In vivo imaging reveals increased eosinophil uptake in the lungs of obese asthmatic patients

Name: Work Video:
Duration: 3 min 30 s
Neda Farahi; Chrystalla Loutsios; Nicola Tregay; Adam Wright; Rachid Berair; Laurence S. C. Lok; Daniel Gillett; Ian Cullum; Rosalind Simmonds; Charlotte Summers; Hiu Yi Wong; Chandra K. Solanki; John Buscombe; Pee Hwee Pang; Arthikkaa Thavakumar; A. Michael Peters; Christopher E. Brightling; Alison M. Condliffe; Edwin R. Chilvers
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'exacerbations': [68, 1057], 'refractory': [70, 1059], 'asthma.N': [72, 1061], 'Engl': [73, 1062], 'J': [74, 182, 264, 1063, 1201, 1284, 1330, 2130], 'Med.': [75, 268, 1064, 1205, 1288, 1334, 2203, 2307, 2425, 2484], '2009;': [76, 1065], '360:': [77, 1066], '973-984Crossref': [78, 1067], '(1524)': [81, 1070], 'Scholar': [83, 194, 276, 500, 579, 1072, 1213, 1296, 1342, 1439, 1700, 1844, 1988, 2208, 2320, 2438, 2497, 2585, 2644, 3596, 4000], 'Although': [84, 1138], 'progress': [85], 'has': [86, 1345, 1489], 'been': [87, 317], 'made': [88], 'understanding': [90], 'mechanisms': [92, 1107], 'responsible': [93], 'for': [94, 391, 450, 1025, 1492, 1503, 1506, 1525, 1534, 1560, 1876, 1919, 2074, 2196, 2516, 2665, 2681, 2900, 3050, 3174, 3182, 3221, 3229, 3280, 3290, 3495, 3535, 3577, 3858, 3899, 3939, 3981, 4106, 4126], 'activation': [96], 'these': [98, 1100, 1913, 2851], 'cells,': [99], 'existing': [100], 'biomarkers': [101, 125], 'inflammation': [104, 345, 654, 721, 1152, 1252, 1615], 'are': [105, 1021, 1085, 1309, 1543, 2240, 2355, 2565, 2710, 3134, 3501, 3841, 3905, 4089, 4187, 4192], 'indirect': [106], 'and/or': [107], 'invasive': [108, 4208], 'do': [110], 'not': [111, 316, 437, 751, 856, 993, 1368, 1749, 1761, 4188], 'always': [112, 2838], 'correlate': [113, 752], 'tissue': [115, 127, 1190], 'eosinophilia.': [116, 128], 'Hence,': [117], 'there': [118], 'is': [119, 277, 1016, 1219, 1248, 1474, 1973, 4206], 'a': [120, 232, 382, 668, 928, 1255, 1379, 1396, 1631, 1738, 1767, 1933, 1967, 2004, 2047, 2261, 2268, 2287, 2299, 2405, 2417, 2464, 2476, 2674, 2684, 2693, 2749, 2755, 3631, 3643, 3655, 3739, 3836, 3862, 3874, 4035, 4047, 4084, 4110, 4203], 'need': [121], 'to': [122, 142, 197, 205, 309, 386, 397, 447, 481, 520, 690, 945, 1118, 1126, 1135, 1157, 1316, 1420, 1450, 1545, 1645, 1681, 1730, 1825, 2082, 2625, 2734, 2802, 2813, 2815, 2846, 2859, 2872, 2913, 2917, 3277, 3287, 3340, 3343, 3349, 3364, 3367, 3370, 3375, 3378, 3384, 3390, 3393, 3396, 3400, 3403, 3406, 3514, 3608, 3637, 3701, 3918, 4012, 4041, 4129, 4164, 4171, 4197], 'develop': [123], 'noninvasive': [124, 4213], 'We': [129, 195, 279, 380, 1087, 1111, 1214, 1516, 1542, 4174], 'have': [130, 1393], 'previously': [131, 1394, 1806, 2102, 2547], 'demonstrated': [132, 1122], 'capacity': [134], 'single': [136, 4151], 'photon': [137, 4152], 'emission': [138, 4153], 'computed': [139, 4154], 'tomography': [140, 4156], '(SPECT)': [141], 'quantify': [143, 206, 4165], 'neutrophil': [144, 170, 558, 2118, 2193], 'uptake': [145, 603, 645, 673, 689, 832, 1114, 1218, 1466, 2086, 2157, 2190, 2223, 2967, 2994, 4116, 4167], 'into': [146, 172, 610, 1714, 2120, 2971, 3142], 'lungs': [148, 174, 612, 1120, 1128, 1472, 2122, 4119], 'patients': [150, 176, 296, 337, 341, 650, 675, 716, 747, 789, 837, 845, 882, 890, 959, 965, 997, 1223, 1229, 1375, 1478, 1484, 1499, 1505, 1605, 1610, 1639, 1757, 2124, 2294, 2412, 2471, 2506, 3176, 3184, 3223, 3231, 3282, 3292, 3679, 3829, 3833, 4077, 4081, 4122], 'chronic': [152, 178, 1197, 2126, 2574], 'obstructive': [153, 179, 1198, 2127, 2575], 'disease.3Ruparelia': [155], 'Szczepura': [157, 2105], 'K.R.': [158, 2106], 'Summers': [159, 471, 510, 1410, 1671, 1815, 2107, 2615], 'C.': [160, 242, 470, 472, 509, 511, 1262, 1311, 1409, 1411, 1670, 1672, 1814, 1816, 1950, 1960, 2108, 2551, 2614, 2616], 'Solanki': [161, 473, 512, 1412, 1673, 1817, 1959, 2109, 2617], 'C.K.': [162, 474, 513, 1413, 1674, 1818, 2110, 2618], 'Balan': [163, 2111], 'K.': [164, 2112], 'Newbold': [165, 2113], 'al.Quantification': [168, 2116], 'migration': [171, 561, 696, 731, 745, 1125, 1140, 1156, 2119, 2211, 2970, 3019], 'disease.Eur': [181, 2129], 'Nucl': [183, 2131, 2202], 'Med': [184, 2132], 'Mol': [185, 2133], 'Imaging.': [186, 2134], '2011;': [187, 2135], '38:': [188, 2136], '911-919Crossref': [189, 2137], '(12)': [192], 'sought': [196], 'determine': [198, 302, 774], 'whether': [199, 775], 'this': [200, 355, 411, 632, 686, 767, 776, 814, 921, 2502], 'methodology': [201, 1150], 'could': [202, 778, 4161], 'be': [203, 1166, 1468, 4162], 'used': [204, 2081, 4163], 'eosinophil': [207, 227, 293, 560, 695, 704, 711, 730, 744, 782, 823, 903, 909, 952, 978, 981, 985, 1014, 1077, 1083, 1109, 1113, 1124, 1139, 1147, 1217, 1258, 1303, 1307, 1326, 1388, 1465, 2085, 2090, 2210, 2222, 2229, 2237, 2440, 2600, 2966, 2969, 2988, 2993, 2999, 3017, 3018, 3093, 3106, 3111, 3114, 3198, 3243, 3247, 3252, 3335, 3790, 3796, 3819, 4066, 4115, 4166, 4181, 4185], 'kinetics': [208, 294, 486, 525, 783, 1425, 1686, 1830, 2630], 'uptake,': [211], 'which': [212, 1972, 2836, 4210], 'may': [213], 'differ': [214, 438], 'among': [215], 'diseases': [216], 'characterized': [217], 'by': [218, 698, 713, 858, 1254, 1571, 1630, 2093, 2098, 2219, 2224, 2331, 3136, 3206, 3630, 4034, 4145], 'inflammation.': [220, 1515, 4201], 'In': [221, 927, 1455], 'particular,': [222], 'obesity,': [231, 2510], 'distinct': [233], 'endotype': [235], 'associated': [236, 1249, 2568], 'increased': [238, 648, 671, 834, 1123, 2566], 'severity,4Desai': [239], 'D.': [240, 1180, 1260], 'Newby': [241, 1261, 2550], 'Symon': [243, 1263], 'F.A.': [244, 1264], 'Haldar': [245, 1265], 'Shah': [247, 1267], 'al.Elevated': [252, 1272], 'sputum': [253, 980, 1034, 1257, 1273, 1306, 2361, 2444, 3110, 3246, 4184], 'interleukin-5': [254, 1274], 'submucosal': [256, 951, 1276], 'eosinophilia': [257, 1187, 1277], 'obese': [259, 793, 836, 881, 958, 1222, 1279, 1477, 1498, 3097, 3124, 3147, 3183, 3230, 3262, 3291, 3411, 3416, 3422, 3428, 3832, 4080, 4121, 4130], 'individuals': [260, 1280, 1755], 'severe': [262, 1282], 'asthma.Am': [263, 1283, 1329], 'Respir': [265, 1202, 1285, 1331, 2306, 2424, 2483], 'Crit': [266, 1203, 1286, 1332], 'Care': [267, 1204, 1287, 1333], '2013;': [269, 1289], '188:': [270, 1290], '657-663Crossref': [271, 1291], '(166)': [274, 1294], 'controversial.': [278], 'hypothesized': [280], 'that': [281, 311, 458, 1089, 1164, 1216, 1244, 1300, 1464, 2904, 3604, 4008, 4150, 4179], 'injection': [282, 326, 1784], 'radiolabeled': [284, 365, 452, 605, 1460, 1746, 2019, 2965, 2992, 3016, 4159], 'eosinophils,': [285, 307, 1932], 'coupled': [286], 'SPECT/CT,': [288], 'would': [289], 'reveal': [290, 779], 'changes': [291, 1445], 'compared': [297, 660, 732, 821, 842, 885, 962, 1226, 1481, 3513, 3917, 4128], 'healthy': [299, 335, 455, 491, 530, 662, 734, 1136, 1430, 1602, 1691, 1754, 1835, 2635, 2750, 3516, 3920], 'volunteers.': [300, 1715], 'To': [301, 599, 773, 1881, 1925], 'initial': [304, 362, 393], 'distribution': [305, 2091, 2215], 'ensure': [310], 'reinjected': [313, 460, 1401], 'cells': [314, 1747], 'had': [315, 726, 1367, 1378, 2909], 'activated,': [318], 'planar': [319, 3323, 3670], 'gamma': [320, 1739, 1934, 2048], 'camera': [321, 1770], 'imaging': [322, 1092, 1358, 1458, 4157], 'was': [323, 370, 419, 646, 667, 833, 855, 876, 954, 1360, 1569, 1628, 1721, 1725, 1866, 1937, 1992, 2080, 2217, 2329, 2511, 2678, 2688, 2697, 2706, 2781, 2828, 2837, 2870, 2893, 2925, 3628, 4032], 'performed': [324, 333, 1867, 1993, 2512, 2648], 'following': [325, 1861], 'technetium-99m–labeled': [328, 1786, 2746, 3154], 'eosinophils.': [329], 'These': [330, 1238, 2234], 'scans': [331], 'were': [332, 445, 462, 617, 911, 992, 1642, 1652, 1703, 1748, 1764, 1803, 1847, 1889, 1915, 2024, 2051, 2247, 2379, 2447, 2522, 2587, 2603, 2647, 2663, 2771, 2855, 2946, 3047, 3493, 3512, 3529, 3753, 3897, 3916, 3933], 'volunteers,': [336, 456], 'asthma,': [339, 1231, 1607], 'focal': [343, 652, 718, 1612], '(Fig': [346, 375, 425, 433, 596, 621, 738, 807, 896, 937, 971, 1999, 2067, 3062, 3071], '1,': [347, 376, 434, 597, 622, 642, 739], 'A;': [348, 809], 'see': [349, 810], 'Tables': [350], 'E1': [351, 409, 1624], 'E2': [353, 630], "article's": [356, 412, 633, 768, 815, 922], 'Online': [357, 413, 634, 769, 816, 923], 'Repository': [358, 414, 635, 770, 817, 924], 'at': [359, 415, 636, 771, 818, 925, 1553, 1727, 1852, 1868, 2026, 2063, 2804, 2817, 2839, 2895, 3160], 'www.jacionline.org).': [360, 416, 637, 772, 926], 'The': [361, 428, 741, 976, 1008, 1567, 1598, 1701, 1716, 1741, 2327, 2544, 2824, 2940], 'transit': [363, 384, 398, 874, 1929], 'eosinophils': [366, 396, 453, 461, 480, 489, 519, 528, 581, 606, 866, 879, 887, 1032, 1094, 1191, 1323, 1419, 1428, 1461, 1496, 1680, 1689, 1702, 1787, 1824, 1833, 2624, 2633, 2747, 3155, 3782, 3786, 4160], 'through': [367], 'lung': [369, 694, 720, 754, 869, 1076, 2055, 2076, 2571, 2727, 2739, 2764, 2776, 2779, 2826, 2935, 2944, 2973, 3316], 'similar': [371, 913], 'all': [373, 422, 1592], 'subjects': [374, 723, 934, 1593, 1599, 1998, 2258, 2322, 3202, 3220, 3228, 3279, 3289, 3320], 'B': [377], 'C).': [379, 898], 'generated': [381, 1938], '"first-pass"': [383], 'curve': [385], 'calculate': [387, 1926], 'time': [389, 875, 1720, 1930, 2065, 2768, 2807, 2818, 2897], 'taken': [390, 2025, 2871], 'bolus': [394, 1782], 'from': [399, 454, 607, 1115, 1168, 1362, 1654, 1939, 2155, 2249, 2381, 2773, 2800, 2830, 2850, 2876, 2911, 2942, 3543, 3749, 3826, 3947, 4074, 4168, 4215], 'right': [401, 1893], 'ventricle': [402], 'across': [403, 421], 'circulation': [406], '(see': [407, 628, 761, 914], 'Fig': [408, 629, 641, 828, 915], 'This': [417, 853, 1487, 2923], 'value': [418, 697, 2701], 'constant': [420], 'study': [423, 441, 1344, 1568, 2328, 3319, 3747, 4144], 'groups': [424, 442], 'E1,': [426], 'B).': [427], '45-minute': [429, 901, 1873, 3086], 'blood': [430, 609, 703, 908, 984, 1074, 1117, 1146, 1170, 1660, 2022, 