Mitochondrial inner membrane permeabilisation enables mt <scp>DNA</scp> release during apoptosis

Name: Work Video:
Duration: 3 min 30 s
Joel S. Riley; Giovanni Quarato; Catherine Cloix; Jonathan Lopez; Jim O’Prey; Matthew Pearson; James Chapman; Hiromi Sesaki; Leo M. Carlin; João F. Passos; Ann P. Wheeler; Andrew Oberst; Kevin M. Ryan; Stephen W. G. Tait
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3537, 3546, 3556, 3567, 3599, 3609, 3621, 3670, 3677, 3701, 3716, 3745, 3755, 3779, 3782, 3797, 3833, 3862, 3884, 3931, 3935, 3958, 3969, 3985, 4019, 4035, 4049, 4136, 4142, 4145, 4154, 4177, 4236, 4250], 'Molecular': [164, 304, 334, 593, 733, 763, 948, 998], 'Medicine,': [165, 228, 335, 594, 657, 764, 949, 990], 'The': [166, 336, 595, 765, 950, 1058, 1627, 3418, 3512], 'Edinburgh,': [169, 170, 339, 340, 598, 599, 768, 769, 953, 954], 'James': [179, 181, 608, 610, 889], 'Chapman': [180, 182, 609, 611], 'Ageing': [183, 194, 199, 275, 286, 291, 612, 623, 628, 704, 715, 720, 967, 972], 'Laboratories,': [185, 277, 614, 706, 958], 'Newcastle': [186, 202, 204, 278, 294, 296, 306, 308, 615, 631, 633, 707, 723, 725, 735, 737, 959, 975, 977, 1000, 1002], 'Ageing,': [190, 282, 619, 711, 963], 'LLHW': [191, 283, 620, 712, 964], 'Centre': [192, 284, 621, 713, 965, 1037], 'Vitality,': [196, 201, 288, 293, 625, 630, 717, 722, 969, 974], 'Campus': [197, 289, 626, 718, 970], 'University,': [203, 295, 307, 632, 724, 736, 976, 1001], 'upon': [205, 297, 309, 634, 726, 738, 978, 1003, 3020], 'Tyne,': [206, 298, 310, 635, 727, 739, 979, 1004], 'Hiromi': [215, 217, 644, 646, 891], 'Sesaki': [216, 218, 645, 647], 'Cell': [221, 302, 650, 731, 983, 996, 2664, 3137], 'Biology,': [222, 651, 984], 'Johns': [223, 652, 985], 'Hopkins': [224, 653, 986], 'School': [226, 655, 988], 'Baltimore,': [229, 658, 991], 'MD,': [230, 659, 992], 'Leo': [239, 242, 668, 671, 893], 'M': [240, 243, 383, 386, 669, 672, 812, 815, 894, 905], 'Carlin': [241, 244, 670, 673], 'orcid.org/0000-0001-7172-5234': [245, 674], 'João': [269, 272, 698, 701, 896], 'F': [270, 273, 699, 702, 897], 'Passos': [271, 274, 700, 703], 'Biosciences,': [305, 734, 999], 'Ann': [319, 322, 748, 751, 899], 'P': [320, 323, 749, 752, 900], 'Wheeler': [321, 324, 750, 753], 'Andrew': [349, 351, 778, 780, 902], 'Oberst': [350, 352, 779, 781], 'Washington,': [358, 371, 787, 800, 1011, 1024], 'Seattle,': [359, 372, 788, 801, 1012, 1025], 'WA,': [360, 373, 789, 802, 1013, 1026], 'Center': [362, 791], 'Innate': [364, 793, 1017], 'Immunity': [365, 794, 1018], 'Immune': [367, 796, 1020], 'Disease,': [368, 797, 1021], 'Kevin': [382, 385, 811, 814, 904], 'Ryan': [384, 387, 813, 816], 'Stephen': [411, 416, 840, 845, 908], 'WG': [412, 417, 841, 846, 909], 'Tait': [413, 418, 842, 847, 910, 1418], 'Corresponding': [414, 843], 'Author': [415, 844, 874], '[email': [419, 848, 1056], 'protected]': [420, 849, 1057], 'orcid.org/0000-0001-7697-132X': [421, 850], 'Information': [875], 'Riley1,2,': [878], 'Quarato3,': [880], 'Cloix1,2,': [882], 'Lopez1,2,10,': [884], "O'Prey1,2,": [886], 'Pearson4,': [888], 'Chapman5,': [890], 'Sesaki6,': [892], 'Carlin1,2,': [895], 'Passos5,7,': [898], 'Wheeler4,': [901], 'Oberst8,9,': [903], 'Ryan1,2': [906], '*,1,2': [911], '1Cancer': [912], '2Institute': [919], '3Department': [928], '4MRC': [939], '5Ageing': [956], '6Department': [981], '7Institute': [994], '8Department': [1006], '9Center': [1015], '10Present': [1028], 'address:': [1029], 'UMR': [1030], 'INSERM': [1031], '1052': [1032], 'CNRS': [1033], '5286,': [1034], 'Lyon': [1039], '(CRCL),': [1040], 'Léon': [1041], 'Bérard': [1042], 'Centre,': [1043], 'Lyon,': [1046, 1047], 'France': [1048], '*Corresponding': [1049], 'author.': [1050], 'Tel:': [1051], '+44': [1052], '1413': [1053], '308703;': [1054], 'E-mail:': [1055], 'EMBO': [1059], 'Journal': [1060], '(2018)37:e99238https://doi.org/10.15252/embj.201899238': [1061], 'See': [1062, 3817, 3982], 'also:': [1063], 'K': [1064], 'Cosentino': [1065, 1493], '&': [1066, 1107, 1370, 1447, 1494, 1525], 'AJ': [1067], 