Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2888330493', 'doi': 'https://doi.org/10.1021/acs.jmedchem.8b00308', 'title': 'Design of Gut-Restricted Thiazolidine Agonists of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5)', 'display_name': 'Design of Gut-Restricted Thiazolidine Agonists of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5)', 'publication_year': 2018, 'publication_date': '2018-08-24', 'ids': {'openalex': 'https://openalex.org/W2888330493', 'doi': 'https://doi.org/10.1021/acs.jmedchem.8b00308', 'mag': '2888330493', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30141927'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/acs.jmedchem.8b00308', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S162030435', 'display_name': 'Journal of Medicinal Chemistry', 'issn_l': '0022-2623', 'issn': ['0022-2623', '1520-4804'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100357735', 'display_name': 'Tao Chen', 'orcid': 'https://orcid.org/0000-0002-1797-0359'}, 'institutions': [{'id': 'https://openalex.org/I4210147970', 'display_name': 'Ardelyx (United States)', 'ror': 'https://ror.org/03wcj2062', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147970']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Tao Chen', 'raw_affiliation_strings': ['Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States'], 'affiliations': [{'raw_affiliation_string': 'Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States', 'institution_ids': ['https://openalex.org/I4210147970']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029108296', 'display_name': 'Nicholas William Reich', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210147970', 'display_name': 'Ardelyx (United States)', 'ror': 'https://ror.org/03wcj2062', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147970']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nicholas William Reich', 'raw_affiliation_strings': ['Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States'], 'affiliations': [{'raw_affiliation_string': 'Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States', 'institution_ids': ['https://openalex.org/I4210147970']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077682310', 'display_name': 'Noah Bell', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210147970', 'display_name': 'Ardelyx (United States)', 'ror': 'https://ror.org/03wcj2062', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147970']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Noah Bell', 'raw_affiliation_strings': ['Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States'], 'affiliations': [{'raw_affiliation_string': 'Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States', 'institution_ids': ['https://openalex.org/I4210147970']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016496178', 'display_name': 'Patricia D. Finn', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210147970', 'display_name': 'Ardelyx (United States)', 'ror': 'https://ror.org/03wcj2062', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147970']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Patricia D. Finn', 'raw_affiliation_strings': ['Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States'], 'affiliations': [{'raw_affiliation_string': 'Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States', 'institution_ids': ['https://openalex.org/I4210147970']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038848400', 'display_name': 'David Rodríguez', 'orcid': 'https://orcid.org/0000-0001-5745-4968'}, 'institutions': [{'id': 'https://openalex.org/I4210147970', 'display_name': 'Ardelyx (United States)', 'ror': 'https://ror.org/03wcj2062', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147970']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David Rodriguez', 'raw_affiliation_strings': ['Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States'], 'affiliations': [{'raw_affiliation_string': 'Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States', 'institution_ids': ['https://openalex.org/I4210147970']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062025976', 'display_name': 'Jill Kohler', 'orcid': 'https://orcid.org/0000-0003-0594-7239'}, 'institutions': [{'id': 'https://openalex.org/I4210147970', 'display_name': 'Ardelyx (United States)', 'ror': 'https://ror.org/03wcj2062', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147970']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jill Kohler', 'raw_affiliation_strings': ['Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States'], 'affiliations': [{'raw_affiliation_string': 'Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States', 'institution_ids': ['https://openalex.org/I4210147970']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046979450', 'display_name': 'Kenji Kozuka', 'orcid': 'https://orcid.org/0009-0008-7243-6475'}, 'institutions': [{'id': 'https://openalex.org/I4210147970', 'display_name': 'Ardelyx (United States)', 'ror': 'https://ror.org/03wcj2062', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147970']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kenji Kozuka', 'raw_affiliation_strings': ['Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States'], 'affiliations': [{'raw_affiliation_string': 'Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States', 'institution_ids': ['https://openalex.org/I4210147970']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101028604', 'display_name': 'Limin He', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210147970', 'display_name': 'Ardelyx (United States)', 'ror': 'https://ror.org/03wcj2062', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147970']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Limin He', 'raw_affiliation_strings': ['Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States'], 'affiliations': [{'raw_affiliation_string': 'Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States', 'institution_ids': ['https://openalex.org/I4210147970']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002073335', 'display_name': 'Andrew Spencer', 'orcid': 'https://orcid.org/0000-0002-0531-7424'}, 'institutions': [{'id': 'https://openalex.org/I4210147970', 'display_name': 'Ardelyx (United States)', 'ror': 'https://ror.org/03wcj2062', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147970']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Andrew G. Spencer', 'raw_affiliation_strings': ['Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States'], 'affiliations': [{'raw_affiliation_string': 'Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States', 'institution_ids': ['https://openalex.org/I4210147970']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065637245', 'display_name': 'Dominique Charmot', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210147970', 'display_name': 'Ardelyx (United States)', 'ror': 'https://ror.org/03wcj2062', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147970']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dominique Charmot', 'raw_affiliation_strings': ['Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States'], 'affiliations': [{'raw_affiliation_string': 'Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States', 'institution_ids': ['https://openalex.org/I4210147970']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063233785', 'display_name': 'Marc Navre', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210147970', 'display_name': 'Ardelyx (United States)', 'ror': 'https://ror.org/03wcj2062', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147970']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Marc Navre', 'raw_affiliation_strings': ['Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States'], 'affiliations': [{'raw_affiliation_string': 'Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States', 'institution_ids': ['https://openalex.org/I4210147970']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086885853', 'display_name': 'Christopher W. Carreras', 'orcid': 'https://orcid.org/0000-0001-7360-2350'}, 'institutions': [{'id': 'https://openalex.org/I4210147970', 'display_name': 'Ardelyx (United States)', 'ror': 'https://ror.org/03wcj2062', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147970']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christopher W. Carreras', 'raw_affiliation_strings': ['Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States'], 'affiliations': [{'raw_affiliation_string': 'Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States', 'institution_ids': ['https://openalex.org/I4210147970']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087942431', 'display_name': 'Samantha Koo-McCoy', 'orcid': 'https://orcid.org/0000-0002-6383-2221'}, 'institutions': [{'id': 'https://openalex.org/I4210147970', 'display_name': 'Ardelyx (United States)', 'ror': 'https://ror.org/03wcj2062', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147970']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Samantha Koo-McCoy', 'raw_affiliation_strings': ['Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States'], 'affiliations': [{'raw_affiliation_string': 'Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States', 'institution_ids': ['https://openalex.org/I4210147970']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091763205', 'display_name': 'Jocelyn Tabora', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210147970', 'display_name': 'Ardelyx (United States)', 'ror': 'https://ror.org/03wcj2062', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147970']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jocelyn Tabora', 'raw_affiliation_strings': ['Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States'], 'affiliations': [{'raw_affiliation_string': 'Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States', 'institution_ids': ['https://openalex.org/I4210147970']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034490603', 'display_name': 'Jeremy S. Caldwell', 'orcid': 'https://orcid.org/0000-0003-0558-7085'}, 'institutions': [{'id': 'https://openalex.org/I4210147970', 'display_name': 'Ardelyx (United States)', 'ror': 'https://ror.org/03wcj2062', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147970']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jeremy S. Caldwell', 'raw_affiliation_strings': ['Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States'], 'affiliations': [{'raw_affiliation_string': 'Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States', 'institution_ids': ['https://openalex.org/I4210147970']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086027097', 'display_name': 'Jeffrey Jacobs', 'orcid': 'https://orcid.org/0000-0002-5893-4397'}, 'institutions': [{'id': 'https://openalex.org/I4210147970', 'display_name': 'Ardelyx (United States)', 'ror': 