Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W282734715', 'doi': 'https://doi.org/10.1016/j.jmb.2015.05.009', 'title': 'The First Crystal Structure of the UP1 Domain of hnRNP A1 Bound to RNA Reveals a New Look for an Old RNA Binding Protein', 'display_name': 'The First Crystal Structure of the UP1 Domain of hnRNP A1 Bound to RNA Reveals a New Look for an Old RNA Binding Protein', 'publication_year': 2015, 'publication_date': '2015-10-01', 'ids': {'openalex': 'https://openalex.org/W282734715', 'doi': 'https://doi.org/10.1016/j.jmb.2015.05.009', 'mag': '282734715', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26003924', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4586317'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.jmb.2015.05.009', 'pdf_url': 'https://www.sciencedirect.com/science/article/am/pii/S0022283615002934', 'source': {'id': 'https://openalex.org/S46058472', 'display_name': 'Journal of Molecular Biology', 'issn_l': '0022-2836', 'issn': ['0022-2836', '1089-8638'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.sciencedirect.com/science/article/am/pii/S0022283615002934', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5020175761', 'display_name': 'Christopher E. Morgan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I58956616', 'display_name': 'Case Western Reserve University', 'ror': 'https://ror.org/051fd9666', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I58956616']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christopher E. Morgan', 'raw_affiliation_strings': ['Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106 (USA)'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106 (USA)', 'institution_ids': ['https://openalex.org/I58956616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027601671', 'display_name': 'Jennifer L. Meagher', 'orcid': 'https://orcid.org/0000-0003-1250-4575'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jennifer L. Meagher', 'raw_affiliation_strings': ['Life Sciences Institute; University of Michigan; Ann Arbor MI 48109 USA'], 'affiliations': [{'raw_affiliation_string': 'Life Sciences Institute; University of Michigan; Ann Arbor MI 48109 USA', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054787602', 'display_name': 'Jeffrey D. Levengood', 'orcid': 'https://orcid.org/0000-0003-1018-4301'}, 'institutions': [{'id': 'https://openalex.org/I58956616', 'display_name': 'Case Western Reserve University', 'ror': 'https://ror.org/051fd9666', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I58956616']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jeffrey D. Levengood', 'raw_affiliation_strings': ['Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106 (USA)'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106 (USA)', 'institution_ids': ['https://openalex.org/I58956616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037676246', 'display_name': 'James Delproposto', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James Delproposto', 'raw_affiliation_strings': ['Life Sciences Institute; University of Michigan; Ann Arbor MI 48109 USA'], 'affiliations': [{'raw_affiliation_string': 'Life Sciences Institute; University of Michigan; Ann Arbor MI 48109 USA', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045423593', 'display_name': 'Carrie Rollins', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I58956616', 'display_name': 'Case Western Reserve University', 'ror': 'https://ror.org/051fd9666', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I58956616']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Carrie Rollins', 'raw_affiliation_strings': ['Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106 (USA)'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106 (USA)', 'institution_ids': ['https://openalex.org/I58956616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024364780', 'display_name': 'Jeanne A. Stuckey', 'orcid': 'https://orcid.org/0000-0002-4192-8900'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jeanne A. Stuckey', 'raw_affiliation_strings': ['Life Sciences Institute; University of Michigan; Ann Arbor MI 48109 USA'], 'affiliations': [{'raw_affiliation_string': 'Life Sciences Institute; University of Michigan; Ann Arbor MI 