2228, 2365, 2446, 2987, 2998, 3087, 3092, 3105, 3115, 3159, 3197, 3251, 3334, 3795, 4170], 'recovery': [431, 904, 2601, 3088], 'values': [432, 905, 2602, 3056, 3089, 3188, 3235, 3296, 3511, 3851, 3915, 4099], 'D)': [435], 'did': [436, 750], 'between': [439, 784, 996, 1752, 2010, 2184, 2933, 2964, 2991, 3015, 3613, 4017], 'and,': [443, 2785], 'importantly,': [444], 'comparable': [446], 'published': [448, 1395], 'levels': [449, 991, 3121, 3259], 'unmanipulated': [451], 'indicating': [457], 'nonactivated.5Farahi': [463], 'N.': [464, 503, 1184, 1403, 1664, 1808, 2608], 'Singh': [465, 504, 1404, 1665, 1809, 1951, 2609], 'N.R.': [466, 505, 1405, 1666, 1810, 1952, 2610], 'Heard': [467, 506, 1406, 1667, 1811, 2611], 'Loutsios': [469, 508, 1408, 1669, 1813, 2613], 'al.Use': [476, 515, 1415, 1676, 1820, 2620], '111-indium-labeled': [478, 517, 1417, 1678, 1822, 2622], 'autologous': [479, 518, 1418, 1658, 1679, 1823, 2623], 'establish': [482, 521, 1421, 1682, 1826, 2626], 'vivo': [485, 524, 1091, 1424, 1685, 1718, 1829, 2629], 'human': [488, 527, 557, 1427, 1688, 1832, 2192, 2632], 'subjects.Blood.': [492, 531, 1431, 1692, 1836, 2636], '2012;': [493, 532, 1432, 1693, 1837, 2637], '120:': [494, 533, 1433, 1694, 1838, 2638], '4068-4071Crossref': [495, 534, 1434, 1695, 1839, 2639], '(27)': [498, 537, 1437], 'As': [501, 638, 825], 'predicted,5Farahi': [502], '6Lukawska': [540], 'J.J.': [541], 'Livieratos': [542], 'L.': [543, 1313], 'Sawyer': [544], 'B.M.': [545], 'Lee': [546], 'T.': [547], "O'Doherty": [548], 'M.': [549, 1182, 2178], 'Blower': [550], 'P.J.': [551], 'al.Real-time': [553], 'differential': [554], 'tracking': [555], 'vivo.J': [563], '2014;': [567, 1335, 1981], '133:': [568], '233-239.e1Abstract': [569], '(26)': [577], 'circulating': [580], 'accumulated': [582], 'rapidly': [583], 'within': [584, 591, 1548], 'liver': [586], 'spleen,': [588], 'most': [589], 'likely': [590], 'known': [592], 'marginated': [593], 'intravascular': [594], 'pools': [595], 'E-G).': [598], 'measure': [600, 2083], 'time-dependent': [602], '("pulmonary': [613], 'uptake"),': [614], 'serial': [615], 'images': [616, 1846, 2062, 2732], 'acquired': [618, 1848], 'using': [619, 1459, 1899, 2649, 2667, 3058, 3190, 3237, 3298, 3519, 3531, 3853, 3861, 3923, 3935, 4101, 4109, 4158], 'SPECT/CT': [620, 947, 1457, 1769, 3101, 3201, 3325, 3673], 'H)': [623], 'Patlak-Rutland': [625, 2078, 2953], 'analysis': [626, 2079, 2500, 2724, 3061, 3070], 'undertaken': [627], 'shown': [639, 826], 'I,': [643], 'significantly': [647, 955, 994, 1750], '(0.002': [655], 'mL/min/mL;': [656, 679, 849], 'P': [657, 680, 850, 2700, 3055, 3187, 3234, 3295, 3345, 3351, 3380, 3386, 3510, 3850, 3914, 4098], '=': [658, 681, 851, 894, 969, 2363, 2367, 2372, 2377, 3346, 3352, 3359, 3381, 3387], '.02)': [659], 'volunteers': [663, 735, 1529], '(0.0003': [664, 848], 'mL/min/mL).': [665], 'There': [666], 'trend': [669], 'toward': [670], '(0.0008': [678], '.14).': [682], 'However,': [683, 4202], 'conversion': [684], 'rate': [687], 'absolute': [692], 'whole': [693], 'multiplying': [699, 2220], 'peripheral': [702, 907, 983, 1145, 1387, 2227, 2986, 2997, 3091, 3104, 3113, 3250], 'count': [705, 953, 1172, 1304, 1308, 2230, 3094, 3336, 3791, 3797, 4182, 4186], 'revealed': [706], 'full': [708], 'extent': [709, 742], 'accumulation': [712], 'lungs;': [715], 'higher': [727], 'rates': [728], '(32': [736], 'eosinophils/min/mL)': [737], 'J).': [740], 'function': [755, 1448, 2572, 3317], 'or': [756, 799, 1910, 1945, 2716, 2968, 3067, 3507, 3523, 3639, 3642, 3911, 3927, 4043, 4046], 'fractional': [757], 'nitric': [758], 'oxide': [759], '(Feno)': [760], 'Figs': [762], 'E3': [763, 812, 1005], 'E4': [765], 'technique': [777], 'differences': [780], 'endotypes,': [786], 'we': [787, 1298, 1392, 1440], 'stratified': [788, 940, 3205], 'as': [792, 1041, 1661, 1805, 2101, 2449, 2546, 2589, 2595, 2605, 2656, 2712, 2950, 3208, 3503, 3843, 3907, 4091], '(body': [794, 801], 'mass': [795, 802, 3139, 3304, 3476, 3816, 3879, 4063], 'index': [796, 803, 3140], '≥30': [797], 'kg/m2)': [798, 806, 3145], 'nonobese': [800, 844, 889, 964, 1228, 1483, 3099, 3126, 3143, 3175, 3222, 3264, 3281, 3828, 4076], '<': [804, 3755], '30': [805, 2816, 3840, 4088], '2,': [808, 829, 897, 938, 972, 1855, 2027], 'Table': [811, 2358, 3658, 3742], 'www.jacionline.org),': [819], 'their': [822, 1080, 3137], 'uptake.': [824], 'B,': [830, 919, 3195], '(0.001': [840], 'mL/min/mL)': [841], '.02).': [852], 'effect': [854], 'explained': [857], 'increase': [860], 'early': [863, 2806], 'retention': [864, 1963], 'because': [870, 2001, 2927], 'first-pass': [872, 1928], 'mean': [873, 1941, 2713, 3168, 3508, 3912], 'faster': [877], '(P': [893, 968, 3358], '.038)': [895], 'Furthermore,': [899], 'postinjection': [902, 1733, 2042], 'counts': [910, 1907, 1942, 2071, 2941, 3199], 'also': [912], 'E4,': [916], 'A': [917, 1863, 2498, 2699, 3064], 'parallel': [929], 'but': [930, 1079, 1315], 'separate': [931], 'group': [932], 'D),': [939], 