Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2884762657', 'doi': 'https://doi.org/10.1200/jco.2018.77.9827', 'title': 'Abiraterone Alone or in Combination With Enzalutamide in Metastatic Castration-Resistant Prostate Cancer With Rising Prostate-Specific Antigen During Enzalutamide Treatment', 'display_name': 'Abiraterone Alone or in Combination With Enzalutamide in Metastatic Castration-Resistant Prostate Cancer With Rising Prostate-Specific Antigen During Enzalutamide Treatment', 'publication_year': 2018, 'publication_date': '2018-07-20', 'ids': {'openalex': 'https://openalex.org/W2884762657', 'doi': 'https://doi.org/10.1200/jco.2018.77.9827', 'mag': '2884762657', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30028657', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6118405'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1200/jco.2018.77.9827', 'pdf_url': 'https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2018.77.9827', 'source': {'id': 'https://openalex.org/S15137598', 'display_name': 'Journal of Clinical Oncology', 'issn_l': '0732-183X', 'issn': ['0732-183X', '1527-7755'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2018.77.9827', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5000156180', 'display_name': 'Gerhardt Attard', 'orcid': 'https://orcid.org/0000-0002-4811-7983'}, 'institutions': [{'id': 'https://openalex.org/I125671874', 'display_name': 'National Health Service', 'ror': 'https://ror.org/02wnqcb97', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I125671874', 'https://openalex.org/I1311074006']}, {'id': 'https://openalex.org/I204337017', 'display_name': 'Aarhus University', 'ror': 'https://ror.org/01aj84f44', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I204337017']}, {'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I4210088881', 'display_name': 'London Cancer', 'ror': 'https://ror.org/005kpb876', 'country_code': 'GB', 'type': 'other', 'lineage': ['https://openalex.org/I4210088881']}], 'countries': ['DK', 'GB'], 'is_corresponding': True, 'raw_author_name': 'Gerhardt Attard', 'raw_affiliation_strings': ['Gerhardt Attard, The Institute of Cancer Research and the Royal Marsden National Health Service Foundation Trust, London, United Kingdom; Michael Borre, Aarhus University Hospital, Aarhus, Denmark; Howard Gurney, Macquarie University, Sydney, New South Wales, Australia; Yohann Loriot, Gustave Roussy, Institut National de la Santé et de la Recherche Médicale U981, University of Paris Saclay, Villejuif, France; Corina Andresen-Daniil, Ranjith Kalleda, and Trinh Pham, Pfizer, New York, NY; and Mary-Ellen...', "University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley St, London WC1E 6DD, United Kingdom;"], 'affiliations': [{'raw_affiliation_string': 'Gerhardt Attard, The Institute of Cancer Research and the Royal Marsden National Health Service Foundation Trust, London, United Kingdom; Michael Borre, Aarhus University Hospital, Aarhus, Denmark; Howard Gurney, Macquarie University, Sydney, New South Wales, Australia; Yohann Loriot, Gustave Roussy, Institut National de la Santé et de la Recherche Médicale U981, University of Paris Saclay, Villejuif, France; Corina Andresen-Daniil, Ranjith Kalleda, and Trinh Pham, Pfizer, New York, NY; and Mary-Ellen...', 'institution_ids': ['https://openalex.org/I125671874', 'https://openalex.org/I204337017']}, {'raw_affiliation_string': "University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley St, London WC1E 6DD, United Kingdom;", 'institution_ids': ['https://openalex.org/I45129253', 'https://openalex.org/I4210088881']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070573139', 'display_name': 'Michael Borre', 'orcid': 'https://orcid.org/0000-0002-1519-9185'}, 'institutions': [{'id': 'https://openalex.org/I125671874', 'display_name': 'National Health Service', 'ror': 'https://ror.org/02wnqcb97', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I125671874', 'https://openalex.org/I1311074006']}, {'id': 'https://openalex.org/I204337017', 'display_name': 'Aarhus University', 'ror': 'https://ror.org/01aj84f44', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I204337017']}], 'countries': ['DK', 'GB'], 'is_corresponding': False, 'raw_author_name': 'Michael Borre', 'raw_affiliation_strings': ['Gerhardt Attard, The Institute of Cancer Research and the Royal Marsden National Health Service Foundation Trust, London, United Kingdom; Michael Borre, Aarhus University Hospital, Aarhus, Denmark; Howard Gurney, Macquarie University, Sydney, New South Wales, Australia; Yohann Loriot, Gustave Roussy, Institut National de la Santé et de la Recherche Médicale U981, University of Paris Saclay, Villejuif, France; Corina Andresen-Daniil, Ranjith Kalleda, and Trinh Pham, Pfizer, New York, NY; and Mary-Ellen...'], 'affiliations': [{'raw_affiliation_string': 'Gerhardt Attard, The Institute of Cancer Research and the Royal Marsden National Health Service Foundation Trust, London, United Kingdom; Michael Borre, Aarhus University Hospital, Aarhus, Denmark; Howard Gurney, Macquarie University, Sydney, New South Wales, Australia; Yohann Loriot, Gustave Roussy, Institut National de la Santé et de la Recherche Médicale U981, University of Paris Saclay, Villejuif, France; Corina Andresen-Daniil, Ranjith Kalleda, and Trinh Pham, Pfizer, New York, NY; and Mary-Ellen...', 'institution_ids': ['https://openalex.org/I125671874', 'https://openalex.org/I204337017']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041526616', 'display_name': 'Howard Gurney', 'orcid': 'https://orcid.org/0000-0003-0217-5261'}, 'institutions': [{'id': 'https://openalex.org/I125671874', 'display_name': 'National Health Service', 'ror': 'https://ror.org/02wnqcb97', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I125671874', 'https://openalex.org/I1311074006']}, {'id': 'https://openalex.org/I204337017', 'display_name': 'Aarhus University', 'ror': 'https://ror.org/01aj84f44', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I204337017']}], 'countries': ['DK', 'GB'], 'is_corresponding': False, 'raw_author_name': 'Howard Gurney', 'raw_affiliation_strings': ['Gerhardt Attard, The Institute of Cancer Research and the Royal Marsden National Health Service Foundation Trust, London, United Kingdom; Michael Borre, Aarhus University Hospital, Aarhus, Denmark; Howard Gurney, Macquarie University, Sydney, New South Wales, Australia; Yohann Loriot, Gustave Roussy, Institut National de la Santé et de la Recherche Médicale U981, University of Paris Saclay, Villejuif, France; Corina Andresen-Daniil, Ranjith Kalleda, and Trinh Pham, Pfizer, New York, NY; and Mary-Ellen...'], 'affiliations': [{'raw_affiliation_string': 'Gerhardt Attard, The Institute of Cancer Research and the Royal Marsden National Health Service Foundation Trust, London, United Kingdom; Michael Borre, Aarhus University Hospital, Aarhus, Denmark; Howard Gurney, Macquarie University, Sydney, New South Wales, Australia; Yohann Loriot, Gustave Roussy, Institut National de la Santé et de la Recherche Médicale U981, University of Paris Saclay, Villejuif, France; Corina Andresen-Daniil, Ranjith Kalleda, and Trinh Pham, Pfizer, New York, NY; and Mary-Ellen...', 'institution_ids': ['https://openalex.org/I125671874', 'https://openalex.org/I204337017']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027991868', 'display_name': 'Yohann Loriot', 'orcid': 'https://orcid.org/0000-0002-8338-1739'}, 'institutions': [{'id': 'https://openalex.org/I125671874', 'display_name': 'National Health Service', 'ror': 'https://ror.org/02wnqcb97', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I125671874', 'https://openalex.org/I1311074006']}, {'id': 'https://openalex.org/I204337017', 'display_name': 'Aarhus University', 'ror': 'https://ror.org/01aj84f44', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I204337017']}], 'countries': ['DK', 'GB'], 'is_corresponding': False, 'raw_author_name': 'Yohann Loriot', 'raw_affiliation_strings': ['Gerhardt Attard, The Institute of Cancer Research and the Royal Marsden National Health Service Foundation Trust, London, United Kingdom; Michael Borre, Aarhus University Hospital, Aarhus, Denmark; Howard Gurney, Macquarie University, Sydney, New South Wales, Australia; Yohann Loriot, Gustave Roussy, Institut National de la Santé et de la Recherche Médicale U981, University of Paris Saclay, Villejuif, France; Corina Andresen-Daniil, Ranjith Kalleda, and Trinh Pham, Pfizer, New York, NY; and Mary-Ellen...'], 'affiliations': [{'raw_affiliation_string': 'Gerhardt Attard, The Institute of Cancer Research and the Royal Marsden National Health Service Foundation Trust, London, United Kingdom; Michael Borre, Aarhus University Hospital, Aarhus, Denmark; Howard Gurney, Macquarie University, Sydney, New South Wales, Australia; Yohann Loriot, Gustave Roussy, Institut National de la Santé et de la Recherche Médicale U981, University of Paris Saclay, Villejuif, France; Corina Andresen-Daniil, Ranjith Kalleda, and Trinh Pham, Pfizer, New York, NY; and Mary-Ellen...', 'institution_ids': ['https://openalex.org/I125671874', 'https://openalex.org/I204337017']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034119932', 'display_name': 'Corina Andresen-Daniil', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I125671874', 'display_name': 'National Health Service', 'ror': 'https://ror.org/02wnqcb97', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I125671874', 'https://openalex.org/I1311074006']}, {'id': 'https://openalex.org/I204337017', 'display_name': 'Aarhus University', 'ror': 'https://ror.org/01aj84f44', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I204337017']}], 'countries': ['DK', 'GB'], 'is_corresponding': False, 'raw_author_name': 'Corina Andresen-Daniil', 'raw_affiliation_strings': ['Gerhardt Attard, The Institute of Cancer Research and the Royal Marsden National Health Service Foundation Trust, London, United Kingdom; Michael Borre, Aarhus University Hospital, Aarhus, Denmark; Howard Gurney, Macquarie University, Sydney, New South Wales, Australia; Yohann Loriot, Gustave Roussy, Institut National de la Santé et de la Recherche Médicale U981, University of Paris Saclay, Villejuif, France; Corina Andresen-Daniil, Ranjith Kalleda, and Trinh Pham, Pfizer, New York, NY; and Mary-Ellen...'], 'affiliations': [{'raw_affiliation_string': 'Gerhardt Attard, The Institute of Cancer Research and the Royal Marsden National Health Service Foundation Trust, London, United Kingdom; Michael Borre, Aarhus University Hospital, Aarhus, Denmark; Howard Gurney, Macquarie University, Sydney, New South Wales, Australia; Yohann Loriot, Gustave Roussy, Institut National de la Santé et de la Recherche Médicale U981, University of Paris Saclay, Villejuif, France; Corina Andresen-Daniil, Ranjith Kalleda, and Trinh Pham, Pfizer, New York, NY; and Mary-Ellen...', 'institution_ids': ['https://openalex.org/I125671874', 'https://openalex.org/I204337017']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088141738', 'display_name': 'Ranjith Kalleda', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I125671874', 'display_name': 'National Health Service', 'ror': 'https://ror.org/02wnqcb97', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I125671874', 'https://openalex.org/I1311074006']}, {'id': 'https://openalex.org/I204337017', 'display_name': 'Aarhus University', 'ror': 'https://ror.org/01aj84f44', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I204337017']}], 'countries': ['DK', 'GB'], 'is_corresponding': False, 'raw_author_name': 'Ranjith Kalleda', 'raw_affiliation_strings': ['Gerhardt Attard, The Institute of Cancer Research and the Royal Marsden National Health Service Foundation Trust, London, United Kingdom; Michael Borre, Aarhus University Hospital, Aarhus, Denmark; Howard Gurney, Macquarie University, Sydney, New South Wales, Australia; Yohann Loriot, Gustave Roussy, Institut National de la Santé et de la Recherche Médicale U981, University of Paris Saclay, Villejuif, France; Corina Andresen-Daniil, Ranjith Kalleda, and Trinh Pham, Pfizer, New York, NY; and Mary-Ellen...'], 'affiliations': [{'raw_affiliation_string': 'Gerhardt Attard, The Institute of Cancer Research and the Royal Marsden National Health Service Foundation Trust, London, United Kingdom; Michael Borre, Aarhus University Hospital, Aarhus, Denmark; Howard Gurney, Macquarie University, Sydney, New South Wales, Australia; Yohann Loriot, Gustave Roussy, Institut National de la Santé et de la Recherche Médicale U981, University of Paris Saclay, Villejuif, France; Corina Andresen-Daniil, Ranjith Kalleda, and Trinh Pham, Pfizer, New York, NY; and Mary-Ellen...', 'institution_ids': ['https://openalex.org/I125671874', 'https://openalex.org/I204337017']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105716913', 'display_name': 'Trinh Pham', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204337017', 'display_name': 'Aarhus University', 'ror': 'https://ror.org/01aj84f44', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I204337017']}, {'id': 'https://openalex.org/I125671874', 'display_name': 'National Health Service', 'ror': 'https://ror.org/02wnqcb97', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I125671874', 'https://openalex.org/I1311074006']}], 'countries': ['DK', 'GB'], 'is_corresponding': False, 'raw_author_name': 'Trinh Pham', 'raw_affiliation_strings': ['Gerhardt Attard, The Institute of Cancer Research and the Royal Marsden National Health Service Foundation Trust, London, United Kingdom; Michael Borre, Aarhus University Hospital, Aarhus, Denmark; Howard Gurney, Macquarie University, Sydney, New South Wales, Australia; Yohann Loriot, Gustave Roussy, Institut National de la Santé et de la Recherche Médicale U981, University of Paris Saclay, Villejuif, France; Corina Andresen-Daniil, Ranjith Kalleda, and Trinh Pham, Pfizer, New York, NY; and Mary-Ellen...'], 'affiliations': [{'raw_affiliation_string': 'Gerhardt Attard, The Institute of Cancer Research and the Royal Marsden National Health Service Foundation Trust, London, United Kingdom; Michael Borre, Aarhus University Hospital, Aarhus, Denmark; Howard Gurney, Macquarie University, Sydney, New South Wales, Australia; Yohann Loriot, Gustave Roussy, Institut National de la Santé et de la Recherche Médicale U981, University of Paris Saclay, Villejuif, France; Corina Andresen-Daniil, Ranjith Kalleda, and Trinh Pham, Pfizer, New York, NY; and Mary-Ellen...', 'institution_ids': ['https://openalex.org/I204337017', 'https://openalex.org/I125671874']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111605855', 'display_name': 'Mary-Ellen Taplin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I125671874', 'display_name': 'National Health Service', 'ror': 'https://ror.org/02wnqcb97', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I125671874', 'https://openalex.org/I1311074006']}, {'id': 'https://openalex.org/I204337017', 'display_name': 'Aarhus University', 'ror': 'https://ror.org/01aj84f44', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I204337017']}], 'countries': ['DK', 'GB'], 'is_corresponding': False, 'raw_author_name': 'Mary-Ellen Taplin', 'raw_affiliation_strings': ['Gerhardt Attard, The Institute of Cancer Research and the Royal Marsden National Health Service Foundation Trust, London, United Kingdom; Michael Borre, Aarhus University Hospital, Aarhus, Denmark; Howard Gurney, Macquarie University, Sydney, New South Wales, Australia; Yohann Loriot, Gustave Roussy, Institut National de la Santé et de la Recherche Médicale U981, University of Paris Saclay, Villejuif, France; Corina Andresen-Daniil, Ranjith Kalleda, and Trinh Pham, Pfizer, New York, NY; and Mary-Ellen...'], 'affiliations': [{'raw_affiliation_string': 'Gerhardt Attard, The Institute of Cancer Research and the Royal Marsden National Health Service Foundation Trust, London, United Kingdom; Michael Borre, Aarhus University Hospital, Aarhus, Denmark; Howard Gurney, Macquarie University, Sydney, New South Wales, Australia; Yohann Loriot, Gustave Roussy, Institut National de la Santé et de la Recherche Médicale U981, University of Paris Saclay, Villejuif, France; Corina Andresen-Daniil, Ranjith Kalleda, and Trinh Pham, Pfizer, New York, NY; and Mary-Ellen...', 'institution_ids': ['https://openalex.org/I125671874', 'https://openalex.org/I204337017']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5000156180'], 'corresponding_institution_ids': ['https://openalex.org/I125671874', 'https://openalex.org/I204337017', 'https://openalex.org/I45129253', 'https://openalex.org/I4210088881'], 'apc_list': None, 'apc_paid': None, 'fwci': 17.243, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 148, 'citation_normalized_percentile': {'value': 0.999972, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '36', 'issue': '25', 'first_page': '2639', 'last_page': '2646'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11146', 'display_name': 'Hormonal and reproductive studies', 'score': 0.9899, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12465', 'display_name': 'Cancer, Lipids, and Metabolism', 'score': 0.9829, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/enzalutamide', 'display_name': 'Enzalutamide', 'score': 0.9654212}, {'id': 'https://openalex.org/keywords/abiraterone-acetate', 'display_name': 'Abiraterone acetate', 'score': 0.84210825}, {'id': 'https://openalex.org/keywords/clinical-endpoint', 'display_name': 'Clinical endpoint', 'score': 0.6288462}, {'id': 'https://openalex.org/keywords/progression-free-survival', 'display_name': 'Progression-free survival', 'score': 0.5772063}], 'concepts': [{'id': 'https://openalex.org/C2776551883', 'wikidata': 'https://www.wikidata.org/wiki/Q1996756', 'display_name': 'Enzalutamide', 'level': 5, 'score': 0.9654212}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.9113958}, {'id': 'https://openalex.org/C2775832370', 'wikidata': 'https://www.wikidata.org/wiki/Q27888393', 'display_name': 'Abiraterone acetate', 'level': 5, 'score': 0.84210825}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.81640995}, {'id': 'https://openalex.org/C203092338', 'wikidata': 'https://www.wikidata.org/wiki/Q1340863', 'display_name': 'Clinical endpoint', 'level': 3, 'score': 0.6288462}, {'id': 'https://openalex.org/C27081682', 'wikidata': 'https://www.wikidata.org/wiki/Q269829', 'display_name': 'Placebo', 'level': 3, 'score': 0.5969984}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5830522}, {'id': 'https://openalex.org/C2780739268', 'wikidata': 'https://www.wikidata.org/wiki/Q2112244', 'display_name': 'Progression-free survival', 'level': 3, 'score': 0.5772063}, {'id': 'https://openalex.org/C126894567', 'wikidata': 'https://www.wikidata.org/wiki/Q105650', 'display_name': 'Urology', 'level': 1, 'score': 0.5720461}, {'id': 'https://openalex.org/C2778720950', 'wikidata': 'https://www.wikidata.org/wiki/Q424972', 'display_name': 'Prednisone', 'level': 2, 'score': 0.53253245}, {'id': 'https://openalex.org/C2781406297', 'wikidata': 'https://www.wikidata.org/wiki/Q409450', 'display_name': 'Prostate-specific antigen', 'level': 4, 'score': 0.47006473}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.4501316}, {'id': 'https://openalex.org/C207103383', 'wikidata': 'https://www.wikidata.org/wiki/Q3930246', 'display_name': 'Hazard ratio', 'level': 3, 'score': 0.44256428}, {'id': 'https://openalex.org/C2777899217', 'wikidata': 'https://www.wikidata.org/wiki/Q4759439', 'display_name': 'Androgen deprivation therapy', 'level': 4, 'score': 0.39657745}, {'id': 'https://openalex.org/C168563851', 'wikidata': 'https://www.wikidata.org/wiki/Q1436668', 'display_name': 'Randomized controlled trial', 'level': 2, 'score': 0.38676435}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.38519308}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.3564285}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.30992737}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.22907764}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.10020578}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C44249647', 'wikidata': 'https://www.wikidata.org/wiki/Q208498', 'display_name': 'Confidence interval', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000736', 'descriptor_name': 'Androstenes', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D064129', 'descriptor_name': 'Prostatic Neoplasms, Castration-Resistant', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D001549', 'descriptor_name': 'Benzamides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004311', 'descriptor_name': 'Double-Blind Method', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009570', 'descriptor_name': 'Nitriles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010669', 'descriptor_name': 'Phenylthiohydantoin', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D000077982', 'descriptor_name': 'Progression-Free Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017430', 'descriptor_name': 'Prostate-Specific Antigen', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 7, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1200/jco.2018.77.9827', 'pdf_url': 'https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2018.77.9827', 'source': {'id': 'https://openalex.org/S15137598', 'display_name': 'Journal of Clinical Oncology', 'issn_l': '0732-183X', 'issn': ['0732-183X', '1527-7755'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6118405', 'pdf_url': 'https://europepmc.org/articles/pmc6118405?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://pure.au.dk/ws/files/166742734/jco.2018.77.9827.pdf', 'pdf_url': 'https://pure.au.dk/ws/files/166742734/jco.2018.77.9827.pdf', 'source': {'id': 'https://openalex.org/S4306400063', 'display_name': 'Scopus (Elsevier)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://discovery.ucl.ac.uk/id/eprint/10058569/', 'pdf_url': 'https://discovery.ucl.ac.uk/10058569/1/jco.2018.77.9827.pdf', 'source': {'id': 'https://openalex.org/S4306400024', 'display_name': 'UCL Discovery (University College London)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I45129253', 'host_organization_name': 'University College London', 'host_organization_lineage': ['https://openalex.org/I45129253'], 'host_organization_lineage_names': ['University College London'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://discovery.ucl.ac.uk/id/eprint/10058569/1/jco.2018.77.9827.pdf', 'pdf_url': 'https://discovery.ucl.ac.uk/id/eprint/10058569/1/jco.2018.77.9827.pdf', 'source': {'id': 'https://openalex.org/S4306400024', 'display_name': 'UCL Discovery (University College London)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I45129253', 'host_organization_name': 'University College London', 'host_organization_lineage': ['https://openalex.org/I45129253'], 'host_organization_lineage_names': ['University College London'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118405', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30028657', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1200/jco.2018.77.9827', 'pdf_url': 'https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2018.77.9827', 'source': {'id': 'https://openalex.org/S15137598', 'display_name': 'Journal of Clinical Oncology', 'issn_l': '0732-183X', 'issn': ['0732-183X', '1527-7755'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.86}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W1996389184', 'https://openalex.org/W2006352011', 'https://openalex.org/W2014751188', 'https://openalex.org/W2055346449', 'https://openalex.org/W2080748037', 'https://openalex.org/W2088318211', 'https://openalex.org/W2092172518', 'https://openalex.org/W2110534364', 'https://openalex.org/W2110841612', 'https://openalex.org/W2118564089', 'https://openalex.org/W2120148445', 'https://openalex.org/W2121023961', 'https://openalex.org/W2121098984', 'https://openalex.org/W2137467802', 'https://openalex.org/W2138504446', 'https://openalex.org/W2166918329', 'https://openalex.org/W2167331614', 'https://openalex.org/W2168500832', 'https://openalex.org/W2170544517', 'https://openalex.org/W2611922828', 'https://openalex.org/W2746053356', 'https://openalex.org/W2938497258'], 'related_works': ['https://openalex.org/W4383294799', 'https://openalex.org/W4383225189', 'https://openalex.org/W4378375589', 'https://openalex.org/W4285594353', 'https://openalex.org/W2989723302', 'https://openalex.org/W2981596434', 'https://openalex.org/W2796274789', 'https://openalex.org/W2506739073', 'https://openalex.org/W2344063726', 'https://openalex.org/W1745328274'], 'abstract_inverted_index': {'Purpose': [0], 'Enzalutamide': [1], 'resistance': [2], 'could': [3], 'result': [4], 'from': [5], 'raised': [6], 'androgens': [7], 'and': [8, 31, 59, 69, 91, 136, 167, 200, 227, 241], 'be': [9], 'overcome': [10], 'by': [11, 112], 'combination': [12, 165, 216, 249], 'with': [13, 37, 50, 97, 224, 237, 248], 'abiraterone': [14, 86, 225], 'acetate.': [15], 'PLATO': [16], '(': [17], 'ClinicalTrials.gov': [18], 'identifier:': [19], 'NCT01995513)': [20], 'interrogated': [21], 'this': [22], 'hypothesis': [23], 'using': [24], 'a': [25, 79], 'randomized,': [26], 'double-blind,': [27], 'placebo-controlled': [28], 'design.': [29], 'Patients': [30], 'Methods': [32], 'In': [33], 'period': [34, 83, 140, 148, 155], 'one,': [35, 149], 'men': [36], 'chemotherapy-naïve': [38], 'metastatic': [39], 'castration-resistant': [40], 'prostate': [41], 'cancer': [42], 'received': [43], 'open-label': [44], 'enzalutamide': [45, 99, 223, 238], '160': [46], 'mg': [47, 89, 94], 'daily.': [48], 'Men': [49], 'no': [51, 187], 'prostate-specific': [52], 'antigen': [53], '(PSA)': [54], 'increase': [55, 68], 'at': [56, 78], 'weeks': [57], '13': [58], '21': [60], 'were': [61, 151, 211], 'treated': [62], 'until': [63, 107], 'PSA': [64, 134, 137, 233], 'progression': [65, 109, 123, 135, 234], '(≥': [66], '25%': [67], '≥': [70], '2': [71], 'ng/mL': [72], 'above': [73], 'nadir),': [74], 'then': [75], 'randomly': [76, 152], 'assigned': [77, 153], 'one-to-one': [80], 'ratio': [81], 'in': [82, 139, 147, 154, 163, 170, 189, 214], 'two': [84], 'to': [85, 133, 180], 'acetate': [87, 226], '1,000': [88], 'daily': [90, 96], 'prednisone': [92, 228], '5': [93], 'twice': [95], 'either': [98], 'or': [100, 103, 120, 124, 206], 'placebo': [101], '(combination': [102], 'control': [104, 172, 219], 'group,': [105], 'respectively)': [106], 'disease': [108], 'as': [110], 'defined': [111], 'the': [113, 164, 171, 190, 215, 218], 'primary': [114], 'end': [115, 129, 192], 'point:': [116], 'progression-free': [117, 158], 'survival': [118, 159], '(radiographic': [119], 'unequivocal': [121], 'clinical': [122], 'death': [125], 'during': [126, 235], 'study).': [127], 'Secondary': [128], 'points': [130], 'included': [131], 'time': [132], 'response': [138], 'two.': [141, 156], 'Results': [142], 'Of': [143], '509': [144], 'patients': [145], 'enrolled': [146], '251': [150], 'Median': [157], 'was': [160, 186], '5.7': [161], 'months': [162, 169], 'group': [166, 173], '5.6': [168], '(hazard': [174], 'ratio,': [175], '0.83;': [176], '95%': [177], 'CI,': [178], '0.61': [179], '1.12;': [181], 'P': [182], '=': [183], '.22).': [184], 'There': [185], 'difference': [188], 'secondary': [191], 'points.': [193], 'Grade': [194], '3': [195], 'hypertension': [196, 240], '(10%': [197], 'v': [198, 204, 209], '2%)': [199, 205], 'increased': [201], 'ALT': [202], '(6%': [203], 'AST': [207], '(2%': [208], '0%)': [210], 'more': [212, 246], 'frequent': [213, 247], 'than': [217], 'group.': [220], 'Conclusion': [221], 'Combining': [222], 'is': [229], 'not': [230], 'indicated': [231], 'after': [232], 'treatment': [236], 'alone;': [239], 'elevated': [242], 'liver': [243], 'enzymes': [244], 'are': [245], 'therapy.': [250]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2884762657', 'counts_by_year': [{'year': 2024, 'cited_by_count': 14}, {'year': 2023, 'cited_by_count': 18}, {'year': 2022, 'cited_by_count': 29}, {'year': 2021, 'cited_by_count': 32}, {'year': 2020, 'cited_by_count': 29}, {'year': 2019, 'cited_by_count': 23}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-12-17T10:09:11.036456', 'created_date': '2018-08-03'}