Abstract 1931: Targeting master neuronal transcription factor BRN2 in neuroendocrine prostate cancer

Name: Work Video:
Duration: 3 min 30 s
Daksh Thaper; Ravi S. N. Munuganti; Shaghayegh Norouzi; Sahil Kumar; Soojin Kim; Kriti Singh; Sepideh Vahid; Jennifer L. Bishop; Amina Zoubeidi
{'id': 'https://openalex.org/W2887898086', 'doi': 'https://doi.org/10.1158/1538-7445.am2018-1931', 'title': 'Abstract 1931: Targeting master neuronal transcription factor BRN2 in neuroendocrine prostate cancer', 'display_name': 'Abstract 1931: Targeting master neuronal transcription factor BRN2 in neuroendocrine prostate cancer', 'publication_year': 2018, 'publication_date': '2018-07-01', 'ids': {'openalex': 'https://openalex.org/W2887898086', 'doi': 'https://doi.org/10.1158/1538-7445.am2018-1931', 'mag': '2887898086'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2018-1931', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5056176506', 'display_name': 'Daksh Thaper', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Daksh Thaper', 'raw_affiliation_strings': ['University of British Columbia, Vancouver, British Columbia, Canada.'], 'affiliations': [{'raw_affiliation_string': 'University of British Columbia, Vancouver, British Columbia, Canada.', 'institution_ids': ['https://openalex.org/I141945490']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055762119', 'display_name': 'Ravi S. N. Munuganti', 'orcid': 'https://orcid.org/0009-0006-5084-510X'}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Ravi Munuganti', 'raw_affiliation_strings': ['University of British Columbia, Vancouver, British Columbia, Canada.'], 'affiliations': [{'raw_affiliation_string': 'University of British Columbia, Vancouver, British Columbia, Canada.', 'institution_ids': ['https://openalex.org/I141945490']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031916236', 'display_name': 'Shaghayegh Norouzi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Shaghayegh Norouzi', 'raw_affiliation_strings': ['University of British Columbia, Vancouver, British Columbia, Canada.'], 'affiliations': [{'raw_affiliation_string': 'University of British Columbia, Vancouver, British Columbia, Canada.', 'institution_ids': ['https://openalex.org/I141945490']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049699271', 'display_name': 'Sahil Kumar', 'orcid': 'https://orcid.org/0000-0002-4868-0741'}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Sahil Kumar', 'raw_affiliation_strings': ['University of British Columbia, Vancouver, British Columbia, Canada.'], 'affiliations': [{'raw_affiliation_string': 'University of British Columbia, Vancouver, British Columbia, Canada.', 'institution_ids': ['https://openalex.org/I141945490']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100327316', 'display_name': 'Soojin Kim', 'orcid': 'https://orcid.org/0009-0008-4092-8942'}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Soojin Kim', 'raw_affiliation_strings': ['University of British Columbia, Vancouver, British Columbia, Canada.'], 'affiliations': [{'raw_affiliation_string': 'University of British Columbia, Vancouver, British Columbia, Canada.', 'institution_ids': ['https://openalex.org/I141945490']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101829947', 'display_name': 'Kriti Singh', 'orcid': 'https://orcid.org/0000-0002-7862-8952'}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Kriti Singh', 'raw_affiliation_strings': ['University of British Columbia, Vancouver, British Columbia, Canada.'], 'affiliations': [{'raw_affiliation_string': 'University of British Columbia, Vancouver, British Columbia, Canada.', 'institution_ids': ['https://openalex.org/I141945490']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055642554', 'display_name': 'Sepideh Vahid', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Sepideh Vahid', 'raw_affiliation_strings': ['University of British Columbia, Vancouver, British Columbia, Canada.'], 'affiliations': [{'raw_affiliation_string': 'University of British Columbia, Vancouver, British Columbia, Canada.', 