Publication Information

{'id': 'https://openalex.org/W2886878286', 'doi': 'https://doi.org/10.1089/hum.2018.106', 'title': 'Combinatorial<i>Prg4</i>and<i>Il-1ra</i>Gene Therapy Protects Against Hyperalgesia and Cartilage Degeneration in Post-Traumatic Osteoarthritis', 'display_name': 'Combinatorial<i>Prg4</i>and<i>Il-1ra</i>Gene Therapy Protects Against Hyperalgesia and Cartilage Degeneration in Post-Traumatic Osteoarthritis', 'publication_year': 2018, 'publication_date': '2018-08-02', 'ids': {'openalex': 'https://openalex.org/W2886878286', 'doi': 'https://doi.org/10.1089/hum.2018.106', 'mag': '2886878286', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30070147', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6383580'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1089/hum.2018.106', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S39730559', 'display_name': 'Human Gene Therapy', 'issn_l': '1043-0342', 'issn': ['1043-0342', '1557-7422'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320443', 'host_organization_name': 'Mary Ann Liebert, Inc.', 'host_organization_lineage': ['https://openalex.org/P4310320443'], 'host_organization_lineage_names': ['Mary Ann Liebert, Inc.'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc6383580?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5005386846', 'display_name': 'Adrianne Stone', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Adrianne Stone', 'raw_affiliation_strings': ['Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.', 'Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, Texas.'], 'affiliations': [{'raw_affiliation_string': 'Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, Texas.', 'institution_ids': ['https://openalex.org/I181547552']}, {'raw_affiliation_string': 'Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076988359', 'display_name': 'Matthew W. Grol', 'orcid': 'https://orcid.org/0000-0001-6514-9066'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Matthew W. Grol', 'raw_affiliation_strings': ['Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112881428', 'display_name': 'Merry Z. C. Ruan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Merry Z. C. Ruan', 'raw_affiliation_strings': ['Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113571744', 'display_name': 'Brian Dawson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Brian Dawson', 'raw_affiliation_strings': ['Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100454914', 'display_name': 'Yuqing Chen', 'orcid': 'https://orcid.org/0000-0002-5243-5116'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yuqing Chen', 'raw_affiliation_strings': ['Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101602391', 'display_name': 'Ming‐Ming Jiang', 'orcid': 'https://orcid.org/0000-0002-7727-5294'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ming-Ming Jiang', 'raw_affiliation_strings': ['Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063223059', 'display_name': 'I-Wen Song', 'orcid': 'https://orcid.org/0000-0003-1579-4328'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'I-wen Song', 'raw_affiliation_strings': ['Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002682191', 'display_name': 'Prathap Jayaram', 'orcid': 'https://orcid.org/0000-0001-6209-5410'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}, {'id': 'https://openalex.org/I2799301129', 'display_name': 'Ben Taub Hospital', 'ror': 'https://ror.org/042ze4p12', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799301129', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Prathap Jayaram', 'raw_affiliation_strings': ['Department of Orthopedic Surgery, Baylor College of Medicine, Houston, Texas.', 'H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas.'], 'affiliations': [{'raw_affiliation_string': 'H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas.', 'institution_ids': ['https://openalex.org/I181547552', 'https://openalex.org/I2799301129']}, {'raw_affiliation_string': 'Department of Orthopedic Surgery, Baylor College of Medicine, Houston, Texas.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014700042', 'display_name': 'Racel Cela', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Racel Cela', 'raw_affiliation_strings': ['Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051587177', 'display_name': 'Francis H. Gannon', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Francis Gannon', 'raw_affiliation_strings': ['Department of Pathology, Baylor College of Medicine, Houston, Texas.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, Baylor College of Medicine, Houston, Texas.