'https://ror.org/03wcj2062', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147970']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jeffrey W. Jacobs', 'raw_affiliation_strings': ['Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States'], 'affiliations': [{'raw_affiliation_string': 'Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States', 'institution_ids': ['https://openalex.org/I4210147970']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5070880664', 'display_name': 'Jason G. Lewis', 'orcid': 'https://orcid.org/0000-0002-1419-653X'}, 'institutions': [{'id': 'https://openalex.org/I4210147970', 'display_name': 'Ardelyx (United States)', 'ror': 'https://ror.org/03wcj2062', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147970']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Jason Gustaf Lewis', 'raw_affiliation_strings': ['Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States'], 'affiliations': [{'raw_affiliation_string': 'Ardelyx, Inc., 34175 Ardenwood Blvd, Fremont, California 94555, United States', 'institution_ids': ['https://openalex.org/I4210147970']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5070880664'], 'corresponding_institution_ids': ['https://openalex.org/I4210147970'], 'apc_list': None, 'apc_paid': None, 'fwci': 1.785, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 31, 'citation_normalized_percentile': {'value': 0.999957, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '61', 'issue': '17', 'first_page': '7589', 'last_page': '7613'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10570', 'display_name': 'Mechanisms of Multidrug Resistance in Cancer', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10570', 'display_name': 'Mechanisms of Multidrug Resistance in Cancer', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10401', 'display_name': 'Management of Diabetes Mellitus and Cardiovascular Risk', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10671', 'display_name': 'Diagnosis and Management of Gastroesophageal Reflux Disease', 'score': 0.9935, 'subfield': {'id': 'https://openalex.org/subfields/2715', 'display_name': 'Gastroenterology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/farnesoid-x-receptor', 'display_name': 'Farnesoid X receptor', 'score': 0.52684206}, {'id': 'https://openalex.org/keywords/bile-acids', 'display_name': 'Bile Acids', 'score': 0.49467}], 'concepts': [{'id': 'https://openalex.org/C39321552', 'wikidata': 'https://www.wikidata.org/wiki/Q18052005', 'display_name': 'G protein-coupled bile acid receptor', 'level': 3, 'score': 0.9902818}, {'id': 'https://openalex.org/C2779399885', 'wikidata': 'https://www.wikidata.org/wiki/Q413288', 'display_name': 'Bile acid', 'level': 2, 'score': 0.6306911}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5286323}, {'id': 'https://openalex.org/C203862802', 'wikidata': 'https://www.wikidata.org/wiki/Q14905041', 'display_name': 'Farnesoid X receptor', 'level': 5, 'score': 0.52684206}, {'id': 'https://openalex.org/C2777148285', 'wikidata': 'https://www.wikidata.org/wiki/Q64386', 'display_name': 'Gallbladder', 'level': 2, 'score': 0.45621553}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.4523103}, {'id': 'https://openalex.org/C51785407', 'wikidata': 'https://www.wikidata.org/wiki/Q2627568', 'display_name': 'Effector', 'level': 2, 'score': 0.41159397}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.36636612}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.33163786}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.32945997}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.26172286}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.21787888}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.2092512}, {'id': 'https://openalex.org/C63932345', 'wikidata': 'https://www.wikidata.org/wiki/Q422500', 'display_name': 'Nuclear receptor', 'level': 4, 'score': 0.12711525}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D005704', 'descriptor_name': 'Gallbladder', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D005765', 'descriptor_name': 'Gastrointestinal Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D043562', 'descriptor_name': 'Receptors, G-Protein-Coupled', 'qualifier_ui': 'Q000819', 'qualifier_name': 'agonists', 'is_major_topic': True}, {'descriptor_ui': 'D053778', 'descriptor_name': 'Thiazolidines', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004285', 'descriptor_name': 'Dogs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015195', 'descriptor_name': 'Drug Design', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004353', 'descriptor_name': 'Drug Evaluation, Preclinical', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D004353', 'descriptor_name': 'Drug Evaluation, Preclinical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005704', 'descriptor_name': 'Gallbladder', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005765', 'descriptor_name': 'Gastrointestinal Agents', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D005765', 'descriptor_name': 'Gastrointestinal Agents', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D005765', 'descriptor_name': 'Gastrointestinal Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052216', 'descriptor_name': 'Glucagon-Like Peptide 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D052216', 'descriptor_name': 'Glucagon-Like Peptide 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061985', 'descriptor_name': 