2347, 2352, 2364, 2376, 2392, 2417, 2425, 2509, 2531, 2558, 2590, 2658, 2717, 2789, 2814, 2843, 2865, 2879, 2884, 3046, 3081, 3105, 3193, 3274, 3279, 3328, 3423, 3425, 3430, 3601, 3622, 3825, 3832, 3843, 3848, 3930, 3991, 3994, 4005, 4019, 4023, 4119, 4149, 4153, 4157, 4174, 4180, 4189], 'Ion': [51, 233, 2232, 2238, 2296, 2303, 2310, 2317, 2426, 3329, 3371], 'Torrent': [52, 234, 2393, 2427, 3330], 'Personal': [53, 235, 2297, 3331], 'Genome': [54, 236, 2298, 3332], 'Machine': [55, 237, 2299, 3333], 'was': [56, 91, 238, 273, 1099, 1289, 1370, 1560, 1571, 1672, 1685, 1717, 1737, 1750, 1760, 2334, 2382, 2675, 2722, 2798, 2807, 3440, 3835, 3874, 3937, 4026, 4098, 4101], 'applied': [57, 239, 1100], 'identify': [59, 241, 3045], 'clonal': [60, 84, 242, 266, 1912, 3181, 3631], 'IGH': [61, 85, 100, 116, 180, 243, 267, 282, 298, 362, 632, 2108, 2660, 3051, 3078, 3632, 3826, 3918, 4184, 4258], 'gene': [62, 244, 633, 1917, 2667, 3186, 3281, 3722, 3828, 3914, 3919], 'rearrangements': [63, 245, 634, 1020, 3920], 'plasma': [66, 72, 95, 173, 248, 254, 277, 355, 1095, 1693], 'cells': [67, 249, 493, 892, 1024, 1396, 1416, 1437], '(PCs)': [68, 250, 1438], 'serial': [71, 253, 1064], 'samples': [73, 174, 255, 356, 1106, 1241, 1265, 1293, 1334, 2339, 2708], '25': [75, 257, 1145, 2815, 3612], 'patients': [76, 176, 258, 358, 648, 669, 852, 1091, 1146, 1258, 2816, 2832, 2838, 2857, 3248, 3613, 3824, 3863, 4069, 4177], 'with': [77, 103, 177, 259, 285, 359, 376, 498, 638, 650, 764, 853, 1092, 1308, 1418, 1789, 1948, 2012, 2101, 2286, 2302, 2342, 2351, 2398, 2545, 2677, 2724, 2739, 3249, 3614, 3748, 3887, 3973, 3978, 4070, 4084, 4167], 'MM': [78, 178, 260, 360, 1093, 1122, 3615], 'receiving': [79, 261], 'second-line': [80, 262, 1140], 'therapy.': [81, 263, 1141], 'The': [82, 264, 364, 438, 787, 1037, 1097, 1556, 1731, 1939, 2003, 2123, 2173, 3360, 3442], 'same': [83, 265, 2348, 2353, 2377, 2659, 3431, 4006], 'rearrangement': [86, 268], 'identified': [87, 269, 3605, 4160, 4183], 'PCs': [90, 123, 272, 305, 1577, 2863, 2877, 3065], 'detected': [92, 274], 'paired': [94, 276], 'samples,': [96, 278, 3424], 'levels': [98, 118, 171, 280, 300, 353, 2860], 'cfDNA': [101, 117, 154, 283, 299, 336, 882, 1040, 1684, 1716, 1749, 1777, 2004], 'correlated': [102, 284], 'outcome': [104, 286], 'mirrored': [106, 288], 'dynamics': [108, 290], 'evaluated': [109, 291], 'conventional': [111, 293], 'laboratory': [112, 294], 'parameters.': [113, 295], 'In': [114, 296, 1073, 2640, 3745, 4145], 'addition,': [115, 297, 3746], 'reflected': [119, 301], 'number': [121, 303, 2681], 'enumerated': [124, 306], 'by': [125, 136, 147, 179, 307, 318, 329, 361, 628, 673, 677, 974, 1015, 1739, 1762, 2073, 2336, 2424, 2923, 2932, 3068, 3724, 4161], 'MFC': [126, 137, 308, 319, 674], 'immunophenotyping': [127, 309, 1507], 'even': [128, 310], 'response': [132, 314, 390, 1150, 1224], 'context.': [133, 315], 'Patients': [134, 316], 'determined': [135, 317], 'be': [139, 321, 781, 1056, 2500], 'free': [140, 322, 1351, 2996, 3025], 'minimal': [142, 324, 608, 747, 3524, 3690, 3728], 'disease': [144, 326, 471, 518, 610, 625, 749, 785, 793, 1052, 1244, 3526, 3692, 3730], 'were': [145, 327, 656, 1246, 1266, 1335, 1389, 1397, 1439, 1538, 1943, 2007, 2067, 2115, 2165, 2207, 2229, 2253, 2282, 2368, 2406, 2434, 2455, 2490, 2506, 2513, 2587, 2644, 2709, 2746, 2786, 3066, 3368, 3384, 3413, 3842, 3961, 4082], 'characterized': [146, 328], 'low': [148, 330], 'frequencies': [149, 331, 3850, 4187], 'clonotypes': [152, 334, 2647, 2686], 'longer': [156, 338, 639], 'survival.': [157, 339], 'This': [158, 340], 'pilot': [159, 341], 'study': [160, 342, 1254, 1273], 'supports': [161, 343], 'clinical': [163, 345, 1111, 1270, 3335], 'applicability': [164, 346], 'noninvasive': [167, 349], 'monitoring': [168, 350, 798, 850, 903, 1053, 1245, 3731], 'sequencing.': [181, 363, 3014, 3043], 'treatment': [365], 'has': [370], 'changed': [371], 'during': [372, 1151, 1268], 'past': [374], 'decade': [375], 'introduction': [378], 'several': [380], 'classes': [381], 'new': [383, 1655, 2159, 3019], 'effective': [384], 'drugs': [385], 'that': [386, 487, 679, 775, 779, 1082, 3367, 3383, 4165], 'greatly': [388], 'improved': [389], 'rates,1Kumar': [391], 'S.K.': [392], 'Rajkumar': [393, 1217], 'S.V.': [394, 1218], 'Dispenzieri': [395], 'A.': [396, 441, 588, 727, 989, 991, 999, 1009, 1186, 1463, 1488, 1498, 1828, 1892, 3097, 3161, 3225, 3504, 3670, 3776, 3797, 3899, 4046], 'Lacy': [397], 'M.Q.': [398], 'Hayman': [399], 'S.R.': [400, 404], 'Buadi': [401], 'F.K.': [402], 'Zeldenrust': [403], 'Dingli': [405], 'D.': [406, 1194, 1196, 1822, 1882, 3091, 3151, 3223, 3754, 3760, 3762, 3764, 3895, 4044], 'Russell': [407, 3226, 4047], 'S.J.': [408, 3570, 4222], 'Lust': [409], 'J.A.': [410], 'Greipp': [411], 'P.R.': [412], 'Kyle': [413, 1197], 'R.A.': [414], 'Gertz': [415, 1169], 'M.A.': [416, 567, 706, 2600, 3483, 3649], 'Improved': [417], 'survival': [418, 501, 646, 3246, 4067], 'impact': [424], 'novel': [426, 652, 1832, 3101], 'therapies.Blood.': [427], '2008;': [428, 4137], '111:': [429], '2516-2520Crossref': [430], 'PubMed': [431, 457, 534, 618, 757, 872, 914, 983, 1032, 1232, 1360, 1517, 1850, 1932, 3119, 3201, 3255, 3314, 3355, 3534, 3596, 3700, 3740, 3816, 4076, 4140, 4248], 'Scopus': [432, 458, 535, 619, 758, 873, 915, 984, 1033, 1233, 1361, 1518, 1851, 1933, 2634, 3120, 3202, 3256, 3315, 3356, 3535, 3597, 3701, 3741, 3817, 4077, 4141, 4249], '(1845)': [433], 'Google': [434, 460, 537, 621, 760, 875, 917, 986, 1035, 1235, 1363, 1520, 1853, 1935, 2636, 3122, 3204, 3258, 3317, 3358, 3537, 3599, 3703, 3743, 3819, 3927, 4079, 4143, 4251], 'Scholar,': [435, 918, 987, 1854, 3123, 3205, 3318, 3538, 3704], '2Anderson': [436], 'K.C.': [437], '39th': [439], 'David': [440], 'Karnofsky': [442], 'lecture:': [443], 'bench-to-bedside': [444], 'translation': [445], 'targeted': [447], 'therapies': [448], 'myeloma.J': [451], 'Clin': [452, 529], 'Oncol.': [453, 530, 863], '2012;': [454, 1514, 2581, 3813], '30:': [455], '445-452Crossref': [456], '(112)': [459], 'Scholar': [461, 538, 622, 761, 876, 1036, 1236, 1364, 1521, 1936, 2584, 2637, 2773, 3259, 3359, 3600, 3744, 3820, 3928, 4080, 4144, 4252], 'highlighting': [462], 'need': [464], 'assessment.': [472], 'Several': [473], 'studies': [474, 878, 3969], 'or': [480, 1770, 1807, 1983, 2047, 2485, 2565], 'allele-specific': [481], 'oligonucleotide': [482], 'quantitative': [483], 'PCR': [484, 1764, 1905, 1941, 2005, 2065, 2121, 2171, 2205, 3070, 3074, 3174, 3266, 3271, 4001], 'found': [486], 'presence': [489, 664], 'after': [494, 1275, 1413, 3236, 4057], 'therapy': [495, 1152], 'is': [496, 635, 1042, 2127, 2177, 2699, 2845], 'associated': [497, 637], 'shorter': [499], 'progression-free': [500], '(PFS).3Mailankody': [502], 'S.': [503, 561, 700, 818, 1342, 1453, 2552, 3324, 3477, 3566, 3643, 3706, 3752, 3766, 3793, 4218], 'Korde': [504], 'N.': [505, 509, 565, 704, 1003, 3227, 3481, 3647, 4048], 'Lesokhin': [506], 'A.M.': [507, 924], 'Lendvai': [508], 'Hassoun': [510], 'H.': [511, 926, 1178, 3211, 3548, 4032, 4200], 'Stetler-Stevenson': [512], 'M.': [513, 559, 575, 577, 584, 598, 698, 714, 716, 723, 737, 814, 820, 826, 842, 897, 960, 993, 1001, 1005, 1011, 1170, 1172, 1182, 1188, 1190, 1204, 1480, 1484, 1492, 1818, 1820, 1826, 1861, 1865, 1888, 1890, 1898, 2596, 3087, 3089, 3095, 3130, 3134, 3157, 3159, 3167, 3209, 3221, 3322, 3475, 3491, 3493, 3500, 3514, 3546, 3641, 3657, 3659, 3666, 3680, 3756, 3758, 3772, 3799, 3801, 3897, 4030, 4042, 4198], 'Landgren': [514], 'O.': [515, 1494], 'Minimal': [516], 'myeloma:': [521], 'bringing': [522], 'bench': [524], 'bedside.Nat': [527], 'Rev': [528], '2015;': [531, 864, 2631, 3347], '12:': [532], '1-10Crossref': [533], '(86)': [536, 3316], 'More': [539], 'recently,': [540], 'next-generation': [541, 1016, 3013, 3042, 3725], '(NGS)': [543], 'techniques': [544, 774], '(BM)': [548], 'aspirates': [549, 778, 1412], 'been': [551], 'used.4Martinez-Lopez': [552], 'J.': [553, 594, 692, 733, 838, 997, 1164, 1174, 1184, 1455, 1461, 1880, 3149, 3469, 3510, 3562, 3568, 3635, 3676, 3710, 4214, 4220], 'Lahuerta': [554, 693, 3470, 3636], 'J.J.': [555, 694, 934, 3471, 3637], 'Pepin': [556, 695, 821, 3472, 3638], 'F.': [557, 696, 822, 920, 1344, 1346, 1871, 3140, 3473, 3639, 3780, 3784], 'González': [558, 697, 1881, 1889, 3150, 3158, 3474, 3640, 3896], 'Barrio': [560, 699, 3476, 3642], 'Ayala': [562, 701, 3478, 3644], 'R.': [563, 592, 600, 702, 731, 739, 954, 1198, 1200, 1208, 1478, 1875, 3144, 3289, 3320, 3479, 3508, 3516, 3645, 3674, 3682, 3778, 3791, 3903, 3907], 'Puig': [564, 703, 3480, 3646], 'Montalban': [566, 705, 3482, 3648], 'Paiva': [568, 707, 3484, 3650], 'B.': [569, 708, 995, 1166, 3485, 3651, 3768], 'Weng': [570, 709, 3486, 3652], 'L.': [571, 586, 710, 725, 940, 1451, 1482, 3487, 3502, 3653, 3668, 3786], 'Jiménez': [572, 711, 3488, 3654], 'C.': [573, 712, 832, 942, 1816, 1884, 3085, 3153, 3215, 3231, 3489, 3564, 3655, 4036, 4052, 4216], 'Sopena': [574, 713, 3490, 3656], 'Moorhead': [576, 715, 819, 3492, 3658], 'Cedena': [578, 717, 3494, 3660], 'T.': [579, 718, 1473, 1475, 3495, 3661], 'Rapado': [580, 719, 3496, 3662], 'I.': [581, 720, 1192, 3217, 3497, 3663, 4038], 'Victoria': [582, 721, 3498, 3664], 'Mateos': [583, 722, 3499, 3665], 'Rosiñol': [585, 724, 3501, 3667], 'Oriol': [587, 726, 3503, 3669], 'Blanchard': [589, 728, 3505, 3671], 'M.J.': [590, 729, 3506, 3672], 'Martínez': [591, 730, 3507, 3673], 'Bladé': [593, 732, 1163, 3509, 3675], 'Miguel': [595, 734, 1161, 3511, 3677, 3909], 'J.S.': [596, 735, 1162, 3512, 3678], 'Faham': [597, 736, 841, 3513, 3545, 3679, 4197], 'García-Sanz': [599, 738, 1874, 3143, 3515, 3681, 3906], 'Prognostic': [601, 740, 3517, 3683], 'value': [602, 741, 3518, 3684], 'deep': [604, 743, 2578, 3300, 3520, 3686], 'method': [606, 745, 1081, 1098, 2330, 3522, 3603, 3688], 'detection': [611, 750, 1837, 1910, 3106, 3179, 3527, 3579, 3693, 4231], 'myeloma.Blood.': [614, 753, 3251, 3530, 3696, 4072], '2014;': [615, 754, 3531, 3697], '123:': [616, 755, 3532, 3698], '3073-3079Crossref': [617, 756, 3533, 3699], '(327)': [620, 759, 3536, 3702], 'Minimum': [623], '(MRD)': [626], 'negativity': [627], 'NGS': [629, 2574, 3628, 3995, 4162, 4181], 'significantly': [636, 3962], 'time': [640, 1286, 2855], 'progression': [642], 'better': [644, 3244, 4065], 'overall': [645], 'treated': [649], 'front-line': [651], 'therapies.': [653], 'Similar': [654], 'results': [655], 'observed': [657, 689, 3875, 3941], 'MFC,': [659], 'although': [660], 'authors': [661], 'report': [662, 1922, 3191], 'subset': [667], 'who': [670, 1147], 'tested': [671, 1738, 2335], 'positive': [672, 2386], 'negative': [676], 'probably': [680], 'reflects': [681], 'patchy': [683], 'pattern': [684], 'BM': [686, 777, 1068, 1262, 1394, 1411, 1575, 2866, 2912, 2921, 2930, 3063], 'infiltration': [687, 2913, 2922, 2931], 'typically': [688], 'MM.4Martinez-Lopez': [691], 'This,': [762], 'together': [763, 2117, 2167], 