Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2883877984', 'doi': 'https://doi.org/10.1080/1061186x.2018.1502775', 'title': 'Effect of cationic lipid in cationic liposomes on siRNA delivery into the lung by intravenous injection of cationic lipoplex', 'display_name': 'Effect of cationic lipid in cationic liposomes on siRNA delivery into the lung by intravenous injection of cationic lipoplex', 'publication_year': 2018, 'publication_date': '2018-09-07', 'ids': {'openalex': 'https://openalex.org/W2883877984', 'doi': 'https://doi.org/10.1080/1061186x.2018.1502775', 'mag': '2883877984', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30024300'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/1061186x.2018.1502775', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S100629371', 'display_name': 'Journal of drug targeting', 'issn_l': '1026-7158', 'issn': ['1026-7158', '1029-2330', '1061-186X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://figshare.com/articles/journal_contribution/Effect_of_cationic_lipid_in_cationic_liposomes_on_siRNA_delivery_into_the_lung_by_intravenous_injection_of_cationic_lipoplex/7058042/1/files/12980657.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5038246750', 'display_name': 'Yoshiyuki Hattori', 'orcid': 'https://orcid.org/0000-0002-4731-0407'}, 'institutions': [{'id': 'https://openalex.org/I36296616', 'display_name': 'Hoshi University', 'ror': 'https://ror.org/01mrvbd33', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I36296616']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Yoshiyuki Hattori', 'raw_affiliation_strings': ['Department of Drug Delivery Research, Hoshi University, Tokyo, Japan;'], 'affiliations': [{'raw_affiliation_string': 'Department of Drug Delivery Research, Hoshi University, Tokyo, Japan;', 'institution_ids': ['https://openalex.org/I36296616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020385033', 'display_name': 'Mari Nakamura', 'orcid': 'https://orcid.org/0000-0002-8191-0027'}, 'institutions': [{'id': 'https://openalex.org/I36296616', 'display_name': 'Hoshi University', 'ror': 'https://ror.org/01mrvbd33', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I36296616']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Mari Nakamura', 'raw_affiliation_strings': ['Department of Drug Delivery Research, Hoshi University, Tokyo, Japan;'], 'affiliations': [{'raw_affiliation_string': 'Department of Drug Delivery Research, Hoshi University, Tokyo, Japan;', 'institution_ids': ['https://openalex.org/I36296616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007897621', 'display_name': 'Nozomi Takeuchi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I36296616', 'display_name': 'Hoshi University', 'ror': 'https://ror.org/01mrvbd33', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I36296616']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Nozomi Takeuchi', 'raw_affiliation_strings': ['Department of Drug Delivery Research, Hoshi University, Tokyo, Japan;'], 'affiliations': [{'raw_affiliation_string': 'Department of Drug Delivery Research, Hoshi University, Tokyo, Japan;', 'institution_ids': ['https://openalex.org/I36296616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068555081', 'display_name': 'Kyoko Tamaki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I36296616', 'display_name': 'Hoshi University', 'ror': 'https://ror.org/01mrvbd33', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I36296616']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kyoko Tamaki', 'raw_affiliation_strings': ['Department of Drug Delivery Research, Hoshi University, Tokyo, Japan;'], 'affiliations': [{'raw_affiliation_string': 'Department of Drug Delivery Research, Hoshi University, Tokyo, Japan;', 'institution_ids': ['https://openalex.org/I36296616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079738245', 'display_name': 'Satono Shimizu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I36296616', 'display_name': 'Hoshi University', 'ror': 'https://ror.org/01mrvbd33', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I36296616']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Satono Shimizu', 'raw_affiliation_strings': ['Department of Drug Delivery Research, Hoshi University, Tokyo, Japan;'], 'affiliations': [{'raw_affiliation_string': 'Department of Drug Delivery Research, Hoshi University, Tokyo, Japan;', 'institution_ids': ['https://openalex.org/I36296616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072314199', 'display_name': 'Yuki Yoshiike', 'orcid': 'https://orcid.org/0000-0002-0056-1276'}, 'institutions': [{'id': 'https://openalex.org/I36296616', 'display_name': 'Hoshi University', 'ror': 