Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2871023201', 'doi': 'https://doi.org/10.1093/brain/awy187', 'title': 'High-frequency stimulation of anterior nucleus of thalamus desynchronizes epileptic network in humans', 'display_name': 'High-frequency stimulation of anterior nucleus of thalamus desynchronizes epileptic network in humans', 'publication_year': 2018, 'publication_date': '2018-06-16', 'ids': {'openalex': 'https://openalex.org/W2871023201', 'doi': 'https://doi.org/10.1093/brain/awy187', 'mag': '2871023201', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29985998'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/brain/awy187', 'pdf_url': 'https://academic.oup.com/brain/article-pdf/141/9/2631/25590605/awy187.pdf', 'source': {'id': 'https://openalex.org/S118357697', 'display_name': 'Brain', 'issn_l': '0006-8950', 'issn': ['0006-8950', '1460-2156'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/brain/article-pdf/141/9/2631/25590605/awy187.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5030319289', 'display_name': 'Tao Yu', 'orcid': 'https://orcid.org/0000-0001-6885-7105'}, 'institutions': [{'id': 'https://openalex.org/I183519381', 'display_name': 'Capital Medical University', 'ror': 'https://ror.org/013xs5b60', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183519381']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Tao Yu', 'raw_affiliation_strings': ['Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China', 'institution_ids': ['https://openalex.org/I183519381']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100636253', 'display_name': 'Xueyuan Wang', 'orcid': 'https://orcid.org/0000-0003-2463-748X'}, 'institutions': [{'id': 'https://openalex.org/I183519381', 'display_name': 'Capital Medical University', 'ror': 'https://ror.org/013xs5b60', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183519381']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xueyuan Wang', 'raw_affiliation_strings': ['Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China', 'institution_ids': ['https://openalex.org/I183519381']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100668797', 'display_name': 'Yongjie Li', 'orcid': 'https://orcid.org/0000-0003-0627-630X'}, 'institutions': [{'id': 'https://openalex.org/I183519381', 'display_name': 'Capital Medical University', 'ror': 'https://ror.org/013xs5b60', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183519381']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yongjie Li', 'raw_affiliation_strings': ['Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China', 'institution_ids': ['https://openalex.org/I183519381']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100374292', 'display_name': 'Guojun Zhang', 'orcid': 'https://orcid.org/0000-0003-3946-3988'}, 'institutions': [{'id': 'https://openalex.org/I183519381', 'display_name': 'Capital Medical University', 'ror': 'https://ror.org/013xs5b60', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183519381']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Guojun Zhang', 'raw_affiliation_strings': ['Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China', 'institution_ids': ['https://openalex.org/I183519381']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070511138', 'display_name': 'Gregory A. Worrell', 'orcid': 'https://orcid.org/0000-0003-2916-0553'}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}, {'id': 'https://openalex.org/I2802423016', 'display_name': 'WinnMed', 'ror': 'https://ror.org/02s47w807', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2802423016']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gregory Worrell', 'raw_affiliation_strings': ['Mayo Systems Electrophysiology Laboratory, Departments of Neurology and Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA'], 'affiliations': [{'raw_affiliation_string': 'Mayo Systems Electrophysiology Laboratory, Departments of Neurology and Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA', 'institution_ids': ['https://openalex.org/I1330342723', 'https://openalex.org/I2802423016']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031558481', 'display_name': 'Patrick Chauvel', 'orcid': 'https://orcid.org/0000-0003-2161-6077'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I21491767', 'display_name': 'Aix-Marseille Université', 'ror': 'https://ror.org/035xkbk20', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I21491767']}, {'id': 'https://openalex.org/I1316902750', 'display_name': 'Cleveland Clinic', 'ror': 'https://ror.org/03xjacd83', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316902750']}, {'id': 'https://openalex.org/I4210110495', 'display_name': 'Institut de Neurosciences