'extramedullary': [765], 'disease,': [766], 'represents': [767], 'potential': [769], 'pitfall': [770], 'common': [771], 'all': [773, 3278, 3822, 4146], 'use': [776, 788, 3433, 3830], 'nonrepresentative': [782], 'infiltration.': [786], 'alternative': [790], 'assessment,': [794], 'such': [795], 'as': [796, 883, 1139, 2267, 2384, 2711, 3465], 'circulating': [800, 905, 975, 1022, 2875, 3581, 4233], 'cell-free': [801, 1026], '(cfDNA),': [804], 'could': [805, 2499], 'improve': [806], 'estimation': [808], 'risk': [811], 'progression.5Roschewski': [813], 'Dunleavy': [815], 'K.': [816, 824, 1168, 1212], 'Pittaluga': [817], 'Kong': [823, 3543, 4195], 'Shovlin': [825], 'Jaffe': [827], 'E.S.': [828], 'Staudt': [829, 898], 'L.M.': [830, 899], 'Lai': [831], 'Steinberg': [833], 'S.M.': [834], 'Chen': [835, 3555, 4207], 'C.C.': [836], 'Zheng': [837], 'Willis': [839], 'T.D.': [840], 'Wilson': [843, 900], 'W.H.': [844, 901], 'Circulating': [845, 1349, 1705], 'tumour': [846, 3582, 4234], 'CT': [849], 'untreated': [854], 'diffuse': [855], 'large': [856], 'B-cell': [857, 1383, 3308, 3892], 'lymphoma:': [858], 'correlative': [860], 'biomarker': [861], 'study.Lancet': [862], '16:': [865], '541-549Abstract': [866], 'Full': [867, 869, 3350, 3352], 'Text': [868, 870, 3351, 3353], 'PDF': [871, 3354], '(278)': [874], 'Ongoing': [877], 'are': [879, 2821], 'examining': [880], 'sensitive': [885], 'measure': [886], 'small': [888], 'amounts': [889], 'lymphoma': [894, 972], 'myeloma.6Roschewski': [896], 'Dynamic': [902], 'non-Hodgkin': [909], 'lymphoma.Blood.': [910], '2016;': [911, 980, 3593, 4245], '127:': [912], '3127-3133Crossref': [913], '(49)': [916], '7Scherer': [919], 'Kurtz': [921], 'D.M.': [922, 936, 2620], 'Newman': [923], 'Stehr': [925], 'Craig': [927], 'A.F.M.': [928], 'Esfahani': [929], 'M.S.': [930], 'Lovejoy': [931], 'A.F.': [932, 3540, 4192], 'Chabon': [933], 'Klass': [935], 'Liu': [937], 'C.L.': [938], 'Zhou': [939], 'Glover': [941], 'Visser': [943], 'B.C.': [944], 'Poultsides': [945], 'G.A.': [946, 3293], 'Advani': [947], 'R.H.': [948], 'Maeda': [949], 'L.S.': [950], 'Gupta': [951], 'N.K.': [952], 'Levy': [953], 'Ohgami': [955], 'R.S.': [956], 'Kunder': [957], 'C.A.': [958], 'Diehn': [959], 'Alizadeh': [961], 'A.A.': [962], 'Distinct': [963], 'biological': [964, 1240], 'subtypes': [965], 'patterns': [967], 'genome': [969], 'evolution': [970], 'revealed': [973], 'DNA.Sci': [977], 'Transl': [978], 'Med.': [979, 3736], '8:': [981, 2582], '364ra155Crossref': [982], '(269)': [985], '8Oberle': [988], 'Brandt': [990], 'Voigtlaender': [992], 'Thiele': [994], 'Radloff': [996], 'Schulenkorf': [998], 'Alawi': [1000], 'Akyüz': [1002], 'März': [1004], 'Ford': [1006], 'C.T.': [1007], 'Krohn-Grimberghe': [1008], 'Binder': [1010], 'Monitoring': [1012], 'V(D)J': [1019, 3052, 3432, 3827, 4150], 'from': [1021, 1094, 1390, 1399, 1687, 2508, 2573, 2984, 3061, 3299, 4018], 'DNA.Haematologica.': [1028], '2017;': [1029, 3737], '102:': [1030, 3253, 4074], '1105-1111Crossref': [1031], '(73)': [1034], 'sensitivity': [1038], 'still': [1043], 'unknown,': [1044], 'but': [1045, 2873], 'development': [1047], 'peripheral': [1049], 'blood': [1050, 1415], '(PB)–based': [1051], 'approaches': [1054], 'should': [1055], 'goal': [1058], 'because': [1059], 'it': [1060], 'would': [1061], 'allow': [1062], 'sampling': [1065], 'without': [1066], 'repeated': [1067], 'biopsies': [1069], '(BMBs)': [1070], 'MM.': [1072], 'present': [1075], 'study,': [1076, 1144], 'we': [1077], 'describe': [1078], 'deep-sequencing': [1080], 'allows': [1083], 'identifying': [1084], 'quantifying': [1086], 'burden': [1089], 'samples.': [1096], 'cohort': [1103, 2844], 'collected': [1107, 1242, 1294], 'prospectively': [1108], 'within': [1109, 1305], 'trial.': [1112], 'We': [1113], 'conducted': [1114, 2787], 'prospective': [1116], 'randomized': [1117], 'phase': [1118], '3': [1119, 1306, 1690, 1811, 2151, 2201, 2653], 'trial': [1120], 'at': [1123, 1272, 1284, 1312, 1324, 1331, 1337, 1752, 2093, 2817, 3847, 3872, 4022, 4186], 'first': [1124, 1310, 2819], 'relapse': [1125, 2820], 'comparing': [1126], 'activity': [1128], 'bortezomib,': [1130], 'cyclophosphamide,': [1131, 1136], 'dexamethasone': [1133, 1138], 'versus': [1134, 3942], 'lenalidomide,': [1135], 'Within': [1142], 'this': [1143, 1253], 'achieved': [1148], '(International': [1153], 'Myeloma': [1154, 1220, 1445], 'Working': [1155, 1221], 'Group': [1156], 'guidelines)9Durie': [1157], 'B.G.M.': [1158], 'Harousseau': [1159], 'J.-L.': [1160], 'Barlogie': [1165], 'Anderson': [1167], 'Dimopoulos': [1171], 'Westin': [1173], 'Sonneveld': [1175], 'P.': [1176, 1210, 1214, 1469, 1830, 2554, 3099, 3207, 3219, 3295, 3576, 3774, 4028, 4040, 4228], 'Ludwig': [1177], 'Gahrton': [1179, 3232, 4053], 'G.': [1180, 1202, 1206, 1216, 3213, 3233, 3789, 3795, 4034, 4054], 'Beksac': [1181], 'Crowley': [1183], 'Belch': [1185], 'Boccadaro': [1187], 'Cavo': [1189, 3208, 4029], 'Turesson': [1191], 'Joshua': [1193], 'Vesole': [1195], 'Alexanian': [1199], 'Tricot': [1201], 'Attal': [1203], 'Merlini': [1205], 'Powles': [1207], 'Richardson': [1209], 'Shimizu': [1211], 'Tosi': [1213], 'Morgan': [1215, 1895, 3164], 'International': [1219, 3000, 3029], 'GroupInternational': [1222], 'uniform': [1223], 'criteria': [1225], 'myeloma.Leukemia.': [1228], '2006;': [1229], '20:': [1230], '1467-1473Crossref': [1231], '(2223)': [1234], 'had': [1238, 2858, 3446], 'longitudinal': [1239], 'analyzed.': [1247], 'Our': [1248], 'institutional': [1249], 