Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2888083824', 'doi': 'https://doi.org/10.1016/j.dnarep.2018.08.012', 'title': 'APE1: A skilled nucleic acid surgeon', 'display_name': 'APE1: A skilled nucleic acid surgeon', 'publication_year': 2018, 'publication_date': '2018-11-01', 'ids': {'openalex': 'https://openalex.org/W2888083824', 'doi': 'https://doi.org/10.1016/j.dnarep.2018.08.012', 'mag': '2888083824', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30170830', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6491353'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.dnarep.2018.08.012', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3892243', 'display_name': 'DNA repair', 'issn_l': '1568-7856', 'issn': ['1568-7856', '1568-7864'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1016/j.dnarep.2018.08.012', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5084528982', 'display_name': 'Amy M. Whitaker', 'orcid': 'https://orcid.org/0000-0002-3915-1979'}, 'institutions': [{'id': 'https://openalex.org/I4210097601', 'display_name': 'The University of Kansas Cancer Center', 'ror': 'https://ror.org/00cj35179', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097601']}, {'id': 'https://openalex.org/I4210128618', 'display_name': 'University of Kansas Medical Center', 'ror': 'https://ror.org/036c9yv20', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128618']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Amy M. Whitaker', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA', 'institution_ids': ['https://openalex.org/I4210097601', 'https://openalex.org/I4210128618']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5042463108', 'display_name': 'Bret Freudenthal', 'orcid': 'https://orcid.org/0000-0003-1449-4710'}, 'institutions': [{'id': 'https://openalex.org/I4210097601', 'display_name': 'The University of Kansas Cancer Center', 'ror': 'https://ror.org/00cj35179', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097601']}, {'id': 'https://openalex.org/I4210128618', 'display_name': 'University of Kansas Medical Center', 'ror': 'https://ror.org/036c9yv20', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128618']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Bret D. Freudenthal', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA', 'institution_ids': ['https://openalex.org/I4210097601', 'https://openalex.org/I4210128618']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5042463108'], 'corresponding_institution_ids': ['https://openalex.org/I4210097601', 'https://openalex.org/I4210128618'], 'apc_list': {'value': 3770, 'currency': 'USD', 'value_usd': 3770, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.505, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 119, 'citation_normalized_percentile': {'value': 0.453167, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '71', 'issue': None, 'first_page': '93', 'last_page': '100'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10123', 'display_name': 'Molecular Mechanisms of DNA Damage Response', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10123', 'display_name': 'Molecular Mechanisms of DNA Damage Response', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11827', 'display_name': 'Polyomavirus-Associated Carcinogenesis and Clinical Manifestations', 'score': 0.9927, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10950', 'display_name': 'Epidemiology and Treatment of Childhood Leukemia', 'score': 0.9766, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ap-endonuclease', 'display_name': 'AP endonuclease', 'score': 0.75143534}, {'id': 'https://openalex.org/keywords/dna-damage', 'display_name': 'DNA Damage', 'score': 0.542337}], 'concepts': [{'id': 'https://openalex.org/C150777479', 'wikidata': 'https://www.wikidata.org/wiki/Q176783', 'display_name': 'AP site', 'level': 4, 'score': 0.9088907}, {'id': 'https://openalex.org/C187206112', 'wikidata': 'https://www.wikidata.org/wiki/Q3113091', 'display_name': 'Base excision repair', 'level': 4, 'score': 0.83517724}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.760363}, {'id': 'https://openalex.org/C1009745', 'wikidata': 'https://www.wikidata.org/wiki/Q4653506', 'display_name': 'AP endonuclease', 'level': 5, 'score': 0.75143534}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.64238644}, {'id': 'https://openalex.org/C134935766', 'wikidata': 'https://www.wikidata.org/wiki/Q210538', 'display_name': 'DNA repair', 'level': 3, 'score': 0.63746506}, {'id': 'https://openalex.org/C192396546', 'wikidata': 'https://www.wikidata.org/wiki/Q413156', 'display_name': 'DNA glycosylase', 'level': 