Publication Information

{'id': 'https://openalex.org/W2886446260', 'doi': 'https://doi.org/10.53846/goediss-4712', 'title': 'Feinkartierung humoraler Immunantworten von Makaken nach Immunisierung und/oder viraler Infektion mittels Peptid - Microarray', 'display_name': 'Feinkartierung humoraler Immunantworten von Makaken nach Immunisierung und/oder viraler Infektion mittels Peptid - Microarray', 'publication_year': 2014, 'publication_date': '2014-01-01', 'ids': {'openalex': 'https://openalex.org/W2886446260', 'doi': 'https://doi.org/10.53846/goediss-4712', 'mag': '2886446260'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.53846/goediss-4712', 'pdf_url': 'https://ediss.uni-goettingen.de/bitstream/11858/00-1735-0000-0023-98F2-2/1/Dissertation.pdf', 'source': None, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'dissertation', 'type_crossref': 'dissertation', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://ediss.uni-goettingen.de/bitstream/11858/00-1735-0000-0023-98F2-2/1/Dissertation.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5001550341', 'display_name': 'Sven‐Kevin Hotop', 'orcid': 'https://orcid.org/0000-0002-3394-0432'}, 'institutions': [{'id': 'https://openalex.org/I74656192', 'display_name': 'University of Göttingen', 'ror': 'https://ror.org/01y9bpm73', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I74656192']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Sven-Kevin Hotop', 'raw_affiliation_strings': ['der Georg-August-Universität Göttingen im Grundprogramm Biologie der Georg-August University School of Science (GAUSS)'], 'affiliations': [{'raw_affiliation_string': 'der Georg-August-Universität Göttingen im Grundprogramm Biologie der Georg-August University School of Science (GAUSS)', 'institution_ids': ['https://openalex.org/I74656192']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5001550341'], 'corresponding_institution_ids': ['https://openalex.org/I74656192'], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.92, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 66, 'max': 73}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10112', 'display_name': 'HIV Research and Treatment', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2406', 'display_name': 'Virology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10112', 'display_name': 'HIV Research and Treatment', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2406', 'display_name': 'Virology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10580', 'display_name': 'Immunotherapy and Immune Responses', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/polyclonal-antibodies', 'display_name': 'Polyclonal antibodies', 'score': 0.692536}, {'id': 'https://openalex.org/keywords/simian-immunodeficiency-virus', 'display_name': 'Simian immunodeficiency virus', 'score': 0.5462132}, {'id': 'https://openalex.org/keywords/protein-array-analysis', 'display_name': 'Protein Array Analysis', 'score': 0.4669415}], 'concepts': [{'id': 'https://openalex.org/C956191', 'wikidata': 'https://www.wikidata.org/wiki/Q930144', 'display_name': 'Polyclonal antibodies', 'level': 3, 'score': 0.692536}, {'id': 'https://openalex.org/C195616568', 'wikidata': 'https://www.wikidata.org/wiki/Q128711', 'display_name': 'Epitope', 'level': 3, 'score': 0.62551963}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.5784312}, {'id': 'https://openalex.org/C2780868878', 'wikidata': 'https://www.wikidata.org/wiki/Q1660197', 'display_name': 'Immunogenicity', 'level': 3, 'score': 0.55935234}, {'id': 'https://openalex.org/C2777995582', 'wikidata': 'https://www.wikidata.org/wiki/Q1890246', 'display_name': 'Simian immunodeficiency virus', 'level': 3, 'score': 0.5462132}, {'id': 'https://openalex.org/C186836561', 'wikidata': 'https://www.wikidata.org/wiki/Q1931516', 'display_name': 'Microarray', 