Publication Information

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'Address:': [177], '[email protected]': [178], 'ItalyPublished': [195], 'Online:24': [196], 'Aug': [197], '2018https://doi.org/10.2217/fon-2018-0158AboutSectionsPDF/EPUB': [198], 'ToolsAdd': [199], 'to': [200, 249, 281, 350, 387, 392, 441, 455, 555, 557, 717, 773, 853, 971, 976, 1036, 1151, 1188, 1219, 1249, 1272, 1282, 1287, 1342, 1359, 1421, 1445, 1466, 1517, 1536, 1540, 1562, 1623, 1667, 1689, 1703, 1758, 1812, 1879, 1891, 1901, 1931, 2074, 2214, 2257, 2796, 2942, 3041, 3068], 'favoritesDownload': [201], 'CitationsTrack': [202], 'CitationsPermissionsReprints': [203], 'ShareShare': [204], 'onFacebookTwitterLinkedInReddit': [205], 'Keywords:': [206], 'angiogenesisbone': [207, 3177], 'metastasiscabozantinibcastration-resistant': [208, 3178], 'cancerMET': [210, 3180], 'inhibitormetastatic': [211, 3181], 'RCCmultityrosine': [212, 3182], 'kinases': [213, 491, 497, 1308, 3183], 'inhibitorosteoblastic': [214, 3184], 'activationrenal': [215, 3185], 'carcinomatarget': [217, 3187], 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3011], 'al.': [563, 567, 776, 1455, 1532, 1834, 1838, 2113, 2180, 2207, 2273, 2307, 2337, 2424, 2501, 2547, 2602, 2631, 2676, 2716, 2818, 2849, 2913, 2934, 3012], 'Choueiri': [565, 1836, 2494], 'described': [569], 'achieved': [573, 1386], 'clear-cell': [582, 845, 1209, 1856], 'component': [583, 846, 1210], 'treated': [584, 729, 2555, 2650], 'versus': [587, 865, 2503, 2638], 'everolimus': [588, 2471, 2504, 2524], 'METEOR': [591, 817, 1388, 2445], 'trial': [592, 712, 1389, 1558], '[11,12].Although': [593], 'this': [594, 676, 876, 1185, 1220, 1230, 1902, 2051, 3251], 'study': [595, 1829, 2550], 'not': [597, 848, 1577, 1632, 2570, 2971], 'powered': [598], 'statistical': [600], 'analysis': [601, 2442, 2633, 2693], 'subgroups,': [603], 'obtained': [606], 'very': [608, 686], 'interesting': [609], 'terms': [611, 723, 829, 860, 1897], 'progression-free': [613, 2460], '(7.4': [615], 'vs': [616, 625, 632, 742], '2.7': [617], 'months,': [618, 634], 'HR:': [619, 635], '0.33),': [620], 'objective': [621, 2465], 'response': [622, 737, 809, 1811, 2466], 'rate': [623, 638, 671, 738, 2467], '(17': [624], '0%)': [626], 'overall': [628, 2462, 2573, 2685], '(OS;': [630], '20.1': [631], '10.7': [633], '0.45).': [636], 'skeletal-related': [640], 'events': [641], 'was': [642, 1469, 1621, 2045, 2456, 2518, 3245], '23%': [643, 1473], '29%': [647], 'everolimus.': [649], 'were': [653], 'also': [654, 696, 1066, 1259, 1683], 'seen': [655, 838], 'visceral': [662], 'metastases.': [663, 760, 771, 1154], 'Considering': [664, 1371], 'poor': [666, 998, 2162], 'prognosis': [667, 831, 999], 'high': [670], 'complications': [673], 'observed': [674, 1397, 1470], 'subpopulation': [677], 'patients,': [681, 1888], 'data': [683], 'important': [687, 882, 1394, 1842], 'value': [688, 1516], 'from': [689, 969, 1034, 1168, 1464, 2093, 3060], 'oncologic': [691], 'view.Cabozantinib': [694], 'tested': [698], '(CRPCa)': [706], 'Phase': [709, 1555, 2548], 'III': [710, 2549], '(COMET-1),': [713], 'where': [714, 988, 1040], 'it': [715, 1041, 1212, 1379, 1816], 'failed': [716, 1890], 'demonstrate': [718, 821, 1892], 'OS': [725, 836, 