'review': [1250], 'board': [1251], 'approved': [1252], '(INT': [1255], '57/10),': [1256], 'provided': [1259], 'informed': [1260], 'consent.': [1261], 'PB': [1264, 1292, 1365], 'obtained': [1267, 1290, 4003], 'routine': [1269], 'evaluations': [1271], 'entry;': [1274], '3,': [1276, 4111], '6,': [1277], '9': [1279], 'cycles': [1280, 2075], 'therapy;': [1282], 'follow-up': [1285, 2841], 'points.': [1287], 'Plasma': [1288, 1333, 1436], 'processing': [1291], 'K2-EDTA': [1296], 'tubes': [1297], '(BD': [1298], 'Vacutainer,': [1299], 'Becton': [1300], 'Dickinson,': [1301], 'Franklin': [1302], 'Lakes,': [1303], 'NJ)': [1304], 'hours,': [1307], 'centrifugation': [1311, 1323], '1500': [1313], '×': [1314, 1326], 'g': [1315, 1327], '10': [1317, 1329, 1367, 1430, 1978, 2042, 2070, 2096], 'minutes': [1318, 1330, 2071], 'second': [1321], 'high-speed': [1322], '16,000': [1325], '4°C.': [1332], 'stored': [1336, 1751, 2710], '−80°C': [1338], 'until': [1339, 1754], 'extraction.10El': [1340], 'Messaoudi': [1341], 'Rolet': [1343], 'Mouliere': [1345], 'Thierry': [1347], 'A.R.': [1348, 3550, 4202], 'cell': [1350, 1387, 1845, 2380, 2569, 2626, 3057, 3114, 3240, 3587, 4061, 4239], 'DNA:': [1352], 'preanalytical': [1353], 'considerations.Clin': [1354], 'Chim': [1355], 'Acta.': [1356], '2013;': [1357, 3311], '424:': [1358], '222-230Crossref': [1359], '(398)': [1362], 'healthy': [1368], 'donors': [1369], 'also': [1371], 'collected.': [1372], 'Namalwa': [1373, 2379], '(human': [1374, 1381], 'Burkitt': [1375], 'lymphoma;': [1376], 'ACC': [1377, 1385], '24)': [1378], 'JVM-2': [1380], 'chronic': [1382, 3342], 'leukemia;': [1384], '12)': [1386], 'lines': [1388], 'DSMZ': [1391], '(Braunschweig,': [1392], 'Germany).': [1393, 1536, 1683, 1748], 'nucleated': [1395], 'isolated': [1398, 3062], 'median': [1401, 1772, 2892, 2917, 2926, 2934, 2941, 2948, 2953, 2986, 2989, 3448], '8': [1403], 'mL': [1404, 1691], '(range,': [1405, 1778, 2848, 3452], '7': [1406], '14': [1408], 'mL)': [1409], 'red': [1414], 'lysis': [1417], 'hypotonic': [1420], 'solution': [1421], '(NH4Cl,': [1422], '1.5': [1423], 'mol/L;': [1424], 'KHCo3,': [1425], '100': [1426, 2144, 2194], 'nmol/L;': [1427, 1431], 'Na4EDTA,': [1429], 'pH': [1432], '7.2': [1433], '7.4).': [1435], 'stained': [1440], 'according': [1441, 1783, 2262], 'European': [1444], 'Network': [1446, 3296], 'guidelines11van': [1447], 'Dongen': [1448, 1856, 3125], 'J.J.M.': [1449, 1857, 3126], 'Lhermitte': [1450], 'Böttcher': [1452], 'Almeida': [1454], 'Van': [1456], 'Der': [1457], 'Velden': [1458], 'V.H.J.': [1459], 'Flores-Montero': [1460], 'Rawstron': [1462], 'Asnafi': [1464], 'V.': [1465, 2550, 3229, 3782, 4050, 4117], 'Lécrevisse': [1466], 'Q.': [1467], 'Lucio': [1468], 'Mejstrikova': [1470], 'E.': [1471, 1490, 1869, 1873, 2548, 3138, 3142, 3770], 'Szczepaski': [1472], 'Kalina': [1474], 'De': [1476], 'Tute': [1477], 'Brüggemann': [1479, 1860, 3129], 'Sedek': [1481], 'Cullen': [1483], 'Langerak': [1485, 1858, 3127], 'A.W.': [1486, 1859, 3128], 'Mendonça': [1487], 'MacIntyre': [1489], 'Martin-Ayuso': [1491], 'Hrusak': [1493], 'Vidriales': [1495], 'M.B.': [1496], 'Orfao': [1497], 'EuroFlow': [1499], 'antibody': [1500, 1525, 2566], 'panels': [1501], 'standardized': [1503, 4129], 'n-dimensional': [1504], 'cytometric': [1506], 'normal,': [1509], 'reactive': [1510], 'malignant': [1512, 3893], 'leukocytes.Leukemia.': [1513], '26:': [1515], '1908-1975Crossref': [1516], '(603)': [1519], 'eight-color': [1523], 'monoclonal': [1524], 'combinations': [1526], '(Table': [1527, 1937, 4260], '1)': [1528], 'MACSQuant': [1531], 'Analyzer': [1532], '(Miltenyi': [1533, 1545, 1582], 'Biotec,': [1534, 1593, 1596, 1599, 1603, 1606, 1610, 1618, 1622, 1625, 1629, 1644], 'Gladbach,': [1535, 1594, 1597, 1600, 1604, 1607, 1611, 1619, 1623, 1626, 1630, 1645], 'Data': [1537], 'analyzed': [1539, 2456, 2723, 4102], 'MACSQuantify': [1541], 'software': [1542, 1549, 2395, 2594], 'version': [1543, 1550, 2396, 2638, 2750, 2777, 2795, 4087], '2.6': [1544], 'Biotec)': [1546], 'FlowJo': [1548], '10.2': [1551], '(FlowJo': [1552], 'LLC,': [1553], 'Ashland,': [1554], 'OR).': [1555], 'target': [1557], 'collection': [1559], '>500,000': [1561], 'cellular': [1562], 'events': [1563], 'each': [1565, 1976, 2040, 2280, 2389], 'tube.': [1566], 'An': [1567], 'immunomagnetic': [1568], 'bead–based': [1569], 'strategy': [1570, 1834, 3103], 'used': [1572, 2383, 2799, 3414], 'isolate': [1574], 'CD138+': [1576, 2862, 2876, 3064], 'AutoMACS': [1580], 'ProSeparator': [1581], 'Biotec).Table': [1583], '1List': [1584], 'Monoclonal': [1586], 'Antibodies': [1587], 'Used': [1588, 2106], 'Flow': [1590], 'Cytometric': [1591], 'AnalysisAntigenFluorochromeCloneCD19∗Miltenyi': [1592], 'Germany.PELT19CD20†VioBlueLT20CD27∗Miltenyi': [1595], 'Germany.FITCM-T271CD28∗Miltenyi': [1598], 'Germany.PE': [1601, 1612], 'Vio77015E8CD38†BV500HIT2CD45∗Miltenyi': [1602], 'Germany.VioBlue5B1CD45∗Miltenyi': [1605], 'Germany.APC': [1608, 1627], 'Vio7705B1CD56∗Miltenyi': [1609], 'Vio770REA196CD56†Biolegend,': [1613], 'San': [1614, 1648, 2781, 3908], 'Diego,': [1615, 1649, 2782], 'CA.PE': [1616], 'Cy7MEM-188CD81∗Miltenyi': [1617], 'Germany.PerCP': [1620], 'Vio700REA513CD117∗Miltenyi': [1621], 'Germany.PEA3C6E2CD117∗Miltenyi': [1624], 'Vio770A3C6E2CD138∗Miltenyi': [1628], 'Germany.APC44F9APC,': [1631], 'allophycocyanin;': [1632, 1658], 'FITC,': [1633, 1659], 'fluorescein': [1634, 1660], 'isothiocyanate;': [1635, 1661], 'PE,': [1636, 1662], 'phycoerythrin;': [1637, 1663], 'PerCP,': [1638, 1664], 'peridinin': [1639, 1665], 'chlorophyll': [1640, 1666], 'protein': [1641, 1667], 'complex.