'García-Sáez': [1068], '(September': [1069], '2018)': [1070], 'PDFDownload': [1071], 'PDF': [1072], 'article': [1074], 'text': [1075], 'main': [1077, 1609], 'figures.': [1078], 'Peer': [1079], 'ReviewDownload': [1080], 'a': [1081, 1200, 1323, 1408, 1501, 1558, 1608, 1635, 1717, 1873, 1991, 2290, 2833, 2849, 2980, 3085, 3096, 3106, 3116, 3425, 3654, 3827], 'summary': [1082], 'the': [1084, 1132, 1160, 1180, 1219, 1224, 1252, 1261, 1273, 1281, 1295, 1318, 1344, 1349, 1375, 1442, 1462, 1483, 1508, 1540, 1591, 1645, 1675, 1682, 1727, 1736, 1748, 1757, 1773, 1824, 1827, 1855, 1888, 1913, 1972, 2068, 2395, 2891, 2942, 3099, 3431, 3460, 3473, 3484, 3507, 3525, 3563, 3586, 3604, 3630, 3635, 3667, 3697, 3856, 3860, 4081, 4093, 4098, 4101, 4112, 4127, 4140, 4159, 4181, 4198, 4201, 4218, 4233], 'editorial': [1085, 1089], 'decision': [1086, 1090], 'including': [1088, 1382, 4016, 4046], 'letters,': [1091], 'reviewer': [1092], 'comments': [1093], 'responses': [1096], 'to': [1097, 1100, 1166, 1173, 1286, 1390, 1479, 1510, 1582, 1617, 1631, 1667, 1688, 1708, 1734, 1761, 1822, 1906, 1979, 2006, 2029, 2188, 2535, 2637, 2647, 2918, 2954, 2966, 3404, 3439, 3503, 3524, 3541, 3614, 3641, 3666, 3711, 3911, 4111, 4195], 'feedback.': [1098], 'ToolsAdd': [1099], 'favoritesDownload': [1101], 'CitationsTrack': [1102], 'CitationsPermissions': [1103], 'ShareFacebookTwitterLinked': [1104], 'InMendeleyWechatReddit': [1105], 'Figures': [1106], 'Info': [1108], 'Abstract': [1109], 'During': [1110], 'apoptosis,': [1111, 1170, 1810, 1882, 1952, 2882], 'pro-apoptotic': [1112, 1463], 'BAX': [1113, 1333, 1466, 1473, 2190, 2212, 2470, 2557, 3069, 3300], 'BAK': [1115, 1475, 2214, 2472, 2483, 2490, 2554, 2559, 3302, 3312, 3320], 'are': [1116, 1476, 1867, 2378, 2419, 2520, 2602, 2619, 2678, 2773, 2800, 2817, 3151, 3224, 3252, 3294, 3342, 3350, 3368, 3381, 3869, 3885, 3893, 4023, 4053, 4063], 'activated,': [1117, 1477], 'causing': [1118], 'mitochondrial': [1119, 1152, 1161, 1209, 1220, 1236, 1275, 1296, 1300, 1309, 1319, 1360, 1363, 1378, 1484, 1544, 1683, 1774, 1787, 1828, 1881, 1951, 2008, 2051, 2069, 2141, 2161, 2398, 2843, 2881, 2933, 2956, 2970, 3419, 3513, 3526, 3658, 3920, 4094, 4103], 'outer': [1120, 1210, 1274, 1310, 1320, 1364, 1485, 1829, 1857, 1875, 2009, 2070, 2142, 2957, 3372, 3420, 3514, 3725, 4095], '(MOMP),': [1123], 'caspase': [1124, 1135, 1387, 1395, 1535, 1547, 1613, 1746, 1965, 3023], 'activation': [1125, 1155, 1347, 1566, 2847, 3104], 'cell': [1127, 1144, 1244, 1266, 1356, 1429, 1505, 1517, 1553, 1593, 1621, 1781, 1794, 1923, 1959, 1969, 2221, 2404, 2508, 2592, 2900, 2920, 2968, 2997, 3564, 3861, 4223, 4239], 'death.': [1128, 1267, 1782, 4240], 'However,': [1129, 1663], 'even': [1130], 'in': [1131, 1277, 1317, 1322, 1427, 1482, 1848, 1912, 1971, 2074, 2095, 2148, 2215, 2289, 2475, 2593, 2941, 3205, 3233, 3260, 3273, 3304, 3318, 3452, 3627, 3634, 3653, 3823, 3844, 3990, 4126, 4169, 4197], 'absence': [1133, 1916], 'activity,': [1136, 1396], 'cells': [1137, 1279, 1397, 1884, 1926, 1998, 2020, 2043, 2096, 2112, 2217, 2299, 2323, 2358, 2438, 2477, 2487, 2544, 2646, 2650, 2694, 2730, 2884, 2946, 3123, 3166, 3207, 3235, 3264, 3277, 3306, 3325, 3396, 3534, 3617, 3732, 3774, 3877, 3927, 3954, 4026, 4056, 4121, 4242], 'usually': [1138], 'die': [1139, 2648], 'following': [1140, 1197, 1206, 1246, 1402, 1551, 1726, 1803, 2060, 2153, 2223, 2255, 2274, 2287, 2364, 2405, 3081, 3386, 3561, 3688, 4188], 'MOMP.': [1141, 1198, 1248, 3615], 'Such': [1142], 'caspase-independent': [1143, 1265, 2996, 4222], 'death': [1145, 1245, 1554, 1622, 1960, 1970, 2222, 2901, 2921, 2998, 4224], 'is': [1146, 1164, 1192, 1329, 1432, 1499, 1537, 1549, 1665, 1686, 1799, 2270, 2283], 'accompanied': [1147], 'inflammation': [1149, 1619, 1633], 'that': [1150, 1190, 1205, 1235, 1292, 1385, 1534, 1594, 1725, 1772, 1864, 2097, 2240, 2266, 2922, 3378, 3657, 4088, 4213], 'requires': [1151, 1362, 1640], 'DNA': [1153, 1301, 1648, 1678, 1862, 2004, 2238, 2399, 2952, 3455, 3468, 4137], '(mtDNA)': [1154, 2400], 'cGAS-STING': [1157, 1182, 1350, 1647, 1677, 1714, 