862, 1201, 1718], '[13–15].': [726], 'However,': [727, 1646], 'showed': [732, 1743], 'scan': [736, 1609], '(42%': [739], '3%': [743], 'prednisone),': [745], 'biomarkers': [747, 791], 'decrease': [748], 'circulating': [750, 963], 'conversion': [753], 'suggesting': [754, 1675], 'effect': [757, 1614], 'on': [758, 1417, 1546, 1596, 1617, 1975, 2993, 3145], 'No': [761], 'distinguish': [762], 'made': [765], 'between': [766, 1375, 2756, 2851], 'lytic': [767], 'condensing': [769], 'According': [772], 'Som': [774, 2669], '[16],': [777], 'serum': [778], "'measurements": [779], 'turnover': [782, 2680], 'metabolites': [783], 'during': [784, 2682, 2827, 2916], 'therapy': [785, 2216, 2683], 'function': [786], 'clinically': [788], 'informative': [789], 'predictive': [790], 'skeletal': [799], "metastases'": [800], 'could': [802, 867, 956, 1083, 1110, 1138, 1222, 1347, 1357, 1525, 1731, 1904], 'used': [804], 'surrogate': [807], 'efficacy.': [812], 'results': [814, 991, 1790], 'COMET-1': [819], 'trials': [820, 2939], 'effective': [826, 1299], 'metastases,': [834], 'CRPCa.Biological': [850], 'related': [852, 1878], 'cabozantinibThis': [856], 'CRPCa': [866, 1462, 1583, 1887], 'partially': [869], 'explained': [870], 'drug.': [877], 'One': [878], 'target': [883, 1250, 1418, 1581, 2122, 2975], '(or': [888], 'HGFR)': [889], 'which': [890, 1095], 'plays': [891], 'critical': [893], 'role': [894, 980, 1869, 1978, 2398], 'metastases': [897, 1304, 2480, 3040], 'development.': [898], 'c-MET': [900], 'oncogene': [901, 2824], '"encodes': [902], 'receptor': [904, 924, 2719], 'HGF/scatter': [907], 'factor,': [908], 'cytokine': [910], 'stimulates': [912, 1029], 'growth': [915, 1619, 1636, 2766, 2790, 2880, 2952], 'normal': [917, 1009, 2153], 'neoplastic': [919, 1011], 'cells"': [920], '[17].': [921, 938], '"The': [922], 'MET/HGF': [923, 941], 'expressed': [926], 'epithelial': [928], 'its': [931, 989, 1722, 1779, 1873, 3022], 'ligand': [932], 'mesenchymal': [936], 'origin"': [937], 'Through': [939], 'receptor,': [942, 1776], 'CD14+': [944, 1017], 'monocytes': [945, 1018], 'differentiated': [947], 'into': [948, 1423, 1565, 1954], 'mature': [949], 'osteoclasts': [950, 1020], '(Figure': [951, 1413], '1A).': [952], 'triggered': [958], 'osteoblasts': [960, 1028, 1597, 2994], 'resulting': [961, 1021, 1260], '(including': [965], 'cells)': [967], 'migration': [968, 1030, 1276], 'blood': [970, 1035], 'bone.': [972], 'Therefore,': [973], 'seems': [975], 'assume': [977], 'since': [981], 'early': [983], 'phases': [984], 'more': [994], '[18,19].Figure': [1000], '1.': [1001], 'Role': [1002], 'cells.(A)': [1012], 'HGF': [1013, 1025, 2855], 'induces': [1014], 'differentiation': [1015], 'osteolysis.': [1023], 'produced': [1026], 'marrow': [1038], 'space': [1039], 'supports': [1042], 'growth.': [1045, 2352], '(B)': [1046], 'Mesenchymal–epithelial': [1047, 1062, 1102], 'activate': [1051], 'common': [1052], 'intermediates': [1054], 'ERK,': [1057], 'MAPK,': [1058], 'AKT': [1059], 'FAK.': [1061], 'can': [1065, 1746, 2792], 'induce': [1067], 'VEGFA': [1068, 1349], 'through': [1072, 1086, 1351, 2284, 2763, 2885], 'SHCs': [1073], '(SRC': [1074], 'homology': [1075], '2': [1076], 'domain': [1077], 'containing': [1078], 'proteins).': [1079], 