des Systèmes', 'ror': 'https://ror.org/019kqby73', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I21491767', 'https://openalex.org/I4210087487', 'https://openalex.org/I4210110495']}], 'countries': ['FR', 'US'], 'is_corresponding': False, 'raw_author_name': 'Patrick Chauvel', 'raw_affiliation_strings': ['Epilepsy Center, Cleveland Clinic, Cleveland, OH 44195, USA', 'UMR 1106 INSERM, Institut de Neurosciences des Systemes, Aix-Marseille University, Marseille, France; Epilepsy Center, Cleveland Clinic, Cleveland, OH 44195, USA'], 'affiliations': [{'raw_affiliation_string': 'UMR 1106 INSERM, Institut de Neurosciences des Systemes, Aix-Marseille University, Marseille, France; Epilepsy Center, Cleveland Clinic, Cleveland, OH 44195, USA', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I21491767', 'https://openalex.org/I1316902750', 'https://openalex.org/I4210110495']}, {'raw_affiliation_string': 'Epilepsy Center, Cleveland Clinic, Cleveland, OH 44195, USA', 'institution_ids': ['https://openalex.org/I1316902750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062671009', 'display_name': 'Duanyu Ni', 'orcid': 'https://orcid.org/0000-0002-9090-1501'}, 'institutions': [{'id': 'https://openalex.org/I183519381', 'display_name': 'Capital Medical University', 'ror': 'https://ror.org/013xs5b60', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183519381']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Duanyu Ni', 'raw_affiliation_strings': ['Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China', 'institution_ids': ['https://openalex.org/I183519381']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100515826', 'display_name': 'Liang Qiao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I183519381', 'display_name': 'Capital Medical University', 'ror': 'https://ror.org/013xs5b60', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183519381']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Liang Qiao', 'raw_affiliation_strings': ['Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China', 'institution_ids': ['https://openalex.org/I183519381']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100353156', 'display_name': 'Chang Liu', 'orcid': 'https://orcid.org/0000-0001-6619-7019'}, 'institutions': [{'id': 'https://openalex.org/I183519381', 'display_name': 'Capital Medical University', 'ror': 'https://ror.org/013xs5b60', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183519381']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chang Liu', 'raw_affiliation_strings': ['Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China', 'institution_ids': ['https://openalex.org/I183519381']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5107901662', 'display_name': 'Liping Li', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I183519381', 'display_name': 'Capital Medical University', 'ror': 'https://ror.org/013xs5b60', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183519381']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Liping Li', 'raw_affiliation_strings': ['Comprehensive Epilepsy Center of Beijing, The Beijing Key Laboratory of Neuromodulation, Department of Neurology, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Comprehensive Epilepsy Center of Beijing, The Beijing Key Laboratory of Neuromodulation, Department of Neurology, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China', 'institution_ids': ['https://openalex.org/I183519381']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062309084', 'display_name': 'Liankun Ren', 'orcid': 'https://orcid.org/0000-0001-5147-3068'}, 'institutions': [{'id': 'https://openalex.org/I183519381', 'display_name': 'Capital Medical University', 'ror': 'https://ror.org/013xs5b60', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183519381']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Liankun Ren', 'raw_affiliation_strings': ['Comprehensive Epilepsy Center of Beijing, The Beijing Key Laboratory of Neuromodulation, Department of Neurology, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Comprehensive Epilepsy Center of Beijing, The Beijing Key Laboratory of Neuromodulation, Department of Neurology, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China', 'institution_ids': ['https://openalex.org/I183519381']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100339112', 'display_name': 'Yuping Wang', 'orcid': 'https://orcid.org/0000-0002-6482-9710'}, 'institutions': [{'id': 'https://openalex.org/I183519381', 'display_name': 'Capital Medical University', 'ror': 'https://ror.org/013xs5b60', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183519381']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Yuping Wang', 