'identical': [943], 'manner': [944], 'cohort,': [948, 3102], 'bronchial': [950, 1036, 1302, 2254, 3128, 3265, 3751, 4180, 4199, 4204], 'elevated': [956], '.024)': [970], 'E': [973], 'F).': [975], 'epithelial': [977, 3108], 'count,': [979, 982, 986, 1148, 3000, 3107, 3116], 'Feno': [987, 1385, 2375, 3043, 3117, 3606, 3612, 3621, 3893, 4010, 4016, 4025], 'levels,': [988, 3118], 'IgE': [990, 3120, 3258, 3807], 'different': [995, 1751], 'without': [1002, 2509, 3441, 3466], 'obesity': [1003, 1247, 4127], '(Figs': [1004], 'E4).': [1007], 'impact': [1009], 'antieosinophil': [1011, 2536], 'therapies': [1012, 1039], 'on': [1013, 1082, 1105, 1384, 1633, 1994, 2056, 2787, 3569, 3835, 3973, 4083], 'trafficking': [1015, 1084], 'poorly': [1017], 'understood.': [1018], 'Inhaled': [1019], 'corticosteroids': [1020], 'mainstay': [1023], 'treatment': [1024], 'reduce': [1028, 1073], 'number': [1030, 2006, 2795], 'biopsies.': [1037], 'Biological': [1038], 'such': [1040, 2903], 'mepolizumab2Haldar': [1042], 'counts,': [1078, 3244, 3248, 3253], 'effects': [1081], 'unknown.': [1086], 'anticipate': [1088], 'will': [1095], 'inform': [1096], 'development': [1098], 'therapies,': [1101], 'shed': [1103], 'light': [1104], 'controlling': [1108], 'migration.': [1110], 'quantified': [1112, 1469], 'our': [1130, 1149, 1235, 1351], 'cohort': [1131, 1352], 'relative': [1134], 'controls.': [1137], 'part': [1142], 'reflects': [1143, 1189], 'localizes': [1151], 'quantifies': [1154], '"whole': [1159], 'lung"': [1160], 'parenchyma,': [1161], 'providing': [1162], 'information': [1163], 'cannot': [1165, 1441], 'obtained': [1167, 2248], 'cell': [1171, 1447, 1451], 'alone.7Turato': [1173], 'G.': [1174, 2284, 2402, 2461], 'Semenzato': [1175], 'U.': [1176], 'Bazzan': [1177], 'E.': [1178], 'Biondini': [1179], 'Tine': [1181], 'Torrecilla': [1183], 'al.Blood': [1186], 'neither': [1188], 'nor': [1192], 'worsens': [1193], 'clinical': [1194, 3600, 4004], 'outcomes': [1195], 'disease.Am': [1200], '2018;': [1206], '197:': [1207], '1216-1219Crossref': [1208], '(56)': [1211], 'observed': [1215], 'enhanced': [1220, 1475], 'agreement': [1233], 'histology': [1236], 'study.': [1237], 'results': [1239, 3046, 3492, 3896], 'challenge': [1240], 'current': [1242], 'dogma': [1243], 'noneosinophilic': [1251], '(demonstrated': [1253], 'low': [1256, 3605, 4009], 'count),4Desai': [1259], 'propose': [1299], 'uncoupled.8Persson': [1310], 'Uller': [1312], 'Theirs': [1314], 'die': [1317], 'do:': [1319], 'primary': [1320, 1363], 'lysis': [1321], 'free': [1325], 'granules': [1327], '189:': [1336], '628-633Crossref': [1337], '(51)': [1340], 'Our': [1343], 'some': [1346], 'limitations.': [1347], 'First,': [1348], '50%': [1349], '(studied': [1355], 'protocol)': [1359], 'recruited': [1361], 'care,': [1364], 'hence': [1366], 'undergone': [1369], 'in-depth': [1370], 'phenotyping,': [1371], 'only': [1373, 3049], '3': [1374, 1609, 2383, 3413, 3712], 'clearly': [1380], 'phenotype': [1382], 'based': [1383, 3834, 4082], 'count.': [1389, 2989], 'Second,': [1390], 'although': [1391], 'rigorous': [1397], 'assessment': [1398], 'eosinophils,5Farahi': [1402], 'absolutely': [1442], 'exclude': [1443], 'subtle': [1444], 'due': [1449], 'isolation': [1452], 'labeling.': [1454], 'conclusion,': [1456], 'provides': [1462], 'evidence': [1463], 'can': [1467], 'asthma.': [1486, 3186, 3233, 3294], 'finding': [1488], 'implications': [1491, 2195], 'selecting': [1504], 'targeted': [1507], 'therapy': [1508], 'context': [1511], 'type': [1513, 3460], '2': [1514, 1574, 2272, 2291, 2409, 2468, 3430, 3461, 3710], 'thank': [1517], 'Dr': [1518, 1522, 1531], 'Robin': [1519], 'Gore': [1520], 'James': [1523], 'Nathan': [1524], 'help': [1526], 'recruiting': [1528], 'Latifa': [1532], 'Chachi': [1533], 'her': [1535], 'advice': [1536], 'practical': [1538], 'expertise': [1539], 'microscopy.': [1541], 'grateful': [1544], 'staff': [1547], 'Nuclear': [1550], 'Medicine': [1551], 'Department': [1552], "Addenbrooke's": [1554], 'Hospital': [1555], 'National': [1558], 'Institute': [1559], 'Health': [1561], 'Research': [1562, 1565, 1575, 2337], 'Cambridge': [1563], 'Clinical': [1564, 4135], 'Facility.': [1566], 'approved': [1570, 2330], 'Cambridgeshire': [1573], 'Ethics': [1576, 2338], 'Committee': [1577, 1586], '(09/H0308/119)': [1578], 'Administration': [1581], 'Radioactive': [1583], 'Substances': [1584], 'Advisory': [1585], 'United': [1589], 'Kingdom': [1590], '(83/3130/25000);': [1591], 'gave': [1594, 2929], 'written': [1595, 2324], 'informed': [1596, 2325], 'consent.': [1597, 2326], 'comprised': [1600], '8': [1601], 'individuals,': [1603], '15': [1604, 1995, 2803, 2814], '(eosinophilic': [1616], 'pneumonia,': [1617], 'ANCA-positive': [1618], 'vasculitis,': [1619], 'IgG4-related': [1621], 'disease)': [1622], '(Tables': [1623], 'E2).': [1626], 'Asthma': [1627, 3675, 3811], 'diagnosed': [1629], 'physician': [1632], 'basis': [1635], 'symptoms,': [1637], 'classified': [1643, 3135], 'according': [1644], 'British': [1646, 