4, 'score': 0.54171735}, {'id': 'https://openalex.org/C2777028655', 'wikidata': 'https://www.wikidata.org/wiki/Q415601', 'display_name': 'Endonuclease', 'level': 3, 'score': 0.4711655}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.45678362}, {'id': 'https://openalex.org/C104451858', 'wikidata': 'https://www.wikidata.org/wiki/Q2714458', 'display_name': 'Nucleotide excision repair', 'level': 4, 'score': 0.4515563}, {'id': 'https://openalex.org/C24107716', 'wikidata': 'https://www.wikidata.org/wiki/Q123619', 'display_name': 'Nucleic acid', 'level': 2, 'score': 0.4514585}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.4126737}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.3964435}], 'mesh': [{'descriptor_ui': 'D020134', 'descriptor_name': 'Catalytic Domain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004260', 'descriptor_name': 'DNA Repair', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D043603', 'descriptor_name': 'DNA-(Apurinic or Apyrimidinic Site) Lyase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D043603', 'descriptor_name': 'DNA-(Apurinic or Apyrimidinic Site) Lyase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013379', 'descriptor_name': 'Substrate Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.dnarep.2018.08.012', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3892243', 'display_name': 'DNA repair', 'issn_l': '1568-7856', 'issn': ['1568-7856', '1568-7864'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491353', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6491353', 'pdf_url': 'https://europepmc.org/articles/pmc6491353?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30170830', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.dnarep.2018.08.012', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3892243', 'display_name': 'DNA repair', 'issn_l': '1568-7856', 'issn': ['1568-7856', '1568-7864'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.81, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 111, 'referenced_works': ['https://openalex.org/W1482046317', 'https://openalex.org/W1485424996', 'https://openalex.org/W1912177776', 'https://openalex.org/W1927019480', 'https://openalex.org/W1964275203', 'https://openalex.org/W1968895302', 'https://openalex.org/W1969030243', 'https://openalex.org/W1969995067', 'https://openalex.org/W1972717311', 'https://openalex.org/W1973819350', 'https://openalex.org/W1976987484', 'https://openalex.org/W1977106716', 'https://openalex.org/W1981258651', 'https://openalex.org/W1984290310', 'https://openalex.org/W1986647268', 'https://openalex.org/W1987024877', 'https://openalex.org/W1987456989', 'https://openalex.org/W1992282559', 'https://openalex.org/W1995921090', 'https://openalex.org/W1996202279', 'https://openalex.org/W1996432141', 'https://openalex.org/W2001330742', 'https://openalex.org/W2003646698', 'https://openalex.org/W2004142027', 'https://openalex.org/W2010420888', 'https://openalex.org/W2010932414', 'https://openalex.org/W2011649399', 'https://openalex.org/W2012579169', 'https://openalex.org/W2014433193', 'https://openalex.org/W2017783254', 'https://openalex.org/W2022749712', 'https://openalex.org/W2026233878', 'https://openalex.org/W2032707644', 'https://openalex.org/W2035579104', 'https://openalex.org/W2035960468', 'https://openalex.org/W2037431380', 'https://openalex.org/W2037710127', 'https://openalex.org/W2038211199', 'https://openalex.org/W2040825860', 'https://openalex.org/W2041145998', 'https://openalex.org/W2042157758', 'https://openalex.org/W2042932259', 'https://openalex.org/W2044677980', 'https://openalex.org/W2044974504', 'https://openalex.org/W2047924613', 'https://openalex.org/W2052908721', 'https://openalex.org/W2055303191', 'https://openalex.org/W2055428551', 'https://openalex.org/W2061588056', 'https://openalex.org/W2064538331', 'https://openalex.org/W2068060149', 'https://openalex.org/W2071905091', 'https://openalex.org/W2072630654', 'https://openalex.org/W2074598863', 'https://openalex.org/W2075677662', 'https://openalex.org/W2076203534', 'https://openalex.org/W2080982746', 'https://openalex.org/W2082586163', 'https://openalex.org/W2082749639', 'https://openalex.org/W2082829202', 'https://openalex.org/W2083039683', 'https://openalex.org/W2083404095', 'https://openalex.org/W2089138105', 'https://openalex.org/W2091521381', 'https://openalex.org/W2097026870', 'https://openalex.org/W2097432692', 'https://openalex.org/W2097738814', 'https://openalex.org/W2100796216', 'https://openalex.org/W2100904609', 'https://openalex.org/W2101896454', 'https://openalex.org/W2102607372', 'https://openalex.org/W2105312449', 