1763, 2871], 'signalling.': [1158, 1715], 'Because': [1159, 1422, 3492], 'thought': [1165, 1285, 1687], 'remain': [1167, 1287, 1689], 'intact': [1168, 1690, 2870], 'we': [1171, 1188, 1203, 1705, 1723, 1811, 2183, 2856, 2864, 3505, 3602, 4230], 'sought': [1172], 'address': [1174], 'how': [1175, 1669, 1710], 'matrix': [1176, 1670, 2267, 4182], 'could': [1178, 1712], 'activate': [1179, 1386, 1632, 1674, 1713, 1762], 'cytosolic': [1181, 1253, 1306, 1646, 1676, 2093, 2115, 2129, 2138, 2159, 2169, 2251], 'signalling': [1183, 1764, 2872], 'pathway.': [1184, 1352], 'Using': [1185, 1716], 'super-resolution': [1186, 1813, 2294], 'imaging,': [1187, 4015, 4045], 'show': [1189, 1291, 2265, 3809], 'efficiently': [1193, 1513], 'released': [1194, 1800, 2271, 2284, 3382, 3584, 3690, 3996, 4037], 'from': [1195, 1801, 2272, 2285, 2315, 2352, 2384, 2425, 2466, 2582, 2608, 2722, 2761, 2770, 2779, 2793, 2806, 3195, 3383, 3709, 3765, 3830, 3870, 3880, 3945, 4012, 4024, 4042, 4054], 'mitochondria': [1196, 1802, 1856, 1870, 2273, 2286, 3384, 3461, 3651, 3687, 3807, 3872, 4000], 'In': [1199, 4156], 'temporal': [1201], 'manner,': [1202, 3656], 'find': [1204, 1724], 'MOMP,': [1207, 1404, 1552, 1730, 2045, 2182, 3562], 'BAX/BAK-mediated': [1208, 1731], 'pores': [1212, 1316, 1732, 3374, 3674, 3727], 'gradually': [1213], 'widen.': [1214], 'This': [1215, 1580, 4211], 'allows': [1216, 4077], 'extrusion': [1217, 1737, 3721], 'into': [1223, 1343, 1756, 3585, 4080], 'cytosol': [1225, 4082], 'whereupon': [1226], 'it': [1227, 1406, 1664, 1760, 3694], 'permeablises': [1228], 'allowing': [1229, 1507, 1759], 'release.': [1231, 3683, 3811], 'Our': [1232, 3375], 'data': [1233, 1290, 1770, 2264, 2618, 2816, 3094, 3349, 3376, 3892, 4062, 4086], 'demonstrate': [1234, 1771, 3095, 4087], '(MIMP)': [1240, 1339], 'can': [1241, 1595, 1673, 1777, 4215], 'occur': [1242], 'BAX/BAK-dependent': [1247, 1324, 2275, 2291, 2643], 'Importantly,': [1249, 1783, 1817, 3464, 3684, 4187], 'enabling': [1251], 'mtDNA,': [1256, 1786, 4143], 'underpins': [1260], 'immunogenic': [1262], 'effects': [1263], 'Synopsis': [1268], 'BAX/BAK': [1269, 2492, 3322], 'pore': [1270, 3611, 3863], 'formation': [1271], 'ruptures': [1272], 'apoptotic': [1278, 1471, 1612], 'while': [1280], 'was': [1284, 2072, 2145, 2179, 2666, 2902, 2923, 2974, 2985, 3017, 3139, 3422, 3499, 3516, 3583, 3705, 4114, 4164, 4193], 'intact.': [1288], 'New': [1289], 'induces': [1299, 1314], 'signaling': [1304, 1351], 'via': [1305, 1436, 3370], 'cGAS-STING.': [1307], 'Apoptotic': [1308], 'permeabilization': [1312, 1338], '(MOMP)': [1313], 'widening': [1315, 1332, 3612, 3671], 'manner.': [1325], 'extruded': [1330, 1749, 3369], 'through': [1331, 3033, 3723], 'pores.': [1334], 'cytoplasm': [1345], 'Introduction': [1353], 'To': [1354, 1805, 1879, 1921, 2174, 2878, 3391, 4117, 4226], 'initiate': [1355, 1596], 'death,': [1357, 1506], 'intrinsic': [1358], 'or': [1359, 1367, 1791, 1915, 1937, 2204, 2440, 2484, 2491, 2545, 2555, 2708, 3313, 3321, 3875, 4003, 4106], 'permeabilisation,': [1366, 1790], 'MOMP': [1368, 1373, 1431, 1488, 1630, 1804, 1989, 2031, 2100, 2197, 2219, 2276, 2288, 2644, 3088, 3387, 3543, 3689, 3700, 4189], '(Tait': [1369], 'Green,': [1371], '2013).': [1372], 'causes': [1374], 'intermembrane': [1379], 'space': [1380], 'proteins,': [1381], 'cytochrome': [1383, 2026, 2052, 2767, 2790], 'c,': [1384], 'proteases': [1388], 'leading': [1389, 1478], 'apoptosis.': [1391, 2934], 'Nevertheless,': [1392], 'irrespective': [1393], 'typically': [1398], 'do': [1399, 4002, 4004], 'not': [1400, 2246, 3073, 3500, 3685, 4005, 4115], 'survive': [1401], 'widespread': [1403, 1988], 'defining': [1405], 'as': [1407, 1604, 1835, 1840, 2046, 2079, 2380, 2421, 2522, 2604, 2680, 2775, 2802, 3153, 3440, 3850, 3887, 4008], 'point-of-no-return': [1409], '(Haraguchi': [1410], 'et': [1411, 1415, 1419, 1490, 1569, 1573, 1577, 1600, 1624, 1652, 1656, 1660, 1695, 1699, 1898, 2199, 2875, 2896, 3055, 3059, 3063, 3443, 3447], 'al,': [1412, 1416, 1420, 1491, 1570, 1574, 1578, 1601, 1625, 1653, 1657, 1661, 