Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2884253050', 'doi': 'https://doi.org/10.3747/co.25.3936', 'title': 'Overcoming Resistance in a BRAF V600e–Mutant Adenocarcinoma of the Lung', 'display_name': 'Overcoming Resistance in a BRAF V600e–Mutant Adenocarcinoma of the Lung', 'publication_year': 2018, 'publication_date': '2018-06-01', 'ids': {'openalex': 'https://openalex.org/W2884253050', 'doi': 'https://doi.org/10.3747/co.25.3936', 'mag': '2884253050', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29962848', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6023556'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3747/co.25.3936', 'pdf_url': 'https://current-oncology.com/index.php/oncology/article/download/3936/2728', 'source': {'id': 'https://openalex.org/S113449754', 'display_name': 'Current Oncology', 'issn_l': '1198-0052', 'issn': ['1198-0052', '1718-7729'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://current-oncology.com/index.php/oncology/article/download/3936/2728', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5052353929', 'display_name': 'Thomas Schmid', 'orcid': 'https://orcid.org/0000-0002-2204-0850'}, 'institutions': [{'id': 'https://openalex.org/I4210135747', 'display_name': 'St. Claraspital', 'ror': 'https://ror.org/04ahnxd67', 'country_code': 'CH', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210135747']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'T. Schmid', 'raw_affiliation_strings': ['Department of Oncology, St. Claraspital, Kleinriehenstrasse 30, Basel 4016, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, St. Claraspital, Kleinriehenstrasse 30, Basel 4016, Switzerland', 'institution_ids': ['https://openalex.org/I4210135747']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5070081010', 'display_name': 'Martin Buess', 'orcid': 'https://orcid.org/0000-0001-6590-1203'}, 'institutions': [{'id': 'https://openalex.org/I4210135747', 'display_name': 'St. Claraspital', 'ror': 'https://ror.org/04ahnxd67', 'country_code': 'CH', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210135747']}], 'countries': ['CH'], 'is_corresponding': True, 'raw_author_name': 'M. Buess', 'raw_affiliation_strings': ['Department of Oncology, St. Claraspital, Kleinriehenstrasse 30, Basel 4016, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, St. Claraspital, Kleinriehenstrasse 30, Basel 4016, Switzerland', 'institution_ids': ['https://openalex.org/I4210135747']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5070081010'], 'corresponding_institution_ids': ['https://openalex.org/I4210135747'], 'apc_list': {'value': 1800, 'currency': 'CHF', 'value_usd': 1949, 'provenance': 'doaj'}, 'apc_paid': {'value': 1800, 'currency': 'CHF', 'value_usd': 1949, 'provenance': 'doaj'}, 'fwci': 0.732, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 8, 'citation_normalized_percentile': {'value': 0.523479, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 84, 'max': 85}, 'biblio': {'volume': '25', 'issue': '3', 'first_page': '217', 'last_page': '219'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11533', 'display_name': 'Mammalian MAP Kinase Signaling Pathways', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11533', 'display_name': 'Mammalian MAP Kinase Signaling Pathways', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10417', 'display_name': 'Advancements in Lung Cancer Research', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12318', 'display_name': 'Chemistry and Pharmacology of Quinazoline Compounds', 'score': 0.9949, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dabrafenib', 'display_name': 'Dabrafenib', 'score': 0.9882771}, {'id': 'https://openalex.org/keywords/trametinib', 'display_name': 'Trametinib', 'score': 0.98785496}, {'id': 'https://openalex.org/keywords/v600e', 'display_name': 'V600E', 'score': 0.62181073}, {'id': 'https://openalex.org/keywords/cancer-therapy', 'display_name': 'Cancer Therapy', 'score': 0.447076}], 'concepts': [{'id': 'https://openalex.org/C2778830669', 'wikidata': 'https://www.wikidata.org/wiki/Q3011604', 'display_name': 'Dabrafenib', 'level': 5, 'score': 0.9882771}, {'id': 'https://openalex.org/C2778472372', 'wikidata': 'https://www.wikidata.org/wiki/Q7833138', 'display_name': 'Trametinib', 'level': 4, 'score': 0.98785496}, {'id': 'https://openalex.org/C2776131300', 'wikidata': 'https://www.wikidata.org/wiki/Q423111', 'display_name': 'Vemurafenib', 'level': 4, 'score': 0.9833542}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.80736244}, {'id': 'https://openalex.org/C2781182431', 'wikidata': 'https://www.wikidata.org/wiki/Q356033', 'display_name': 'Adenocarcinoma', 'level': 3, 'score': 0.62861246}, {'id': 