Title: A General Approach to Site‐Specific, Intramolecular C−H Functionalization Using Dithiocarbamates
Abstract: Angewandte Chemie International EditionVolume 57, Issue 40 p. 13106-13109 Communication A General Approach to Site-Specific, Intramolecular C−H Functionalization Using Dithiocarbamates Correction(s) for this article Corrigendum: A General Approach to Site-Specific, Intramolecular C−H Functionalization Using Dithiocarbamates Christina G. Na, Erik J. Alexanian, Volume 60Issue 2Angewandte Chemie International Edition pages: 535-535 First Published online: January 4, 2021 Christina G. Na, Christina G. Na Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599 USASearch for more papers by this authorProf. Erik J. Alexanian, Corresponding Author Prof. Erik J. Alexanian [email protected] orcid.org/0000-0002-0256-2133 Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599 USASearch for more papers by this author Christina G. Na, Christina G. Na Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599 USASearch for more papers by this authorProf. Erik J. Alexanian, Corresponding Author Prof. Erik J. Alexanian [email protected] orcid.org/0000-0002-0256-2133 Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599 USASearch for more papers by this author First published: 07 August 2018 https://doi.org/10.1002/anie.201806963Citations: 45Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Smart up your HAT: A site-specific C−H functionalization is presented that significantly increases the synthetic scope and convergency of reactions proceeding via intramolecular hydrogen atom transfer. Stable, isolable dithiocarbamates are used as precursors to amidyl radicals formed via either light or radical initiation to efficiently deliver highly versatile alkyl dithiocarbamates across a wide range of complex structures. Abstract Intramolecular hydrogen atom transfer is an established approach for the site-specific functionalization of unactivated, aliphatic C−H bonds. Transformations using this strategy typically require unstable intermediates formed using strong oxidants and have mainly targeted C−H halogenations or intramolecular aminations. Herein, we report a site-specific C−H functionalization that significantly increases the synthetic scope and convergency of reactions proceeding via intramolecular hydrogen atom transfer. Stable, isolable N-dithiocarbamates are used as precursors to amidyl radicals formed via either light or radical initiation to efficiently deliver highly versatile alkyl dithiocarbamates across a wide range of complex structures. Citing Literature Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description anie201806963-sup-0001-misc_information.pdf8.8 MB Supplementary Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume57, Issue40October 1, 2018Pages 13106-13109 RelatedInformation