1696, 1700, 1899, 2200, 2876, 2897, 3056, 3060, 3064, 3444, 3448], '2000;': [1413, 1697], 'Ekert': [1414], '2004;': [1417], '2010).': [1421], 'central': [1425], 'role': [1426], 'dictating': [1428], 'fate,': [1430], 'tightly': [1433], 'controlled,': [1434], 'primarily': [1435], 'pro-': [1437], 'anti-apoptotic': [1439, 1453], 'members': [1440, 1456], 'BCL-2': [1443, 1454, 1894], 'protein': [1444, 1859, 3415, 3429], 'family': [1445, 1455], '(Lopez': [1446], 'Tait,': [1448], '2015).': [1449, 1527, 3449], 'Under': [1450, 1743, 1993, 2036, 2106, 2230, 3558, 3576], 'homeostatic': [1451], 'conditions,': [1452, 1996, 2038, 2065, 2108, 2232, 3560, 3578], '(e.g.': [1457], 'BCL-2,': [1458], 'BCL-xL,': [1459, 1893], 'MCL-1)': [1460], 'block': [1461], 'actions': [1464], 'BAK.': [1468], 'Following': [1469, 2935, 2993], 'an': [1470, 1521, 1587, 2511, 2669, 2840, 2869, 3142], 'trigger,': [1472], 'their': [1480], 'oligomerisation': [1481], '(Wei': [1489, 2198], '2001;': [1492], 'Garcia-Saez,': [1495], '2017).': [1496, 1579, 1602, 1662, 2877], 'considered': [1500], 'non-inflammatory': [1502, 1541], 'form': [1503], 'host': [1509], 'quickly': [1511], 'clear': [1514], 'away': [1515], 'dead': [1516], 'corpses': [1518], 'without': [1519], 'provoking': [1520], 'immune': [1522, 1588], 'response': [1523, 1563, 1589, 1639, 2836, 2984, 3002, 3121], '(Arandjelovic': [1524], 'Ravichandran,': [1526], 'Recently,': [1528], 'others': [1529, 3049], 'ourselves': [1531, 3051], 'have': [1532, 2532, 2865, 2868], 'shown': [1533, 2867], 'activity': [1536, 1548, 1614], 'essential': [1538, 2195], 'nature': [1542], 'apoptosis;': [1545], 'if': [1546], 'blocked': [1550, 3039], 'still': [1555], 'occurs,': [1556], 'but': [1557, 1977, 2245, 3072], 'type': [1559, 1636, 3118], 'I': [1560, 1637, 3119], 'interferon': [1561, 2835, 2851, 2983, 3108, 3120], '(IFN)': [1562], 'NF-κB': [1565], 'ensues': [1567], '(Rongvaux': [1568, 1651], '2014;': [1571, 1575, 1654, 1658, 3061], 'White': [1572, 1655, 3062], 'Giampazolias': [1576, 1659, 3054], 'leads': [1581], 'pro-inflammatory': [1583], 'cytokine': [1584], 'production': [1585], 'towards': [1590], 'dying': [1592], 'anti-tumour': [1597], 'immunity': [1598], '(Giampazolias': [1599, 2874], 'Therefore,': [1603], 'proposed': [1605], 'others,': [1607], 'function': [1610, 3024], 'may': [1615], 'be': [1616], 'silence': [1618], '(Martin': [1623], '2012).': [1626], 'ability': [1628], 'IFN': [1638, 1766, 3001], 'recognition': [1641], 'sensing': [1649, 1679], 'pathway': [1650, 1680, 2873], 'challenging': [1666], 'reconcile': [1668], 'localised': [1671, 2268, 3523, 4176], 'since': [1681], '(von': [1693], 'Ahsen': [1694], 'Waterhouse': [1698], '2001).': [1701], 'Given': [1702], 'paradox,': [1704], 'set': [1706], 'out': [1707], 'define': [1709], 'variety': [1718], 'high-resolution': [1720], 'imaging': [1721, 1932, 2911, 3494, 3550, 3643, 3771, 3951, 4149], 'techniques,': [1722], 'onset': [1728], 'widen': [1733], 'allow': [1735, 1823, 1980], 'newly': [1739], 'unstructured': [1740], 'membrane.': [1742], 'conditions': [1744, 2103, 2990], 'inhibition,': [1747], 'permeabilises': [1752], 'facilitating': [1753], 'cytoplasm,': [1758, 4199], 'synthesis.': [1767], 'Unexpectedly,': [1768], 'our': [1769, 3590, 4085], 'undergo': [1778, 3542], 'releasing': [1785], 'MIMP,': [1792], 'death-associated': [1795], 'inflammation.': [1796], 'Results': [1797], 'visualise': [1806, 2007, 2955, 4139], 'dynamics': [1808, 3485], 'used': [1812, 2184, 2857], 'Airyscan': [1814, 2295, 2319, 2434, 2538, 2726, 3162, 3728, 3770, 3923, 3950, 4014, 4044, 4148], 'confocal': [1815], 'microscopy.': [1816], 'provides': [1819], 'sufficient': [1820], 'resolution': [1821], 'visualisation': [1825], 'matrix-resident': [1832], 'molecules': [1833], '(such': [1834], 'TFAM': [1836, 3458, 3470, 3691, 3704, 3810, 3921, 4007, 4036], 'containing': [1837], 'nucleoids)': [1839], 'distinct': [1841], 'entities': [1842], 'under': [1843, 2063, 2101, 2277, 2988, 3388], 'sub-diffraction-limiting': [1844], 'conditions.': [1845, 2279, 3390], 'As': [1846, 