Title: Image-Guided Method in the Rat for Inducing Cortical or Striatal Infarction and for Controlling Cerebral Blood Flow Under MRI
Abstract: Background and Purpose—Experimental models are essential for research on ischemic stroke, the second most common cause of death worldwide. The failure of clinical trials on neuroprotective treatment may be due in part to poor animal models. To push the translation of new therapies, we describe a new rat model that captures key elements of human brain ischemia. The model includes imaging and neurointerventional tools that represent the near future of clinical diagnosis and treatment of stroke. Methods—Using Sprague-Dawley rats (n=26), we navigated a microwire with fluoroscopy and MRI guidance from the ventral tail artery to 2 different positions in the middle cerebral artery to establish local occlusion. Animals were scanned with 9.4-T MRI before occlusion, during ischemia, and after reperfusion. Results—We detected stroke lesions, corresponding to the level of occlusion, in all animals by diffusion-weighted and T2 images. We measured lesion volume (mm3±SD) on T2 scans at 24 hours to be 23.2±29.8 in the so...
Publication Year: 2012
Publication Date: 2012-09-01
Language: en
Type: article
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