Title: Familial Aggregation of Hypospadias in South Indian Population
Abstract: Introduction: Hypospadias is one of the most common birth
defects in male. However, its etiology remains largely
unknown. Several authors have investigated the
contribution of genetic and environmental factors to familial
aggregation of hypospadias. We retrospectively analyzed
our hospital data for boys who were operated for
hypospadias at our center and had relatives with
hypospadias.
Materials and Methods: We retrospectively reviewed the
records of 234 children ( 18 yrs.) admitted for surgical
correction of hypospadias at the department of pediatric
urology in a single tertiary care centre of South India, from
Jan 2007 to Dec 2017.
Results: During the 10 year study period a total of 234
children (≤18 yrs.) were operated for hypospadias. Twenty
one (9%) children reported on additional members of the
family having hypospadias.
Conclusions: Nine percent of the children operated for
hypospadias reported on additional members of the family
having hypospadias. These findings underline the heavy
influence of genetic factors on hypospadias development.
Genetic factors could be responsible for a certain
percentage of cases of hypospadias.
Publication Year: 2018
Publication Date: 2018-01-01
Language: en
Type: article
Access and Citation
Cited By Count: 1
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot