Title: Abstract 553: p53 target BRMS1A is a metastatic suppressor
Abstract: Abstract Tumor suppressor p53 plays an important role in the cell fate determination in response to diverse upstream signals. As a transcription factor, p53 regulates a number of genes that are involved in cell-cycle arrest, apoptosis, senescence, and maintenance of genomic stability. Recent studies revealed that p53 is critical for the regulation of cell invasion and migration. Microarray analysis showed that breast cancer metastasis-suppressor 1-like (BRMS1L) is upregulated by p53. We identified two responsive sequences of p53 in the first intron and upstream of the BRMS1L gene. These two response elements are well conserved among mammals. Functional analysis showed that ectopic expression of BRMS1L inhibited cancer cell invasion and migration. In contrast, knockdown of BRMS1L by siRNA induced the opposite effect. Notably, clinical databases revealed that reduced BRMS1L expression correlated with poor prognosis in patients with breast and brain cancer. Altogether, these results strongly indicate that BRMS1L is one of the mediators downstream of the p53 pathway, and inhibits cancer cell invasion and migration, which are essential steps in cancer metastasis. Collectively, our results demonstrate that BRMS1L is involved in cancer cell invasion and migration, and may be a therapeutic target for cancer. Citation Format: Takashi Tokino, Ryota Koyama, Masashi Idogawa, Yasushi Sasaki. p53 target BRMS1A is a metastatic suppressor [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 553.
Publication Year: 2018
Publication Date: 2018-07-01
Language: en
Type: article
Indexed In: ['crossref']
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot