Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2884261249', 'doi': 'https://doi.org/10.1080/00498254.2018.1495345', 'title': '<i>In vitro</i> characterization of the glucuronidation pathways of licochalcone A mediated by human UDP-glucuronosyltransferases', 'display_name': '<i>In vitro</i> characterization of the glucuronidation pathways of licochalcone A mediated by human UDP-glucuronosyltransferases', 'publication_year': 2018, 'publication_date': '2018-07-25', 'ids': {'openalex': 'https://openalex.org/W2884261249', 'doi': 'https://doi.org/10.1080/00498254.2018.1495345', 'mag': '2884261249', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30044687'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/00498254.2018.1495345', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S48760969', 'display_name': 'Xenobiotica', 'issn_l': '0049-8254', 'issn': ['0049-8254', '1366-5928'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5089164263', 'display_name': 'Yangliu Xia', 'orcid': 'https://orcid.org/0000-0002-5742-7182'}, 'institutions': [{'id': 'https://openalex.org/I27357992', 'display_name': 'Dalian University of Technology', 'ror': 'https://ror.org/023hj5876', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I27357992']}, {'id': 'https://openalex.org/I4210092944', 'display_name': 'Dalian University', 'ror': 'https://ror.org/00g2ypp58', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210092944']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Yang-Liu Xia', 'raw_affiliation_strings': ['School of Life Science and Medicine, Dalian University of Technology, Panjin, China;'], 'affiliations': [{'raw_affiliation_string': 'School of Life Science and Medicine, Dalian University of Technology, Panjin, China;', 'institution_ids': ['https://openalex.org/I27357992', 'https://openalex.org/I4210092944']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050920786', 'display_name': 'Tong‐Yi Dou', 'orcid': 'https://orcid.org/0000-0002-4252-5038'}, 'institutions': [{'id': 'https://openalex.org/I4210092944', 'display_name': 'Dalian University', 'ror': 'https://ror.org/00g2ypp58', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210092944']}, {'id': 'https://openalex.org/I27357992', 'display_name': 'Dalian University of Technology', 'ror': 'https://ror.org/023hj5876', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I27357992']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Tong-Yi Dou', 'raw_affiliation_strings': ['School of Life Science and Medicine, Dalian University of Technology, Panjin, China;'], 'affiliations': [{'raw_affiliation_string': 'School of Life Science and Medicine, Dalian University of Technology, Panjin, China;', 'institution_ids': ['https://openalex.org/I4210092944', 'https://openalex.org/I27357992']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102845651', 'display_name': 'Xia Lv', 'orcid': 'https://orcid.org/0000-0003-0509-7975'}, 'institutions': [{'id': 'https://openalex.org/I61565387', 'display_name': 'Dalian Minzu University', 'ror': 'https://ror.org/02hxfx521', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I61565387']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xia Lv', 'raw_affiliation_strings': ['College of Life Science, Dalian Minzu University, Dalian, China;'], 'affiliations': [{'raw_affiliation_string': 'College of Life Science, Dalian Minzu University, Dalian, China;', 'institution_ids': ['https://openalex.org/I61565387']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5043073852', 'display_name': 'Guang‐Bo Ge', 'orcid': 'https://orcid.org/0000-0002-9670-4349'}, 'institutions': [{'id': 'https://openalex.org/I4210098460', 'display_name': 'Shanghai University of Traditional Chinese Medicine', 'ror': 'https://ror.org/00z27jk27', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210098460']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Guang-Bo Ge', 'raw_affiliation_strings': ['Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China', 'institution_ids': ['https://openalex.org/I4210098460']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5089164263', 'https://openalex.org/A5043073852'], 'corresponding_institution_ids': ['https://openalex.org/I27357992', 'https://openalex.org/I4210092944', 'https://openalex.org/I4210098460'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.456, 'has_fulltext': False, 