'https://openalex.org/W2105516767', 'https://openalex.org/W2106422943', 'https://openalex.org/W2107574612', 'https://openalex.org/W2108931268', 'https://openalex.org/W2112276287', 'https://openalex.org/W2112333437', 'https://openalex.org/W2114507050', 'https://openalex.org/W2116310586', 'https://openalex.org/W2116791963', 'https://openalex.org/W2117348363', 'https://openalex.org/W2120041375', 'https://openalex.org/W2120993848', 'https://openalex.org/W2125456745', 'https://openalex.org/W2131780854', 'https://openalex.org/W2134259738', 'https://openalex.org/W2142433701', 'https://openalex.org/W2143064529', 'https://openalex.org/W2148019381', 'https://openalex.org/W2148100870', 'https://openalex.org/W2149174597', 'https://openalex.org/W2273998766', 'https://openalex.org/W2318310371', 'https://openalex.org/W2321311698', 'https://openalex.org/W2480995883', 'https://openalex.org/W2568009011', 'https://openalex.org/W2585186968', 'https://openalex.org/W2588394019', 'https://openalex.org/W2605284725', 'https://openalex.org/W2608130068', 'https://openalex.org/W2609765635', 'https://openalex.org/W2621831790', 'https://openalex.org/W2738246362', 'https://openalex.org/W2757972128', 'https://openalex.org/W2767803820', 'https://openalex.org/W2789306761', 'https://openalex.org/W2789485290', 'https://openalex.org/W2792726713', 'https://openalex.org/W2802956924', 'https://openalex.org/W91996105'], 'related_works': ['https://openalex.org/W2528508621', 'https://openalex.org/W2171725228', 'https://openalex.org/W2168882862', 'https://openalex.org/W2144712334', 'https://openalex.org/W2084382787', 'https://openalex.org/W2068220611', 'https://openalex.org/W2031101499', 'https://openalex.org/W1991985168', 'https://openalex.org/W1970566518', 'https://openalex.org/W134870157'], 'abstract_inverted_index': {'Before': [0], 'a': [1, 116], 'deleterious': [2], 'DNA': [3, 27, 40, 58, 83, 112, 120], 'lesion': [4, 13], 'can': [5], 'be': [6, 16], 'replaced': [7], 'with': [8, 75, 149], 'its': [9, 57, 97, 111, 181], 'undamaged': [10], 'counterpart,': [11], 'the': [12, 19, 32, 46, 82, 86, 145], 'must': [14], 'first': [15], 'removed': [17], 'from': [18], 'genome.': [20], 'This': [21], 'process': [22], 'of': [23, 35, 119, 165], 'removing': [24], 'and': [25, 78, 109, 121, 130, 139, 159, 176], 'replacing': [26], 'lesions': [28], 'is': [29, 45, 128, 168], 'accomplished': [30], 'by': [31, 80], 'careful': [33], 'coordination': [34], 'several': [36], 'protein': [37, 99], 'factors': [38], 'during': [39, 65], 'repair.': [41], 'One': [42], 'such': [43], 'factor': [44], 'multifunctional': [47], 'enzyme': [48], 'human': [49, 155], 'apurinic/apyrimidinic': [50], 'endonuclease': [51], '1': [52], '(APE1),': [53], 'known': [54, 129], 'best': [55], 'for': [56, 93, 170], 'backbone': [59], 'cleavage': [60, 87, 113, 134], 'activity': [61, 114], 'at': [62], 'AP': [63, 72], 'sites': [64], 'base': [66], 'excision': [67], 'repair': [68, 183], '(BER).': [69], 'APE1': [70, 133, 150, 166], 'preforms': [71], 'site': [73, 88], 'incision': [74], 'surgical': [76, 107], 'precision': [77], 'skill,': [79], 'sculpting': [81], 'to': [84, 115, 153, 179], 'place': [85], 'in': [89, 144], 'an': [90], 'optimal': [91], 'position': [92], 'nucleophilic': [94], 'attack': [95], 'within': [96], 'compact': [98], 'active': [100], 'site.': [101], 'APE1,': [102], 'however,': [103], 'has': [104], 'demonstrated': [105], 'broad': [106], 'expertise,': [108], 'applies': [110], 'wide': [117], 'variety': [118], 'RNA': [122], 'substrates.': [123], 'Here,': [124], 'we': [125], 'discuss': [126], 'what': [127], 'unknown': [131], 'about': [132], 'mechanisms,': [135], 'focusing': [136], 'on': [137], 'structural': [138], 'mechanistic': [140], 'considerations.': [141], 'Importantly,': [142], 'disruptions': [143], 'biological': [146], 'functions': [147], 'associated': [148, 182], 'are': [151], 'linked': [152], 'numerous': [154], 'maladies,': [156], 'including': [157], 'cancer': [158], 'neurodegenerative': [160], 'diseases.': [161], 'The': [162], 'continued': [163], 'elucidation': [164], 'mechanisms': [167], 'required': [169], 'rational': [171], 'drug': [172], 'design': [173], 'towards': [174], 'novel': [175], 'strategic': [177], 'ways': [178], 'target': [180], 'pathways.': [184]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2888083824', 'counts_by_year': [{'year': 2024, 'cited_by_count': 18}, {'year': 2023, 'cited_by_count': 20}, {'year': 2022, 'cited_by_count': 30}, {'year': 2021, 'cited_by_count': 21}, {'year': 2020, 'cited_by_count': 26}, {'year': 2019, 'cited_by_count': 4}], 'updated_date': '2024-09-01T07:21:24.307734', 'created_date': '2018-08-31'}