'level': 4, 'score': 0.52669865}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4985428}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.4764995}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.46809295}, {'id': 'https://openalex.org/C2910703447', 'wikidata': 'https://www.wikidata.org/wiki/Q494918', 'display_name': 'Protein Array Analysis', 'level': 5, 'score': 0.4669415}, {'id': 'https://openalex.org/C147483822', 'wikidata': 'https://www.wikidata.org/wiki/Q103537', 'display_name': 'Antigen', 'level': 2, 'score': 0.46561766}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.38018057}, {'id': 'https://openalex.org/C95371953', 'wikidata': 'https://www.wikidata.org/wiki/Q591745', 'display_name': 'DNA microarray', 'level': 4, 'score': 0.3460642}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.30936164}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.29437304}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.11699888}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.11557078}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.10718131}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.53846/goediss-4712', 'pdf_url': 'https://ediss.uni-goettingen.de/bitstream/11858/00-1735-0000-0023-98F2-2/1/Dissertation.pdf', 'source': None, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.53846/goediss-4712', 'pdf_url': 'https://ediss.uni-goettingen.de/bitstream/11858/00-1735-0000-0023-98F2-2/1/Dissertation.pdf', 'source': None, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.64}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 119, 'referenced_works': ['https://openalex.org/W151528296', 'https://openalex.org/W1518023932', 'https://openalex.org/W1525912444', 'https://openalex.org/W1544923801', 'https://openalex.org/W1572252257', 'https://openalex.org/W1594936269', 'https://openalex.org/W1884766802', 'https://openalex.org/W1889322612', 'https://openalex.org/W1895800559', 'https://openalex.org/W1918211917', 'https://openalex.org/W1964048941', 'https://openalex.org/W1966343819', 'https://openalex.org/W1968273438', 'https://openalex.org/W1972341594', 'https://openalex.org/W1973001577', 'https://openalex.org/W1976969442', 'https://openalex.org/W1977282539', 'https://openalex.org/W1978599968', 'https://openalex.org/W1984511583', 'https://openalex.org/W1987888541', 'https://openalex.org/W1988778940', 'https://openalex.org/W1991670386', 'https://openalex.org/W1992007798', 'https://openalex.org/W1994285477', 'https://openalex.org/W1994697309', 'https://openalex.org/W1994744932', 'https://openalex.org/W1997365637', 'https://openalex.org/W1998488424', 'https://openalex.org/W1999361194', 'https://openalex.org/W2005284010', 'https://openalex.org/W2006975604', 'https://openalex.org/W2009929706', 'https://openalex.org/W2010161902', 'https://openalex.org/W2010458160', 'https://openalex.org/W2010959676', 'https://openalex.org/W2017635869', 'https://openalex.org/W2017757915', 'https://openalex.org/W2020969008', 'https://openalex.org/W2021885135', 'https://openalex.org/W2022257442', 'https://openalex.org/W2023434411', 'https://openalex.org/W2025005245', 'https://openalex.org/W2027458871', 'https://openalex.org/W2031365470', 'https://openalex.org/W2031501484', 'https://openalex.org/W2032682068', 'https://openalex.org/W2034136192', 'https://openalex.org/W2036019172', 'https://openalex.org/W2037346443', 'https://openalex.org/W2038200783', 'https://openalex.org/W2040313539', 'https://openalex.org/W2042064054', 'https://openalex.org/W2046445910', 'https://openalex.org/W2046892423', 'https://openalex.org/W2048255133', 'https://openalex.org/W2052300349', 'https://openalex.org/W2057935758', 'https://openalex.org/W2058368107', 'https://openalex.org/W2069508712', 'https://openalex.org/W2072553081', 'https://openalex.org/W2075078512', 