Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2883936328', 'doi': 'https://doi.org/10.7554/elife.39383', 'title': 'Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA', 'display_name': 'Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA', 'publication_year': 2018, 'publication_date': '2018-07-25', 'ids': {'openalex': 'https://openalex.org/W2883936328', 'doi': 'https://doi.org/10.7554/elife.39383', 'mag': '2883936328', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30044221', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6086659'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.7554/elife.39383', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S1336409049', 'display_name': 'eLife', 'issn_l': '2050-084X', 'issn': ['2050-084X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311710', 'host_organization_name': 'eLife Sciences Publications Ltd', 'host_organization_lineage': ['https://openalex.org/P4310311710'], 'host_organization_lineage_names': ['eLife Sciences Publications Ltd'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://doi.org/10.7554/elife.39383', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5015811676', 'display_name': 'Swastik Phulera', 'orcid': 'https://orcid.org/0000-0002-1272-7712'}, 'institutions': [{'id': 'https://openalex.org/I2802707198', 'display_name': 'Vollum Institute', 'ror': 'https://ror.org/054hm6j14', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I2802707198']}, {'id': 'https://openalex.org/I165690674', 'display_name': 'Oregon Health & Science University', 'ror': 'https://ror.org/009avj582', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165690674']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Swastik Phulera', 'raw_affiliation_strings': ['Vollum Institute, Oregon Health and Science University, Portland, United States'], 'affiliations': [{'raw_affiliation_string': 'Vollum Institute, Oregon Health and Science University, Portland, United States', 'institution_ids': ['https://openalex.org/I2802707198', 'https://openalex.org/I165690674']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101907620', 'display_name': 'Hongtao Zhu', 'orcid': 'https://orcid.org/0000-0003-1522-0500'}, 'institutions': [{'id': 'https://openalex.org/I2802707198', 'display_name': 'Vollum Institute', 'ror': 'https://ror.org/054hm6j14', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I2802707198']}, {'id': 'https://openalex.org/I165690674', 'display_name': 'Oregon Health & Science University', 'ror': 'https://ror.org/009avj582', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165690674']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hongtao Zhu', 'raw_affiliation_strings': ['Vollum Institute, Oregon Health and Science University, Portland, United States'], 'affiliations': [{'raw_affiliation_string': 'Vollum Institute, Oregon Health and Science University, Portland, United States', 'institution_ids': ['https://openalex.org/I2802707198', 'https://openalex.org/I165690674']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033620350', 'display_name': 'Jie Yu', 'orcid': 'https://orcid.org/0000-0001-9227-038X'}, 'institutions': [{'id': 'https://openalex.org/I2802707198', 'display_name': 'Vollum Institute', 'ror': 'https://ror.org/054hm6j14', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I2802707198']}, {'id': 'https://openalex.org/I165690674', 'display_name': 'Oregon Health & Science University', 'ror': 'https://ror.org/009avj582', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165690674']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jie Yu', 'raw_affiliation_strings': ['Vollum Institute, Oregon Health and Science University, Portland, United States'], 'affiliations': [{'raw_affiliation_string': 'Vollum Institute, Oregon Health and Science University, Portland, United States', 'institution_ids': ['https://openalex.org/I2802707198', 'https://openalex.org/I165690674']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024917074', 'display_name': 'Derek P. Claxton', 'orcid': 'https://orcid.org/0000-0002-1374-7176'}, 'institutions': [{'id': 'https://openalex.org/I2802707198', 'display_name': 'Vollum Institute', 'ror': 'https://ror.org/054hm6j14', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I2802707198']}, {'id': 'https://openalex.org/I165690674', 'display_name': 'Oregon Health & Science University', 'ror': 'https://ror.org/009avj582', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165690674']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Derek P Claxton', 'raw_affiliation_strings': ['Vollum Institute, Oregon Health and Science University, Portland, United States'], 'affiliations': [{'raw_affiliation_string': 'Vollum Institute, Oregon Health and Science University, Portland, United States', 'institution_ids': ['https://openalex.org/I2802707198', 