'cited_by_count': 4, 'citation_normalized_percentile': {'value': 0.645778, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 77, 'max': 79}, 'biblio': {'volume': '49', 'issue': '6', 'first_page': '671', 'last_page': '677'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12817', 'display_name': 'Pharmacological Effects of Natural Compounds', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12817', 'display_name': 'Pharmacological Effects of Natural Compounds', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12346', 'display_name': 'Phytochemistry and biological activity of medicinal plants', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12477', 'display_name': 'Toxin Mechanisms and Immunotoxins', 'score': 0.9853, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ugt2b7', 'display_name': 'UGT2B7', 'score': 0.85801196}, {'id': 'https://openalex.org/keywords/glucuronide', 'display_name': 'Glucuronide', 'score': 0.82069075}, {'id': 'https://openalex.org/keywords/glucuronosyltransferase', 'display_name': 'Glucuronosyltransferase', 'score': 0.5471389}, {'id': 'https://openalex.org/keywords/biotransformation', 'display_name': 'Biotransformation', 'score': 0.544492}], 'concepts': [{'id': 'https://openalex.org/C2779907587', 'wikidata': 'https://www.wikidata.org/wiki/Q14901439', 'display_name': 'Glucuronidation', 'level': 4, 'score': 0.9951572}, {'id': 'https://openalex.org/C2777469378', 'wikidata': 'https://www.wikidata.org/wiki/Q14907739', 'display_name': 'UGT2B7', 'level': 5, 'score': 0.85801196}, {'id': 'https://openalex.org/C2779186261', 'wikidata': 'https://www.wikidata.org/wiki/Q137786', 'display_name': 'Glucuronide', 'level': 3, 'score': 0.82069075}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.75834143}, {'id': 'https://openalex.org/C87644729', 'wikidata': 'https://www.wikidata.org/wiki/Q547502', 'display_name': 'Microsome', 'level': 3, 'score': 0.66504204}, {'id': 'https://openalex.org/C2781278898', 'wikidata': 'https://www.wikidata.org/wiki/Q419543', 'display_name': 'Glucuronosyltransferase', 'level': 4, 'score': 0.5471389}, {'id': 'https://openalex.org/C27881333', 'wikidata': 'https://www.wikidata.org/wiki/Q864895', 'display_name': 'Biotransformation', 'level': 3, 'score': 0.544492}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.5004022}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.4130327}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.33326668}], 'mesh': [{'descriptor_ui': 'D047188', 'descriptor_name': 'Chalcones', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014453', 'descriptor_name': 'Glucuronosyltransferase', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D053858', 'descriptor_name': 'Metabolic Networks and Pathways', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047188', 'descriptor_name': 'Chalcones', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D047188', 'descriptor_name': 'Chalcones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004285', 'descriptor_name': 'Dogs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014453', 'descriptor_name': 'Glucuronosyltransferase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014453', 'descriptor_name': 'Glucuronosyltransferase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014453', 'descriptor_name': 'Glucuronosyltransferase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006168', 'descriptor_name': 'Guinea Pigs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008252', 'descriptor_name': 'Macaca fascicularis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008862', 'descriptor_name': 'Microsomes, Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020033', 'descriptor_name': 'Protein Isoforms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020033', 'descriptor_name': 'Protein Isoforms', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D020033', 'descriptor_name': 'Protein Isoforms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020033', 'descriptor_name': 'Protein Isoforms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011817', 'descriptor_name': 'Rabbits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013552', 'descriptor_name': 'Swine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013556', 'descriptor_name': 'Swine, Miniature', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/00498254.2018.1495345', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S48760969', 