'https://openalex.org/W2078211589', 'https://openalex.org/W2078225503', 'https://openalex.org/W2080312964', 'https://openalex.org/W2084176286', 'https://openalex.org/W2086703018', 'https://openalex.org/W2094158458', 'https://openalex.org/W2094930358', 'https://openalex.org/W2098781795', 'https://openalex.org/W2099182602', 'https://openalex.org/W2099540110', 'https://openalex.org/W2103735815', 'https://openalex.org/W2106957331', 'https://openalex.org/W2110529853', 'https://openalex.org/W2110917275', 'https://openalex.org/W2112491289', 'https://openalex.org/W2114651598', 'https://openalex.org/W2121498145', 'https://openalex.org/W2122851743', 'https://openalex.org/W2123089636', 'https://openalex.org/W2125468869', 'https://openalex.org/W2130031722', 'https://openalex.org/W2131317050', 'https://openalex.org/W2133160469', 'https://openalex.org/W2133449490', 'https://openalex.org/W2134578475', 'https://openalex.org/W2136836618', 'https://openalex.org/W2145033973', 'https://openalex.org/W2148467176', 'https://openalex.org/W2151310245', 'https://openalex.org/W2154933215', 'https://openalex.org/W2154963941', 'https://openalex.org/W2155779547', 'https://openalex.org/W2156896172', 'https://openalex.org/W2160330684', 'https://openalex.org/W2162955890', 'https://openalex.org/W2164701456', 'https://openalex.org/W2165197737', 'https://openalex.org/W2167863101', 'https://openalex.org/W2169344740', 'https://openalex.org/W2170547465', 'https://openalex.org/W2280394928', 'https://openalex.org/W2316646354', 'https://openalex.org/W2318375356', 'https://openalex.org/W2410218563', 'https://openalex.org/W2724708725', 'https://openalex.org/W2908910668', 'https://openalex.org/W3177210961', 'https://openalex.org/W376488881', 'https://openalex.org/W4211264160', 'https://openalex.org/W4230567441', 'https://openalex.org/W4230869930', 'https://openalex.org/W4243467589', 'https://openalex.org/W4246686612', 'https://openalex.org/W4250265195', 'https://openalex.org/W4252218374', 'https://openalex.org/W86423223', 'https://openalex.org/W88883664', 'https://openalex.org/W96423581'], 'related_works': ['https://openalex.org/W4233699124', 'https://openalex.org/W4232333928', 'https://openalex.org/W3203113381', 'https://openalex.org/W2415545834', 'https://openalex.org/W2366558827', 'https://openalex.org/W2153399204', 'https://openalex.org/W2041540252', 'https://openalex.org/W170658859', 'https://openalex.org/W1594655861', 'https://openalex.org/W1547158732'], 'abstract_inverted_index': {'The': [0, 177, 295, 322, 350, 513, 574, 598, 626, 685], 'aim': [1], 'of': [2, 40, 46, 79, 91, 105, 118, 127, 171, 196, 233, 267, 276, 279, 293, 297, 304, 313, 320, 325, 333, 373, 393, 481, 493, 507, 517, 544, 563, 567, 572, 577, 600, 607, 644, 660, 669, 692, 696, 709, 719, 744], 'this': [3, 326, 356, 446, 472, 526, 630, 679], 'study': [4], 'was': [5, 26, 58, 140, 217, 428, 500, 533, 556], 'to': [6, 65, 75, 93, 115, 142, 210, 255, 432, 496, 535, 558, 683, 689, 722, 738, 747], 'map': [7], 'humoral': [8], 'immune': [9], 'responses': [10], 'in': [11, 223, 239, 300, 317, 424, 489, 569, 604, 629], 'rhesus': [12], 'macaques': [13, 471], '(RM)': [14], 'which': [15, 60, 205, 364, 427, 698], 'had': [16, 186], 'either': [17], 'been': [18, 187, 367], 'immunized': [19], 'and/or': [20], 'infected': [21, 307, 380], 'with': [22, 124, 288, 308, 369, 382, 470, 624], 'different': [23, 190], 'viruses.': [24], 'This': [25, 219, 554], 'achieved': [27], 'by': [28, 503, 510], 'screening': [29, 643, 668, 701], 'serum': [30, 80, 101, 179], 'samples': [31, 95, 102, 180, 303], 'using': [32, 153], 'peptide': [33, 67, 155, 384, 634, 676], 'microarrays.': [34], 'Further': [35], 'goals': [36], 'were': [37, 84, 161, 182, 258, 269, 422, 552], 'the': [38, 41, 44, 47, 52, 103, 116, 119, 132, 150, 154, 164, 172, 197, 224, 229, 240, 264, 280, 289, 311, 318, 334, 346, 389, 394, 