'addition,': [1081, 1768], 'supported': [1085, 1157], 'inhibition': [1088, 1195, 1289, 1369, 1408, 1585, 1603, 1663, 2235, 2953, 2982], 'HGF/SF': [1089], 'mediated': [1090], 'thrombospondin': [1092, 2890], '1': [1093, 1465, 2891], '(TSP1)': [1094], 'negative': [1098, 2889], 'regulator': [1099], 'angiogenesis.MET:': [1101], 'transition.It': [1103], 'possible': [1105, 1335, 1381], 'step': [1114], 'invasion,': [1117], 'shared': [1118], 'tumors': [1121, 1696], 'types,': [1122, 1177], 'head': [1132, 1179], 'neck': [1134, 1181], 'carcinoma.': [1135, 2128, 2220, 2508], "'prerogative'": [1141], 'specific': [1143], 'clones': [1144], 'able': [1150, 1248], 'develop': [1152], 'distant': [1153, 1172], 'fact': [1160], 'there': [1162], 'differences': [1164], 'primary': [1169, 1612, 1653], 'metastasis': [1173, 1278, 1849, 2283, 2759], '[20].': [1183], 'All': [1184], 'gives': [1186], 'support': [1187, 2797], 'efficacy': [1191], 'metastases.Why': [1198], 'while': [1211, 1305], 'fails': [1213], 'other': [1215, 1242, 1306, 1710, 1725, 1876, 1942, 1965], 'tumors?': [1216], 'answer': [1218], 'question': [1221], 'searched': [1224, 1906], 'activity': [1228, 1750, 1761, 1910, 1961], 'features': [1238, 2164], 'RCC.': [1240], 'Indeed,': [1241, 1312], 'than': [1243, 2149, 2522], 'inhibition,': [1245], 'additional': [1251], 'receptors,': [1253], 'VEGFR,': [1257], 'thus': [1258, 1280], 'inhibition.': [1264, 1345], 'coinhibition': [1266, 1292], 'leads': [1271, 1666], 'reduction': [1273], 'development,': [1279], 'helping': [1281], 'overcome': [1283, 1343], 'acquired': [1285, 1680, 2255], 'explanation': [1295], 'why': [1296], 'not.': [1311], 'activating': [1326], '[5].MET': [1331], 'hyperexpression': [1332], 'another': [1334], 'way': [1336], 'followed': [1337], 'stimulate': [1348], 'Src': [1352], 'lead': [1358], 'ERK/MAPK/AKT/FAK': [1364], 'cascade': [1365], 'TSP1': [1368], '[21,22].': [1370], 'close': [1373], 'relationship': [1374, 1984], 'favorable': [1384], 'outcome': [1385], 'consequence': [1404], 'simultaneous': [1407], '1B).Patients': [1414], 'selection': [1415], 'based': [1416], 'expressionAnother': [1419], 'issue': [1420], 'take': [1422], 'consideration': [1424], 'among': [1434, 1925, 2525], 'various': [1435, 1926], 'tumors.': [1436, 1927, 2190], 'means': [1438], 'should': [1441, 1951], 'selected': [1443, 2826], 'according': [1444, 1930], 'their': [1446, 1932, 1983], 'cancer-expression': [1447], "cabozantinib's": [1449, 1505, 1936], 'before': [1451], 'treatment.': [1452], 'Verhoef': [1453, 2905], 'found': [1456], 'protein': [1459], 'ranged': [1463], '20%': [1467], 'hormone': [1475], 'resistant': [1476], 'at': [1480, 1507], 'palliative': [1481], 'trans-urethral': [1482], 'resection': [1483], '[23].': [1484], 'immunohistochemistry': [1486], 'revealed': [1487], '20–100%': [1490], '18/23': [1495], '(78%)': [1496], 'metastasis.': [1500], 'Assessing': [1501], 'stages': [1509], 'determine': [1518], 'whether': [1519], 'subpopulations': [1520], 'identified': [1527], 'stratification.Varkaris': [1530], '[24],': [1533], 'order': [1535], 'understand': [1537, 2943], 'leading': [1539], 'these': [1541, 2488], 'responses,': [1542], 'conducted': [1543], 'parallel': [1544], 'investigations': [1545], 'well-defined,': [1547], 