3450, 3520], 'expected,': [1847, 3451, 3521], 'healthy': [1849, 3453, 4157], 'U2OS': [1850, 1883, 1925, 1997, 2019, 2042, 2216, 2298, 2322, 2476, 2486, 2541, 2594, 2649, 2693, 2729, 3395, 3533, 3616, 3731, 3773, 3926, 3953, 4120, 4241], 'cells,': [1851, 2078, 2862, 4158], 'dual': [1852, 2233], 'immunostaining': [1853, 2085, 2234], 'TOM20': [1860, 2084, 2236], 'revealed': [1863], 'nucleoids': [1866, 2962, 3367, 3380], 'contained': [1868], 'within': [1869, 3459, 4165, 4180], 'surrounded': [1871], 'continuous': [1874], '(Fig': [1877, 1943, 1961, 1975, 1984, 2016, 2032, 2055, 2086, 2104, 2117, 2131, 2156, 2206, 2258, 2912, 2963, 3010, 3028, 3037, 3052, 3089, 3416, 3462, 3531, 3551, 3595, 3644, 3675, 3714, 4150, 4183], '1A).': [1878], 'engage': [1880], 'were': [1885, 1927, 1999, 2021, 2164, 2885, 2947, 3008, 3397, 3539, 3623, 3788, 3963, 4038, 4122, 4246], 'treated': [1886, 2324, 2441, 2496, 2560, 2651, 2695, 2731, 2886, 3124, 3167, 3208, 3236, 3278, 3326, 3398, 3624, 3737, 3789, 3964, 4123, 4247], 'with': [1887, 1902, 1948, 1964, 1987, 2001, 2023, 2301, 2325, 2340, 2366, 2407, 2442, 2454, 2478, 2488, 2497, 2546, 2561, 2652, 2696, 2732, 2747, 2832, 2887, 2890, 2930, 2949, 3045, 3125, 3168, 3183, 3209, 3237, 3279, 3327, 3399, 3457, 3476, 3529, 3570, 3589, 3625, 3629, 3738, 3753, 3790, 3929, 3933, 3965, 4124, 4171, 4248], 'BH3-mimetic': [1889], 'ABT-737,': [1890, 2328, 2369, 2410, 2564, 2735, 3171, 3212, 3240, 3282, 3330, 3741, 3793], 'which': [1891, 2863, 3808, 4001], 'inhibits': [1892], 'BCL-w': [1896], '(Oltersdorf': [1897], '2005)': [1900], 'together': [1901, 2205, 2889], 'actinomycin': [1903], 'D': [1904], '(ActD,': [1905], 'inhibit': [1907], 'transcription': [1908], 'labile': [1910], 'MCL-1),': [1911], 'presence': [1914, 2943, 3636, 4128], 'pan-caspase': [1918], 'inhibitor': [1919, 1966, 2893, 3632], 'qVD-OPh.': [1920, 2376, 2417, 2663, 2719, 3136], 'assess': [1922], 'viability,': [1924], 'imaged': [1928, 3547, 4232], 'using': [1929, 2510, 2614, 2668, 2785, 2812, 2991, 3141, 3265, 3424, 3497, 3518], 'IncuCyte': [1930, 2512, 2670, 2909, 3143], 'live-cell': [1931, 2513, 2671, 2910, 3144, 3490, 3493, 3549, 3642, 4013, 4043], 'SYTOX': [1934, 2516, 2674, 2905, 3147], 'Green': [1935, 2517, 2675, 2906, 3148], 'uptake': [1936, 2907], 'assessed': [1938, 3851, 4009, 4039], 'long-term': [1940, 1981], 'clonogenic': [1941, 1982], 'survival': [1942, 1983, 2690], 'EV1A': [1944], 'B).': [1946], 'Consistent': [1947], 'engagement': [1949, 2931, 2994, 3571], 'ABT-737/ActD': [1953, 2061, 4125], 'co-treatment': [1954], 'rapidly': [1955, 3565], 'synchronously': [1957], 'induced': [1958, 3540], 'EV1A).': [1962], 'Co-treatment': [1963], 'qVD-OPh': [1967, 2335, 2449, 2571, 2707, 2742, 3026, 3178, 3219, 3247, 3289, 3337, 3545, 3638, 3748, 3800, 3972], 'prevented': [1968, 2218, 2250], 'short': [1973], 'term': [1974], 'EV1A)': [1976], 'failed': [1978], 'EV1B),': [1985], 'consistent': [1986, 2929, 3044, 3475, 3569, 3588], 'being': [1990, 2986, 4173], 'point-of-no-return.': [1992], 'identical': [1994, 2231], 'MOMP-inducing': [1995], 'immunostained': [2000, 2022, 2300, 2339, 2453, 2746, 2948, 3182, 3752, 3932, 4131, 4167, 4205], 'anti-TOM20': [2002, 2024, 2302, 2341, 2455, 2748, 2950, 3184, 3934], 'antibodies': [2005, 2028, 2953], 'integrity': [2011, 2959, 4099], 'mtDNA-containing': [2013, 2172, 2961, 3479], 'nucleoids,': [2014], 'respectively': [2015], '1B).': [2017, 2105], 'Alternatively,': [2018], 'c': [2027, 2053, 2752, 2768, 2791], 'determine': [2030, 2175], 'EV1C': [2033, 2056], 'D).': [2035, 2058, 3717], 'these': [2037, 2107, 2263, 2989], 'over': [2039, 2075, 2109, 2124], '90%': [2040], 'underwent': [2044], 'determined': [2047], 'loss': [2049], 'staining': [2054], 'Specifically': [2059], 'treatment,': [2062, 3083, 3581], 'caspase-inhibited': [2064, 2102, 2278, 3389, 3577], 'observed': [2073, 2147], '80%': [2076, 2110, 2125], 'evidenced': [2080], 'discontinuous,': [2082], 'crescent-like': [2083], '1B': [2087], 'C).': [2089], 'Strikingly,': [2090], 'displayed': [2092, 2113, 2128], 