3733, 4058], 'Thoracic': [1647, 3598, 3734, 4002, 4059], 'Society': [1648, 3587, 3599, 3991, 4003], 'Step': [1649, 3660], 'classification.': [1650], 'isolated': [1653], '160': [1655], 'mL': [1656], 'venous': [1659], 'described': [1662, 2606, 3209], 'previously.E1Farahi': [1663, 2607], '(49)': [1698, 1842, 2642], 'labeled': [1704], 'technetium-99m–hexamethylpropyleneamine': [1706], 'oxime': [1707], '(GE': [1708, 1771], 'Healthcare,': [1709], 'Buckinghamshire,': [1710], 'UK),': [1711], 'before': [1712, 2952], 'reinjection': [1713, 2016, 2744], 'ex': [1717], 'preparation': [1719], '3.75': [1722], 'hours.': [1723], 'Blood': [1724, 2160, 2599], 'collected': [1726, 2380], 'intervals': [1728], 'up': [1729, 2858], '9': [1731, 1859], 'hours': [1732, 1860, 2742, 2821], 'radioactivity': [1735, 2044], 'measured': [1736, 2045], 'counter.': [1740, 2049], 'injected': [1742, 3153], 'activities': [1743, 1796], '(data': [1760], 'shown).': [1762], 'Volunteers': [1763], 'positioned': [1765], 'double-headed': [1768], 'Discovery': [1772], '670,': [1773], 'GE': [1774, 1904], 'Healthcare),': [1775], 'fitted': [1776], 'low-energy,': [1778], 'parallel-hole': [1779], 'collimators.': [1780], 'After': [1781], 'intravenous': [1783], '(mean,': [1788], '120': [1789, 2013], 'MBq;': [1790], 'range,': [1791], '46-199': [1792], 'MBq': [1793], 'injected/subject),': [1794], 'chest': [1799], 'upper': [1801, 2738], 'abdomen': [1802], 'recorded': [1804, 1916], 'described.E1Farahi': [1807], 'SPECT': [1845, 1874, 2061, 2731], 'over': [1849, 1891, 2053], '20': [1850], 'minutes': [1851, 2041, 3162], '45': [1853, 3161], 'minutes,': [1854], '4,': [1856, 2028], '6,': [1857, 2029], 'reinjection.': [1862, 3164], 'CT': [1864], 'scan': [1865, 2892], 'end': [1870], 'acquisition': [1875], 'anatomical': [1877], 'coregistration': [1878], 'SPECT.': [1880], 'generate': [1882], 'time-activity': [1883], 'curves,': [1884], 'regions': [1885], 'interest': [1887, 4142], '(ROIs)': [1888], 'drawn': [1890, 2052, 2772, 2798, 2829, 2857], 'lung,': [1894, 2792, 2835], 'liver,': [1896], 'spleen': [1898], 'Xeleris': [1900], 'software': [1901], '(Version': [1902], '3.1,': [1903], 'Healthcare).': [1905], 'Mean': [1906, 3650, 3866], 'per': [1908, 1943, 2072, 2087, 2212, 3040, 3488, 3824, 3891, 4071], 'pixel': [1909, 1944], 'voxel': [1911, 1946, 2073], 'ROIs': [1914, 2050, 2770, 2854], 'corrected': [1918], 'physical': [1920], 'decay': [1921], 'radionuclide.': [1924], 'variate': [1935, 1990], 'fit': [1936, 1991], 'lung.E2Summers': [1949], 'White': [1953, 2175, 2761], 'J.F.': [1954, 2176], 'Mackenzie': [1955], 'I.M.': [1956], 'Johnston': [1957], 'al.Pulmonary': [1962], 'primed': [1965], 'neutrophils:': [1966], 'novel': [1968], 'protective': [1969], 'host': [1970], 'response,': [1971], 'impaired': [1974], 'acute': [1977], 'respiratory': [1978, 2185], 'distress': [1979], 'syndrome.Thorax.': [1980], '69:': [1982], '623-629Crossref': [1983], '(97)': [1986], 'Gamma': [1989], '22': [1997, 3051, 3496, 3900], 'E1),': [2000], 'it': [2002, 2928], 'required': [2003], 'minimum': [2005], 'data': [2008, 2683], 'points': [2009, 2808, 2819], '0': [2011], 'seconds': [2014], 'after': [2015, 2743, 2811, 3163], 'cells.': [2020], 'Peripheral': [2021, 3196], 'samples': [2023], '8,': [2030], '10,': [2031], '15,': [2032], '30,': [2033], '45,': [2034], '90,': [2035], '120,': [2036], '240,': [2037], '360,': [2038], '540': [2040], 'transaxial': [2057], 'sections': [2058, 2529, 2740, 2774, 2797, 2842], 'each': [2064, 2075, 2232, 2767, 2896, 2901, 2943, 3681], 'point': [2066, 2898], 'E2)': [2068], 'average': [2070, 2226], 'determined.': [2077], 'unit': [2088, 2213], 'volume': [2092, 2216], 'dividing': [2094], 'plot': [2096], 'gradient': [2097, 2239], 'intercept,': [2100], 'described.E3Ruparelia': [2103], '(19)': [2140], 'E4Patlak': [2143], 'C.S.': [2144], 'Blasberg': [2145], 'R.G.': [2146], 'Fenstermacher': [2147], 'J.D.': [2148], 'Graphical': [2149], 'evaluation': [2150], 'blood-to-brain': [2152], 'transfer': [2153], 'constants': [2154], 'multiple-time': [2156], 'data.J': [2158], 'Cereb': [2159], 'Flow': [2161], 'Metab.': [2162], '1983;': [2163], '3:': [2164], '1-7Crossref': [2165], '(2354)': [2168], 'E5Jones': [2171], 'H.A.': [2172], 'Cadwallader': [2173], 'K.A.': [2174], 'Uddin': [2177], 'Peters': [2179], 'A.M.': [2180], 'Chilvers': [2181], 'E.R.': [2182], 'Dissociation': [2183], 'burst': [2186], 'activity': [2187], 'deoxyglucose': [2189], 'granulocytes:': [2194], 'interpretation': [2197], '(18)F-FDG': [2199], 'PET': [2200], 'images.J': [2201], '2002;': [2204], '43:': [2205], '652-657PubMed': [2206], 'Total': [2209], 'calculated': [2218, 2604, 3057, 3189, 3236, 3297, 3530, 3852, 3934, 4100], 'subject.': [2233], 'measures': [2235], 'blood/lung': [2238], 'independent': [2241], 'administered': [2244], 'activity.': [2245], 'Data': [2246, 2662, 3165, 3211, 3268, 3500, 3904, 4073], 'pretreatment': [2251, 2386], 'investigations': [2252], 'biopsies': [2255, 3752, 4191], '61': [2257], 'participating': [2259], 