'representative': [1548], 'patient-derived': [1549], 'xenografts': [1550], 'conjunction': [1552], 'II': [1556], 'provide': [1563], 'insights': [1564], 'unanticipated': [1567], 'findings.': [1569], 'They': [1570], 'demonstrated': [1571], 'persistent': [1579, 2973], 'VEGF-R2': [1587], 'endothelial': [1591, 2859, 2988], 'direct': [1594, 2991], 'responsible': [1599, 2996], 'cabozantinib-induced': [1601, 2998], 'compelling': [1607], 'changes.': [1610], 'long-term': [1613], 'inhibition/regression': [1620], 'due': [1622], 'microenvironment': [1627, 2762], 'required': [1633, 1702], 'sustained': [1635], 'vitro': [1642, 1738], 'vivo.': [1645], 'vascular': [1647], 'heterogeneity': [1648], 'represents': [1649, 1840, 2482], 'one': [1650, 1818], 'source': [1651], 'VEGFR-2': [1656], 'targeted.': [1658], 'Furthermore': [1659], 'genetic': [1660], 'pharmacologic': [1662], 'induction': [1668], 'FGFR-1': [1670], 'potential': [1677, 2120], 'mechanism': [1678, 1803], 'resistance.': [1681], 'It': [1682], 'emerged': [1684], 'withdrawal': [1687], 'rapid,': [1690], 'immediate': [1691], 'exponential': [1692], 'regrowth': [1693], 'all': [1695, 2143], 'inhibit': [1704, 1759], 'regrowth.Cabozantinib': [1706], 'modalities"Despite': [1712], 'lack': [1714], 'increase': [1716, 1747], 'alone,': [1721], 'modalities': [1727], 'abiraterone': [1730, 1757, 1813, 1823, 2588, 2655], 'potentially': [1732], 'optimize': [1733], 'outcomes"': [1735], '[25].': [1736], 'experiments': [1742], 'antitumor': [1749], 'abiraterone.': [1752], 'Enhancing': [1753], 'ability': [1755], 'AR': [1760], 'line-dependent': [1765], 'manner.': [1766], 'inhibits': [1770, 3014], 'phosphorylation': [1772, 3019], 'IGF': [1774], 'I': [1775], 'consequently': [1778], 'downstream': [1782], 'MEK1/2': [1785], 'ERK1/2,': [1787], 'normally': [1789], 'maintenance': [1792], 'antagonizing': [1797], 'proteins': [1798], 'involved': [1799], 'apoptosis.': [1801], 'acts': [1804, 2182], 'compensatory': [1807], 'patients.ConclusionThe': [1828], 'presented': [1830], '[11,12]': [1839], 'contribute': [1843], 'component.': [1857], 'investigation': [1861], 'suggests': [1862], 'some': [1863], 'excellent': [1864], 'ideas': [1865], 'about': [1866], 'interaction': [1874], 'angiogenesis,': [1880], 'process.': [1885], 'OS.': [1899], 'Answers': [1900], 'Selecting': [1928], 'cancer-': [1933], 'combinating': [1939], 'modalities,': [1944], 'abiraterone,': [1947], 'suggestions': [1949], 'taken': [1953], 'consideration.': [1955], 'Further': [1956], 'exploring': [1958], "inhibitors'": [1960], 'neoplasms': [1963], 'organs': [1966], 'tissue': [1968, 2155], 'will': [1969], 'sure': [1971], 'improve': [1972, 2572], 'our': [1973], 'cabozantinib.Financial': [1988], 'competing': [1990, 3190], 'interests': [1991, 3191], 'disclosureThe': [1992, 3192], 'authors': [1993, 3193], 'no': [1995, 3195], 'relevant': [1996, 3196], 'affiliations': [1997, 3197], 'financial': [1999, 2008, 2012, 3199, 3208, 3212], 'involvement': [2000, 3200], 'any': [2002, 3202], 'organization': [2003, 3203], 'entity': [2005, 3205], 'interest': [2009, 3209], 'conflict': [2013, 3213], 'subject': [2016, 3216], 'matter': [2017, 3217], 'materials': [2019, 3219], 'discussed': [2020, 3220], 'manuscript.': [2023, 3223], 