're-localisation': [2094, 2170, 2178, 3488], 'had': [2098], 'undergone': [2099], '1C)': [2118], 'and,': [2119, 3692], 'on': [2120, 2181], 'average': [2121], 'per': [2122, 2403, 2591], 'cell,': [2123], 'localisation': [2130, 2139, 3508, 4107], '1D).': [2132], 'A': [2133], 'similar': [2134, 2166], 'pattern': [2135], 'also': [2146, 3077], 'E1A/Ras': [2149], 'transformed': [2150], 'MEF': [2151, 2437], 'specifically': [2152], 'ABT-737/ActD/qVD-OPh': [2154, 4249], 'treatment': [2155, 2225, 2257, 2365, 2406, 2916, 2940], '1E).': [2157], 'Both': [2158], 'structures': [2163], 'size,': [2167], 'suggesting': [2168], 'nucleoids.': [2173, 3480], 'whether': [2176, 2979], 'dependent': [2180], 'CRISPR-Cas9': [2185, 2495], 'genome': [2186, 3035], 'editing': [2187, 3036], 'delete': [2189], 'BAK,': [2192, 3071], 'two': [2193, 2426, 3159, 3255, 3297, 3345, 3766, 3881, 3946, 4028, 4058], 'proteins': [2194], '2001)': [2201], 'either': [2202, 2248, 2550, 3075], 'singly': [2203], '1F).': [2207], 'Only': [2208], 'combined': [2209, 2241], 'deletion': [2210, 2242, 2480, 2493, 2548, 3067, 3309], 'ABT-737/S63845': [2224, 2915, 2939], '(Figs': [2226], '1G': [2227], 'EV1E).': [2229], 'demonstrated': [2239], 'BAX/BAK,': [2244], 'alone,': [2249, 3076], 'ABT-737/S63845/qVD-OPh': [2256, 3082, 3400], '1H': [2259], 'I).': [2261], 'Collectively,': [2262], 'Figure': [2280, 2628, 2641, 3110, 3359, 3718, 3902, 3915], '1.': [2281], 'manner': [2292], 'Fixed': [2293], 'images': [2296, 2314, 2320, 2351, 2435, 2465, 2539, 2581, 2721, 2727, 2760, 3163, 3194, 3729, 3764, 3944], '(green)': [2303, 2749], 'anti-DNA': [2305, 2343, 2457, 3186, 3754, 3936], '(red)': [2306, 3781], 'antibodies.': [2307, 2344, 2458, 3187, 3757, 3937], 'Scale': [2308, 2345, 2459, 2575, 2754, 3188, 3758, 3812, 3836, 3938, 3977], 'bar': [2309, 2346, 2460, 2576, 2755, 3189, 3759, 3813, 3837, 3939, 3978], '=': [2310, 2347, 2461, 2577, 2756, 3190, 3760, 3803, 3814, 3838, 3940, 3975, 3979], '10': [2311, 2326, 2348, 2367, 2408, 2443, 2462, 2498, 2562, 2578, 2653, 2697, 2709, 2733, 2757, 3126, 3130, 3169, 3172, 3191, 3210, 3213, 3238, 3241, 3280, 3283, 3328, 3331, 3710, 3739, 3761, 3791, 3794, 3815, 3941, 3966, 3980], 'μm.': [2312, 2349, 2463, 2579, 2758, 3192, 3762, 3816, 3840, 3942, 3981], 'Representative': [2313, 2350, 2464, 2580, 2720, 2759, 3193, 3763, 3943], 'three': [2316, 2353, 2385, 2467, 2528, 2583, 2609, 2686, 2723, 2762, 2780, 2807, 3196, 3227, 3266, 3871, 3876], 'independent': [2317, 2354, 2386, 2427, 2468, 2529, 2584, 2610, 2687, 2724, 2763, 2781, 2808, 3160, 3197, 3228, 3256, 3267, 3298, 3346, 3767, 3882, 3947, 4029, 4059], 'experiments.': [2318, 2355, 2469, 2585, 2688, 2725, 2764, 3161, 3198, 3229, 3257, 3299, 3347, 3768, 3948, 4030, 4060], 'μM': [2327, 2330, 2334, 2368, 2371, 2375, 2409, 2412, 2416, 2444, 2448, 2499, 2503, 2563, 2566, 2570, 2654, 2658, 2662, 2698, 2702, 2706, 2710, 2714, 2718, 2734, 2737, 2741, 3127, 3131, 3135, 3170, 3173, 3177, 3211, 3214, 3218, 3239, 3242, 3246, 3281, 3284, 3288, 3329, 3332, 3336, 3740, 3743, 3747, 3792, 3795, 3799, 3967, 3971], '1': [2329, 2370, 2411, 2629, 2657, 2713, 2736, 3839], 'ActD': [2331, 2372, 2413, 2659, 2715, 2738], '20': [2333, 2374, 2415, 2447, 2569, 2661, 2705, 2717, 2740, 3134, 3176, 3217, 3245, 3287, 3335, 3746, 3798, 3970], '3': [2337, 2451, 2573, 2744, 2936, 3180, 3221, 3291, 3339, 3402, 3750, 3903], 'h,': [2338, 2452, 2745, 3181, 3751], 'Quantification': [2356, 2393, 2586, 2765, 2788, 3998], 'exhibiting': [2359], '>': [2360], '10%': [2361], 'Data': [2377, 2418, 2519, 2601, 2626, 2677, 2772, 2799, 3150, 3223, 3251, 3293, 3341, 3357, 3868, 3900, 4022, 4052], 'expressed': [2379, 2420, 2521, 2603, 2679, 2774, 2801, 3152, 3886], 'mean': [2381, 2422, 2523, 2605, 2681, 2776, 2803, 3154, 3888], '±': [2382, 2423, 2524, 2606, 2660, 2682, 2704, 2716, 2777, 2804, 3133, 3155, 3244, 3544, 3889], 'SD': [2383, 2424, 2607, 2778, 2805], 'experiments': [2387, 2428, 2611, 2782, 2809, 3883], 'analysed': [2389, 2430, 2506, 2613, 2667, 2784, 2811, 3140, 4146], "Student's": [2391, 2432, 2615, 2786, 2813], 