Publication Information

{'id': 'https://openalex.org/W2884028208', 'doi': None, 'title': 'MicroRNA-451 Exacerbates Lipotoxicity in Cardiac Myocytes and High-Fat Diet-Induced Cardiac Hypertrophy in Mice Through Suppression of the LKB1/AMPK Pathway', 'display_name': 'MicroRNA-451 Exacerbates Lipotoxicity in Cardiac Myocytes and High-Fat Diet-Induced Cardiac Hypertrophy in Mice Through Suppression of the LKB1/AMPK Pathway', 'publication_year': 2015, 'publication_date': '2015-01-01', 'ids': {'openalex': 'https://openalex.org/W2884028208', 'mag': '2884028208'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://www.ahajournals.org/doi/abs/10.1161/circresaha.116.304707?hits=10&FIRSTINDEX=0&searchid=1&related-urls=yes&resourcetype=HWFIG&legid=circresaha%3B116%2F2%2F279&RESULTFORMAT=&maxtoshow=&fulltext=cardiac', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S10652568', 'display_name': 'Circulation Research', 'issn_l': '0009-7330', 'issn': ['0009-7330', '1524-4571'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5081067352', 'display_name': 'YasuhideKuwabara', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'YasuhideKuwabara', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022373872', 'display_name': 'TakahiroHorie', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'TakahiroHorie', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050004496', 'display_name': 'OsamuBaba', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'OsamuBaba', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001909698', 'display_name': 'ShinWatanabe', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'ShinWatanabe', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031182408', 'display_name': 'MasatakaNishiga', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'MasatakaNishiga', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053919177', 'display_name': 'ShunsukeUsami', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'ShunsukeUsami', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001412775', 'display_name': 'MasayasuIzuhara', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'MasayasuIzuhara', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030562069', 'display_name': 'TetsushiNakao', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'TetsushiNakao', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090922153', 'display_name': 'TomohiroNishino', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'TomohiroNishino', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018842690', 'display_name': 'KinyaOtsu', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'KinyaOtsu', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069647927', 'display_name': 'ToruKita', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'ToruKita', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077022203', 'display_name': 'TakeshiKimura', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'TakeshiKimura', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5076732536', 'display_name': 'KohOno', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'KohOno', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 66}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11457', 'display_name': 'Adipose Tissue and Metabolism', 'score': 0.9945, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11457', 'display_name': 'Adipose Tissue and Metabolism', 'score': 0.9945, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12979', 'display_name': 'Cardiovascular Disease and Adiposity', 'score': 0.9943, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10062', 'display_name': 'MicroRNA in disease regulation', 'score': 0.9923, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lipotoxicity', 'display_name': 'Lipotoxicity', 'score': 0.9703654}, {'id': 'https://openalex.org/keywords/diabetic-cardiomyopathy', 'display_name': 'Diabetic Cardiomyopathy', 'score': 0.85036004}], 'concepts': [{'id': 'https://openalex.org/C44353895', 'wikidata': 'https://www.wikidata.org/wiki/Q6556772', 'display_name': 'Lipotoxicity', 'level': 4, 'score': 0.9703654}, {'id': 'https://openalex.org/C2776553924', 'wikidata': 'https://www.wikidata.org/wiki/Q5270132', 'display_name': 'Diabetic cardiomyopathy', 'level': 4, 'score': 0.85036004}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.8120079}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.8068266}, {'id': 'https://openalex.org/C111566952', 'wikidata': 'https://www.wikidata.org/wiki/Q1303462', 'display_name': 'Cardiac function curve', 'level': 3, 'score': 0.6229012}, {'id': 