419, 450, 476, 479, 490, 505, 528, 536, 542, 548, 560, 564, 601, 622, 653, 658, 667, 690, 710, 728], 'optimization': [39], 'analysis': [42, 185, 576], 'and': [43, 70, 252, 398, 401, 407, 467, 499, 509, 638], 'minimization': [45], 'required': [48], 'sample': [49], 'volumes.': [50], 'For': [51], 'readout,': [53], 'an': [54, 62, 125, 305, 425, 461], 'independent': [55], 'computer-assisted': [56], 'algorithm': [57], 'formulated': [59], 'provided': [61], 'objective': [63], 'method': [64, 712], 'optimize': [66], 'microarray': [68, 156, 385, 550], 'production': [69], 'data': [71, 353, 551], 'mining.': [72], 'In': [73, 99, 152, 194, 525, 717], 'order': [74], 'screen': [76], 'large': [77], 'numbers': [78], 'samples,': [81], 'new': [82, 273, 405, 694], 'tools': [83, 640], 'developed': [85], 'that': [86, 145, 181, 355, 584, 615, 633], 'allowed': [87], 'a': [88, 211, 272, 330, 342, 361, 383, 436, 482, 545, 580, 618, 693, 706], 'safe': [89], 'handling': [90], 'up': [92], 'four': [94], 'per': [96], 'slide': [97], 'simultaneously.': [98], 'polyclonal': [100], 'length': [104], 'closely': [106], 'related': [107], 'epitopes': [108, 246, 671], 'could': [109, 448, 474], 'not': [110, 208, 366], 'be': [111, 221, 497], 'determined': [112], 'precisely': [113], 'due': [114, 431], 'design': [117], 'array,': [120], 'i.e.': [121], 'tiled': [122], 'peptides': [123, 387, 650, 735, 752], 'offset': [126], 'three': [128], 'amino': [129, 290, 314, 390, 539], 'acids.': [130, 540], 'Thus,': [131], 'more': [133, 587], 'fitting': [134], 'term': [135], '“antibody': [136], 'target': [137], 'region”': [138], '(ATR)': [139], 'given': [141], 'describe': [143], 'antibodies': [144, 227, 261, 285, 414, 720], 'recognize': [146], 'such': [147, 726, 740], 'regions': [148], 'on': [149, 163, 329, 418, 455], 'antigen.': [151], 'technology,': [157], '27': [158], 'distinct': [159], 'ATRs': [160, 406], 'identified': [162, 270, 357], 'envelope': [165], 'spike': [166], 'glycoprotein': [167], '(gp)': [168], '160': [169], 'precursor': [170], 'simian': [173], 'immunodeficiency': [174, 336], 'virus': [175, 337, 378, 440], '(SIV).': [176], 'respective': [178], 'used': [183, 557, 652], 'for': [184, 464, 478, 641, 702], 'collected': [188], 'during': [189, 621], 'AIDS-macaque': [191], 'model': [192], 'studies.': [193], 'one': [195, 214, 409, 416], 'studies,': [198], 'performing': [199], 'multiple': [200], 'low': [201, 661], 'dose': [202], 'viral': [203, 298], 'exposures': [204], 'however': [206], 'did': [207], 'lead': [209, 688], 'productive': [212], 'infection,': [213], 'particular': [215], 'ATR': [216, 358, 417, 447, 488], 'detected.': [218], 'might': [220, 359], 'involved': [222], 'protection': [225], 'through': [226, 435, 674], 'against': [228, 244, 263, 415, 445], 'constant': [230], 'region': [231, 319], 'five': [232], 'gp120.': [234], 'Remarkably,': [235], 'no': [236], 'qualitative': [237], 'differences': [238], 'antibody': [241, 605, 745], 'reaction': [242], 'pattern': [243], 'linear': [245], 'between': [247], 'SIV-infected': [248], 'long-term': [249], 'survivors': [250], '(LTS)': [251], 'animals': [253, 608], 'progressing': [254], 'AIDS-like': [256], 'disease': [257], 'observed.': [259], 'Furthermore,': [260], 'directed': [262], 'N-terminal': [265], 'end': [266, 566, 724, 750], 'SIVgp120': [268], 'as': [271, 727], 'early': [274], 'seromarker': [275], 'SIV-infection.': [277], 'Irrespective': [278], 'inoculated': [281], 'SIV': [282], 'strain': [283], 'those': [284], 'reacted': [286], 'exclusively': [287], 'acid': [291, 315, 391], 'sequence': [292], 'SIVmac251.': [294], 'sequencing': [296], 'RNA': [299], 'serial': [301], 'plasma': [302], 'animal': [306, 465], 'SIVmac239': [309], 'demonstrated': [310], 'lack': [312, 599], 'exchanges': [316], 'interest.': [321], 'predicted': [323], 'structure': [324], 'epitope': [327, 