'display_name': 'Xenobiotica', 'issn_l': '0049-8254', 'issn': ['0049-8254', '1366-5928'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30044687', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320309612', 'funder_display_name': 'Natural Science Foundation of Shanghai', 'award_id': '500'}, {'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': 'DUT18LK39'}], 'datasets': [], 'versions': [], 'referenced_works_count': 30, 'referenced_works': ['https://openalex.org/W1910224951', 'https://openalex.org/W1965912922', 'https://openalex.org/W1975741996', 'https://openalex.org/W1987248421', 'https://openalex.org/W1993194753', 'https://openalex.org/W1995254901', 'https://openalex.org/W2017011289', 'https://openalex.org/W2019518392', 'https://openalex.org/W2019643499', 'https://openalex.org/W2037744796', 'https://openalex.org/W2038893680', 'https://openalex.org/W2039368371', 'https://openalex.org/W2046644529', 'https://openalex.org/W2052562717', 'https://openalex.org/W2054457593', 'https://openalex.org/W2072205393', 'https://openalex.org/W2073433258', 'https://openalex.org/W2076825621', 'https://openalex.org/W2087593774', 'https://openalex.org/W2088103680', 'https://openalex.org/W2095125338', 'https://openalex.org/W2096801003', 'https://openalex.org/W2135807045', 'https://openalex.org/W2137297158', 'https://openalex.org/W2146850374', 'https://openalex.org/W2150869404', 'https://openalex.org/W2163784855', 'https://openalex.org/W2258466302', 'https://openalex.org/W4285719527', 'https://openalex.org/W580269463'], 'related_works': ['https://openalex.org/W3124413224', 'https://openalex.org/W2884261249', 'https://openalex.org/W2769815100', 'https://openalex.org/W2171173198', 'https://openalex.org/W2164700394', 'https://openalex.org/W2152712687', 'https://openalex.org/W2136434035', 'https://openalex.org/W2111495323', 'https://openalex.org/W2093461594', 'https://openalex.org/W2018491836'], 'abstract_inverted_index': {'This': [0], 'study': [1], 'aimed': [2], 'to': [3, 22, 46, 63, 144, 164], 'characterize': [4], 'the': [5, 24, 48, 53, 85, 106, 113, 127, 141, 152, 161, 165], 'glucuronidation': [6, 30, 54, 86], 'pathway': [7], 'of': [8, 26, 32, 55, 88, 108, 129, 154, 167], 'licochalcone': [9], 'A': [10], '(LCA)': [11], 'in': [12, 52, 57, 66, 90, 105, 117, 126, 151, 174], 'human': [13], 'liver': [14, 91], 'microsomes': [15, 92], '(HLM).': [16], 'HLM': [17], 'incubation': [18], 'systems': [19], 'were': [20, 82, 124], 'employed': [21], 'catalyze': [23], 'formation': [25, 107, 128, 153, 166], 'LCA': [27, 39, 56, 59, 89], 'glucuronide.': [28], 'The': [29], 'activity': [31, 116], 'commercially': [33], 'recombinant': [34], 'UDP-glucuronosyltransferase': [35], '(UGT)': [36], 'isoforms': [37, 50], 'toward': [38], 'was': [40, 44, 140, 160], 'screened.': [41], 'Kinetic': [42, 135], 'analysis': [43, 136], 'used': [45], 'identify': [47], 'UGT': [49], 'involved': [51, 125], 'HLM.': [58], 'could': [60], 'be': [61], 'metabolized': [62], 'two': [64], 'monoglucuronides': [65], 'HLM,': [67], 'including': [68], 'a': [69, 75], 'major': [70, 142, 162], 'monoglucuronide,': [71, 77], 'namely,': [72, 78], '4-O-glucuronide,': [73, 109], 'and': [74, 102, 122, 157, 177], 'minor': [76], "4'-O-glucuronide.": [79, 158], 'Species-dependent': [80], 'differences': [81], 'observed': [83], 'among': [84], 'profiles': [87], 'from': [93], 'different': [94], 'species.': [95], 'UGT1A1,': [96], 'UGT1A3,': [97], 'UGT1A7,': [98], 'UGT1A8,': [99], 'UGT1A9,': [100], 'UGT1A10': [101], 'UGT2B7': [103], 'participated': [104], 'with': [110], 'UGT1A9': [111, 139, 159], 'exhibiting': [112, 131], 'highest': [114], 'catalytic': [115], 'this': [118], 'biotransformation.': [119], 'Only': [120], 'UGT1A1': [121, 147, 170], 'UGT1A3': [123], "4'-O-glucuronide,": [130], 'similar': [132], 'reaction': [133], 'rates.': [134], 'demonstrated': [137], 'that': [138], 'contributor': [143, 163], 'LCA-4-O-glucuronidation,': [145], 'while': [146, 169], 'played': [148, 171], 'important': [149, 172], 'roles': [150, 173], 'both': [155, 175], 'LCA-4-O-': [156, 176], 'LCA-4-O-glucuronide,': [168], "4'-O-glucuronidation.": [178]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2884261249', 'counts_by_year': [{'year': 2022, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-12-17T05:39:12.056319', 'created_date': '2018-08-03'}