'https://openalex.org/I165690674']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022417832', 'display_name': 'Nate Yoder', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802707198', 'display_name': 'Vollum Institute', 'ror': 'https://ror.org/054hm6j14', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I2802707198']}, {'id': 'https://openalex.org/I165690674', 'display_name': 'Oregon Health & Science University', 'ror': 'https://ror.org/009avj582', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165690674']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nate Yoder', 'raw_affiliation_strings': ['Vollum Institute, Oregon Health and Science University, Portland, United States'], 'affiliations': [{'raw_affiliation_string': 'Vollum Institute, Oregon Health and Science University, Portland, United States', 'institution_ids': ['https://openalex.org/I2802707198', 'https://openalex.org/I165690674']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013854148', 'display_name': 'Craig Yoshioka', 'orcid': 'https://orcid.org/0000-0002-0251-7316'}, 'institutions': [{'id': 'https://openalex.org/I2802707198', 'display_name': 'Vollum Institute', 'ror': 'https://ror.org/054hm6j14', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I2802707198']}, {'id': 'https://openalex.org/I165690674', 'display_name': 'Oregon Health & Science University', 'ror': 'https://ror.org/009avj582', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165690674']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Craig Yoshioka', 'raw_affiliation_strings': ['Vollum Institute, Oregon Health and Science University, Portland, United States'], 'affiliations': [{'raw_affiliation_string': 'Vollum Institute, Oregon Health and Science University, Portland, United States', 'institution_ids': ['https://openalex.org/I2802707198', 'https://openalex.org/I165690674']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5088125571', 'display_name': 'Eric Gouaux', 'orcid': 'https://orcid.org/0000-0002-8549-2360'}, 'institutions': [{'id': 'https://openalex.org/I2802707198', 'display_name': 'Vollum Institute', 'ror': 'https://ror.org/054hm6j14', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I2802707198']}, {'id': 'https://openalex.org/I165690674', 'display_name': 'Oregon Health & Science University', 'ror': 'https://ror.org/009avj582', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165690674']}, {'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Eric Gouaux', 'raw_affiliation_strings': ['Howard Hughes Medical Institute, Oregon Health and Science University, Portland, United States', 'Vollum Institute, Oregon Health and Science University, Portland, United States'], 'affiliations': [{'raw_affiliation_string': 'Vollum Institute, Oregon Health and Science University, Portland, United States', 'institution_ids': ['https://openalex.org/I2802707198', 'https://openalex.org/I165690674']}, {'raw_affiliation_string': 'Howard Hughes Medical Institute, Oregon Health and Science University, Portland, United States', 'institution_ids': ['https://openalex.org/I1344073410', 'https://openalex.org/I165690674']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3000, 'currency': 'USD', 'value_usd': 3000, 'provenance': 'doaj'}, 'apc_paid': {'value': 3000, 'currency': 'USD', 'value_usd': 3000, 'provenance': 'doaj'}, 'fwci': 10.048, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 142, 'citation_normalized_percentile': {'value': 0.999833, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '7', 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10077', 'display_name': 'Neuroscience and Neuropharmacology Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10077', 'display_name': 'Neuroscience and Neuropharmacology Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11818', 'display_name': 'Nicotinic Acetylcholine Receptors Study', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12236', 'display_name': 'Photoreceptor and optogenetics research', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/gabaa-rho-receptor', 'display_name': 'GABAA-rho receptor', 'score': 0.5829694}, {'id': 'https://openalex.org/keywords/gamma-aminobutyric-acid', 'display_name': 'Gamma-Aminobutyric Acid', 'score': 0.45393622}, {'id': 'https://openalex.org/keywords/gaba-receptor', 'display_name': 'GABA receptor', 'score': 0.42067328}], 'concepts': [{'id': 'https://openalex.org/C168258287', 'wikidata': 'https://www.wikidata.org/wiki/Q60147', 'display_name': 'GABAA receptor', 'level': 3, 'score': 0.9467944}, {'id': 'https://openalex.org/C2778173252', 'wikidata': 'https://www.wikidata.org/wiki/Q83871', 'display_name': 'Benzodiazepine', 'level': 3, 'score': 0.75122935}, {'id': 'https://openalex.org/C9224880', 'wikidata': 'https://www.wikidata.org/wiki/Q798179', 'display_name': 'GABAA-rho receptor', 'level': 4, 'score': 