'https://ror.org/01mrvbd33', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I36296616']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yuki Yoshiike', 'raw_affiliation_strings': ['Department of Drug Delivery Research, Hoshi University, Tokyo, Japan;'], 'affiliations': [{'raw_affiliation_string': 'Department of Drug Delivery Research, Hoshi University, Tokyo, Japan;', 'institution_ids': ['https://openalex.org/I36296616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037987545', 'display_name': 'Masamitsu Taguchi', 'orcid': 'https://orcid.org/0009-0005-9891-6459'}, 'institutions': [{'id': 'https://openalex.org/I25998863', 'display_name': 'Kyoto Pharmaceutical University', 'ror': 'https://ror.org/01ytgve10', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I25998863']}, {'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masamitsu Taguchi', 'raw_affiliation_strings': ['Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan;'], 'affiliations': [{'raw_affiliation_string': 'Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan;', 'institution_ids': ['https://openalex.org/I25998863', 'https://openalex.org/I22299242']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013135912', 'display_name': 'Hiroaki Ohno', 'orcid': 'https://orcid.org/0000-0002-3246-4809'}, 'institutions': [{'id': 'https://openalex.org/I25998863', 'display_name': 'Kyoto Pharmaceutical University', 'ror': 'https://ror.org/01ytgve10', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I25998863']}, {'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroaki Ohno', 'raw_affiliation_strings': ['Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan;'], 'affiliations': [{'raw_affiliation_string': 'Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan;', 'institution_ids': ['https://openalex.org/I25998863', 'https://openalex.org/I22299242']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105986742', 'display_name': 'Kei‐ichi Ozaki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I90237989', 'display_name': 'Osaka University of Pharmaceutical Sciences', 'ror': 'https://ror.org/029yaft79', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I90237989']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kei-Ichi Ozaki', 'raw_affiliation_strings': ['Education and Research Center for Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan'], 'affiliations': [{'raw_affiliation_string': 'Education and Research Center for Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan', 'institution_ids': ['https://openalex.org/I90237989']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5000205552', 'display_name': 'Hiraku Onishi', 'orcid': 'https://orcid.org/0000-0002-1678-8563'}, 'institutions': [{'id': 'https://openalex.org/I36296616', 'display_name': 'Hoshi University', 'ror': 'https://ror.org/01mrvbd33', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I36296616']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiraku Onishi', 'raw_affiliation_strings': ['Department of Drug Delivery Research, Hoshi University, Tokyo, Japan;'], 'affiliations': [{'raw_affiliation_string': 'Department of Drug Delivery Research, Hoshi University, Tokyo, Japan;', 'institution_ids': ['https://openalex.org/I36296616']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5038246750'], 'corresponding_institution_ids': ['https://openalex.org/I36296616'], 'apc_list': None, 'apc_paid': None, 'fwci': 2.195, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 53, 'citation_normalized_percentile': {'value': 0.999983, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '27', 'issue': '2', 'first_page': '217', 'last_page': '227'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10725', 'display_name': 'Mechanisms and Applications of RNA Interference', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10725', 'display_name': 'Mechanisms and Applications of RNA Interference', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10207', 'display_name': 'DNA Nanotechnology and Bioanalytical Applications', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10062', 'display_name': 'MicroRNA Regulation in Cancer and Development', 'score': 0.9876, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cationic-polymerization', 'display_name': 'Cationic polymerization', 'score': 0.9711951}, {'id': 'https://openalex.org/keywords/sirna-delivery', 'display_name': 'siRNA Delivery', 'score': 0.518054}, {'id': 'https://openalex.org/keywords/lipid-nanoparticles', 'display_name': 'Lipid Nanoparticles', 'score': 0.503746}], 'concepts': [{'id': 'https://openalex.org/C183882617', 'wikidata': 'https://www.wikidata.org/wiki/Q3046749', 'display_name': 'Cationic polymerization', 'level': 2, 'score': 0.9711951}, {'id': 'https://openalex.org/C155887181', 'wikidata': 'https://www.wikidata.org/wiki/Q5053552', 