48109 USA', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5089573577', 'display_name': 'Blanton S. Tolbert', 'orcid': 'https://orcid.org/0000-0003-2456-0443'}, 'institutions': [{'id': 'https://openalex.org/I58956616', 'display_name': 'Case Western Reserve University', 'ror': 'https://ror.org/051fd9666', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I58956616']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Blanton S. Tolbert', 'raw_affiliation_strings': ['Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106 (USA)'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106 (USA)', 'institution_ids': ['https://openalex.org/I58956616']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4250, 'currency': 'USD', 'value_usd': 4250, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.835, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 36, 'citation_normalized_percentile': {'value': 0.865308, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '427', 'issue': '20', 'first_page': '3241', 'last_page': '3257'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10604', 'display_name': 'Regulation of RNA Processing and Function', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10604', 'display_name': 'Regulation of RNA Processing and Function', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10521', 'display_name': 'Ribosome Structure and Translation Mechanisms', 'score': 0.9949, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11112', 'display_name': 'Aetiology, Diagnosis, and Management of Myocarditis', 'score': 0.9802, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/rna-structure', 'display_name': 'RNA Structure', 'score': 0.583775}, {'id': 'https://openalex.org/keywords/rna-recognition-motif', 'display_name': 'RNA recognition motif', 'score': 0.5269616}, {'id': 'https://openalex.org/keywords/rna-binding-proteins', 'display_name': 'RNA-Binding Proteins', 'score': 0.518494}, {'id': 'https://openalex.org/keywords/nucleic-acid-structure', 'display_name': 'Nucleic acid structure', 'score': 0.48513278}, {'id': 'https://openalex.org/keywords/riboswitch', 'display_name': 'Riboswitch', 'score': 0.4553015}, {'id': 'https://openalex.org/keywords/linker', 'display_name': 'Linker', 'score': 0.4274308}], 'concepts': [{'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.7523496}, {'id': 'https://openalex.org/C41282012', 'wikidata': 'https://www.wikidata.org/wiki/Q3928341', 'display_name': 'RNA-binding protein', 'level': 4, 'score': 0.65300393}, {'id': 'https://openalex.org/C75934600', 'wikidata': 'https://www.wikidata.org/wiki/Q419245', 'display_name': 'Ribonucleoprotein', 'level': 4, 'score': 0.57231945}, {'id': 'https://openalex.org/C158730165', 'wikidata': 'https://www.wikidata.org/wiki/Q24768845', 'display_name': 'RNA recognition motif', 'level': 5, 'score': 0.5269616}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5138755}, {'id': 'https://openalex.org/C107824862', 'wikidata': 'https://www.wikidata.org/wiki/Q616005', 'display_name': 'Binding site', 'level': 2, 'score': 0.50246644}, {'id': 'https://openalex.org/C126142528', 'wikidata': 'https://www.wikidata.org/wiki/Q3771876', 'display_name': 'Nucleic acid structure', 'level': 4, 'score': 0.48513278}, {'id': 'https://openalex.org/C94671646', 'wikidata': 'https://www.wikidata.org/wiki/Q207551', 'display_name': 'Intron', 'level': 3, 'score': 0.48163477}, {'id': 'https://openalex.org/C54458228', 'wikidata': 'https://www.wikidata.org/wiki/Q237218', 'display_name': 'RNA splicing', 'level': 4, 'score': 0.46632412}, {'id': 'https://openalex.org/C148625055', 'wikidata': 'https://www.wikidata.org/wiki/Q418840', 'display_name': 'Riboswitch', 'level': 5, 'score': 0.4553015}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.4299751}, {'id': 'https://openalex.org/C2780557392', 'wikidata': 'https://www.wikidata.org/wiki/Q523796', 'display_name': 'Linker', 'level': 2, 'score': 0.4274308}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.35835546}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.32863232}, {'id': 'https://openalex.org/C194993378', 'wikidata': 'https://www.wikidata.org/wiki/Q427087', 'display_name': 'Non-coding RNA', 'level': 4, 'score': 