532], 'based': [328], 'known': [331], '3D-structure': [332, 506], 'human': [335, 456], 'type': [338, 441], '1': [339, 442], '(HIV-1)': [340], 'revealed': [341, 403, 519], 'sharp': [343], 'bend': [344], 'at': [345, 520], 'original': [347], 'binding': [348, 721, 746], 'site.': [349], 'above': [351, 654], 'mentioned': [352, 655], 'imply': [354], 'represent': [360], 'conformation-dependent': [362, 498, 670], 'epitope,': [363], 'has': [365, 713], 'seen': [368], 'previous': [370], 'methods.': [371], 'Analysis': [372], 'sera': [374], 'from': [375, 579], 'herpes': [376, 438], 'B': [377, 397], '(BV)': [379], 'monkeys': [381], 'containing': [386, 751], 'covering': [388], 'sequences': [392], 'two': [395, 522, 538], 'glycoproteins': [396], 'D': [399], '(gB': [400], 'gD)': [402], '17': [404], 'confirmed': [408], 'previously': [410, 529], 'described': [411, 530], 'epitope.': [412], 'Interestingly,': [413], 'BV': [420, 459, 570, 585], 'gD': [421, 518, 568, 729], 'detected': [423, 487], 'animal,': [426], 'considered': [429], 'uninfected': [430], 'negative': [433], 'testing': [434], 'cross-reactive': [437], 'simplex': [439], '(HSV-1)-ELISA.': [443], 'Antibodies': [444], 'block': [449], 'main': [451], 'entry': [452], 'receptor': [453], 'Nectin-1': [454], 'cells.': [457], 'Since': [458], 'poses': [460], 'occupational': [462], 'hazard': [463], 'keepers': [466], 'others': [468], 'dealing': [469], 'result': [473], 'pave': [475], 'way': [477], 'development': [480, 691], 'peptide-based': [483, 546], 'vaccination': [484], 'strategy.': [485], 'Another': [486], 'crown': [491], 'domain': [492], 'gB': [494], 'seems': [495], 'further': [501], 'characterized': [502], 'adopting': [504], 'HSV-1': [508], 'alanine': [511], 'scan.': [512], 'highly': [514], 'immunogenic': [515], 'endodomain': [516], 'least': [521], 'distinguishable': [523], 'epitopes.': [524, 704], 'case,': [527], 'C-terminal': [531, 565, 730, 749], 'mapped': [534], 'last': [537], 'Through': [541], 'establishment': [543, 659], 'ELISA': [547, 555], 'BV-peptide': [549], 'confirmed.': [553], 'prove': [559], 'serological': [561, 645, 663], 'relevance': [562], 'infection': [571, 623], 'RM.': [573], 'longitudinal': [575], 'RM': [578], 'breeding': [581], 'group': [582], 'suggested': [583], 'is': [586, 617, 672, 681, 753], 'likely': [588], 'transmitted': [589], 'via': [590], 'sexual': [591], 'contacts': [592], 'rather': [593], 'than': [594], 'bites': [595], 'or': [596, 733], 'scratches.': [597], 'repeated': [602], 'rise': [603], 'levels': [606], 'kept': [609], 'under': [610], 'experimental': [611], 'conditions': [612], 'may': [613, 687, 736], 'indicate': [614], 'recurrence': [616], 'rare': [619], 'event': [620], 'BV.': [625], 'results': [627, 656, 686], 'obtained': [628], 'thesis': [631], 'demonstrate': [632], 'microarrays': [635], 'are': [636, 651], 'useful': [637], 'powerful': [639], 'initial': [642], 'markers.': [646], 'When': [647], 'standardized': [648], 'synthetized': [649], 'allow': [657, 699], 'cost': [662], 'tests.': [664], 'To': [665], 'date,': [666], 'done': [673], 'random': [675], 'libraries': [677], 'but': [678], 'technique': [680], 'prone': [682], 'errors.': [684], 'generation': [695], 'biochips,': [697], 'inexpensive': [700], 'conformational': [703], 'However,': [705], 'detailed': [707], 'assessment': [708], 'established': [711], 'indicated': [714], 'some': [715], 'limitations:': [716], 'case': [718], '“open”': [723], 'structures,': [725], 'end,': [731], 'linked-': [732], 'conjugated': [734], 'fail': [737], 'detect': [739], 'antibodies.': [741], 'A': [742], 'validation': [743], 'unlinked': [748], 'therefore': [754], 'essential.': [755]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2886446260', 'counts_by_year': [{'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-12-09T21:56:22.246718', 'created_date': '2018-08-22'}