0.5829694}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.51313764}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.49757555}, {'id': 'https://openalex.org/C2777771985', 'wikidata': 'https://www.wikidata.org/wiki/Q210021', 'display_name': 'gamma-Aminobutyric acid', 'level': 3, 'score': 0.45393622}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.42203653}, {'id': 'https://openalex.org/C2776674594', 'wikidata': 'https://www.wikidata.org/wiki/Q306252', 'display_name': 'GABA receptor', 'level': 4, 'score': 0.42067328}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.39433056}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.39143276}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.370749}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.35951787}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.18236935}], 'mesh': [{'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D011963', 'descriptor_name': 'Receptors, GABA-A', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D009435', 'descriptor_name': 'Synaptic Transmission', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D005680', 'descriptor_name': 'gamma-Aminobutyric Acid', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001569', 'descriptor_name': 'Benzodiazepines', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D001569', 'descriptor_name': 'Benzodiazepines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009420', 'descriptor_name': 'Nervous System', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009420', 'descriptor_name': 'Nervous System', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D009420', 'descriptor_name': 'Nervous System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055503', 'descriptor_name': 'Protein Multimerization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055503', 'descriptor_name': 'Protein Multimerization', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011963', 'descriptor_name': 'Receptors, GABA-A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011963', 'descriptor_name': 'Receptors, GABA-A', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009435', 'descriptor_name': 'Synaptic Transmission', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005680', 'descriptor_name': 'gamma-Aminobutyric Acid', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005680', 'descriptor_name': 'gamma-Aminobutyric Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.7554/elife.39383', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S1336409049', 'display_name': 'eLife', 'issn_l': '2050-084X', 'issn': ['2050-084X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311710', 'host_organization_name': 'eLife Sciences Publications Ltd', 'host_organization_lineage': ['https://openalex.org/P4310311710'], 'host_organization_lineage_names': ['eLife Sciences Publications Ltd'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/a92fc16f5f7b442fb41ea394d64de88c', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6086659', 'pdf_url': 'https://europepmc.org/articles/pmc6086659?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086659', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30044221', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.7554/elife.39383', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S1336409049', 'display_name': 'eLife', 'issn_l': '2050-084X', 'issn': ['2050-084X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311710', 'host_organization_name': 'eLife Sciences Publications Ltd', 'host_organization_lineage': ['https://openalex.org/P4310311710'], 'host_organization_lineage_names': ['eLife Sciences Publications Ltd'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.79, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320306082', 'funder_display_name': 'Howard Hughes Medical Institute', 'award_id': None}, {'funder': 'https://openalex.org/F4320337354', 'funder_display_name': 'National Institute of General Medical Sciences', 'award_id': 'R01 GM100400'}], 'datasets': [], 'versions': [], 'referenced_works_count': 76, 'referenced_works': ['https://openalex.org/W1482497049', 'https://openalex.org/W1485428340', 'https://openalex.org/W1531270254', 'https://openalex.org/W1684501056', 'https://openalex.org/W1894940769', 'https://openalex.org/W1965670539', 'https://openalex.org/W1971708837', 'https://openalex.org/W1975239375', 'https://openalex.org/W1977184155', 'https://openalex.org/W1978627986', 'https://openalex.org/W1982371070', 'https://openalex.org/W1988182305', 'https://openalex.org/W1994895778', 'https://openalex.org/W1998050348', 'https://openalex.org/W2011559303', 'https://openalex.org/W2024647941', 'https://openalex.org/W2028470175', 'https://openalex.org/W2031368977', 'https://openalex.org/W2032146255', 'https://openalex.org/W2038039828', 'https://openalex.org/W2043911150', 'https://openalex.org/W2050790720', 