Correlation of Severity of Human Tick-Borne Encephalitis Virus Disease and Pathogenicity in Mice

Name: Work Video:
Duration: 3 min 30 s
Description: We compared 2 tick-borne encephalitis virus strains isolated from 2 different foci that cause different symptoms in tick-borne encephalitis patients, from neurologic to mild gastrointestinal symptoms. We compared neuroinvasiveness, neurovirulence, and proinflammatory cytokine response in mice and found unique differences that contribute to our understanding of pathogenesis.
Chaitanya Kurhade; Sarah Schreier; Yi-Ping Lee; Loreen Zegenhagen; Marika Hjertqvist; Gerhard Dobler; Andrea Kröger; Anna K. Överby
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Dobler);', 'DZIF Partner Site Munich, Munich', 'Department of Clinical Microbiology, Virology, Umeå University.', 'Helmholtz Centre for Infection Research, Braunschweig, Germany', 'National Cheng Kung University, Tainan, Taiwan.', 'Otto-von-Guericke-University Magdeburg, Magdeburg, Germany', 'Public Health Agency of Sweden, Solna, Sweden (M. 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