Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2864366823', 'doi': 'https://doi.org/10.1021/acs.langmuir.8b00354', 'title': 'Nanoparticle Induced Conformational Switch Between α-Helix and β-Sheet Attenuates Immunogenic Response of MPT63', 'display_name': 'Nanoparticle Induced Conformational Switch Between α-Helix and β-Sheet Attenuates Immunogenic Response of MPT63', 'publication_year': 2018, 'publication_date': '2018-07-09', 'ids': {'openalex': 'https://openalex.org/W2864366823', 'doi': 'https://doi.org/10.1021/acs.langmuir.8b00354', 'mag': '2864366823', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29986589'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/acs.langmuir.8b00354', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S75741262', 'display_name': 'Langmuir', 'issn_l': '0743-7463', 'issn': ['0743-7463', '1520-5827'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5035457363', 'display_name': 'Achinta Sannigrahi', 'orcid': 'https://orcid.org/0000-0002-6037-2805'}, 'institutions': [{'id': 'https://openalex.org/I160344538', 'display_name': 'Indian Institute of Chemical Biology', 'ror': 'https://ror.org/01kh0x418', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I160344538', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Achinta Sannigrahi', 'raw_affiliation_strings': ['Structural Biology & Bio-Informatics Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S. C. Mallick Road, Kolkata 700032, India'], 'affiliations': [{'raw_affiliation_string': 'Structural Biology & Bio-Informatics Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S. C. Mallick Road, Kolkata 700032, India', 'institution_ids': ['https://openalex.org/I160344538']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026541704', 'display_name': 'Sayantani Chall', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I160344538', 'display_name': 'Indian Institute of Chemical Biology', 'ror': 'https://ror.org/01kh0x418', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I160344538', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Sayantani Chall', 'raw_affiliation_strings': ['Structural Biology & Bio-Informatics Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S. C. Mallick Road, Kolkata 700032, India'], 'affiliations': [{'raw_affiliation_string': 'Structural Biology & Bio-Informatics Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S. C. Mallick Road, Kolkata 700032, India', 'institution_ids': ['https://openalex.org/I160344538']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018731603', 'display_name': 'Junaid Jibran Jawed', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I152754861', 'display_name': 'Bose Institute', 'ror': 'https://ror.org/01a5mqy88', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I152754861']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Junaid Jibran Jawed', 'raw_affiliation_strings': ['Department of Molecular Medicine, Bose Institute, Kolkata 700054, India'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Medicine, Bose Institute, Kolkata 700054, India', 'institution_ids': ['https://openalex.org/I152754861']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045196443', 'display_name': 'Amrita Kundu', 'orcid': 'https://orcid.org/0000-0002-1499-7564'}, 'institutions': [{'id': 'https://openalex.org/I160344538', 'display_name': 'Indian Institute of Chemical Biology', 'ror': 'https://ror.org/01kh0x418', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I160344538', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Amrita Kundu', 'raw_affiliation_strings': ['Structural Biology & Bio-Informatics Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S. C. Mallick Road, Kolkata 700032, India'], 'affiliations': [{'raw_affiliation_string': 'Structural Biology & Bio-Informatics Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S. C. Mallick Road, Kolkata 700032, India', 'institution_ids': ['https://openalex.org/I160344538']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101441539', 'display_name': 'Subrata Majumdar', 'orcid': 'https://orcid.org/0000-0002-2306-8396'}, 'institutions': [{'id': 'https://openalex.org/I152754861', 'display_name': 'Bose Institute', 'ror': 'https://ror.org/01a5mqy88', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I152754861']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Subrata Majumdar', 'raw_affiliation_strings': ['Department of Molecular Medicine, Bose Institute, Kolkata 700054, India'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Medicine, Bose Institute, Kolkata 700054, India', 'institution_ids': ['https://openalex.org/I152754861']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5052537544', 'display_name': 'Krishnananda Chattopadhyay', 'orcid': 'https://orcid.org/0000-0002-1449-8909'}, 'institutions': [{'id': 'https://openalex.org/I160344538', 'display_name': 'Indian Institute of Chemical Biology', 'ror': 'https://ror.org/01kh0x418', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I160344538', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': True, 'raw_author_name': 'Krishnananda Chattopadhyay', 'raw_affiliation_strings': ['Structural Biology & Bio-Informatics Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S. C. Mallick Road, Kolkata 700032, India'], 'affiliations': [{'raw_affiliation_string': 'Structural Biology & Bio-Informatics Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S. C. Mallick Road, Kolkata 700032, India', 'institution_ids': ['https://openalex.org/I160344538']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5052537544'], 'corresponding_institution_ids': ['https://openalex.org/I160344538'], 'apc_list': None, 'apc_paid': None, 'fwci': 1.245, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 14, 'citation_normalized_percentile': {'value': 0.652733, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 88, 'max': 89}, 'biblio': {'volume': '34', 'issue': '30', 'first_page': '8807', 'last_page': '8817'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12856', 'display_name': 'Transgenic Plants and Applications', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12856', 'display_name': 'Transgenic Plants and Applications', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11048', 'display_name': 'Bacteriophages and microbial interactions', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/2303', 'display_name': 'Ecology'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11016', 'display_name': 'Monoclonal and Polyclonal Antibodies Research', 'score': 0.986, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/helix', 'display_name': 'Helix (gastropod)', 'score': 0.605088}, {'id': 'https://openalex.org/keywords/conformational-change', 'display_name': 'Conformational change', 'score': 0.5579206}, {'id': 'https://openalex.org/keywords/protein-engineering', 'display_name': 'Protein Engineering', 'score': 0.44700763}], 'concepts': [{'id': 'https://openalex.org/C155672457', 'wikidata': 'https://www.wikidata.org/wiki/Q61231', 'display_name': 'Nanoparticle', 'level': 2, 'score': 0.72008884}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.6416182}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.62458473}, {'id': 'https://openalex.org/C2778530040', 'wikidata': 'https://www.wikidata.org/wiki/Q1937315', 'display_name': 'Helix (gastropod)', 'level': 3, 'score': 0.605088}, {'id': 'https://openalex.org/C2777339483', 'wikidata': 'https://www.wikidata.org/wiki/Q647203', 'display_name': 'Conformational change', 'level': 2, 'score': 0.5579206}, {'id': 'https://openalex.org/C2777975735', 'wikidata': 'https://www.wikidata.org/wiki/Q130971', 'display_name': 'Mycobacterium tuberculosis', 'level': 3, 'score': 0.4925781}, {'id': 'https://openalex.org/C161624437', 'wikidata': 'https://www.wikidata.org/wiki/Q1988322', 'display_name': 'Small molecule', 'level': 2, 'score': 0.49165517}, {'id': 'https://openalex.org/C147816474', 'wikidata': 'https://www.wikidata.org/wiki/Q169525', 'display_name': 'Protein engineering', 'level': 3, 'score': 0.44700763}, {'id': 'https://openalex.org/C112613896', 'wikidata': 'https://www.wikidata.org/wiki/Q898370', 'display_name': 'Conjugated system', 'level': 3, 'score': 0.43744022}, {'id': 'https://openalex.org/C47701112', 'wikidata': 'https://www.wikidata.org/wiki/Q735188', 'display_name': 'Protein structure', 'level': 2, 'score': 0.41077197}, {'id': 'https://openalex.org/C51639874', 'wikidata': 'https://www.wikidata.org/wiki/Q167149', 'display_name': 'Plasma protein binding', 'level': 2, 'score': 0.4105421}, {'id': 'https://openalex.org/C171250308', 'wikidata': 'https://www.wikidata.org/wiki/Q11468', 'display_name': 'Nanotechnology', 'level': 1, 'score': 0.34703517}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.26777023}, {'id': 'https://openalex.org/C192562407', 'wikidata': 'https://www.wikidata.org/wiki/Q228736', 'display_name': 'Materials science', 'level': 0, 'score': 0.17375827}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.14832988}, {'id': 'https://openalex.org/C521977710', 'wikidata': 'https://www.wikidata.org/wiki/Q81163', 'display_name': 'Polymer', 'level': 2, 'score': 0.1320833}, {'id': 'https://openalex.org/C2781069245', 'wikidata': 'https://www.wikidata.org/wiki/Q12204', 'display_name': 'Tuberculosis', 'level': 2, 'score': 0.090026796}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C18903297', 'wikidata': 'https://www.wikidata.org/wiki/Q7150', 'display_name': 'Ecology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C2779965526', 'wikidata': 'https://www.wikidata.org/wiki/Q308841', 'display_name': 'Snail', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D053758', 'descriptor_name': 'Nanoparticles', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000995', 'descriptor_name': 'Antitubercular Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000995', 'descriptor_name': 'Antitubercular Agents', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000995', 'descriptor_name': 'Antitubercular Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009169', 'descriptor_name': 'Mycobacterium tuberculosis', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D009169', 'descriptor_name': 'Mycobacterium tuberculosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009169', 'descriptor_name': 'Mycobacterium tuberculosis', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D053758', 'descriptor_name': 