'randomised,': [2262, 2301, 2419, 2478], 'double-blind,': [2263, 2302, 2420, 2479], 'placebo-controlled': [2264, 2304, 2422, 2481], 'trial': [2265], 'fevipiprant,': [2267], 'prostaglandin': [2269, 2288, 2406, 2465], 'D2': [2270, 2289, 2407, 2466], 'receptor': [2271, 2290, 2408, 2467], 'antagonist.E6Gonem': [2273], 'Berair': [2275, 2393, 2452, 2558], 'R.': [2276, 2280, 2394, 2398, 2453, 2457, 2559, 3558, 3962], 'Singapuri': [2277, 2395, 2454], 'Hartley': [2279, 2397, 2456, 2552], 'Laurencin': [2281, 2399, 2458], 'M.F.M.': [2282, 2400, 2459], 'Bacher': [2283, 2401, 2460], 'al.Fevipiprant,': [2286, 2404, 2463], 'antagonist,': [2292, 2410, 2469], 'persistent': [2296, 2414, 2473], 'asthma:': [2298, 2416, 2475], 'single-centre,': [2300, 2418, 2477], 'parallel-group,': [2303, 2421, 2480], 'trial.Lancet': [2305, 2423, 2482], '2016;': [2308, 2426, 2485], '4:': [2309, 2427, 2486], '699-707Abstract': [2310, 2428, 2487], '(198)': [2318, 2436, 2495], 'All': [2321], 'provided': [2323, 2356], 'Leicestershire,': [2333], 'Northamptonshire,': [2334], 'Rutland': [2336], 'Committees': [2339], '(11/EM/0402)': [2340], 'UK': [2343], 'Medicines': [2344], 'Healthcare': [2346], 'Products': [2347], 'Regulatory': [2348], 'Agency.': [2349], 'Details': [2350], 'patient': [2353, 2756], 'characteristics': [2354, 3744], 'E3.': [2359], 'Induced': [2360], '(n': [2362, 2366, 2371, 2376], '59),': [2364], '61),': [2368], 'endobronchial': [2369], 'biopsy': [2370, 3129, 3266, 4205], '34),': [2373], '60)': [2378], 'visit': [2382], 'phase': [2387], 'fevipiprant': [2390], 'trial.E6Gonem': [2391], 'Absolute': [2439], 'numbers': [2441], 'induced': [2443], 'determined': [2448], 'described.E6Gonem': [2450], 'cross-sectional': [2499], 'data,': [2503, 2673, 2692, 3860, 4108], 'comparing': [2504], 'presented': [2514, 3502, 3842, 3906, 4090], 'here': [2515], 'first': [2518, 2825, 2919], 'time.': [2519], 'Biopsy': [2520], 'specimens': [2521], 'embedded': [2523], 'glycol': [2525], 'methacrylate': [2526], '2-μm': [2528], 'stained': [2530], 'hematoxylin': [2532], 'eosin': [2534], 'major': [2537], 'basic': [2538], 'protein': [2539], '(Clone': [2540], 'BMK-13,': [2541], 'Monosan,': [2542], 'Uden,': [2543], 'Netherlands)': [2545], 'detailed.E7Wright': [2548], 'A.K.A.': [2549], 'R.A.': [2553], 'Mistry': [2554], 'V.': [2555], 'al.Myeloid-derived': [2561], 'suppressor': [2562], 'cell-like': [2563], 'fibrocytes': [2564], 'preserved': [2570], 'disease.Allergy.': [2577], '2017;': [2578], '72:': [2579], '645-655Crossref': [2580], '(13)': [2583], 'expressed': [2588, 2711, 2949], 'cells/mm2': [2590, 2596], 'lamina': [2592], 'propria': [2593], 'epithelium.': [2598], 'Statistical': [2645], 'analyses': [2646], 'GraphPad': [2650], 'Prism': [2651], '(6.0d,': [2652], 'San': [2653], 'Diego,': [2654], 'Calif)': [2655], 'detailed': [2657], 'figure': [2660], 'legends.': [2661], 'tested': [2664], 'normality': [2666], 'Shapiro-Wilk': [2669], 'test.': [2670, 3194, 3240, 3301, 3526, 3930, 4113], 'For': [2671, 2690, 2886], 'nonparametric': [2672], 'Mann-Whitney': [2675, 3238, 3299, 3520, 3854, 3924, 4102], 'U': [2676, 3239, 3300, 3521, 3855, 3925, 4103], 'test': [2677, 2687, 2696, 3522, 3635, 3856, 3926, 4039, 4104], 'applied': [2679], 'parametric': [2682], 'Student': [2685, 3192, 3524, 3928], 't': [2686, 3193, 3525, 3929], 'used.': [2689, 2698], 'categorical': [2691, 3859, 4107], 'Fisher': [2694, 3863, 4111], 'exact': [2695, 3864, 4112], 'less': [2703], 'than': [2704], '.05': [2705], 'considered': [2707], 'significant.': [2708], 'Values': [2709], '±': [2714, 3169], 'SEM': [2715, 3170], 'median': [2718, 3214, 3271, 3504, 3844, 3908, 4092], 'interquartile': [2720, 3216, 3273], 'range.Fig': [2721], 'E2SPECT': [2722], 'image': [2723, 2960, 3081, 3311], 'ROIs.': [2728], 'Examples': [2729], 'corresponding': [2733], 'lower,': [2735], 'middle,': [2736], '6': [2741, 2820], 'volunteer': [2751, 2902, 3517, 3921], '(left': [2752], 'panel)': [2753], '(right': [2759], 'panel).': [2760], 'lines': [2762], 'represent': [2763, 3166, 3212, 3269], 'ROI.': [2765], 'At': [2766], 'point,': [2769], 'images.': [2777], 'Each': [2778], 'section': [2780, 2945], '4.42': [2782], 'mm': [2783], 'thick': [2784], 'depending': [2786], 'size': [2789], 'total': [2794], 'ranged': [2799], '10': [2801], '(45': [2809], 'min': [2810], 'reinjection)': [2812], 'later.': [2823], 'ROI': [2827], 'base': [2832], 'least': [2840], '4': [2841, 3418, 3440, 3717], 'above': [2843], 'liver/spleen': [2845], 'avoid': [2847, 2873], 'any': [2848, 3442, 3467], 'scatter': [2849], 'organs.': [2852], 'Sequential': [2853], 'then': [2856, 2916], 'top': [2861], 'lung.': [2864], 'When': [2865], 'drawing': [2866], 'ROI,': [2868], 'care': [2869], 'signal': [2875], 'mediastinum': [2878], 'bone': [2880], 'marrow': [2881], '(vertebra,': [2882], 'sternum,': [2883], 'ribs).': [2885], 'consistency,': [2887], 'saturation': [2889, 2924], 'adjusted': [2894], 'vertebral': [2906], 'body': [2907, 3138], 'color': [2908], 'changed': [2910], 'blue': [2912], 'yellow,': [2914], 'hint': [2920], 'white.': [2922], 'chosen': [2926], 'optimal': [2931], 'contrast': [2932], 'thoracic': [2937], 'bony': [2938], 'skeleton.': [2939], 'summed': [2947], 'counts/voxel': [2951], 'analysis.View': [2954], 'Large': [2955, 3076, 3306], 'Image': [2956, 3077, 3307], 'Figure': [2957, 3078, 3308], 'ViewerDownload': [2958, 3079, 3309], 'Hi-res': [2959, 3080, 3310], 'Download': [2961, 3082, 3312], '(PPT)Fig': [2962, 3083], 'E3Correlations': [2963], 'FEV1': [2975, 3022], '(%': [2976, 2979, 3009, 3023, 3029, 3372], 'predicted),': [2977, 2980, 3010, 3024, 3030], 'FVC': [2978, 3008, 3028], 'Feno,': [2981, 3255], 'Z': [2982, 3004, 3541, 3945], 'score': [2983, 3005], '(FEV1/FVC),': [2984, 3006], 'Correlations': [2990, 3014], '(A)': [2996], '(B)': [3001], 'FEV1,': [3002], '(C)': [3003, 3241], '(D)': [3007, 3245], '(E)': [3012, 3249], 'Feno.': [3013, 3033], '(F)': [3021, 3254], '(G)': [3025, 3257], 'FEV1/FVC,': [3026], '(H)': [3027], '(I)': [3032], 'FVC,': [3034, 3480, 3883], 'forced': [3035, 3481, 3564, 3884, 3968], 'vital': [3036, 3482, 3885], 'capacity;': [3037, 3483, 3886], 'PPB,': [3038, 3486, 3610, 3618, 3822, 3889, 4014, 4022, 4069], 'parts': [3039, 3487, 3823, 3890, 4070], 'billion.': [3041, 3892, 4072], 'Both': [3042], 'spirometry': [3045, 3491, 3895], 'available': [3048, 3494, 3898], '26': [3053, 3498, 3902], 'subjects.': [3054, 3499, 3903], 'Spearman': [3059], 'correlation': [3060, 3069], 'E3,': [3063, 3072], 'G)': [3066], 'Pearson': [3068], 'B-F': [3073], 'H-I).View': [3075], 'E4Comparison': [3084], 'asthmatic': [3100, 3127], 'numbers,': [3112], 'cohort.': [3130, 3267], 'Subjects': [3131], '(kg/m2)': [3141], '(<30': [3144], '(≥30': [3148], 'kg/m2).': [3149], 'A,': [3150], 'Proportion': [3151], 'remaining': [3156], '7': [3172, 3180, 3219, 3227, 3465], 'experiments': [3173, 3181], 'unpaired': [3191], 'BMI': [3207, 3837, 4085], 'above.': [3210], 'range': [3217, 3274], 'Epithelial': [3242], '12': [3276], '33': [3278, 3827, 4075], '13': [3286], '28': [3288, 3831, 4079], 'BMI,': [3302, 3877, 4061], 'Body': [3303, 3475, 3815, 3878, 4062], 'index.View': [3305], '(PPT)Table': [3313], 'E1Demographic': [3314], 'protocolCharacteristicHealthyAsthmaFocal': [3326], 'inflammationN8153Sex:': [3328], 'F/M5/37/80/3Age': [3329], '(y)64': [3330], '(4)60': [3331], '(2)57': [3332], '(6)Peripheral': [3333], '(×': [3337], '109/L)0.11': [3338], '(0.08': [3339], '0.14)0.27': [3341], '(0.16': [3342], '0.54,': [3344], '.0008)0.85': [3347], '(0.72': [3348], '2.60,': [3350], '.012)BMI': [3353], '(kg/m2)∗Mean': [3354, 3769], '(SEM).25': [3355], '(1.46)28': [3356], '(0.82)': [3357], '.04)22': [3360], '(1.76)Feno': [3361], '(PPB)14.0': [3362], '(8.8': [3363], '23.0)25.5': [3365], '(13.5': [3366], '35.0)11.0': [3368], '(8.0': [3369], '35.0)FEV1': [3371], 'pred)99.0': [3373], '(88.0': [3374], '112.0)82.0': [3376], '(70.5': [3377], '90.3,': [3379], '.015)62.0': [3382], '(52.0': [3383], '75.0,': [3385], '.017)FEV1/FVC72.0': [3388], '(62.0': [3389], '79.0)64.5': [3391], '(57.3': [3392], '78.3)60.0': [3394], '(56.0': [3395], '64.0)FEV1/FVCZ': [3397], 'score−1.16': [3398], '(−1.92': [3399], '−0.23)−0.13': [3401], '(−4.09': [3402], '−0.03)−2.24': [3404], '(−2.47': [3405], '−2.01)Smoking': [3407], 'status': [3408, 3627, 4031], '(current/previous/never)0/2/50/7': [3409], '(4': [3410], 'nonobese)/8': [3414], '(3': [3415], 'nonobese)1/1/1Atopic/nonatopic0/510': [3419], 'atopics': [3420], '(5': [3421], '5': [3424, 3723], 'nonobese)/4': [3425], 'nonatopic': [3426], '(2': [3427], 'nonobese)1/3Comorbidities': [3431], '(no.': [3432, 3677, 3704], 'patients)Cardiovascular': [3434], 'disease': [3435, 3445, 3448], '(3),': [3436, 3446], 'depression': [3437], '(1),': [3438, 3451, 3453, 3455, 3457, 3459, 3463], 'stated': [3443, 3468], 'comorbiditiesCardiovascular': [3444], 'gastrointestinal': [3447], '(2),': [3449], 'hypothyroidism': [3450], 'arthritis': [3452], 'cirrhosis': [3454], 'anxiety': [3456], 'hernia': [3458], 'diabetes': [3462], 'comorbiditiesAsthma': [3469], '(1);': [3470], 'small': [3471], 'joint': [3472], 'polyarthropathy': [3473], '(1)BMI,': [3474], 'index;': [3477, 3817, 3880, 4064], 'F,': [3478, 3881], 'female;': [3479, 3882], 'M,': [3484, 3887], 'male;': [3485, 3888], 'billion.Feno': [3489], '(interquartile': [3505, 3845, 3909, 4093], 'range)': [3506, 3846, 3910, 4094], '(SEM).': [3509, 3651, 3913], 'values,': [3518, 3922], 'Spirometric': [3527, 3931], 'measurements': [3528, 3932], 'European': [3533, 3575, 3585, 3937, 3979, 3989], 'Community': [3534, 3576, 3938, 3980], 'Coal': [3536, 3578, 3940, 3982], 'Steel': [3538, 3942], 'protocol,': [3539, 3943], 'scores': [3542, 3946], 'Global': [3545, 3949], 'Lung': [3546, 3561, 3950, 3965], 'Initiative': [3547, 3951], 'site': [3548, 3952], '(http://gligastransfer.org.au/calcs/spiro.htm).E8Quanjer': [3549, 3953], 'P.H.': [3550, 3954], 'Tammeling': [3551, 3955], 'G.J.': [3552, 3956], 'Cotes': [3553, 3957], 'J.E.': [3554, 3958], 'Pedersen': [3555, 