'raw_affiliation_strings': ['Comprehensive Epilepsy Center of Beijing, The Beijing Key Laboratory of Neuromodulation, Department of Neurology, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Comprehensive Epilepsy Center of Beijing, The Beijing Key Laboratory of Neuromodulation, Department of Neurology, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China', 'institution_ids': ['https://openalex.org/I183519381']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 7, 'corresponding_author_ids': ['https://openalex.org/A5062309084', 'https://openalex.org/A5100339112'], 'corresponding_institution_ids': ['https://openalex.org/I183519381', 'https://openalex.org/I183519381'], 'apc_list': {'value': 3658, 'currency': 'GBP', 'value_usd': 4486, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 10.848, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 144, 'citation_normalized_percentile': {'value': 0.999913, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10919', 'display_name': 'Neurological disorders and treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10919', 'display_name': 'Neurological disorders and treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11601', 'display_name': 'Neuroscience and Neural Engineering', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10581', 'display_name': 'Neural dynamics and brain function', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2805', 'display_name': 'Cognitive Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2779246727', 'wikidata': 'https://www.wikidata.org/wiki/Q184215', 'display_name': 'Thalamus', 'level': 2, 'score': 0.8564054}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.80886745}, {'id': 'https://openalex.org/C24998067', 'wikidata': 'https://www.wikidata.org/wiki/Q4114622', 'display_name': 'Stimulation', 'level': 2, 'score': 0.60613126}, {'id': 'https://openalex.org/C148762608', 'wikidata': 'https://www.wikidata.org/wiki/Q3748185', 'display_name': 'Hippocampal formation', 'level': 2, 'score': 0.59582835}, {'id': 'https://openalex.org/C2780723820', 'wikidata': 'https://www.wikidata.org/wiki/Q1934178', 'display_name': 'Nucleus', 'level': 2, 'score': 0.5867398}, {'id': 'https://openalex.org/C2778542668', 'wikidata': 'https://www.wikidata.org/wiki/Q618076', 'display_name': 'Deep brain stimulation', 'level': 4, 'score': 0.5800996}, {'id': 'https://openalex.org/C2778186239', 'wikidata': 'https://www.wikidata.org/wiki/Q41571', 'display_name': 'Epilepsy', 'level': 2, 'score': 0.4959689}, {'id': 'https://openalex.org/C2781161787', 'wikidata': 'https://www.wikidata.org/wiki/Q48360', 'display_name': 'Hippocampus', 'level': 2, 'score': 0.46385834}, {'id': 'https://openalex.org/C17755696', 'wikidata': 'https://www.wikidata.org/wiki/Q16564780', 'display_name': 'Ictal', 'level': 3, 'score': 0.44939005}, {'id': 'https://openalex.org/C17077164', 'wikidata': 'https://www.wikidata.org/wiki/Q1185869', 'display_name': 'Inhibitory postsynaptic potential', 'level': 2, 'score': 0.44359407}, {'id': 'https://openalex.org/C2781041448', 'wikidata': 'https://www.wikidata.org/wiki/Q75839', 'display_name': 'Cerebral cortex', 'level': 2, 'score': 0.4378045}, {'id': 'https://openalex.org/C15744967', 'wikidata': 'https://www.wikidata.org/wiki/Q9418', 'display_name': 'Psychology', 'level': 0, 'score': 0.34304917}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.27127564}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.07204822}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C2779734285', 'wikidata': 'https://www.wikidata.org/wiki/Q11085', 'display_name': "Parkinson's disease", 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D020643', 'descriptor_name': 'Anterior Thalamic Nuclei', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D046690', 'descriptor_name': 'Deep Brain Stimulation', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D004827', 'descriptor_name': 'Epilepsy', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020643', 'descriptor_name': 'Anterior Thalamic Nuclei', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002540', 'descriptor_name': 'Cerebral Cortex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002540', 'descriptor_name': 'Cerebral Cortex', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D002681', 'descriptor_name': 'China', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003344', 'descriptor_name': 'Cortical Synchronization', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D003344', 'descriptor_name': 'Cortical Synchronization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046690', 'descriptor_name': 'Deep Brain Stimulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004567', 'descriptor_name': 