Title: Role of uricacid & hs-CRP as renal & cardiovascular risk markers in type 1 diabetic patients with low GFR
Abstract: Recent studies have reported that high serum levels of uric acid and hs-CRP
are strongly associated with impaired renal function and cardio vascular disease.
This study aims to find out the role of uric acid & hs-CRP in detection of early renal
function decline before the onset of proteinuria and detection of cardiovascular risk
in type 1 Diabetic patients .
METHODOLOGY:
A total of 130 type 1 Diabetic patients (65 normoalbuminuric &
65microalbuminuric) were recruited in the cross sectional study. Uric acid & hs-CRP
were measured by enzymatic colorimetric method & ELISA method respectively.
Other metabolic parameters blood pressure, bodymassindex,HbA1c, Fasting plasma
glucose, Plasma lipid profile, serum creatinine, urine albumin creatinine ratio were
assessed. Estimated Glomerular filtration rate was calculated by CKD-EPI equation.
RESULTS:
The respective mean uric acid levels in normoalbuminuria &
microalbuminuria were 3.92+/-1.59 & 4.99+/-2.48mg/dL(p-0.004) .Mean hs-CRP
levels in normoalbuminuria was 1.93+/-2.14mg/L and in microalbuminuria it was
4.47+/-3.05mg/L(p<0.001). Urinary albumin creatinine ratio in normoalbuminuria
was 13.64+/-7.66 and in Microalbuminuria it was 127.98+/-81.23(p <0.001).In
normoalbuminuria mean GFR levels were 110.40+/-20.30ml/min and in
microalbuminurics it was 100.25+/-27.12ml/min.(p-0.02). eGFR >90ml/min was
present in 54.5% of normoalbuminurics & 45.5% of microalbuminurics. eGFR
<90ml/min was present in 34.5% of normoalbuminurics and 65.5 % of
microalbuminurics. Lower GFR was strongly & independently associated with
elevated serum uric acid & increased urinary albumin creatinine ratio. hs-CRP was
positively correlated with uric acid (p-0.04) and Uric acid was negatively correlated
with e GFR (p-<0.001).
CONCLUSION:
Serum uric acid in high normal range & elevated hs-CRP levels were
associated with impaired renal function in patients with type1 diabetes. Therefore it
can be used as markers for detecting cardiovascular risk & early renal function
decline in patients with type 1 diabetes in Indian clinical setting , where detection rate
is lower & complications are higher.
Publication Year: 2016
Publication Date: 2016-04-01
Language: en
Type: dissertation
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