'https://openalex.org/W2055992758', 'https://openalex.org/W2059230624', 'https://openalex.org/W2061108756', 'https://openalex.org/W2064190418', 'https://openalex.org/W2067237230', 'https://openalex.org/W2068375642', 'https://openalex.org/W2068510105', 'https://openalex.org/W2075824676', 'https://openalex.org/W2085451507', 'https://openalex.org/W2086126018', 'https://openalex.org/W2086547360', 'https://openalex.org/W2089187573', 'https://openalex.org/W2099883420', 'https://openalex.org/W2102431257', 'https://openalex.org/W2103133373', 'https://openalex.org/W2104234755', 'https://openalex.org/W2104244040', 'https://openalex.org/W2112979767', 'https://openalex.org/W2123606404', 'https://openalex.org/W2124759299', 'https://openalex.org/W2128784337', 'https://openalex.org/W2132629607', 'https://openalex.org/W2133675069', 'https://openalex.org/W2143014450', 'https://openalex.org/W2143336421', 'https://openalex.org/W2143411102', 'https://openalex.org/W2144081223', 'https://openalex.org/W2149525061', 'https://openalex.org/W2152619638', 'https://openalex.org/W2154714625', 'https://openalex.org/W2162746575', 'https://openalex.org/W2166720212', 'https://openalex.org/W2170087378', 'https://openalex.org/W2170917522', 'https://openalex.org/W2201997235', 'https://openalex.org/W2289886798', 'https://openalex.org/W2415663722', 'https://openalex.org/W2529942470', 'https://openalex.org/W2587625522', 'https://openalex.org/W2593511418', 'https://openalex.org/W2611143478', 'https://openalex.org/W2747277216', 'https://openalex.org/W2766274239', 'https://openalex.org/W2767629627', 'https://openalex.org/W2780408016', 'https://openalex.org/W2786390877', 'https://openalex.org/W2788833468', 'https://openalex.org/W2796317660', 'https://openalex.org/W2799832466', 'https://openalex.org/W2801019684', 'https://openalex.org/W2805411535', 'https://openalex.org/W2950967305', 'https://openalex.org/W2951520458', 'https://openalex.org/W4317707744'], 'related_works': ['https://openalex.org/W960329349', 'https://openalex.org/W4319915900', 'https://openalex.org/W4251535289', 'https://openalex.org/W292107068', 'https://openalex.org/W2213193974', 'https://openalex.org/W210976936', 'https://openalex.org/W2057303481', 'https://openalex.org/W2017795547', 'https://openalex.org/W2016393227', 'https://openalex.org/W193944754'], 'abstract_inverted_index': {'Fast': [0], 'inhibitory': [1], 'neurotransmission': [2], 'in': [3, 48, 60, 82], 'the': [4, 17, 53, 74, 108, 112, 116], 'mammalian': [5], 'nervous': [6], 'system': [7], 'is': [8, 120], 'largely': [9], 'mediated': [10], 'by': [11, 87], 'GABAA': [12, 24, 45, 58, 80, 141], 'receptors,': [13], 'chloride-selective': [14], 'members': [15], 'of': [16, 19, 44, 56, 76, 98, 115, 139, 149], 'superfamily': [18], 'pentameric': [20], 'Cys-loop': [21], 'receptors.': [22], 'Native': [23], 'receptors': [25, 46, 59, 142], 'are': [26], 'heteromeric': [27, 57, 140], 'assemblies': [28], 'sensitive': [29], 'to': [30, 36, 68, 122, 136], 'many': [31], 'important': [32], 'drugs,': [33], 'from': [34], 'sedatives': [35], 'anesthetics': [37], 'and': [38, 62, 101, 119, 126, 143], 'anticonvulsant': [39], 'agents,': [40], 'with': [41, 84], 'mutant': [42], 'forms': [43], 'implicated': [47], 'multiple': [49], 'neurological': [50], 'diseases.': [51], 'Despite': [52], 'profound': [54], 'importance': [55], 'neuroscience': [61], 'medicine,': [63], 'they': [64], 'have': [65], 'proven': [66], 'recalcitrant': [67], 'structure': [69, 75], 'determination.': [70], 'Here': [71], 'we': [72], 'present': [73], 'a': [77, 134, 144], 'tri-heteromeric': [78], 'α1β1γ2SEM': [79], 'receptor': [81, 99, 124], 'complex': [83], 'GABA,': [85], 'determined': [86], 'single': [88], 'particle': [89], 'cryo-EM': [90], 'at': [91], '3.1-3.8': [92], 'Å': [93], 'resolution,': [94], 'elucidating': [95], 'molecular': [96], 'principles': [97], 'assembly': [100, 125], 'agonist': [102], 'binding.': [103], 'Remarkable': [104], 'N-linked': [105], 'glycosylation': [106], 'on': [107], 'α1': [109], 'subunit': [110], 'occludes': [111], 'extracellular': [113], 'vestibule': [114], 'ion': [117, 128], 'channel': [118, 129], 'poised': [121], 'modulate': [123], 'perhaps': [127], 'gating.': [130], 'Our': [131], 'work': [132], 'provides': [133], 'pathway': [135], 'structural': [137], 'studies': [138], 'framework': [145], 'for': [146], 'rational': [147], 'design': [148], 'novel': [150], 'therapeutic': [151], 'agents.': [152]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2883936328', 'counts_by_year': [{'year': 2024, 'cited_by_count': 16}, {'year': 2023, 'cited_by_count': 16}, {'year': 2022, 'cited_by_count': 19}, {'year': 2021, 'cited_by_count': 26}, {'year': 2020, 'cited_by_count': 27}, {'year': 2019, 'cited_by_count': 30}, {'year': 2018, 'cited_by_count': 8}], 'updated_date': '2025-01-12T15:01:04.104463', 'created_date': '2018-08-03'}