'https://openalex.org/C2778797674', 'wikidata': 'https://www.wikidata.org/wiki/Q847583', 'display_name': 'Cardiomyopathy', 'level': 3, 'score': 0.6208908}, {'id': 'https://openalex.org/C207200792', 'wikidata': 'https://www.wikidata.org/wiki/Q428914', 'display_name': 'Myocyte', 'level': 2, 'score': 0.60980713}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5225688}, {'id': 'https://openalex.org/C2780124434', 'wikidata': 'https://www.wikidata.org/wiki/Q12357464', 'display_name': 'AMPK', 'level': 4, 'score': 0.45468876}, {'id': 'https://openalex.org/C167414201', 'wikidata': 'https://www.wikidata.org/wiki/Q1955391', 'display_name': 'Muscle hypertrophy', 'level': 2, 'score': 0.43320155}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.40698972}, {'id': 'https://openalex.org/C2778198053', 'wikidata': 'https://www.wikidata.org/wiki/Q181754', 'display_name': 'Heart failure', 'level': 2, 'score': 0.36646152}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3269586}, {'id': 'https://openalex.org/C2777391703', 'wikidata': 'https://www.wikidata.org/wiki/Q1053470', 'display_name': 'Insulin resistance', 'level': 3, 'score': 0.30314484}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.07012391}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://www.ahajournals.org/doi/abs/10.1161/circresaha.116.304707?hits=10&FIRSTINDEX=0&searchid=1&related-urls=yes&resourcetype=HWFIG&legid=circresaha%3B116%2F2%2F279&RESULTFORMAT=&maxtoshow=&fulltext=cardiac', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S10652568', 'display_name': 'Circulation Research', 'issn_l': '0009-7330', 'issn': ['0009-7330', '1524-4571'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.7, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3034604011', 'https://openalex.org/W3032974487', 'https://openalex.org/W3029830123', 'https://openalex.org/W3006152749', 'https://openalex.org/W2948313745', 'https://openalex.org/W2912194724', 'https://openalex.org/W2893352733', 'https://openalex.org/W2885707861', 'https://openalex.org/W2757539303', 'https://openalex.org/W2511441750', 'https://openalex.org/W2258006475', 'https://openalex.org/W2219887677', 'https://openalex.org/W2171117299', 'https://openalex.org/W2141124825', 'https://openalex.org/W2029068888', 'https://openalex.org/W2022123660', 'https://openalex.org/W2010993941', 'https://openalex.org/W1973432709', 'https://openalex.org/W1970149271', 'https://openalex.org/W1917740744'], 'abstract_inverted_index': {'Rationale:In': [0], 'some': [1], 'patients': [2], 'with': [3, 116], 'type': [4, 52, 72, 92], '2': [5, 53, 73, 93], 'diabetes': [6], 'mellitus': [7], '(DM)': [8], 'without': [9], 'hypertension,': [10], 'cardiac': [11, 15, 114, 142], 'hypertrophy': [12], 'and': [13, 19, 56, 71, 78, 119, 129], 'attenuated': [14], 'function': [16, 135], 'are': [17], 'observed,': [18], 'this': [20], 'insult': [21], 'is': [22, 104], 'termed': [23], 'diabetic': [24, 34, 48, 108], 'cardiomyopathy.': [25], 'To': [26], 'date,': [27], 'microRNA': [28], '(miRNAs': [29], 'or': [30], 'miR)': [31], 'functions': [32, 43], 'in': [33, 47, 90, 126, 139], 'cardiomyopathy': [35, 49], 'remain': [36], 'to': [37], 'be': [38], 'elucidated.': [39], 'Objective:To': [40], 'clarify': [41], 'the': [42, 91], 'of': [44, 100, 107, 133], 'miRNAs': [45], 'involved': [46], 'caused': [50], 'by': [51], 'DM.': [54, 74], 'Methods': [55], 'Results:C57BL/6': [57], 'mice': [58], 'were': [59, 87], 'fed': [60], 'a': [61, 105, 127], 'high-fat': [62], 'diet': [63], '(HFD)': [64], 'for': [65], '20': [66], 'weeks,': [67], 'which': [68], 'induced': [69], 'obesity': [70], 'miRNA': [75], 'microarray': [76], 'analyses': [77], 'real-time': [79], 'polymerase': [80], 'chain': [81], 'reaction': [82], 'revealed': [83], 'that': [84, 121], 'miR-451': [85, 122, 134], 'levels': [86], 'significantly': [88], 'increased': [89, 125], 'DM': [94], 'mouse': [95], 'hearts.': [96], 'Because': [97], 'excess': [98], 'supply': [99], 'saturated': [101], 'fatty': [102], 'acids': [103], 'cause': [106], 'cardiomyopathy,': [109], 'we': [110], 'stimulated': [111], 'neonatal': [112, 140], 'rat': [113, 141], 'myocytes': [115], 'palmitic': [117], 'acid': [118], 'confirmed': [120], 'expression': [123], 'was': [124], 'dose-': [128], 'time-dependent': [130], 'manner.': [131], 'Loss': [132], 'ameliorated': [136], 'palmitate-induced': [137], 'lipotoxicity': [138], 'myocytes.': [143], 'Calcium-bi...': [144]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2884028208', 'counts_by_year': [], 'updated_date': '2024-12-09T06:05:25.932108', 'created_date': '2018-08-03'}