'Electrodes, Implanted', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004569', 'descriptor_name': 'Electroencephalography', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004569', 'descriptor_name': 'Electroencephalography', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D004827', 'descriptor_name': 'Epilepsy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004827', 'descriptor_name': 'Epilepsy', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D005071', 'descriptor_name': 'Evoked Potentials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005071', 'descriptor_name': 'Evoked Potentials', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006624', 'descriptor_name': 'Hippocampus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006624', 'descriptor_name': 'Hippocampus', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009415', 'descriptor_name': 'Nerve Net', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009415', 'descriptor_name': 'Nerve Net', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D012640', 'descriptor_name': 'Seizures', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012640', 'descriptor_name': 'Seizures', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D013788', 'descriptor_name': 'Thalamus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013788', 'descriptor_name': 'Thalamus', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/brain/awy187', 'pdf_url': 'https://academic.oup.com/brain/article-pdf/141/9/2631/25590605/awy187.pdf', 'source': {'id': 'https://openalex.org/S118357697', 'display_name': 'Brain', 'issn_l': '0006-8950', 'issn': ['0006-8950', '1460-2156'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29985998', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/brain/awy187', 'pdf_url': 'https://academic.oup.com/brain/article-pdf/141/9/2631/25590605/awy187.pdf', 'source': {'id': 'https://openalex.org/S118357697', 'display_name': 'Brain', 'issn_l': '0006-8950', 'issn': ['0006-8950', '1460-2156'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.44, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '81771398'}, {'funder': 'https://openalex.org/F4320321572', 'funder_display_name': 'Beijing Municipal Commission of Education', 'award_id': 'TJSH20161002502'}], 'datasets': [], 'versions': [], 'referenced_works_count': 71, 'referenced_works': ['https://openalex.org/W105379328', 'https://openalex.org/W1140435368', 'https://openalex.org/W1547704806', 'https://openalex.org/W1580041071', 'https://openalex.org/W1931612300', 'https://openalex.org/W1934102085', 'https://openalex.org/W1970117905', 'https://openalex.org/W1977172001', 'https://openalex.org/W1979047980', 'https://openalex.org/W1989017031', 'https://openalex.org/W199302910', 'https://openalex.org/W2008953662', 'https://openalex.org/W2009579332', 'https://openalex.org/W2017455791', 'https://openalex.org/W2019418767', 'https://openalex.org/W2022059603', 'https://openalex.org/W2024667826', 'https://openalex.org/W2026153752', 'https://openalex.org/W2028681020', 'https://openalex.org/W2029682193', 'https://openalex.org/W2045747994', 'https://openalex.org/W2056604895', 'https://openalex.org/W2064404816', 'https://openalex.org/W2070011714', 'https://openalex.org/W2070711358', 'https://openalex.org/W2072309637', 'https://openalex.org/W2073318551', 'https://openalex.org/W2079207152', 'https://openalex.org/W2080438790', 'https://openalex.org/W2086762859', 'https://openalex.org/W2088595917', 'https://openalex.org/W2091879518', 'https://openalex.org/W2101661786', 'https://openalex.org/W2103497397', 'https://openalex.org/W2104930442', 'https://openalex.org/W2107974789', 'https://openalex.org/W2109566484', 'https://openalex.org/W2109841850', 'https://openalex.org/W2126012718', 'https://openalex.org/W2135629133', 'https://openalex.org/W2135913462', 'https://openalex.org/W2141554976', 'https://openalex.org/W2146282734', 'https://openalex.org/W2148571148', 'https://openalex.org/W2156969532', 'https://openalex.org/W2158334924', 'https://openalex.org/W2160967456', 'https://openalex.org/W2166543843', 'https://openalex.org/W2167080967', 'https://openalex.org/W2177232575', 'https://openalex.org/W2178538195', 'https://openalex.org/W2265173411', 'https://openalex.org/W2282985911', 'https://openalex.org/W2298806299', 'https://openalex.org/W2333073257', 'https://openalex.org/W2338591783', 'https://openalex.org/W2400513453', 'https://openalex.org/W2409472021', 'https://openalex.org/W2409829112', 'https://openalex.org/W2460220103', 'https://openalex.org/W2520572945', 'https://openalex.org/W2550225294', 'https://openalex.org/W2550961348', 'https://openalex.org/W2559901472', 'https://openalex.org/W2590677391', 'https://openalex.org/W2591607137', 