't-test.': [2392, 2433, 2616, 2787, 2814], 'extent': [2396], 'nucleoid': [2401, 2589], 'untreated': [2439], 'ABT-737': [2445, 2500, 2655, 2699, 2711, 2888, 3128, 3580, 3626, 3968], 'expression': [2473, 3204, 3232, 3259, 3272, 3303, 3317], 'levels': [2474], 'CRISPR-Cas9-mediated': [2479, 2547, 3261, 3308], 'BAX,': [2482, 2489, 2552, 3311, 3319], 'BAX/BAK.': [2485, 3314], '2': [2502, 2565, 2701, 3249, 3360, 3742], 'S63845': [2504, 2567, 2703, 2894, 3132, 3174, 3215, 3243, 3285, 3333, 3633, 3744, 3796], 'viability': [2509, 2665, 3138], 'imager': [2514, 2672, 3145], 'exclusion.': [2518, 2676, 3149], 'SEM,': [2525, 2683, 3156], 'representative': [2526, 2684, 3157, 3225, 3253, 3295, 3343], 'experiments,': [2530], 'been': [2533], 'normalised': [2534], 'starting': [2536], 'confluency.': [2537], '(i)': [2542], 'control': [2543], '(ii)': [2551], '(iii)': [2553], '(iv)': [2556], 'h.': [2574, 3222, 3250, 3292, 3340], 'EMPTYCRISPR,': [2595], 'BAXCRISPR,': [2596], 'BAKCRISPR': [2597], 'BAX/BAKCRISPR': [2599], 'cells.': [2600, 2798], 'available': [2620, 2818, 3351, 3894, 4064], 'online': [2621, 2819, 3352, 3895, 4065], 'figure.': [2624, 2640, 2822, 3355, 3898, 3914, 4068], '[embj201899238-sup-0012-SDataFig1.pdf]': [2630], 'Download': [2631, 2633, 2823, 2825, 3362, 3364, 3905, 3907, 4069, 4071], 'figure': [2632, 2824, 3363, 3906, 4070], 'PowerPoint': [2634, 2826, 3365, 3908, 4072], 'Click': [2635, 3909], 'here': [2636, 3910], 'expand': [2638, 3912], 'EV1.': [2642], 'commits': [2645], 'Clonogenic': [2689], 'assay': [2691], 'anti-cytochrome': [2751], '(red).': [2753], 'mitochondria.': [2771], 'BAX-,': [2794], 'BAK-,': [2795], 'BAX/BAK-deleted': [2797], 'correlates': [2831], 'STING-dependent': [2834, 2850, 2981, 3107], 'We': [2837, 2976, 3481], 'next': [2838, 2977, 3482], 'investigated': [2839, 2978, 3483, 3603], 'association': [2841], 'between': [2842, 3098, 3699], 'response.': [2852, 3109], 'For': [2853], 'purpose,': [2855], 'SVEC': [2858, 2883, 3122, 3165, 3206, 3234, 3263, 3276, 3305, 3324], '4–10': [2859], 'murine': [2860], 'endothelial': [2861], 'previously': [2866], 'induce': [2879, 3405], 'rapid': [2880, 2919], 'MCL-1': [2892], '(Kotschy': [2895], '2016),': [2898], 'monitored': [2903, 3506], '2A).': [2913], 'Combined': [2914, 3066], 'led': [2917], 'inhibited': [2924, 3078], 'addition': [2926, 3027], 'qVD-OPh,': [2928, 2945, 4130], 'h': [2937, 3403], '2B).': [2964], 'Similar': [2965], 'other': [2967], 'types,': [2969], 'detected.': [2975], 'transcriptional': [2982, 3013], 'activated': [2987], 'qRT–PCR.': [2992], '(CICD),': [2999], 'various': [3000], 'genes': [3003], '(Ifnb1,': [3004], 'Irf7': [3005, 3200], 'Oasl1)': [3007], 'upregulated': [3009], '2C).': [3011], 'ABT-737/S63845-induced': [3012], 'upregulation': [3014, 3041, 3080], 'Ifnb1': [3016, 3040, 3079, 3230, 3270, 3315], 'greatly': [3018], 'increased': [3019], 'inhibition': [3021], '2D).': [3029], 'Deletion': [3030], 'STING,': [3032], 'CRISPR/Cas9': [3034], '2E),': [3038], 'CICD,': [3043, 3406, 3466], 'previous': [3046], 'findings': [3047], '2F;': [3053], '2017;': [3057], 'Rongvaux': [3058], '2014).': [3065], 'demonstrating': [3084], 'requirement': [3086], '2G': [3090], 'H).': [3092], 'These': [3093], 'correlation': [3097], '2.': [3111], 'MOMP-induced': [3112], 'initiates': [3115], 'cGAS-STING-dependent': [3117], 'Ifnb1,': [3199], 'Oasl1': [3202], 'mRNA': [3203, 3231, 3271, 3316], 'STING': [3258, 3274], 'STING-deleted': [3262], 'sgRNA': [3268], 'sequences.': [3269], 'CRISPR-Cas9-deleted': [3275, 3323], 'harbouring': [3307], '[embj201899238-sup-0013-SDataFig2.pdf]': [3361], 'expanding': [3371, 3724], 'suggests': [3377, 4212], 'investigate': [3392, 4118, 4227], 'further,': [3394, 4229], 'then': [3407, 3639, 4251], 'simultaneously': [3408, 4231], 'stained': [3409], 'TFAM—a': [3413], 'nucleoid-resident': [3414], '3A).': [3417, 3463], 'visualised': [3423, 3517], 'SNAP-tag': [3426], 'Omp25': [3427], 'fusion': [3428], 'far-red': [3432], 'fluorophore': [3433], 'Janelia': [3434], 'Fluor': [3435], '646': [3436], '(JF646;': [3437], 