'Madin Darby Canine Kidney Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D043562', 'descriptor_name': 'Receptors, G-Protein-Coupled', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D043562', 'descriptor_name': 'Receptors, G-Protein-Coupled', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053778', 'descriptor_name': 'Thiazolidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/acs.jmedchem.8b00308', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S162030435', 'display_name': 'Journal of Medicinal Chemistry', 'issn_l': '0022-2623', 'issn': ['0022-2623', '1520-4804'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30141927', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.83, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 57, 'referenced_works': ['https://openalex.org/W1499768710', 'https://openalex.org/W1564206240', 'https://openalex.org/W1586629783', 'https://openalex.org/W1758829516', 'https://openalex.org/W1788055438', 'https://openalex.org/W1895112498', 'https://openalex.org/W1965796890', 'https://openalex.org/W1967056255', 'https://openalex.org/W1967283548', 'https://openalex.org/W1967442749', 'https://openalex.org/W1970465623', 'https://openalex.org/W1978705163', 'https://openalex.org/W1979686632', 'https://openalex.org/W1985539406', 'https://openalex.org/W1991274011', 'https://openalex.org/W2000210192', 'https://openalex.org/W2016716035', 'https://openalex.org/W2018171683', 'https://openalex.org/W2022279737', 'https://openalex.org/W2028990131', 'https://openalex.org/W2035276743', 'https://openalex.org/W2051119145', 'https://openalex.org/W2052638070', 'https://openalex.org/W2053833972', 'https://openalex.org/W2057447694', 'https://openalex.org/W2060214544', 'https://openalex.org/W2075514437', 'https://openalex.org/W2077091828', 'https://openalex.org/W2078145018', 'https://openalex.org/W2084948079', 'https://openalex.org/W2096418655', 'https://openalex.org/W2096880961', 'https://openalex.org/W2109371472', 'https://openalex.org/W2109745718', 'https://openalex.org/W2115590562', 'https://openalex.org/W2121911364', 'https://openalex.org/W2123561714', 'https://openalex.org/W2135008282', 'https://openalex.org/W2135732933', 'https://openalex.org/W2139351004', 'https://openalex.org/W2143819279', 'https://openalex.org/W2145185779', 'https://openalex.org/W2157101557', 'https://openalex.org/W2164556013', 'https://openalex.org/W2169303530', 'https://openalex.org/W2203303933', 'https://openalex.org/W2215535790', 'https://openalex.org/W2275957705', 'https://openalex.org/W2315996040', 'https://openalex.org/W2345590243', 'https://openalex.org/W2409754556', 'https://openalex.org/W2464084730', 'https://openalex.org/W2601172948', 'https://openalex.org/W2949470933', 'https://openalex.org/W4245650535', 'https://openalex.org/W4253101646', 'https://openalex.org/W4254744010'], 'related_works': ['https://openalex.org/W4221066727', 'https://openalex.org/W3029517394', 'https://openalex.org/W2946787461', 'https://openalex.org/W2766742164', 'https://openalex.org/W2741072374', 'https://openalex.org/W2612631436', 'https://openalex.org/W2552747572', 'https://openalex.org/W2404455624', 'https://openalex.org/W2151806551', 'https://openalex.org/W2089608246'], 'abstract_inverted_index': {'Bile': [0], 'acid': [1, 18, 31], 'signaling': [2], 'and': [3, 39, 60, 77, 91], 'metabolism': [4], 'in': [5, 29, 105], 'the': [6, 26, 70, 89], 'gastrointestinal': [7], 'tract': [8], 'have': [9, 69, 131], 'wide-ranging': [10], 'influences': [11], 'on': [12, 36], 'systemic': [13, 52, 127], 'disease.': [14, 146], 'G': [15], 'protein-coupled': [16], 'bile': [17, 30], 'receptor': [19], '1': [20], '(GPBAR1,': [21], 'TGR5)': [22], 'is': [23], 'one': [24], 'of': [25, 45, 62, 93, 96], 'major': [27], 'effectors': [28], 'sensing,': [32], 'with': [33, 83, 107, 125, 136], 'demonstrated': [34], 'influence': [35], 'metabolic,': [37], 'inflammatory,': [38], 'proliferative': [40], 'processes.': [41], 'The': [42, 111], 'pharmacologic': [43], 'utility': [44], 'TGR5': [46, 66, 98], 'agonists': [47, 99], 'has': [48], 'been': [49], 'limited': [50], 'by': [51], 'target-related': [53], 'effects': [54, 76], 'such': [55], 'as': [56], 'excessive': [57], 'gallbladder': [58, 63], 'filling': [59], 'blockade': [61], 'emptying.': [64], 'Gut-restricted': [65], 'agonists,': [67], 'however,': [68], 'potential': [71], 'to': [72, 134], 'avoid': [73], 'these': [74], 'side': [75], 'consequently': [78], 'be': [79], 'developed': [80], 'into': [81], 'drugs': [82], 'acceptable': [84], 'safety': [85], 'profiles.': [86], 'We': [87], 'describe': [88], 'discovery': [90], 'optimization': [92], 'a': [94, 102, 123], 'series': [95, 112], 'gut-restricted': [97], 'that': [100, 129], 'elicit': [101], 'potent': [103], 'response': [104], 'mice,': [106], 'minimal': [108, 126], 'gallbladder-related': [109], 'effects.': [110], 'includes': [113], '12': [114], '(TGR5': [115], 'EC50:': [116], 'human,': [117], '143': [118], 'nM;': [119], 'mouse,': [120], '1.2': [121], 'nM),': [122], 'compound': [124], 'availability': [128], 'may': [130], 'therapeutic': [132], 'value': [133], 'patients': [135], 'type': [137], '2': [138], 'diabetes': [139], 'mellitus,': [140], 'nonalcoholic': [141], 'steatohepatitis,': [142], 'or': [143], 'inflammatory': [144], 'bowel': [145]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2888330493', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-09-10T15:56:34.850005', 'created_date': '2018-08-31'}