'includes': [2025, 3225], 'employment,': [2026, 3226], 'consultancies,': [2027, 3227], 'honoraria,': [2028, 3228], 'stock': [2029, 3229], 'ownership': [2030, 3230], 'options,': [2032, 3232], 'expert': [2033, 3233], 'testimony,': [2034, 3234], 'grants': [2035, 3235], 'patents': [2037, 3237], 'received': [2038, 3238], 'pending,': [2040, 3240], 'royalties.No': [2042, 3242], 'writing': [2043, 3243], 'assistance': [2044, 3244], 'utilized': [2046, 3246], 'production': [2049, 3249], 'manuscript.Papers': [2052], 'special': [2054], 'note': [2055], 'highlighted': [2058], 'as:': [2059], '•': [2060, 2134], 'interest;': [2062], '••': [2063, 2225, 2453, 2567, 2963], 'considerable': [2065], 'interestReferences1': [2066], 'Bergers': [2067], 'G,': [2068], 'Hanahan': [2069], 'D.': [2070], 'Modes': [2071], 'therapy.': [2076], 'Nat.': [2077, 2096], 'Rev.': [2078, 2097, 2407], 'Cancer': [2079, 2098, 2191, 2321, 2354, 2700, 2773, 2958, 3027, 3053], '8(8),': [2080], '592–603': [2081], '(2008).Crossref,': [2082], 'Medline,': [2083, 2102, 2169, 2196, 2262, 2296, 2326, 2359, 2413, 2490, 2535, 2591, 2620, 2704, 2777, 2806, 2838, 2866, 2901, 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[2363], 'D,': [2364], 'Cappagli': [2365], 'V,': [2366], 'Elisei': [2367], 'R.': [2368], '(XL184)': [2370], 'progressive': [2379, 2583], 'cancer.': [2382, 2405, 2956], '9(8),': [2385], '1083–1092': [2386], '(2013).Link,': [2387], 'Scholar10': [2390], 'Fay': [2391], 'AP,': [2392], 'Albiges': [2393], 'Bellmunt': [2395], 'J.': [2396, 2447, 2511, 2561, 2660, 2699, 2772], 'Current': [2397, 3084], 'Expert': [2406], 'Anticancer': [2408], '15(2),': [2410], '151–156': [2411], 'Scholar11': [2416], 'Powles': [2419, 2498], 'T,': [2420, 2495], 'Motzer': [2421], 'RJ': [2422], 'Cabozantinib,': [2425], 'new': [2427], 'standard': [2428], 'care': [2430], 'metastases?': [2440], 'Subgroup': [2441], 'trial.': [2446], 'Clin.': [2448, 2562, 2661, 2957, 3026], '36(8),': [2450], '765–772': [2451], '(2018).': [2452], 'survival,': [2461], 'compared': [2469, 2575], 'good': [2484], 'option': [2486], 'patients.Crossref,': [2489], 'Scholar12': [2493], 'T': [2499, 2816], 'renal-cell': [2507], 'N.': [2509], 'Engl.': [2510], 'Med.': [2512], '373(19),': [2513], '1814–1823': [2514], '(2015).': [2515], '••Progression-free': [2516], 'longer': [2519], 'had': [2530], 'progressed': [2531], 'VEGFR-targeted': [2533], 'therapy.Crossref,': [2534], 'Scholar13': [2538], 'Smith': [2539, 2623], 'M,': [2540, 2750, 2814], 'De': [2541, 2625, 2909], 'Bono': [2542, 2626], 'Sternberg': [2544, 2628], 'C': [2545, 2600], 'previously': [2554, 2649], 'cancer:': [2559, 2612, 2692], 'COMET-1.': [2560], '34(25),': [2564], '3005–3013': [2565], 'did': [2569], 'significantly': [2571], 'prednisone': [2577, 2639], 'mCRPC': [2581], 'docetaxel': [2586, 2652], 'and/or': [2589, 2657], 'enzalutamide.Crossref,': [2590], 'Scholar14': [2594], 'Modena': [2595], 'A,': [2596, 2670, 2928], 'Met': [2604], 'axis': [2607], "'game": [2613], "over'?": [2614], 'Target': [2615], '11(4),': [2617], '431–446': [2618], '(2016).Crossref,': [2619, 2923], 'Scholar15': [2622], 'MR,': [2624], 'JS,': [2627], 'CN': [2629], 'Final': [2632], 'COMET-1:': [2635], 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