∗': [1642], 'Miltenyi': [1643], 'Germany.†': [1646], 'Biolegend,': [1647], 'CA.': [1650], 'Open': [1651, 2155, 3015], 'table': [1652, 2156, 3016], 'tab': [1656, 2160, 3020], 'APC,': [1657], 'complex.': [1668], 'Genomic': [1669], '(gDNA)': [1671], 'extracted': [1673, 1686], 'Nucleospin': [1675], 'Tissue': [1676], 'kit': [1677, 2222, 2236, 2308, 2315], '(Macherey-Nagel': [1678], 'GmbH': [1679], '&': [1680], 'Co.,': [1681], 'Düren,': [1682], '1': [1688, 1805, 1973, 1997, 2037, 2139, 2189], 'eluted': [1695], '50': [1697, 1946], 'μL': [1698, 1947, 1953, 1959, 1964, 1974, 1990, 2000, 2011, 2017, 2023, 2028, 2038, 2054, 2062], 'Buffer': [1700], 'AVE': [1701], 'QIAamp': [1704], 'Nucleic': [1706], 'Acid': [1707], 'Kit': [1708], '(Qiagen,': [1709], 'Hilden,': [1710], 'Germany)': [1711], 'following': [1712, 1950, 2014, 2247], "manufacturer's": [1713, 2249, 2271], 'instructions.': [1714, 2250], 'Extracted': [1715], 'quantified': [1718], 'high-sensitivity': [1721, 2220], 'benchtop': [1722], 'fluorometer': [1723], '(Qubit': [1724], '2.0,': [1725], 'Thermo': [1726], 'Fisher': [1727, 2245, 2292, 2323, 2402], 'Scientific,': [1728], 'Waltham,': [1729], 'MA).': [1730], 'size': [1732, 2126, 2176, 2266, 2692], 'distribution': [1733], 'fragments': [1736], 'capillary': [1740], 'electrophoresis': [1741], '(Agilent': [1742, 2223], '2100': [1743, 2216], 'Bioanalyzer,': [1744], 'Agilent': [1745, 2215], 'Technologies,': [1746], 'Böblingen,': [1747], '−20°C': [1753], 'amplification': [1755, 2487, 3267, 3361, 3977], 'library': [1757, 2265, 2281], 'preparation.': [1758], 'Amplification': [1759], 'performed': [1761, 1944, 2008, 2230, 2435, 2676, 2747], 'multiplex': [1763, 2120, 2170, 3069, 3270], '500': [1766], 'ng': [1767, 1775], 'gDNA': [1769, 1940, 2338], '20.3': [1774], '8.6': [1779], '45.9': [1781], 'ng)': [1782], 'BIOMED-2': [1786, 1925, 3194], 'concerted': [1787], 'action': [1788], 'consensus': [1791, 3082, 4007, 4096], 'reverse': [1792, 2113, 2163, 2497], 'IGHJ': [1793, 3083, 3931], 'primer': [1794, 1977, 2041, 2141, 2153, 2191, 2203, 2504, 4016], 'forward': [1798, 2495], 'direction': [1799], 'mix': [1801], 'framework': [1803, 1809, 2137, 2149, 2187, 2199], 'region': [1804, 1810, 2138, 2150, 2188, 2200, 2652, 4021], '(FR1)': [1806, 2140, 2190], '(FR3)': [1812, 2152, 2202], 'IGHV': [1813], 'family–specific': [1814], 'primers12Voena': [1815], 'Ladetto': [1817, 3086, 3800], 'Astolfi': [1819, 3088], 'Provan': [1821, 3090], 'Gribben': [1823, 3092], 'J.G.': [1824, 3093], 'Boccadoro': [1825, 3094, 3220, 3798, 4041], 'Pileri': [1827, 3096], 'Corradini': [1829, 3098], 'nested-PCR': [1833, 3102], 'rearranged': [1839, 3050, 3108], 'immunoglobulin': [1840, 1913, 2563, 3109, 3182, 3719, 3809], 'heavy-chain': [1841, 3110], 'genes': [1842, 3111], 'B': [1844, 3113], 'tumors.Leukemia.': [1846, 3115], '1997;': [1847, 3116], '11:': [1848, 2632, 3117], '1793-1798Crossref': [1849, 3118], '(103)': [1852, 3121], '13van': [1855, 3124], 'Evans': [1862, 3131], 'P.A.S.': [1863, 3132], 'Hummel': [1864, 3133], 'Lavender': [1866, 3135], 'F.L.': [1867, 3136], 'Delabesse': [1868, 3137], 'Davi': [1870, 3139], 'Schuuring': [1872, 3141], 'van': [1876, 3145], 'Krieken': [1877, 3146], 'J.H.J.M.': [1878, 3147], 'Droese': [1879, 3148], 'Bastard': [1883, 3152], 'White': [1885, 3154], 'H.E.': [1886, 3155], 'Spaargaren': [1887, 3156], 'Parreira': [1891, 3160], 'Smith': [1893, 3162], 'J.L.': [1894, 3163], 'G.J.': [1896, 3165], 'Kneba': [1897, 3166], 'Macintyre': [1899, 3168], 'E.A.': [1900, 3169], 'Design': [1901, 3170], 'standardization': [1903, 3172], 'primers': [1906, 2114, 2164, 2498, 3075, 3175, 4009], 'protocols': [1908, 3177], 'T-cell': [1915, 3184], 'receptor': [1916, 2570, 2627, 3185, 3305], 'recombinations': [1918, 3187], 'suspect': [1920, 3189], 'lymphoproliferations:': [1921, 3190], 'Concerted': [1926, 3195], 'Action': [1927, 3196], 'BMH4-CT98-3936.Leukemia.': [1928, 3197], '2003;': [1929, 3198, 3252, 4073], '17:': [1930, 3199, 3348], '2257-2317Crossref': [1931, 3200], '(2497)': [1934, 3203], '2).': [1938], 'reactions': [1942, 2006], 'components:': [1951, 2015], '5': [1952, 1958, 1963, 1994, 2058, 2099], 'dNTPs': [1955, 2019], '2': [1956, 2020, 2849], 'mmol/L,': [1957, 2021], 'buffer': [1961, 2025], '10×,': [1962, 2026], 'MgCl2': [1966, 2030], '(FR1:': [1967, 2031, 2095, 2273, 2473], '20': [1968, 2032], 'mmol/L;': [1969, 2033], 'FR3:': [1970, 2034, 2098, 2275, 2476], '15': [1971, 2035], 'mmol/L),': [1972, 2036], 'μmol/L': [1979, 2043], '(seven': [1980, 2044], 'FR1': [1982, 2046, 3079, 4012], 'FR3': [1984, 2048], 'one': [1986, 2050, 3623], 'IGHJ),': [1988, 2052], '0.2': [1989, 2053], 'Taq': [1992, 2056], 'Gold': [1993, 2057], 'U/μL,': [1995, 2059], '26.8': [1999], 'gDNA.': [2002], '85': [2010], '8.5': [2016, 2022, 2027], '45': [2061], 'cfDNA.': [2064], 'conditions': [2066], '96°C': [2068, 2077], 'followed': [2072], '35': [2074], '30': [2079, 2083, 2087], 'seconds,': [2080, 2084, 2088], '62°C': [2081], '72°C': [2085, 2094], 'final': [2091], 'extension': [2092], 'minutes;': [2097], 'minutes)': [2100], 'cooling': [2102], '4°C.Table': [2104], '2Primers': [2105], 'Gene': [2109], "Rearrangements'": [2110], 