'https://openalex.org/C2776470698', 'wikidata': 'https://www.wikidata.org/wiki/Q21851559', 'display_name': 'V600E', 'level': 4, 'score': 0.62181073}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.5007162}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.46932453}, {'id': 'https://openalex.org/C2777658100', 'wikidata': 'https://www.wikidata.org/wiki/Q180614', 'display_name': 'Melanoma', 'level': 2, 'score': 0.46686745}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.41462892}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.37433583}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.35755613}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.15611705}, {'id': 'https://openalex.org/C2994587330', 'wikidata': 'https://www.wikidata.org/wiki/Q180614', 'display_name': 'Metastatic melanoma', 'level': 3, 'score': 0.14972955}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.12517312}, {'id': 'https://openalex.org/C57074206', 'wikidata': 'https://www.wikidata.org/wiki/Q14197552', 'display_name': 'MAPK/ERK pathway', 'level': 3, 'score': 0.106556475}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.096176535}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.092956275}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.07164064}], 'mesh': [{'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D048493', 'descriptor_name': 'Proto-Oncogene Proteins B-raf', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048493', 'descriptor_name': 'Proto-Oncogene Proteins B-raf', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3747/co.25.3936', 'pdf_url': 'https://current-oncology.com/index.php/oncology/article/download/3936/2728', 'source': {'id': 'https://openalex.org/S113449754', 'display_name': 'Current Oncology', 'issn_l': '1198-0052', 'issn': ['1198-0052', '1718-7729'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6023556', 'pdf_url': 'https://europepmc.org/articles/pmc6023556?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://dx.doi.org/10.3747/co.25.3936', 'pdf_url': 'https://www.mdpi.com/1718-7729/25/3/3936/pdf?version=1609334395', 'source': {'id': 'https://openalex.org/S4306400947', 'display_name': 'MDPI (MDPI AG)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210097602', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute (Switzerland)', 'host_organization_lineage': ['https://openalex.org/I4210097602'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute (Switzerland)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023556', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29962848', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3747/co.25.3936', 'pdf_url': 'https://current-oncology.com/index.php/oncology/article/download/3936/2728', 'source': {'id': 'https://openalex.org/S113449754', 'display_name': 'Current Oncology', 'issn_l': '1198-0052', 'issn': ['1198-0052', '1718-7729'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.46, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 10, 'referenced_works': ['https://openalex.org/W1846586690', 'https://openalex.org/W1965370740', 'https://openalex.org/W1997117729', 'https://openalex.org/W2032211985', 'https://openalex.org/W2168930905', 'https://openalex.org/W2335671095', 'https://openalex.org/W2409383155', 'https://openalex.org/W2591615675', 'https://openalex.org/W2736345028', 'https://openalex.org/W3164126191'], 'related_works': ['https://openalex.org/W4249533637', 'https://openalex.org/W3139482786', 'https://openalex.org/W2943666471', 'https://openalex.org/W2884253050', 'https://openalex.org/W2792819107', 'https://openalex.org/W2610300953', 'https://openalex.org/W2236199583', 'https://openalex.org/W2058633833', 'https://openalex.org/W2023835753', 'https://openalex.org/W1965370740'], 'abstract_inverted_index': {'We': [0], 'report': [1, 32], 'on': [2], 'a': [3, 12, 48], 'patient': [4], 'with': [5, 21, 41], 'an': [6], 'adenocarcinoma': [7, 51], 'of': [8, 52], 'the': [9, 35, 53], 'lung': [10], 'harbouring': [11], 'BRAF': [13, 49], 'V600E': [14], 'mutation': [15], 'who': [16], 'benefited': [17], 'from': [18], 'combination': [19, 39], 'therapy': [20, 40], 'dabrafenib-trametinib': [22, 42], 'after': [23], 'developing': [24], 'resistance': [25, 46], 'to': [26], 'vemurafenib.': [27], 'To': [28], 'our': [29, 31], 'knowledge,': [30], 'shows,': [33], 'for': [34], 'first': [36], 'time,': [37], 'that': [38], 'can': [43], 'overcome': [44], 'vemurafenib': [45], 'in': [47], 'V600E-mutated': [50], 'lung.': [54]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2884253050', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 4}], 'updated_date': '2024-08-15T15:15:15.796422', 'created_date': '2018-08-03'}