'https://openalex.org/W2592739175', 'https://openalex.org/W2604172498', 'https://openalex.org/W2619800357', 'https://openalex.org/W4210732881', 'https://openalex.org/W4214953342'], 'related_works': ['https://openalex.org/W2947814579', 'https://openalex.org/W2485956973', 'https://openalex.org/W2419003701', 'https://openalex.org/W2093009172', 'https://openalex.org/W2080864507', 'https://openalex.org/W2071847743', 'https://openalex.org/W2064206514', 'https://openalex.org/W1968175673', 'https://openalex.org/W1648204682', 'https://openalex.org/W1589275161'], 'abstract_inverted_index': {'Epilepsy': [0], 'has': [1, 19, 46], 'been': [2, 20], 'classically': [3], 'seen': [4], 'as': [5, 48, 250], 'a': [6, 49, 70, 132], 'brain': [7, 37, 75, 267], 'disorder': [8], 'resulting': [9], 'from': [10, 90, 177], 'abnormally': [11], 'enhanced': [12], 'neuronal': [13], 'excitability': [14], 'and': [15, 136, 144, 167, 213, 222, 242, 246, 257, 277, 283], 'synchronization.': [16], 'Although': [17], 'it': [18], 'described': [21], 'since': [22], 'antiquity,': [23], 'there': [24], 'are': [25], 'still': [26], 'significant': [27], 'challenges': [28], 'achieving': [29], 'the': [30, 40, 44, 56, 78, 82, 91, 99, 103, 119, 123, 151, 155, 165, 207, 211, 214, 231, 235, 251, 271, 275, 288], 'therapeutic': [31], 'goal': [32], 'of': [33, 39, 43, 59, 73, 77, 81, 98, 102, 122, 150, 154, 159, 186, 198, 210, 230, 234, 274], 'seizure': [34, 255, 284], 'freedom.': [35], 'Deep': [36], 'stimulation': [38, 76, 95, 116, 149, 174, 229, 268], 'anterior': [41, 79, 100, 120, 152, 208, 232, 272], 'nucleus': [42, 80, 101, 121, 153, 209, 233, 273], 'thalamus': [45, 83, 104, 124, 156, 212, 236, 276], 'emerged': [47], 'promising': [50], 'therapy': [51], 'for': [52, 253, 299], 'focal': [53, 110, 241], 'drug-resistant': [54, 109], 'epilepsy;': [55], 'basic': [57], 'mechanism': [58, 72, 252], 'action,': [60], 'however,': [61], 'remains': [62], 'unclear.': [63], 'Here,': [64], 'we': [65], 'show': [66], 'that': [67, 114, 173], 'desynchronization': [68, 197], 'is': [69, 157, 237, 248], 'potential': [71], 'deep': [74, 266], 'by': [84, 218], 'studying': [85], 'local': [86, 188], 'field': [87, 189], 'potentials': [88, 221], 'recordings': [89], 'cortex': [92], 'during': [93], 'high-frequency': [94, 115, 145, 148, 228], '(130': [96], 'Hz)': [97, 195], 'in': [105], 'nine': [106], 'patients': [107, 278], 'with': [108, 184, 279], 'epilepsy.': [111], 'We': [112, 171], 'demonstrate': [113, 262], 'applied': [117, 269], 'to': [118, 179, 239, 270, 303], 'desynchronizes': [125], 'ipsilateral': [126, 199], 'hippocampal': [127, 187, 200], 'background': [128], 'electrical': [129], 'activity': [130, 163], 'over': [131], 'broad': [133], 'frequency': [134], 'range,': [135], 'reduces': [137], 'pathological': [138], 'epileptic': [139, 244], 'discharges': [140], 'including': [141], 'interictal': [142], 'spikes': [143], 'oscillations.': [146], 'Furthermore,': [147], 'capable': [158], 'decoupling': [160], 'large-scale': [161, 243], 'neural': [162], 'involving': [164], 'hippocampus': [166, 215], 'distributed': [168], 'cortical': [169], 'areas.': [170], 'found': [172], 'frequencies': [175, 193], 'ranging': [176], '15': [178], '45': [180], 'Hz': [181], 'were': [182], 'associated': [183], 'synchronization': [185], 'potentials,': [190], 'whereas': [191], 'higher': [192], '(>45': [194], 'promoted': [196], 'activity.': [201], 'Moreover,': [202], 'reciprocal': [203], 'effective': [204], 'connectivity': [205], 'between': [206, 265], 'was': [216], 'demonstrated': [217], 'hippocampal-thalamic': [219], 'evoked': [220, 224], 'thalamic-hippocampal': [223], 'potentials.': [225], 'In': [226], 'summary,': [227], 'shown': [238], 'desynchronize': [240], 'networks,': [245], 'here': [247], 'proposed': [249], 'reducing': [254], 'generation': [256], 'propagation.': [258], 'Our': [259, 294], 'data': [260], 'also': [261], 'position-specific': [263], 'correlation': [264], 'temporal': [280], 'lobe': [281], 'epilepsy': [282], 'onset': [285], 'zone': [286], 'within': [287], 'Papaz': [289], 'circuit': [290], 'or': [291], 'limbic': [292], 'system.': [293], 'observation': [295], 'may': [296], 'prove': [297], 'useful': [298], 'guiding': [300], 'electrode': [301], 'implantation': [302], 'increase': [304], 'clinical': [305], 'efficacy.': [306]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2871023201', 'counts_by_year': [{'year': 2024, 'cited_by_count': 13}, {'year': 2023, 'cited_by_count': 34}, {'year': 2022, 'cited_by_count': 34}, {'year': 2021, 'cited_by_count': 23}, {'year': 2020, 'cited_by_count': 21}, {'year': 2019, 'cited_by_count': 14}, {'year': 2018, 'cited_by_count': 3}], 'updated_date': '2024-12-17T23:26:46.113129', 'created_date': '2018-07-19'}