'AmplificationPrimerSequenceVH1D5′-CCTCAGTGAAGGTCTCCTGCAAGG-3′VH2D5′-TCCTGCGCTGGTGAAAGCCACACA-3′VH3D5′-GGTCCCTGAGACTCTCCTGTGCA-3′VH4aD5′-TCGGAGACCCTGTCCCTCACCTGCA-3′VH4bD5′-CGCTGTCTCTGGTTACTCCATCAG-3′VH5D5′-GAAAAAGCCCGGGGAGTCTCTGAA-3′VH6D5′-CCTGTGCCATCTCCGGGGACAGTG-3′VH1-FR35′-TGGAGCTGAGCAGCCTGAGATCTGA-3′VH2-FR35′-CAATGACCAACATGGACCCTGTGGA-3′VH3-FR35′-TCTGCAAATGAACAGCCTGAGAGCC-3′VH4-FR35′-GAGCTCTGTGACCGCCGCGGACACG-3′VH5-FR35′-CAGCACCGCCTACCTGCAGTGGAGC-3′VH6-FR35′-GTTCTCCCTGCAGCTGAACTCTGTG-3′VH7-FR35′-CAGCACGGCATATCTGCAGATCAG-3′JHD5′-ACCTGAGGAGACGGTGACCAGGGT-3′Forward': [2111], 'pooled': [2116, 2166, 2283], 'reaction.': [2122, 2172], 'expected': [2124, 2174, 3365], 'amplicon': [2125, 2175], 'range': [2130, 2180], '310': [2132, 2182], '360': [2134, 2184], 'bp': [2135, 2147, 2185, 2197], 'set': [2142, 2192, 3981], '170': [2146, 2196], 'set.': [2154, 2204], 'Forward': [2161], 'products': [2206, 3363, 4002], 'controlled': [2208], 'quantity': [2210], 'quality': [2212, 2461, 2467, 3387, 3410], 'an': [2214, 2295, 4014], 'Bioanalyzer': [2217], 'Technologies).': [2224], 'Adapter': [2225], 'ligation': [2226], 'barcoding': [2228], 'Plus': [2233], 'Fragment': [2234], 'Library': [2235], 'Xpress': [2239], 'Barcode': [2240], 'Adapters': [2241], '1-16/17-32': [2242], 'kits': [2243], '(Thermo': [2244, 2291, 2322, 2401], 'Scientific)': [2246, 2293], 'Barcoded': [2251], 'libraries': [2252, 2367], 'purified': [2254], 'AMPure': [2256], 'beads': [2257], '(Beckman': [2258], 'Coulter,': [2259], 'Brea,': [2260], 'CA)': [2261], 'reported': [2268, 3624], 'instructions': [2272], '1×;': [2274], '1.5×).': [2276], 'Equimolar': [2277], 'concentrations': [2278], 'sequenced': [2285, 2369, 3369], 'calibration': [2288], 'standard': [2289], 'panel': [2290], '(PGM)': [2300], 'system': [2301, 4124], 'PGM': [2304, 2311, 2333], 'Hi-Q': [2305, 2312], 'View': [2306, 2313], 'Chef': [2307], 'Sequencing': [2314, 3373], '318': [2318], 'Chips': [2319], 'v2': [2320], 'BC': [2321], 'Scientific).': [2324], 'Reproducibility': [2325], 'high-throughput': [2328], 'running': [2337], 'duplicate': [2341, 2371], 'different': [2344, 3980], 'barcode': [2345, 2354], 'run': [2349], 'separate': [2357], 'run.': [2358, 2390], 'As': [2359], 'cfDNA,': [2361], 'instead,': [2362], 'given': [2363], 'limited': [2365], 'availability,': [2366], 'two': [2373], 'runs': [2374], 'barcode.': [2378], 'line': [2381], 'internal': [2385], 'control': [2387], 'Using': [2391], 'Suite': [2394], '5.0.2': [2397], 'default': [2399, 2546, 2678], 'parameters': [2400, 2679], 'Scientific),': [2403], 'raw': [2404, 2418, 2452], 'reads': [2405, 2432, 2454, 2484, 2512, 2586, 2643, 3382, 3428], 'trimmed': [2407, 2507], 'low-quality': [2409], '3′': [2410, 4024], 'ends': [2411], 'barcodes': [2413], 'demultiplexed,': [2414], 'thus': [2415], 'obtaining': [2416], 'data': [2420], '(FASTQ': [2421], 'format)': [2422], 'produced': [2423], 'PGM.': [2428, 3372], 'Quality': [2429], 'assessment': [2430, 3388], 'filtering': [2433, 3390], 'open-source': [2437], 'tools': [2438], '(FastX-toolkit,': [2439], 'Cutadapt)': [2440], 'custom': [2443], 'bash': [2444], '(Unix': [2445], 'Shell)': [2446], 'script': [2447], '(Supplemental': [2448, 2518, 2672, 3391, 3851, 3876, 3883, 3933], 'Script': [2449, 2519, 2673], 'S1).': [2450, 3393], 'Specifically,': [2451], 'filtered': [2458], 'base': [2460], '(median': [2462], 'Phred': [2463], 'score,': [2464, 2468], '>30;': [2465], 'minimum': [2466], '20)': [2469], 'sequence': [2471, 2656, 3439, 4097, 4133, 4155], 'length': [2472], '>255': [2474], 'bp,': [2475], '>70': [2477], 'bp)': [2478], 'get': [2480], 'rid': [2481], 'incomplete': [2483], 'unspecific': [2486], 'products.': [2488], 'Sequences': [2489, 4081], 'retained': [2491], 'only': [2492], 'if': [2493], 'both': [2494], 'identified,': [2501], 'then': [2503], 'sequences': [2505, 3402, 4185], 'reads.': [2510], 'Filtered': [2511], 'converted': [2514], 'FASTA': [2516], 'format': [2517], 'S1)': [2520, 2674], 'aligned': [2522], 'against': [2523], 'IMGT': [2524], 'germline': [2525], 'database': [2526], '(IMGT,': [2527], 'Montpellier,': [2528], 'France)': [2529], 'IMGT/HighV-QUEST': [2532], 'online': [2533, 4105], 'tool': [2534, 4106], '(http://imgt.org/HighV-QUEST/login.action,': [2535], 'freely': [2536], 'available': [2537], 'registration,': [2539], 'last': [2540, 4108], 'accessed': [2541, 4109], 'October': [2542], '11,': [2543], '2017)': [2544], 'parameters.14Alamyar': [2547], 'Giudicelli': [2549, 4116], 'Li': [2551], 'Duroux': [2553], 'Lefranc': [2555, 4114], 'M.-P.': [2556], 'IMGT/HighV-QUEST:': [2557], 'IGMGT': [2559], 'web': [2560], 'portal': [2561], '(Ig)': [2564], 'T': [2568, 2625], '(TC)': [2571], 'analyses': [2572, 2785], 'high': [2575], 'throughout': [2576], 'sequencing.Immunome': [2579], 'Res.': [2580, 3310, 4136], '1-15Google': [2583], 'Aligned': [2585], 'parsed': [2588], 'open': [2591], 'source': [2592], 'VDJtools': [2593], '(https://github.com/mikessh/vdjtools)15Shugay': [2595], 'Bagaev': [2597], 'D.V.': [2598], 'Turchaninova': [2599], 'Bolotin': [2601], 'D.A.': [2602], 'Britanova': [2603], 'O.V.': [2604], 'Putintseva': [2605], 'E.V.': [2606, 2618], 'Pogorelyy': [2607], 'M.V.': [2608], 'Nazarov': [2609], 'V.I.': [2610, 2614], 'Zvyagin': [2611], 'I.V.': [2612], 'Kirgizova': [2613], 'Kirgizov': [2615], 'K.I.': [2616], 'Skorobogatova': [2617], 'Chudakov': [2619], 'VDJtools:': [2621], 'unifying': [2622], 'post-analysis': [2623], 'repertoires.PLoS': [2628], 'Comput': [2629], 'Biol.': [2630], '1-16Crossref': [2633], '(304)': [2635], '1.1.1.': [2639], 'detail,': [2641], 'mapped': [2642], 'aggregated': [2645], 'into': [2646], 'based': [2648], 'their': [2650, 2818], 