Title: Brain proton magnetic resonance spectroscopy (1H-MRS) in Alzheimer's disease: changes after treatment with xanomeline, an M1 selective cholinergic agonist
Abstract: Back to table of contents Previous article Next article Full AccessBrain proton magnetic resonance spectroscopy (1H-MRS) in Alzheimer's disease: changes after treatment with xanomeline, an M1 selective cholinergic agonistPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.154.10.1459AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractOBJECTIVE: Higher than normal cellular levels of the phospholipid catabolic intermediate glycerophosphocholine have been found in postmortem brain tissue of persons with Alzheimer's disease. Proton magnetic resonance spectroscopy (1H-MRS) can detect a choline resonance that is largely due to glycerophosphocholine. The authors tested the hypothesis that treatment with xanomeline, an M1 selective muscarinic cholinergic agonist, would be associated with a decrease in the 1H-MRS choline resonance. METHOD: Patients with mild to moderate Alzheimer's disease received placebo or xanomeline for 6 months. 1H-MRS spectra were collected at baseline and after treatment discontinuation for 12 patients, two taking placebo and 10 taking xanomeline at a dose of 25 mg t.i.d. (N = 4), 50 mg t.i.d. (N = 3), or 75 mg t.i.d. (N = 3). RESULTS: For the combined group of patients taking xanomeline, there was a significant decrease in the choline/creatine ratio from baseline to endpoint. CONCLUSIONS: Treatment of Alzheimer's disease with a cholinergic agonist is associated with a decrease in the MRS choline resonance. Xanomeline may reduce breakdown of cholinergic neuron membranes by reducing the cellular requirement for free choline for acetylcholine synthesis. FiguresReferencesCited byDetailsCited byMicrostructural imaging and transcriptomics of the basal forebrain in first-episode psychosis1 September 2022 | Translational Psychiatry, Vol. 12, No. 1Dietary lutein plus zeaxanthin and choline intake is interactively associated with cognitive flexibility in middle-adulthood in adults with overweight and obesity15 January 2021 | Nutritional Neuroscience, Vol. 25, No. 7Aging Medicine, Vol. 1, No. 1Neuropsychopharmacology, Vol. 42, No. 11Evidence of altered membrane phospholipid metabolism in the anterior cingulate cortex and striatum of patients with bipolar disorder I: A multi-voxel 1H MRS studyJournal of Psychiatric Research, Vol. 81Magnetic Resonance Spectroscopy in Dementia28 July 2016Journal of Neural Transmission, Vol. 122, No. 4Journal of Neurophysiology, Vol. 114, No. 3Dementia & Neuropsychologia, Vol. 9, No. 4Biological Psychiatry, Vol. 75, No. 9Seminars in Roentgenology, Vol. 49, No. 1Autism Research, Vol. 6, No. 2Journal of Magnetic Resonance Imaging, Vol. 37, No. 4Neuroscience, Vol. 252Neuroimaging Clinics of North America, Vol. 23, No. 3PLoS ONE, Vol. 8, No. 5European Journal of Radiology, Vol. 81, No. 4Longitudinal Magnetic Resonance Spectroscopy as Marker of Cognitive Deterioration in Mild Cognitive Impairment8 February 2012 | American Journal of Alzheimer's Disease & Other Dementiasr, Vol. 26, No. 8NeuroImage, Vol. 57, No. 1Magnetic Resonance Imaging Clinics of North America, Vol. 18, No. 1Proton MR spectroscopy in aging and dementiaThe Journal of Nutrition, Health and Aging, Vol. 13, No. 4Experimental Eye Research, Vol. 88, No. 1Neurologic Clinics, Vol. 27, No. 1Molecular Imaging and Magnetic Resonance Imaging in Early Diagnosis of Alzheimer's Disease1 December 2008 | The Neuroradiology Journal, Vol. 21, No. 6Radiology, Vol. 248, No. 1Neurobiology of Aging, Vol. 28, No. 9Journal of Neurophysiology, Vol. 98, No. 4The British Journal of Radiology, Vol. 80, No. special_issue_2La Lunga Attesa : Towards a Molecular Approach to Neuroimaging and Therapeutics in Alzheimer's Disease27 August 2016 | The Neuroradiology Journal, Vol. 19, No. 4NMR in Biomedicine, Vol. 19, No. 6Journal of Neurochemistry, Vol. 97, No. 6CNS Drugs, Vol. 20, No. 10Predicting Progression of Alzheimer's Disease With Magnetic ResonanceJournal of Clinical Neuroscience, Vol. 12, No. 3Neuroimaging Clinics of North America, Vol. 15, No. 4Expert Review of Neurotherapeutics, Vol. 5, No. 5NeuroRX, Vol. 2, No. 2Brain Research, Vol. 1030, No. 1NeuroRX, Vol. 1, No. 2Biological Psychiatry, Vol. 54, No. 12Journal of Neuroimaging, Vol. 13, No. 3Radiology, Vol. 226, No. 2Hydrogen Proton Magnetic Resonance Spectroscopy in Autism: Preliminary Evidence of Elevated Choline/Creatine Ratio2 July 2016 | Journal of Child Neurology, Vol. 17, No. 4Biological Psychiatry, Vol. 51, No. 3The American Journal of Geriatric Psychiatry, Vol. 10, No. 1CNS Drugs, Vol. 16, No. 7Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy in Dementias29 June 2016 | Journal of Geriatric Psychiatry and Neurology, Vol. 14, No. 3Magnetic resonance spectroscopy in Alzheimer's disease: focus on N -acetylaspartate2 January 2002 | Acta Neurologica Scandinavica, Vol. 102Role of single‐stranded DNA regions and Y‐box proteins in transcriptional regulation of viral and cellular genes1 November 2000 | The FASEB Journal, Vol. 14, No. 14CNS Drugs, Vol. 14, No. 6Brain Biochemistry Using Magnetic Resonance Spectroscopy: Relevance to Psychiatric Illness in the Elderly29 June 2016 | Journal of Geriatric Psychiatry and Neurology, Vol. 12, No. 3Common Pattern of Cortical Pathology in Childhood-Onset and Adult-Onset Schizophrenia as Identified by Proton Magnetic Resonance Spectroscopic ImagingAlessandro Bertolino, M.D., Sanjiv Kumra, M.D., Joseph H. Callicott, M.D., Venkata S. Mattay, M.D., Rachel M. Lestz, B.S., Leslie Jacobsen, M.D., lan S. Barnett, Ph.D., Jeff H. Duyn, Ph.D., Joseph A. Frank, M.D., Judith L. Rapoport, M.D., and Daniel R. Weinberger, M.D.1 October 1998 | American Journal of Psychiatry, Vol. 155, No. 10 Volume 154Issue 10 October 1997Pages 1459-1461 Metrics PDF download History Published online 1 April 2006 Published in print 1 October 1997
Publication Year: 1997
Publication Date: 1997-10-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 75
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