0.26739937}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.11846614}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C111919701', 'wikidata': 'https://www.wikidata.org/wiki/Q9135', 'display_name': 'Operating system', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D034481', 'descriptor_name': 'Heterogeneous-Nuclear Ribonucleoprotein Group A-B', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016601', 'descriptor_name': 'RNA-Binding Proteins', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': True}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018360', 'descriptor_name': 'Crystallography, X-Ray', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000076245', 'descriptor_name': 'Heterogeneous Nuclear Ribonucleoprotein A1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D062105', 'descriptor_name': 'Molecular Docking Simulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009690', 'descriptor_name': 'Nucleic Acid Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012262', 'descriptor_name': 'Ribonucleoside Diphosphate Reductase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D025521', 'descriptor_name': 'Tumor Suppressor Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.jmb.2015.05.009', 'pdf_url': 'https://www.sciencedirect.com/science/article/am/pii/S0022283615002934', 'source': {'id': 'https://openalex.org/S46058472', 'display_name': 'Journal of Molecular Biology', 'issn_l': '0022-2836', 'issn': ['0022-2836', '1089-8638'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://www.osti.gov/biblio/1433735', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402487', 'display_name': 'OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I139351228', 'host_organization_name': 'Office of Scientific and Technical Information', 'host_organization_lineage': ['https://openalex.org/I139351228'], 'host_organization_lineage_names': ['Office of Scientific and Technical Information'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4586317', 'pdf_url': 'https://europepmc.org/articles/pmc4586317?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586317', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26003924', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.jmb.2015.05.009', 'pdf_url': 'https://www.sciencedirect.com/science/article/am/pii/S0022283615002934', 'source': {'id': 'https://openalex.org/S46058472', 'display_name': 'Journal of Molecular Biology', 'issn_l': '0022-2836', 'issn': ['0022-2836', '1089-8638'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320306084', 'funder_display_name': 'U.S. Department of Energy', 'award_id': 'DE-AC02-06CH11357'}, {'funder': 'https://openalex.org/F4320308158', 'funder_display_name': 'Michigan Economic Development Corporation', 'award_id': None}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'P50GM103297'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'R01GM101979'}, {'funder': 'https://openalex.org/F4320337354', 'funder_display_name': 'National Institute of General Medical Sciences', 'award_id': '1S10OD018090-01'}], 'datasets': [], 'versions': [], 'referenced_works_count': 48, 'referenced_works': ['https://openalex.org/W1539796472', 'https://openalex.org/W1808209976', 'https://openalex.org/W1976268142', 'https://openalex.org/W1979906352', 'https://openalex.org/W1982126789', 'https://openalex.org/W1992191979', 'https://openalex.org/W1998374078', 'https://openalex.org/W1999609473', 'https://openalex.org/W2002149155', 'https://openalex.org/W2008487411', 'https://openalex.org/W2029568919', 'https://openalex.org/W2036399606', 'https://openalex.org/W2037748929', 'https://openalex.org/W2042098488', 'https://openalex.org/W2043597495', 'https://openalex.org/W2045672814', 'https://openalex.org/W2050091361', 'https://openalex.org/W2053538195', 'https://openalex.org/W2064266708', 'https://openalex.org/W2066088601', 'https://openalex.org/W2076827938', 'https://openalex.org/W2077169136', 'https://openalex.org/W2077401865', 'https://openalex.org/W2079248832', 'https://openalex.org/W2082111448', 'https://openalex.org/W2082337556', 'https://openalex.org/W2088566989', 'https://openalex.org/W2093653090', 'https://openalex.org/W2108053190', 'https://openalex.org/W2118233996', 'https://openalex.org/W2122339645', 'https://openalex.org/W2124983865', 