'complementary-determining': [2651], '(CDR3)': [2654], 'nucleotide': [2655, 3438], 'variable,': [2661], 'diversity,': [2662], 'joining': [2664], '[IGH': [2665], 'V(D)J]': [2666], 'segment': [2668, 3829, 3915], 'use.': [2669], 'Frequency-based': [2670], 'correction': [2671], '(maximum': [2680], 'mismatches': [2683], 'allowed': [2684], 'between': [2685], 'being': [2687], 'compared,': [2688], '2;': [2689], 'child-to-parent': [2690], 'clonotype': [2691, 2698, 2713, 3608, 3834, 4159], 'ratio': [2693], 'threshold': [2694, 3459], 'under': [2695, 4188], 'which': [2696, 4100], 'child': [2697], 'considered': [2700, 2808], 'erroneous,': [2701], '0.05)': [2702], 'eliminate': [2704], 'erroneous': [2705], 'clonotypes.': [2706], 'Corrected': [2707], 'abundance': [2714], 'tables': [2715], 'subsequent': [2718, 3416], 'analyses.': [2719, 3418], 'Repertoire': [2720], 'overlap': [2721], 'VDJtools.': [2725], "Fisher's": [2726, 3954], 'exact': [2727, 3955], 'test,': [2728, 2733], 'U-test,': [2729], 'Kaplan-Meier': [2730], 'analysis,': [2731], 'log-rank': [2732], 'one-way': [2735], 'variance': [2738], 'posthoc': [2740], 'Tukey': [2741], 'honestly': [2742], 'significant': [2743, 3265], 'difference': [2744], 'test': [2745], 'R': [2749], '3.3.2': [2751], '(R': [2752], 'Development': [2753, 2757], 'Core': [2754, 2758], 'Team;': [2755], 'http://www.r-project.org)16R': [2756], 'TeamR:': [2759], 'language': [2761], 'environment': [2763], 'statistical': [2765], 'computing.R': [2766], 'Found': [2767], 'Stat': [2768], 'Comput.': [2769], '2011;': [2770], '1:': [2771], '409Google': [2772], 'GraphPad': [2775], 'Prism': [2776], '5.0': [2778], '(GraphPad': [2779], 'Software,': [2780], 'CA).': [2783], 'Correlation': [2784], "Pearson's": [2790], 'correlation': [2791], 'coefficient': [2792], '(r).': [2793], 'Venny': [2794], '2.1.0': [2796], '(http://bioinfogp.cnb.csic.es/tools/venny/index.html)': [2797], 'generate': [2801], 'Venn': [2802], 'diagrams.': [2803], 'P': [2804, 3951, 3965], '<': [2805, 3952, 3966], '0.05': [2806], 'statistically': [2809, 3938], 'significant.': [2810], 'Clinical': [2811], 'features': [2812], 'summarized': [2822], 'Table': [2824], '3.': [2825], 'Previous': [2826], 'included': [2828, 3970], 'mainly': [2829], 'bortezomib': [2830], '[nine': [2831], '(36%)]': [2833], 'high-dose': [2835], 'melphalan': [2836], '[16': [2837], '(64%)].': [2839], 'Median': [2840], '17': [2846], 'months': [2847, 2983], '82': [2851], 'months).': [2852], 'At': [2853], 'accrual': [2854], 'point,': [2856], 'variable': [2859], '(median,': [2867], '8.8%;': [2868], 'range,': [2869], '0.05%': [2870], '80%)': [2872], 'no': [2874, 3805], 'PB.Table': [2880], '3Baseline': [2881], 'Characteristics': [2882], 'Study': [2885], 'CohortCharacteristicFinding': [2886], '(n': [2887], '=': [2888], '25)Age': [2889], 'years,': [2891], '(range)65': [2893], '(41–75)Sex,': [2894], 'n': [2895, 2902, 2959, 2971], '(%)': [2896, 2903, 2972], 'Male16': [2897], '(64)': [2898], 'Female9': [2899], '(36)MM': [2900], 'subtype,': [2901], 'IgG13': [2904], '(52)': [2905], 'IgA8': [2906], '(32)': [2907], 'Light': [2908], 'chain4': [2909], '(16)Laboratory': [2910], 'findings': [2911], 'trephine': [2915], 'biopsy,': [2916], '(range),': [2918, 2927, 2935, 2942, 2954, 2990], '%40': [2919], '(10–95)': [2920], 'cytometry,': [2925], '%8.8': [2928], '(0.05–80)': [2929], 'NGS,': [2933, 3012, 3041], '%50.1': [2936], '(1.4–86.7)': [2937], 'Serum': [2938, 2945, 2951], 'M': [2939], 'protein,': [2940], 'g/dL2.60': [2943], '(0.09–9.79)': [2944], 'FLC': [2946], 'ratio,': [2947], '(range)33': [2949], '(0.01–344)': [2950], 'LDH,': [2952, 3003, 3032], 'U/L294': [2955], '(228–433)': [2956], 'Cytogenetic': [2957], 'abnormalities,': [2958], '(%)t4;': [2960], '141': [2961], '(4)t14;': [2962], '162': [2963], '(8)17p-2': [2964], '(8)1q+4': [2965], '(16)>16': [2966], '(24)None5': [2967], '(20)NA5': [2968], '(20)MM': [2969], 'staging,': [2970], 'ISS': [2973, 2976, 2979], 'I10': [2974], '(40)': [2975], 'II6': [2977], '(24)': [2978], 'III9': [2980], '(36)Time': [2981], 'diagnosis,': [2985], '(range)51': [2987], '(22–117)Follow-up,': [2988], 'months17': [2991], '(2–82)BM,': [2992], 'marrow;': [2994, 3023], 'FLC,': [2995, 3024], 'light': [2997, 3026], 'chain;': [2998, 3027], 'ISS,': [2999, 3028], 'Staging': [3001, 3030], 'System;': [3002, 3031], 'lactate': [3004, 3033], 'dehydrogenase;': [3005, 3034], 'MM,': [3006, 3035], 'myeloma;': [3008, 3037], 'NA,': [3009, 3038], 'not': [3010, 3039, 3263], 'applicable;': [3011, 3040], 'BM,': [3021], 'To': [3044, 3419, 3989], 'dominant': [3047], 'clonotype,': [3049], 'loci': [3053], 'genomic': [3055], '(tcDNA)': [3059], 'derived': [3060, 3298, 4017], 'amplified': [3067], 'validated': [3072, 4190], 'degenerate': [3073], 'primer.12Voena': [3084], '17Corradini': [3206], 'Lokhorst': [3210, 4031], 'Martinelli': [3212, 4033], 'Terragna': [3214, 4035], 'Majolino': [3216, 4037], 'Valagussa': [3218, 4039], 'Samson': [3222, 4043], 'Bacigalupo': [3224, 4045], 'Montefusco': [3228, 4049], 'Voena': [3230, 4051], 'Molecular': [3234, 3911, 4055], 'remission': [3235, 4056], 'myeloablative': [3237, 4058], 'allogeneic': [3238, 3585, 4059, 4237], 'stem': [3239, 3586, 4060, 4238], 'transplantation': [3241, 3588, 4062, 4240], 'predicts': [3242, 4063], 'relapse-free': [3245, 4066], '1927-1929Crossref': [3254, 4075], '(170)': [3257, 4078], 'These': [3260], 'oligonucleotides': [3261], 'do': [3262], 'cause': [3264], 'bias': [3268], 'settings,': [3272], 'allowing': [3273], 