'institution_ids': ['https://openalex.org/I141945490']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102968181', 'display_name': 'Jennifer L. Bishop', 'orcid': 'https://orcid.org/0000-0003-3676-8743'}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Jennifer Bishop', 'raw_affiliation_strings': ['University of British Columbia, Vancouver, British Columbia, Canada.'], 'affiliations': [{'raw_affiliation_string': 'University of British Columbia, Vancouver, British Columbia, Canada.', 'institution_ids': ['https://openalex.org/I141945490']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5081653545', 'display_name': 'Amina Zoubeidi', 'orcid': 'https://orcid.org/0000-0002-0498-142X'}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Amina Zoubeidi', 'raw_affiliation_strings': ['University of British Columbia, Vancouver, British Columbia, Canada.'], 'affiliations': [{'raw_affiliation_string': 'University of British Columbia, Vancouver, British Columbia, Canada.', 'institution_ids': ['https://openalex.org/I141945490']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 62}, 'biblio': {'volume': '78', 'issue': '13_Supplement', 'first_page': '1931', 'last_page': '1931'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9947, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9947, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11914', 'display_name': 'PARP inhibition in cancer therapy', 'score': 0.9503, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9482, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/enzalutamide', 'display_name': 'Enzalutamide', 'score': 0.64063275}], 'concepts': [{'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.68710697}, {'id': 'https://openalex.org/C2776551883', 'wikidata': 'https://www.wikidata.org/wiki/Q1996756', 'display_name': 'Enzalutamide', 'level': 5, 'score': 0.64063275}, {'id': 'https://openalex.org/C2777933648', 'wikidata': 'https://www.wikidata.org/wiki/Q21114866', 'display_name': 'SOX2', 'level': 4, 'score': 0.6293184}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.49851394}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.46890676}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.42935905}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.4211942}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.40296146}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.32633728}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.24764648}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.15758526}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.097889036}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2018-1931', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.44}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3122236002', 'https://openalex.org/W3023935924', 'https://openalex.org/W3005243004', 'https://openalex.org/W2931472946', 'https://openalex.org/W2773216890', 'https://openalex.org/W2681186693', 'https://openalex.org/W2593283143', 'https://openalex.org/W2479406918', 'https://openalex.org/W2180958531', 'https://openalex.org/W1984464970'], 'abstract_inverted_index': {'Abstract': [0], 'Introduction:': [1], 'Resistance': [2], 'to': [3, 66, 98, 144, 227, 253, 277], 'newly': [4], 'developed': [5], 'androgen': [6], 'receptor': [7], 'pathway': [8], 'inhibitors': [9], '(ARPIs),': [10], 'such': [11], 'as': [12, 119, 203, 205, 256], 'Enzalutamide': [13], '(ENZ),': [14], 'rapidly': [15], 'emerges': [16], 'and': [17, 46, 127, 134, 160, 170, 238, 262, 280], 'patients': [18, 29, 285], 'generally': [19], 'die': [20], 'within': [21], 'two': [22], 'years.': [23], 'In': [24], 'particular,': [25], 'a': [26, 76, 120, 141, 257], 'subset': [27], 'of': [28, 82, 107, 125, 155, 166, 193, 211, 260, 270, 282, 290, 326], 'who': [30], 'relapse': [31], 'following': [32], 'ARPI': [33], 'therapy': [34], 'exhibit': [35], 'lineage': [36], 'switching': [37], 'whereby': [38], 'tumours': [39], 'shed': [40], 'their': [41], 'dependence': [42], 'on': [43], 'AR': [44], 'signaling': [45], 'emerge': [47], 'with': [48], 'neuroendocrine': [49, 56, 146, 320], 