'referred': [3438], 'JF646-MOM;': [3441], 'Grimm': [3442], '2015;': [3445], 'Katajisto': [3446], 'mitochondria,': [3454, 3474], 'co-localised': [3456, 3471], 'both': [3467], 'outside': [3472, 4200], 'imaging.': [3491], 'PicoGreen': [3498], 'possible': [3501], 'due': [3502], 'photobleaching,': [3504], 'mClover-fused': [3510], 'TFAM.': [3511, 3997], 'JF646-MOM.': [3519], 'TFAM-mScarlet': [3522, 3930], 'matrix,': [3527], 'co-localising': [3528], 'EV2A).': [3532], 'expressing': [3535, 3618, 3734, 3776, 3784, 3956, 3960, 4244], 'JF646-MOM': [3536, 3622, 3735, 3777, 3957, 4245], 'TFAM-mClover': [3538, 3582, 3607, 3682, 3785], 'EV2B,': [3552, 3596], 'Videos': [3553, 3597, 3983, 4152], 'EV1,': [3554], 'EV2': [3555, 3598, 3984], 'EV3).': [3557, 3600], 'caspase-proficient': [3559], 'shrunk': [3566], 'detached,': [3568], '(Video': [3574], 'EV1).': [3575], 'after': [3579], 'cytosol,': [3587], 'earlier': [3591], 'analysis': [3592, 3918], 'Finally,': [3601], 'kinetics': [3605], 'MOM': [3610, 3673], 'relative': [3613, 4110], 'TFAM-mClover,': [3619], 'Omi-mCherry': [3620, 3661, 3780], 'combination': [3628], 'MCL1': [3631], 'subject': [3640], '3B,': [3645], 'Video': [3646, 3818, 3834, 4020, 4050, 4185, 4209], 'EV4).': [3647], 'Analysis': [3648], 'individual': [3650], 'demonstrated,': [3652], 'sequential': [3655], '(denoting': [3662], 'MOMP)': [3663], 'occurs': [3664, 3722], 'prior': [3665], 'visual': [3668], 'appearance': [3669], '3C': [3676], 'D),': [3678], 'finally': [3679], 'followed': [3680], 'all': [3686], 'when': [3693], 'did': [3695], 'occur,': [3696], 'time': [3698, 3822, 3843, 3989], 'highly': [3706], 'variable,': [3707], 'ranging': [3708], '100': [3712], 'min': [3713], 'EV2C': [3715], '3.': [3719], 'stably': [3733, 3775, 3955, 4243], '(magenta)': [3736, 3778], 'anti-TFAM': [3756], 'Live-cell': [3769, 3949], 'transiently': [3783, 3959], '(green).': [3786], 'Cells': [3787, 3962], 'at': [3801, 3973], 't': [3802, 3974], '0.': [3804, 3976], 'Arrows': [3805], 'denote': [3806], 'EV4.': [3819, 3835, 4021, 4051], 'Numbers': [3820, 3841, 3987], 'indicate': [3821, 3842, 3988, 3993], 'minutes.': [3824, 3845, 3991], 'Zoom': [3825], 'single': [3828], 'mitochondrion': [3829], 'Fig': [3831, 4017, 4047, 4207], '3B': [3832, 4018, 4048], 'Loss': [3846], 'Omi': [3848, 3857, 4033], 'intensity': [3849], 'standard': [3853], 'deviation': [3854], 'signal': [3858, 4163], 'across': [3859, 4027, 4057], 'size': [3864], 'plotted': [3865], 'against': [3866], 'time.': [3867], '(pore': [3873], 'size)': [3874], '(Omi': [3878], 'release)': [3879], 'SEM.': [3890], '[embj201899238-sup-0014-SDataFig3.pdf]': [3904], 'EV2.': [3916], 'Kinetic': [3917], 'image': [3924], 'transfected': [3928], 'TFAM-mClover.': [3961], 'EV3.': [3986], 'Arrowheads': [3992], 'instances': [3994], 'eye': [4011, 4041], 'four': [4025, 4055], 'Time': [4031], 'Thus': [4083], 'far,': [4084], 'mtDNA/TFAM': [4089], 'complexes': [4090], 'relocalise': [4091], 'beyond': [4092, 4217], 'membrane;': [4096], 'however,': [4097], '(IMM)': [4105], 'IMM': [4113, 4141, 4235], 'determined.': [4116], 'this,': [4119], 'apoptosis-inducing': [4133], 'factor': [4134], '(AIF)': [4135], '(to': [4138], 'respectively)': [4144], '4A,': [4151, 4184, 4208], 'EV5': [4153], 'EV6).': [4155, 4210], 'majority': [4160], 'AIF': [4166, 4172], 'structures,': [4168], 'line': [4170], 'residing': [4179], 'EV5).': [4186], '(ABT-737/ActD/qVD-OPh': [4190], 'treatment),': [4191], 'found': [4194], 'localise': [4196], '(AIF': [4204], 'structures;': [4206], 'pass': [4216], '(CICD).': [4225], 'MOM,': [4234], 'im': [4252]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2883721603', 'counts_by_year': [{'year': 2024, 'cited_by_count': 90}, {'year': 2023, 'cited_by_count': 78}, {'year': 2022, 'cited_by_count': 85}, {'year': 2021, 'cited_by_count': 52}, {'year': 2020, 'cited_by_count': 45}, {'year': 2019, 'cited_by_count': 33}, {'year': 2018, 'cited_by_count': 6}], 'updated_date': '2024-12-30T21:08:04.024934', 'created_date': '2018-08-03'}
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