'correct': [3275], 'representation': [3276], 'VH': [3280, 3844], 'families.18Bashford-Rogers': [3282], 'R.J.M.': [3283], 'Palser': [3284], 'A.L.': [3285], 'Huntly': [3286], 'B.J.': [3287], 'Rance': [3288], 'Vassiliou': [3290], 'G.S.': [3291], 'Follows': [3292], 'Kellam': [3294], 'properties': [3297], 'human': [3303], 'b-cell': [3304], 'repertoires': [3306], 'delineate': [3307], 'populations.Genome': [3309], '23:': [3312], '1874-1884Crossref': [3313], '19McClure': [3319], 'Mai': [3321], 'McClure': [3323], 'High-throughput': [3325], 'evaluation': [3336, 3986], 'somatic': [3338], 'hypermutation': [3339], 'status': [3340], 'lymphocytic': [3343], 'leukemia.J': [3344], 'Mol': [3345], 'Diagn.': [3346], '145-154Abstract': [3349], '(5)': [3357], 'generated': [3362], 'sizes': [3366], 'yielded': [3374], 'means': [3376, 3395], '±': [3377, 3396, 3400, 3404], 'SD': [3378, 3397], '101,455': [3380], '(79,377)': [3381], 'subjected': [3385], 'Figure': [3392, 3852, 3877, 3884, 3934], '47,755': [3399], '32,787': [3401], '(47%': [3403], '32%': [3405], 'total': [3407], 'reads)': [3408], 'passed': [3409], 'filters': [3411], 'downstream': [3417], 'assess': [3420], 'clonality': [3421, 3723], 'percentage': [3426], 'having': [3429], 'unique': [3436], 'CDR3': [3437, 4154], 'determined.': [3441], 'most': [3443], 'represented': [3444], 'clone': [3445, 3464], 'frequency': [3449, 3458], '50.1%': [3451], '1.4%': [3453], '86.7%).': [3455], 'Setting': [3456], '>5%': [3460], 'define': [3462], 'clonotype,4Martinez-Lopez': [3468], '20Herrera': [3539], 'Kim': [3541, 3709, 4193], 'H.T.': [3542, 4194], 'K.A.': [3544, 3712, 4196], 'Sun': [3547, 4199], 'Sohani': [3549, 4201], 'Alyea': [3551, 4203], 'E.P.': [3552, 4204], 'Carlton': [3553, 4205], 'V.E.': [3554, 4206], 'Y.B.': [3556, 4208], 'Cutler': [3557, 4209], 'C.S.': [3558, 4210], 'Ho': [3559, 4211], 'V.T.': [3560, 4212], 'Koreth': [3561, 4213], 'Kotwaliwale': [3563, 4215], 'Nikiforow': [3565, 4217], 'Ritz': [3567, 4219], 'Rodig': [3569, 4221], 'Soiffer': [3571, 4223], 'R.J.': [3572, 4224], 'Antin': [3573, 4225], 'J.H.': [3574, 4226], 'Armand': [3575, 4227], 'Next-generation': [3577, 4229], 'sequencing-based': [3578, 4230], 'After': [3584, 4236], 'lymphoma.Br': [3590, 4242], 'J': [3591, 4243], 'Haematol.': [3592, 4244], '175:': [3594, 4246], '841-850Crossref': [3595, 4247], '(43)': [3598, 4250], 'successfully': [3604], '22': [3610, 3823, 3862, 4147], '(88%),': [3616], 'indicating': [3617], 'specificity': [3619], 'similar': [3620], 'previously': [3626, 3749], 'described': [3627], 'assays': [3629], 'identification': [3633], '(91%).4Martinez-Lopez': [3634], '21Shin': [3705], 'Hwang': [3707], 'I.S.': [3708], 'Lee': [3711, 3713], 'S.T.': [3714], 'Choi': [3715], 'J.R.': [3716], 'Detection': [3717], 'heavy': [3720, 3810], 'chain': [3721, 3811], 'B-lymphoblastic': [3733], 'leukemia.Ann': [3734], 'Lab': [3735], '37:': [3738], '331-335Crossref': [3739], '(14)': [3742], 'consistent': [3747, 3886], 'published': [3750], 'data,22Ferrero': [3751], 'Capello': [3753], 'Svaldi': [3755], 'Boi': [3757], 'Gatti': [3759], 'Drandi': [3761], 'Rossi': [3763], 'Barbiero': [3765], 'Mantoan': [3767], 'Mantella': [3769], 'Zanni': [3771], 'Ghione': [3773], 'Larocca': [3775], 'Passera': [3777], 'Bertoni': [3779], 'Gattei': [3781], 'Forconi': [3783], 'Laurenti': [3785], 'del': [3787], 'Poeta': [3788], 'Marasca': [3790], 'Cortelazzo': [3792], 'Gaidano': [3794], 'Palumbo': [3796], 'Multiple': [3802], 'shows': [3804], 'intra-disease': [3806], 'clustering': [3807], 'genes.Haematologica.': [3812], '97:': [3814], '849-853Crossref': [3815], '(10)': [3818], 'nonrandom:': [3836], 'IGHV3,': [3837], 'IGHV4,': [3838], 'IGHV1,': [3839], 'IGHV2': [3841], 'families': [3845], 'expressed': [3846], 'highest': [3849], 'S2A),': [3853], 'preferential': [3856], 'expression': [3857], 'VH3-23': [3859], '[4': [3860], '(18%)],': [3864], 'VH1-69,': [3865], 'VH2-5,': [3866], 'VH3-30,': [3867], 'VH3-48,': [3868], 'VH3-7': [3870], '(each': [3871], '9%)': [3873], 'S2B).': [3878], 'IGHD6-19': [3879], 'IGHD6-13': [3881], 'predominated': [3882], 'S2C),': [3885], 'what': [3888], 'seen': [3889], 'other': [3891], 'tumors.23González': [3894], 'Balanzategui': [3898], 'Sarasquete': [3900], 'M.E.': [3901], 'López-Pérez': [3902], 'Chillón': [3904], 'M.C.': [3905], 'J.F.': [3910], 'characteristics': [3912], 'usage': [3916], 'myeloma.Haematologica.': [3923], '2005;': [3924], '90:': [3925], '906-913PubMed': [3926], 'Among': [3929], 'subgroups': [3932], 'S2D),': [3935], 'IGHJ4': [3936], 'overrepresented': [3939], '(45%': [3940], '16.7%': [3943], 'expected,': [3944], 'assuming': [3945], 'random': 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'integrated': [4123], 'IG': [4126], 'TR': [4128], 'V-J': [4130], 'V-D-J': [4132], 'analysis.Nucleic': [4134], 'Acids': [4135], '36:': [4138], '503-508Crossref': [4139], '(830)': [4142], 'patients,': [4148], 'identity': [4151], 'corresponded': [4163], 'inferred': [4166], 'approach.': [4171], 'Moreover,': [4172], 'remaining': [4175], 'three': [4176], 'whom': [4179], 'threshold,20Herrera': [4191], 'highlighted': [4255], 'polyclonal': [4257], 'repertoire': [4259], '4': [4261]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2888853713', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 12}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 4}], 'updated_date': '2024-12-13T23:28:08.659340', 'created_date': '2018-09-07'}
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