'features.': [50], 'These': [51], 'tumours,': [52], 'termed': [53], 'treatment': [54, 68, 275], 'induced': [55], 'prostate': [57, 291, 321], 'cancer': [58, 322], '(t-NEPC),': [59], 'carry': [60], 'an': [61], 'extremely': [62], 'poor': [63], 'prognosis': [64], 'and,': [65], 'date,': [67], 'remains': [69], 'decades': [70], 'old': [71], 'cytotoxic': [72], 'chemotherapy': [73], 'which': [74], 'carries': [75], 'short-lived': [77], 'response': [78], 'at': [79], 'the': [80, 96, 114, 153, 249, 264, 268, 274, 327], 'cost': [81], 'significant': [83], 'toxicity.': [84], 'Therefore,': [85], 'targeted': [86, 100, 271], 'therapies': [87, 242, 272], 'for': [88, 102, 244, 267, 284, 330], 'this': [89, 103], 'deadly': [90, 288], 'disease': [91, 105], 'are': [92], 'desperately': [93], 'needed.': [94], 'Thus,': [95], 'need': [97], 'develop': [99], 'treatments': [101], 'devastating': [104], 'is': [106, 140], 'paramount': [108], 'importance.': [109], 'Recently': [110], 'our': [111, 217], 'group': [112], 'identified': [113], 'neural': [115], 'transcription': [116, 316], 'factor': [117, 317], 'BRN2': [118, 139, 156, 167, 194, 221, 224, 255, 318], 'major': [121], 'clinically': [122], 'relevant': [123], 'driver': [124, 259], 'NEPC': [126, 189, 200, 233], 'aggressive': [128], 'tumor': [129], 'growth,': [130], 'both': [131], 'in': [132, 135, 178, 187, 199, 206, 219, 232, 319], 'vitro': [133], 'vivo,': [136], 'suggesting': [137], 'targeting': [138], 'promising': [142], 'strategy': [143], 'prevent': [145], 'differentiation': [147], 'or': [148], 'treat': [149], 'NEPC.': [150, 247], 'Methods:': [151], 'Study': [152], 'effects': [154], 'inhibition': [157], 'using': [158, 216], 'siRNA': [159, 169], 'CRISPR': [161], 'K/O': [162], 'models.': [163], 'Results:': [164], 'Inhibition': [165], 'by': [168, 171], 'CRISPR/Cas9': [172], 'knockout': [173], 'drastically': [174], 'reduced': [175], 'cell': [176, 181, 201], 'proliferation': [177], '42DENZR': [179], '(NEPC)': [180], 'lines.': [182], 'This': [183, 213], 'data': [184], 'was': [185, 214], 're-capitulated': [186], 'human': [188], 'NCI-H660': [190], 'cells.': [191], 'Loss': [192], 'initiated': [195], 'drastic': [196], 'epigenetic': [197], 'changes': [198], 'lines': [202], 'well': [204], 'G1': [207], 'arrest': [208], 'through': [209], 'up-regulation': [210], 'CDKN1A/1B.': [212], 'confirmed': [215], 'first': [218], 'field': [220], 'inhibitors.': [222], 'Targeting': [223, 313], 'also': [225], 'lead': [226], 'downregulation': [228], 'several': [229], 'known': [230], 'targets': [231], 'like': [234], 'EZH2,': [235], 'AURKA,': [236], 'SOX2': [237], 'Peg10.': [239], 'Conclusion:': [240], 'No': [241], 'exist': [243], 'highly': [245], 'lethal': [246], 'Hence,': [248], 'described': [250], 'work': [251], 'aims': [252], 'verify': [254], 'central': [258], 'NEPC,': [261], 'lay': [263], 'pre-clinical': [265], 'foundation': [266], 'integration': [269], 'into': [273], 'landscape': [276], 'improve': [278], 'survival': [279], 'quality': [281], 'life': [283], 'suffering': [286], 'from': [287], 'form': [289], 'cancer.': [292], 'Citation': [293], 'Format:': [294], 'Daksh': [295], 'Thaper,': [296], 'Ravi': [297], 'Munuganti,': [298], 'Shaghayegh': [299], 'Norouzi,': [300], 'Sahil': [301], 'Kumar,': [302], 'Soojin': [303], 'Kim,': [304], 'Kriti': [305], 'Singh,': [306], 'Sepideh': [307], 'Vahid,': [308], 'Jennifer': [309], 'Bishop,': [310], 'Amina': [311], 'Zoubeidi.': [312], 'master': [314], 'neuronal': [315], '[abstract].': [323], 'In:': [324], 'Proceedings': [325], 'American': [328], 'Association': [329], 'Cancer': [331, 344], 'Research': [332], 'Annual': [333], 'Meeting': [334], '2018;': [335], '2018': [336], 'Apr': [337], '14-18;': [338], 'Chicago,': [339], 'IL.': [340], 'Philadelphia': [341], '(PA):': [342], 'AACR;': [343], 'Res': [345], '2018;78(13': [346], 'Suppl):Abstract': [347], 'nr': [348], '1931.': [349]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2887898086', 'counts_by_year': [], 'updated_date': '2024-12-12T01:03:09.579389', 'created_date': '2018-08-22'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