3959], 'O.F.': [3556, 3960], 'Peslin': [3557, 3961], 'Yernault': [3559, 3963], 'J.C.': [3560, 3964], 'volumes': [3562, 3966], 'ventilatory': [3565, 3969], 'flows.': [3566, 3970], 'Work': [3567, 3971], 'Group': [3568, 3972], 'Standardization': [3570, 3974], 'Respiratory': [3572, 3586, 3976, 3990], 'Function': [3573, 3977], 'Tests.': [3574, 3978], 'Steel.': [3580, 3984], 'Official': [3581, 3985], 'position': [3582, 3986], '[in': [3588, 3992], 'French].Rev': [3589, 3993], 'Mal': [3590, 3994], 'Respir.': [3591, 3995], '1994;': [3592, 3996], '11:': [3593, 3997], '5-40PubMed': [3594, 3998], 'American': [3597, 4001], 'practice': [3601, 4005], 'guidelines': [3602, 4006], 'state': [3603, 4007], 'corresponds': [3607, 4011], '<25': [3609, 4013], 'intermediate': [3611, 4015], '25': [3614, 4018], 'PPB': [3615, 3623, 4019, 4027], '50': [3617, 4021], 'high': [3620, 4024], '>50': [3622, 4026], 'adults.': [3625, 4029], 'Atopy': [3626, 4030], 'assessed': [3629, 4033], 'positive': [3632, 4036], 'skin': [3633, 4037], 'prick': [3634, 4038], 'result': [3636, 4040], '1': [3638, 3707, 4042], 'more': [3640, 4044, 4219], 'allergens': [3641, 4045], 'clear': [3644, 4048], 'history': [3645, 4049], 'seasonal': [3647, 4051], 'allergic': [3648, 4052], 'rhinitis.∗': [3649], 'Open': [3652, 3736, 3871], 'table': [3653, 3737, 3872], 'new': [3656, 3740, 3875], 'tab': [3657, 3741, 3876], 'E2BTS': [3659], 'classification': [3661], 'medication': [3663], 'participants': [3665, 3748], 'dynamic': [3671], 'protocolBTS': [3674], 'step': [3676], 'category)Median': [3682], '(range)': [3683, 3694], 'daily': [3684, 3690], 'ICS': [3685], 'dose': [3686, 3692, 3775], '(μg': [3687], 'BDP': [3688], 'equivalent)Oral': [3689], 'prednisolone': [3691], '(mg)Median': [3693], 'long-acting': [3695], 'β2-adrenoceptor': [3696], 'dose/d': [3697], '(μg)Therapies': [3698], 'addition': [3700], 'prn': [3702], 'salbutamol': [3703], 'patients)FormoterolSalmeterolStep': [3706], '(3)0000Aminophylline': [3708], '(1)Step': [3709, 3722], '(1)400000NoneStep': [3711], '(6)800': [3713], '(700-800)024': [3714], '(24-24)0Montelukast': [3715], '(2)Step': [3716], '(3)1200': [3718], '(1000-1200)0075': [3719], '(50-100)Montelukast': [3720], '(1)Tiotropium': [3721], '(2)800': [3724], '(800-800)7.5': [3725], '(5-10)24': [3726], '(24-24)0Tiotropium': [3727], '(2)Montelukast': [3728], '(1)BDP,': [3729], 'Beclometasone': [3730, 4055], 'dipropionate;': [3731, 4056], 'BTS,': [3732, 4057], 'Society.': [3735, 4060], 'E3Clinical': [3743], 'whom': [3750], 'collectedCharacteristicNonobese(BMI': [3754], '30)Obese(BMI': [3756], '≥': [3757], '30)P': [3758], 'valuenAge': [3759], '(y)∗Mean': [3760], '(SEM).51': [3761], '(3)49': [3762], '(2).465261Sex:': [3763], 'male,': [3764], 'n': [3765], '(%)20': [3766], '(60.6)11': [3767], '(39.3).126161BMI': [3768], '(SEM).26': [3770], '(0.36)36': [3771], '(0.84)<.000161Daily': [3772], 'inhaled': [3773], 'corticosteroid': [3774], '(μg/d)∗Mean': [3776], '(SEM).†Beclomethasone': [3777], 'dipropionate': [3778, 3869], 'equivalent.1267': [3779], '(101)1504': [3780], '(98).238461Submucosal': [3781], '(cells/mm2)8.58': [3783], '(5.91-18.84)16.23': [3784], '(12.37-29.27).023834Epithelial': [3785], '(cells/mm2)0': [3787], '(0-10.5)3.9': [3788], '(0-6.3).491925Sputum': [3789], '(%)5.8': [3792], '(1.9-32.8)4': [3793], '(1.8-10.2).144459Peripheral': [3794], '(109/L)0.34': [3798], '(0.21-0.60)0.25': [3799], '(0.17-0.47).213461ECP': [3800], '(ng/mL)31.9': [3801], '(19.5-54.0)26.8': [3802], '(14.6-55.2).537756Feno': [3803], '(PBB)38.3': [3804], '(19.5-64.8)27.8': [3805], '(18.1-56.9).351260Total': [3806], '(kU/L)172': [3808], '(77-440)158': [3809], '(90-352).812059Atopic/nonatopic29/426/2.678161BTS': [3810], 'step4': [3812], '(4-4)4': [3813], '(4-5).092761BMI,': [3814], 'ECP,': [3818, 4065], 'cationic': [3820, 4067], 'protein;': [3821, 4068], 'billion.Data': [3825], 'threshold': [3838, 4086], 'unless': [3847, 4095], 'otherwise': [3848, 4096], 'stated;': [3849, 4097], 'or,': [3857, 4105], 'test.∗': [3865], '(SEM).†': [3867], 'Beclomethasone': [3868], 'equivalent.': [3870], 'rhinitis.': [4053], 'BDP,': [4054], 'Increased': [4114], 'asthma—to': [4124], 'correct': [4125], 'controlsJournal': [4131], 'ImmunologyVol.': [4136], '143Issue': [4137], '3PreviewWe': [4138], 'read': [4139], 'great': [4141], 'Farahi': [4146, 4216], 'al1': [4148], 'reporting': [4149], 'tomography/computed': [4155], 'lungs.': [4173], 'agree': [4175], 'proposal': [4178], 'correlated.': [4189], 'Bronchial': [4190], 'currently': [4193], 'golden': [4195], 'standard': [4196], 'investigate': [4198], 'procedure,': [4209], 'makes': [4211], 'method': [4214], 'al': [4218], 'interesting.': [4220], 'Full-Text': [4221]}, 'abstract_inverted_index_v3': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2885211253', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 5}], 'updated_date': '2025-01-25T05:04:02.980929', 'created_date': '2018-08-22'}
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