'https://openalex.org/W2135012763', 'https://openalex.org/W2137430348', 'https://openalex.org/W2141344821', 'https://openalex.org/W2142224176', 'https://openalex.org/W2144081223', 'https://openalex.org/W2146724805', 'https://openalex.org/W2149885731', 'https://openalex.org/W2156118456', 'https://openalex.org/W2163341755', 'https://openalex.org/W2164361934', 'https://openalex.org/W2165178850', 'https://openalex.org/W2170671445', 'https://openalex.org/W2173392920', 'https://openalex.org/W2329506014', 'https://openalex.org/W255996521', 'https://openalex.org/W4210586598'], 'related_works': ['https://openalex.org/W98050855', 'https://openalex.org/W4318205411', 'https://openalex.org/W3164457769', 'https://openalex.org/W2922047510', 'https://openalex.org/W2299432597', 'https://openalex.org/W2176021662', 'https://openalex.org/W2141216907', 'https://openalex.org/W2116507553', 'https://openalex.org/W2115603172', 'https://openalex.org/W2005229765'], 'abstract_inverted_index': {'The': [0, 123, 205], 'heterogeneous': [1], 'nuclear': [2], 'ribonucleoprotein': [3], '(hnRNP)': [4], 'A1': [5, 52], 'protein': [6, 12], 'is': [7, 56], 'a': [8, 15, 79, 103, 160, 178], 'multifunctional': [9], 'RNA': [10, 42, 153], 'binding': [11, 154, 174, 217, 227], 'implicated': [13], 'in': [14, 159], 'wide': [16], 'range': [17], 'of': [18, 35, 49, 62, 75, 86, 111, 129, 151, 172, 181, 195, 208, 234], 'biological': [19], 'functions.': [20], 'Mechanisms': [21], 'and': [22, 113, 133, 145, 201], 'putative': [23], 'hnRNP': [24, 51, 63, 89, 247], 'A1–RNA': [25, 64, 90, 248], 'interactions': [26, 143], 'have': [27], 'been': [28], 'inferred': [29], 'primarily': [30], 'from': [31], 'the': [32, 59, 69, 98, 108, 114, 121, 127, 130, 140, 148, 152, 157, 169, 182, 192, 209, 223, 232, 238, 243], 'crystal': [33], 'structure': [34, 72], 'its': [36, 198], 'UP1': [37, 76, 94, 173, 189], 'domain': [38, 200], 'bound': [39, 77], 'to': [40, 78, 163], 'ssDNA.': [41], 'stem': [43, 91], 'loops': [44], 'represent': [45], 'an': [46], 'important': [47], 'class': [48], 'known': [50, 57], 'targets,': [53], 'yet': [54], 'little': [55], 'about': [58], 'structural': [60, 170, 179, 210], 'basis': [61, 171], 'recognition.': [65], 'Here,': [66], 'we': [67, 134], 'report': [68], 'first': [70, 244], 'high-resolution': [71], '(1.92': [73], 'Å)': [74], '5′-AGU-3′': [80], 'trinucleotide': [81], 'that': [82, 139], 'resembles': [83], 'sequence': [84, 101], 'elements': [85], 'several': [87], 'native': [88], 'loop': [92, 194, 225], 'targets.': [93], 'interacts': [95], 'specifically': [96], 'with': [97], 'AG': [99], 'dinucleotide': [100], 'via': [102], '"nucleobase': [104], 'pocket"': [105], 'formed': [106], 'by': [107, 176, 185, 214, 229], 'β-sheet': [109], 'surface': [110, 155], 'RRM1': [112, 199], 'inter-RRM': [115, 124, 202], 'linker;': [116], 'RRM2': [117], 'does': [118], 'not': [119], 'contact': [120], 'RNA.': [122, 165], 'linker': [125, 158, 203], 'forms': [126], 'lid': [128], 'nucleobase': [131], 'pocket': [132], 'show': [135], 'using': [136, 197], 'structure-guided': [137], 'mutagenesis': [138], 'conserved': [141], 'salt-bridge': [142], '(R75:D155': [144], 'R88:D157)': [146], 'on': [147, 191], 'α-helical': [149], 'side': [150], 'stabilize': [156], 'geometry': [161], 'poised': [162], 'bind': [164], 'We': [166], 'further': [167], 'investigated': [168], 'HIViSL3ESS3': [175], 'determining': [177], 'model': [180, 211], 'complex': [183, 235], 'scored': [184], 'small-angle': [186], 'X-ray': [187], 'scattering.': [188], 'docks': [190], 'apical': [193, 224], 'SL3ESS3': [196], 'only.': [204], 'biophysical': [206], 'implications': [207], 'were': [212], 'tested': [213], 'measuring': [215], 'kinetic': [216], 'parameters,': [218], 'where': [219], 'mutations': [220], 'introduced': [221], 'within': [222], 'reduce': [226], 'affinities': [228], 'slowing': [230], 'down': [231], 'rate': [233], 'formation.': [236], 'Collectively,': [237], 'data': [239], 'presented': [240], 'here': [241], 'provide': [242], 'insights': [245], 'into': [246], 'interactions.': [249]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W282734715', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 5}], 'updated_date': '2024-09-13T06:55:58.907315', 'created_date': '2016-06-24'}