'display_name': 'Cationic liposome', 'level': 4, 'score': 0.9307736}, {'id': 'https://openalex.org/C185154212', 'wikidata': 'https://www.wikidata.org/wiki/Q410454', 'display_name': 'Liposome', 'level': 2, 'score': 0.85002446}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.68499416}, {'id': 'https://openalex.org/C2776300020', 'wikidata': 'https://www.wikidata.org/wiki/Q422423', 'display_name': 'Bromide', 'level': 2, 'score': 0.5131238}, {'id': 'https://openalex.org/C119056186', 'wikidata': 'https://www.wikidata.org/wiki/Q1431332', 'display_name': 'Gene silencing', 'level': 3, 'score': 0.41241646}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.39691457}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.34737843}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.2832181}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D008055', 'descriptor_name': 'Lipids', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D008168', 'descriptor_name': 'Lung', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002412', 'descriptor_name': 'Cations', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016503', 'descriptor_name': 'Drug Delivery Systems', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020868', 'descriptor_name': 'Gene Silencing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008055', 'descriptor_name': 'Lipids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008081', 'descriptor_name': 'Liposomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008156', 'descriptor_name': 'Luciferases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008156', 'descriptor_name': 'Luciferases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008168', 'descriptor_name': 'Lung', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061986', 'descriptor_name': 'MCF-7 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015394', 'descriptor_name': 'Molecular Structure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042787', 'descriptor_name': 'Receptor, TIE-2', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D042787', 'descriptor_name': 'Receptor, TIE-2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D042787', 'descriptor_name': 'Receptor, TIE-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/1061186x.2018.1502775', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S100629371', 'display_name': 'Journal of drug targeting', 'issn_l': '1026-7158', 'issn': ['1026-7158', '1029-2330', '1061-186X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://figshare.com/articles/journal_contribution/Effect_of_cationic_lipid_in_cationic_liposomes_on_siRNA_delivery_into_the_lung_by_intravenous_injection_of_cationic_lipoplex/7058042', 'pdf_url': 'https://figshare.com/articles/journal_contribution/Effect_of_cationic_lipid_in_cationic_liposomes_on_siRNA_delivery_into_the_lung_by_intravenous_injection_of_cationic_lipoplex/7058042/1/files/12980657.pdf', 'source': {'id': 'https://openalex.org/S4306402621', 'display_name': 'INDIGO (University of Illinois at Chicago)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I39422238', 'host_organization_name': 'University of Illinois at Chicago', 'host_organization_lineage': ['https://openalex.org/I39422238'], 'host_organization_lineage_names': ['University of Illinois at Chicago'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30024300', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://figshare.com/articles/journal_contribution/Effect_of_cationic_lipid_in_cationic_liposomes_on_siRNA_delivery_into_the_lung_by_intravenous_injection_of_cationic_lipoplex/7058042', 'pdf_url': 'https://figshare.com/articles/journal_contribution/Effect_of_cationic_lipid_in_cationic_liposomes_on_siRNA_delivery_into_the_lung_by_intravenous_injection_of_cationic_lipoplex/7058042/1/files/12980657.pdf', 'source': {'id': 'https://openalex.org/S4306402621', 'display_name': 'INDIGO (University of Illinois at Chicago)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I39422238', 'host_organization_name': 'University of Illinois at Chicago', 'host_organization_lineage': ['https://openalex.org/I39422238'], 'host_organization_lineage_names': ['University of Illinois at Chicago'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/6', 'score': 0.49, 'display_name': 'Clean water and sanitation'}], 'grants': [{'funder': 'https://openalex.org/F4320334764', 'funder_display_name': 'Japan Society for the Promotion of Science', 'award_id': '17K08251'}], 'datasets': [], 'versions': [], 'referenced_works_count': 41, 'referenced_works': ['https://openalex.org/W1972977329', 'https://openalex.org/W1982902233', 'https://openalex.org/W1984166898', 'https://openalex.org/W1985100346', 'https://openalex.org/W1993040033', 'https://openalex.org/W1996487606', 