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5032364421', 'display_name': 'Brendan H. L. Lee', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Brendan H. L. Lee', 'raw_affiliation_strings': ['Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.', 'institution_ids': ['https://openalex.org/I181547552']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5032364421'], 'corresponding_institution_ids': ['https://openalex.org/I181547552'], 'apc_list': None, 'apc_paid': None, 'fwci': 5.648, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 37, 'citation_normalized_percentile': {'value': 0.880488, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '30', 'issue': '2', 'first_page': '225', 'last_page': '235'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10105', 'display_name': 'Osteoarthritis Treatment and Mechanisms', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10105', 'display_name': 'Osteoarthritis Treatment and Mechanisms', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10442', 'display_name': 'Knee injuries and reconstruction techniques', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11068', 'display_name': 'Tendon Structure and Treatment', 'score': 0.9647, 'subfield': {'id': 'https://openalex.org/subfields/2732', 'display_name': 'Orthopedics and Sports Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2776164576', 'wikidata': 'https://www.wikidata.org/wiki/Q62736', 'display_name': 'Osteoarthritis', 'level': 3, 'score': 0.7725651}, {'id': 'https://openalex.org/C2779244835', 'wikidata': 'https://www.wikidata.org/wiki/Q538432', 'display_name': 'Synovitis', 'level': 3, 'score': 0.71613175}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6826258}, {'id': 'https://openalex.org/C2780550940', 'wikidata': 'https://www.wikidata.org/wiki/Q502730', 'display_name': 'Cartilage', 'level': 2, 'score': 0.6660105}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.5383704}, {'id': 'https://openalex.org/C111599444', 'wikidata': 'https://www.wikidata.org/wiki/Q213901', 'display_name': 'Genetic enhancement', 'level': 3, 'score': 0.51783544}, {'id': 'https://openalex.org/C2778122271', 'wikidata': 'https://www.wikidata.org/wiki/Q410943', 'display_name': 'Receptor antagonist', 'level': 4, 'score': 0.42521617}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.4200159}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.32884383}, {'id': 'https://openalex.org/C2777077863', 'wikidata': 'https://www.wikidata.org/wiki/Q170990', 'display_name': 'Arthritis', 'level': 2, 'score': 0.3035104}, {'id': 'https://openalex.org/C2776885963', 'wikidata': 'https://www.wikidata.org/wiki/Q245204', 'display_name': 'Antagonist', 'level': 3, 'score': 0.29673648}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.28182447}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.25861424}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.25125927}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.15335569}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.14958581}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.079538465}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000256', 'descriptor_name': 'Adenoviridae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D002358', 'descriptor_name': 'Cartilage, Articular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015316', 'descriptor_name': 'Genetic Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D006930', 'descriptor_name': 'Hyperalgesia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D053590', 'descriptor_name': 'Interleukin 1 Receptor Antagonist Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D010003', 'descriptor_name': 'Osteoarthritis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011509', 'descriptor_name': 'Proteoglycans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D014161', 'descriptor_name': 'Transduction, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D014947', 'descriptor_name': 'Wounds and Injuries', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002358', 'descriptor_name': 'Cartilage, Articular', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002358', 'descriptor_name': 'Cartilage, Articular', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006930', 'descriptor_name': 'Hyperalgesia', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D006930', 'descriptor_name': 'Hyperalgesia', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D006930', 'descriptor_name': 'Hyperalgesia', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D006930', 'descriptor_name': 'Hyperalgesia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D053590', 'descriptor_name': 'Interleukin 1 Receptor Antagonist Protein', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D053590', 'descriptor_name': 'Interleukin 1 Receptor Antagonist Protein', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010003', 'descriptor_name': 'Osteoarthritis', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010003', 'descriptor_name': 'Osteoarthritis', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D010003', 'descriptor_name': 'Osteoarthritis', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D010003', 'descriptor_name': 'Osteoarthritis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011509', 'descriptor_name': 'Proteoglycans', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D011509', 'descriptor_name': 'Proteoglycans', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014947', 'descriptor_name': 'Wounds and Injuries', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D014947', 'descriptor_name': 'Wounds and Injuries', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': False}, {'descriptor_ui': 'D014947', 'descriptor_name': 'Wounds and Injuries', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014947', 'descriptor_name': 'Wounds and Injuries', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1089/hum.2018.106', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S39730559', 'display_name': 'Human Gene Therapy', 'issn_l': '1043-0342', 'issn': ['1043-0342', '1557-7422'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320443', 'host_organization_name': 'Mary Ann Liebert, Inc.', 'host_organization_lineage': ['https://openalex.org/P4310320443'], 'host_organization_lineage_names': ['Mary Ann Liebert, Inc.'