'Nanoparticles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072756', 'descriptor_name': 'Protein Conformation, alpha-Helical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072756', 'descriptor_name': 'Protein Conformation, alpha-Helical', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D000072757', 'descriptor_name': 'Protein Conformation, beta-Strand', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072757', 'descriptor_name': 'Protein Conformation, beta-Strand', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/acs.langmuir.8b00354', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S75741262', 'display_name': 'Langmuir', 'issn_l': '0743-7463', 'issn': ['0743-7463', '1520-5827'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29986589', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.59, 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320320767', 'funder_display_name': 'University Grants Commission', 'award_id': None}, {'funder': 'https://openalex.org/F4320334771', 'funder_display_name': 'Science and Engineering Research Board', 'award_id': 'PDF/2017/000453'}], 'datasets': [], 'versions': [], 'referenced_works_count': 37, 'referenced_works': ['https://openalex.org/W1600959429', 'https://openalex.org/W1975304761', 'https://openalex.org/W1982621412', 'https://openalex.org/W1983019354', 'https://openalex.org/W1990583552', 'https://openalex.org/W2013768168', 'https://openalex.org/W2014779844', 'https://openalex.org/W2037312364', 'https://openalex.org/W2046994420', 'https://openalex.org/W2070857970', 'https://openalex.org/W2082884007', 'https://openalex.org/W2083645532', 'https://openalex.org/W2096665649', 'https://openalex.org/W2099443896', 'https://openalex.org/W2106878780', 'https://openalex.org/W2107735396', 'https://openalex.org/W2109454628', 'https://openalex.org/W2110634891', 'https://openalex.org/W2114144712', 'https://openalex.org/W2136919736', 'https://openalex.org/W2140850919', 'https://openalex.org/W2144843667', 'https://openalex.org/W2158558808', 'https://openalex.org/W2161946327', 'https://openalex.org/W2174400501', 'https://openalex.org/W2318438543', 'https://openalex.org/W2320866708', 'https://openalex.org/W2324016220', 'https://openalex.org/W2345566575', 'https://openalex.org/W2564568723', 'https://openalex.org/W2586307183', 'https://openalex.org/W2617347503', 'https://openalex.org/W2617801077', 'https://openalex.org/W2734586885', 'https://openalex.org/W2737978516', 'https://openalex.org/W2805405960', 'https://openalex.org/W2891660591'], 'related_works': ['https://openalex.org/W4293918677', 'https://openalex.org/W4214840794', 'https://openalex.org/W2968547367', 'https://openalex.org/W2361811528', 'https://openalex.org/W2322773924', 'https://openalex.org/W2162254443', 'https://openalex.org/W2031298316', 'https://openalex.org/W2020558940', 'https://openalex.org/W2003903287', 'https://openalex.org/W1993952492'], 'abstract_inverted_index': {'Although': [0], 'significant': [1], 'efforts': [2], 'have': [3, 57], 'been': [4], 'devoted': [5], 'to': [6, 65, 88, 94], 'develop': [7], 'nanoparticle-based': [8], 'biopharmaceuticals,': [9], 'it': [10], 'is': [11, 34], 'not': [12], 'understood': [13], 'how': [14], 'protein': [15, 73, 116, 124], 'conformation': [16], 'and': [17, 77, 104], 'nanoparticle': [18, 59, 146], 'surface': [19, 134], 'modulate': [20], 'each': [21], 'other': [22], 'in': [23, 91], 'optimizing': [24], 'the': [25, 30, 98, 102, 111, 115], 'activity': [26], 'and/or': [27], 'toxicity': [28], 'of': [29, 67, 85, 114, 144], 'biological': [31], 'molecules.': [32], 'This': [33, 126], 'particularly': [35], 'important': [36], 'for': [37, 142], 'a': [38, 48, 69, 78, 92, 109, 145], 'protein,': [39], 'which': [40, 119], 'can': [41], 'adopt': [42], 'different': [43], 'conformational': [44, 61, 130], 'states': [45], 'separated': [46], 'by': [47, 123], 'relatively': [49], 'small': [50, 70], 'energy': [51], 'barrier.': [52], 'In': [53], 'this': [54], 'paper,': [55], 'we': [56], 'studied': [58], 'binding-induced': [60], 'switch': [62, 96], 'from': [63, 74], 'β-sheet': [64, 93], 'α-helix': [66, 95], 'MPT63,': [68], 'major': [71], 'secreted': [72], 'Mycobacterium': [75], 'tuberculosis': [76], 'drug': [79], 'target': [80], 'against': [81], 'Tuberculosis.': [82], 'The': [83], 'binding': [84, 135], 'magnetite': [86], 'nanoparticles': [87], 'MPT63': [89], 'results': [90], 'near': [97], 'sequence': [99], 'stretch': [100], 'between': [101], '19th': [103], '30th': [105], 'amino': [106], 'acids.': [107], 'As': [108], 'consequence,': [110], 'immunogenic': [112], 'response': [113], 'becomes': [117], 'compromised,': [118], 'could': [120], 'be': [121], 'restored': [122], 'engineering.': [125], 'study': [127], 'emphasizes': [128], 'that': [129], 'stability': [131], 'toward': [132], 'NP': [133], 'may': [136], 'require': [137], 'optimization': [138], 'involving': [139], 'genetic': [140], 'engineering': [141], 'development': [143], 'conjugated': [147], 'pharmaceutical.': [148]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2864366823', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 4}], 'updated_date': '2024-12-17T15:42:40.346711', 'created_date': '2018-07-19'}