'https://openalex.org/W1996491430', 'https://openalex.org/W2000130544', 'https://openalex.org/W2001799900', 'https://openalex.org/W2013521436', 'https://openalex.org/W2015299325', 'https://openalex.org/W2016373576', 'https://openalex.org/W2021426114', 'https://openalex.org/W2021905258', 'https://openalex.org/W2024102779', 'https://openalex.org/W2025595101', 'https://openalex.org/W2027017068', 'https://openalex.org/W2030621748', 'https://openalex.org/W2046549045', 'https://openalex.org/W2058332691', 'https://openalex.org/W2058435567', 'https://openalex.org/W2066261032', 'https://openalex.org/W2068519358', 'https://openalex.org/W2068942685', 'https://openalex.org/W2070575980', 'https://openalex.org/W2075491501', 'https://openalex.org/W2079840724', 'https://openalex.org/W2083707689', 'https://openalex.org/W2095322944', 'https://openalex.org/W2096813959', 'https://openalex.org/W2108965461', 'https://openalex.org/W2111689106', 'https://openalex.org/W2114231279', 'https://openalex.org/W2114570899', 'https://openalex.org/W2158519239', 'https://openalex.org/W2292609593', 'https://openalex.org/W2335289394', 'https://openalex.org/W2417842909', 'https://openalex.org/W2469771837', 'https://openalex.org/W2562298160', 'https://openalex.org/W2745705803'], 'related_works': ['https://openalex.org/W2949304977', 'https://openalex.org/W2941861342', 'https://openalex.org/W2892544385', 'https://openalex.org/W2883877984', 'https://openalex.org/W2432973135', 'https://openalex.org/W2391412823', 'https://openalex.org/W2088825750', 'https://openalex.org/W1990953223', 'https://openalex.org/W1661636974', 'https://openalex.org/W1544960011'], 'abstract_inverted_index': {'Cationic': [0], 'liposomes': [1, 39, 75], 'composed': [2, 76, 99], 'of': [3, 22, 34, 37, 53, 60, 73, 77, 86, 100, 123, 131, 139, 186, 195, 198], 'dialkyl': [4, 61], 'cationic': [5, 23, 35, 38, 54, 64, 67, 74, 79, 96, 140, 187, 196, 199], 'lipid': [6, 36, 80, 197], 'such': [7], 'as': [8, 66], '1,2-dioleoyl-3-trimethylammonium-propane': [9], '(DOTAP)': [10], 'can': [11], 'efficiently': [12], 'deliver': [13], 'siRNA': [14, 41, 87, 124, 155, 175], 'to': [15, 43], 'the': [16, 19, 32, 44, 126, 136, 158, 174, 183, 193], 'lungs': [17, 45], 'following': [18], 'intravenous': [20, 47, 137, 184], 'injection': [21, 138, 185], 'liposome/siRNA': [24], 'complexes': [25], '(lipoplexes).': [26], 'In': [27], 'this': [28], 'study,': [29], 'we': [30], 'examined': [31], 'effect': [33], 'on': [40], 'delivery': [42], 'after': [46, 135, 182], 'injection.': [48], 'We': [49], 'used': [50], 'six': [51], 'kinds': [52, 59, 72], 'cholesterol': [55], 'derivatives': [56], 'and': [57, 69, 81, 89, 128, 147, 177], '11': [58], 'or': [62, 113], 'trialkyl': [63], 'lipids': [65], 'lipids,': [68], 'prepared': [70], '17': [71], 'a': [78], '1,2-dioleoyl-L-α-glycero-3-phosphatidylethanolamine': [82], '(DOPE)': [83], 'for': [84], 'evaluation': [85], 'biodistribution': [88, 176], 'in': [90, 125, 178], 'vivo': [91, 179], 'gene': [92], 'silencing': [93], 'effects.': [94], 'Among': [95], 'liposomes,': [97], 'those': [98], 'N-hexadecyl-N,N-dimethylhexadecan-1-aminium': [101], 'bromide': [102, 105, 111], '(DC-1-16),': [103], 'N,N-dimethyl-N-octadecyloctadecan-1-aminium': [104], '(DC-1-18),': [106], '2-((1,5-bis(octadecyloxy)-1,5-dioxopentan-2-yl)amino)-N,N,N-trimethyl-2-oxoethan-1-aminium': [107], 'chloride': [108], '(DC-3-18D),': [109], '11-((1,3-bis(dodecanoyloxy)-2-((dodecanoyloxy)methyl)propan-2-yl)amino)-N,N,N-trimethyl-11-oxoundecan-1-aminium': [110], '(TC-1-12),': [112], 'cholesteryl': [114], '(3-((2-hydroxyethyl)amino)propyl)carbamate': [115], 'hydroiodide': [116], '(HAPC-Chol)': [117], 'with': [118, 142, 150, 166], 'DOPE': [119], 'exhibited': [120], 'high': [121], 'accumulation': [122], 'lung': [127, 167], 'significant': [129], 'suppression': [130], 'Tie2': [132, 143], 'mRNA': [133], 'expression': [134], 'lipoplexes': [141, 149, 188], 'siRNA.': [144], 'Furthermore,': [145], 'DC-1-16/DOPE': [146], 'DC-1-18/DOPE': [148], 'protein': [151], 'kinase': [152], 'N3': [153], '(PKN3)': [154], 'could': [156], 'suppress': [157], 'tumour': [159], 'growth': [160], 'when': [161], 'intravenously': [162], 'injected': [163], 'into': [164], 'mice': [165], 'LLC': [168], 'metastasis.': [169], 'These': [170], 'findings': [171], 'indicate': [172], 'that': [173], 'knockdown': [180], 'efficiency': [181], 'were': [189], 'strongly': [190], 'affected': [191], 'by': [192], 'type': [194], 'liposomes.': [200]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2883877984', 'counts_by_year': [{'year': 2024, 'cited_by_count': 11}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 11}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-09-01T07:18:32.377330', 'created_date': '2018-08-03'}