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6383580', 'pdf_url': 'https://europepmc.org/articles/pmc6383580?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383580', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30070147', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6383580', 'pdf_url': 'https://europepmc.org/articles/pmc6383580?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.59}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1630924615', 'https://openalex.org/W1970446320', 'https://openalex.org/W1991120653', 'https://openalex.org/W1993523958', 'https://openalex.org/W1997140718', 'https://openalex.org/W1997957358', 'https://openalex.org/W2002251686', 'https://openalex.org/W2007276010', 'https://openalex.org/W2029958443', 'https://openalex.org/W2030919384', 'https://openalex.org/W2036491373', 'https://openalex.org/W2043834774', 'https://openalex.org/W2053675513', 'https://openalex.org/W2071718640', 'https://openalex.org/W2135245708', 'https://openalex.org/W2138236384', 'https://openalex.org/W2190830971', 'https://openalex.org/W2254426509', 'https://openalex.org/W2317482733', 'https://openalex.org/W2401549699', 'https://openalex.org/W2412034636', 'https://openalex.org/W2518546450', 'https://openalex.org/W2522694580', 'https://openalex.org/W2556140578', 'https://openalex.org/W2574647359', 'https://openalex.org/W2581708220', 'https://openalex.org/W2600452401', 'https://openalex.org/W2613643891', 'https://openalex.org/W2620096814', 'https://openalex.org/W2739254590', 'https://openalex.org/W2767895838', 'https://openalex.org/W2767910004', 'https://openalex.org/W2769872480', 'https://openalex.org/W2772784997', 'https://openalex.org/W2795628111', 'https://openalex.org/W2807060002', 'https://openalex.org/W2883911404', 'https://openalex.org/W3098397065'], 'related_works': ['https://openalex.org/W4206812040', 'https://openalex.org/W3136752781', 'https://openalex.org/W2615559484', 'https://openalex.org/W2587903787', 'https://openalex.org/W2585204074', 'https://openalex.org/W2167795966', 'https://openalex.org/W2165599181', 'https://openalex.org/W2159158172', 'https://openalex.org/W2136143944', 'https://openalex.org/W2122523475'], 'abstract_inverted_index': {'Osteoarthritis': [0], '(OA)': [1], 'is': [2, 192], 'a': [3, 63, 189], 'degenerative': [4], 'disease': [5], 'of': [6, 13, 46, 57, 86, 110, 132, 147, 157, 199], 'synovial': [7], 'joints': [8], 'characterized': [9], 'by': [10, 130], 'progressive': [11], 'loss': [12], 'articular': [14, 119, 133], 'cartilage,': [15], 'subchondral': [16], 'bone': [17], 'remodeling,': [18], 'and': [19, 29, 35, 48, 101, 116, 136, 149, 160], 'intra-articular': [20], 'inflammation': [21, 71], 'with': [22, 72, 144, 154], 'synovitis': [23], 'that': [24, 62, 107, 188], 'results': [25, 186], 'in': [26, 125, 167], 'chronic': [27], 'pain': [28], 'motor': [30], 'impairment.': [31], 'Despite': [32], 'the': [33, 55, 87], 'economic': [34], 'health': [36], 'impacts,': [37], 'current': [38], 'medical': [39], 'therapies': [40], 'are': [41], 'targeted': [42], 'at': [43], 'symptomatic': [44], 'relief': [45], 'OA': [47, 58], 'fail': [49], 'to': [50, 69, 90, 97, 165, 180, 194], 'alter': [51], 'its': [52], 'progression.': [53], 'Given': [54], 'complexity': [56], 'pathogenesis,': [59], 'we': [60, 105], 'hypothesized': [61], 'combinatorial': [64, 171, 190], 'gene': [65, 172], 'therapy': [66, 173], 'approach,': [67], 'designed': [68], 'inhibit': [70], 'interleukin-1': [73], 'receptor': [74], 'antagonist': [75], '(IL-1Ra)': [76], 'while': [77], 'promoting': [78], 'chondroprotection': [79], 'using': [80], 'lubricin': [81], '(PRG4),': [82], 'would': [83], 'improve': [84], 'preservation': [85, 131], 'joint': [88, 168], 'compared': [89, 179], 'monotherapy': [91, 124], 'alone.': [92], 'Employing': [93], 'two': [94], 'surgical': [95], 'techniques': [96], 'model': [98], 'mild,': [99], 'moderate': [100], 'severe': [102], 'posttraumatic': [103, 200], 'OA,': [104], 'found': [106], 'combined': [108], 'delivery': [109], 'helper-dependent': [111], 'adenoviruses': [112], '(HDVs),': [113], 'expressing': [114], 'IL-1Ra': [115], 'PRG4,': [117], 'preserved': [118], 'cartilage': [120, 134, 150], 'better': [121], 'than': [122], 'either': [123, 181], 'both': [126], 'models': [127], 'as': [128], 'demonstrated': [129], 'volume': [135], 'surface': [137], 'area.': [138], 'This': [139], 'improved': [140], 'protection': [141, 175], 'was': [142], 'associated': [143], 'increased': [145], 'expression': [146, 156], 'proanabolic': [148], 'matrix': [151], 'genes': [152, 159], 'together': [153], 'decreased': [155], 'catabolic': [158], 'inflammatory': [161], 'mediators.': [162], 'In': [163], 'addition': [164], 'improvements': [166], 'tissues,': [169], 'this': [170], 'prolonged': [174], 'against': [176], 'thermal': [177], 'hyperalgesia': [178], 'monotherapy.': [182], 'Taken': [183], 'together,': [184], 'our': [185], 'show': [187], 'strategy': [191], 'superior': [193], 'monotherapeutic': [195], 'approaches': [196], 'for': [197], 'treatment': [198], 'OA.': [201]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2886878286', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 2}], 'updated_date': '2024-12-12T09:32:29.714166', 'created_date': '2018-08-22'}