Publication Information

{'id': 'https://openalex.org/W2818760726', 'doi': 'https://doi.org/10.1002/ajh.25206', 'title': 'Immunoglobulin heavy chain variable region gene and prediction of time to first treatment in patients with chronic lymphocytic leukemia: Mutational load or mutational status? Analysis of 1003 cases', 'display_name': 'Immunoglobulin heavy chain variable region gene and prediction of time to first treatment in patients with chronic lymphocytic leukemia: Mutational load or mutational status? Analysis of 1003 cases', 'publication_year': 2018, 'publication_date': '2018-07-09', 'ids': {'openalex': 'https://openalex.org/W2818760726', 'doi': 'https://doi.org/10.1002/ajh.25206', 'mag': '2818760726', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29984867'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/ajh.25206', 'pdf_url': 'https://rss.onlinelibrary.wiley.com/doi/am-pdf/10.1002/ajh.25206', 'source': {'id': 'https://openalex.org/S199810014', 'display_name': 'American Journal of Hematology', 'issn_l': '0361-8609', 'issn': ['0361-8609', '1096-8652'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'type': 'letter', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://rss.onlinelibrary.wiley.com/doi/am-pdf/10.1002/ajh.25206', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5022153283', 'display_name': 'Fortunato Morabito', 'orcid': 'https://orcid.org/0000-0002-2585-7073'}, 'institutions': [{'id': 'https://openalex.org/I4210141322', 'display_name': 'Azienda Sanitaria Locale CN2', 'ror': 'https://ror.org/036g5z675', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210141322']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'Fortunato Morabito', 'raw_affiliation_strings': ['Biotechnology Research Unit, Azienda Sanitaria Provinciale di Cosenza, Aprigliano (CS), Italy'], 'affiliations': [{'raw_affiliation_string': 'Biotechnology Research Unit, Azienda Sanitaria Provinciale di Cosenza, Aprigliano (CS), Italy', 'institution_ids': ['https://openalex.org/I4210141322']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033825180', 'display_name': 'Tait D. Shanafelt', 'orcid': 'https://orcid.org/0000-0002-7106-5202'}, 'institutions': [{'id': 'https://openalex.org/I97018004', 'display_name': 'Stanford University', 'ror': 'https://ror.org/00f54p054', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Tait D Shanafelt', 'raw_affiliation_strings': ['Department of Medicine, Division of Hematology, Stanford University, California'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Division of Hematology, Stanford University, California', 'institution_ids': ['https://openalex.org/I97018004']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016021915', 'display_name': 'Massimo Gentile', 'orcid': 'https://orcid.org/0000-0002-5256-0726'}, 'institutions': [{'id': 'https://openalex.org/I4210102769', 'display_name': 'Azienda Ospedaliera di Cosenza', 'ror': 'https://ror.org/01884b046', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210102769']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Massimo Gentile', 'raw_affiliation_strings': ['Hematology Unit, Department of Onco-hematology, A.O. of Cosenza, Cosenza, Italy'], 'affiliations': [{'raw_affiliation_string': 'Hematology Unit, Department of Onco-hematology, A.O. of Cosenza, Cosenza, Italy', 'institution_ids': ['https://openalex.org/I4210102769']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027648948', 'display_name': 'Gianluigi Reda', 'orcid': 'https://orcid.org/0000-0003-4687-7089'}, 'institutions': [{'id': 'https://openalex.org/I2803066834', 'display_name': "Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico", 'ror': 'https://ror.org/016zn0y21', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2803066834', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Gianluigi Reda', 'raw_affiliation_strings': ['Hematology Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico  Milan Italy'], 'affiliations': [{'raw_affiliation_string': 'Hematology Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico  Milan Italy', 'institution_ids': ['https://openalex.org/I2803066834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021492292', 'display_name': 'Francesca Romana Mauro', 'orcid': 'https://orcid.org/0000-0003-2425-9474'}, 'institutions': [{'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesca Romana Mauro', 'raw_affiliation_strings': ["Hematology, Department of Cellular Biotechnologies and Hematology, 'Sapienza' University, Rome, Italy"], 'affiliations': [{'raw_affiliation_string': "Hematology, Department of Cellular Biotechnologies and Hematology, 'Sapienza' University, Rome, Italy", 'institution_ids': ['https://openalex.org/I861853513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015790909', 'display_name': 'Davide Rossi', 'orcid': 'https://orcid.org/0000-0002-2837-1597'}, 'institutions': [{'id': 'https://openalex.org/I4210101830', 'display_name': 'Institute of Oncology Research', 'ror': 'https://ror.org/01dpyn972', 'country_code': 'CH', 'type': 'facility', 'lineage': ['https://openalex.org/I4210101830', 'https://openalex.org/I57201433']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Davide Rossi', 'raw_affiliation_strings': ['Oncology Institute of Southern Switzerland and Institute of Oncology Research, Bellinzona, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Oncology Institute of Southern Switzerland and Institute of Oncology Research, Bellinzona, Switzerland', 'institution_ids': ['https://openalex.org/I4210101830']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011614506', 'display_name': 'Nicola Di Renzo', 'orcid': 'https://orcid.org/0000-0003-0604-6934'}, 'institutions': [{'id': 'https://openalex.org/I4210152598', 'display_name': 'Ospedale Vito Fazzi', 'ror': 'https://ror.org/04fvmv716', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210099368', 'https://openalex.org/I4210117053', 'https://openalex.org/I4210152598']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Nicola Di Renzo', 'raw_affiliation_strings': ['Unità di Ematologia, Ospedale Vito Fazzi  Lecce Italy'], 'affiliations': [{'raw_affiliation_string': 'Unità di Ematologia, Ospedale Vito Fazzi  Lecce Italy', 'institution_ids': ['https://openalex.org/I4210152598']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061896020', 'display_name': 'Stefano Molica', 'orcid': 'https://orcid.org/0000-0003-2795-6507'}, 'institutions': [{'id': 'https://openalex.org/I4210148440', 'display_name': 'Azienda Ospedaliera Pugliese Ciaccio', 'ror': 'https://ror.org/053y0qd29', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210148440']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Stefano Molica', 'raw_affiliation_strings': ['Department of Oncology and Haematology, Pugliese-Ciaccio Hospital, Catanzaro, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology and Haematology, Pugliese-Ciaccio Hospital, Catanzaro, Italy', 'institution_ids': ['https://openalex.org/I4210148440']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013445468', 'display_name': 'F. Angrilli', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210107523', 'display_name': 'Ospedale di Santo Spirito', 'ror': 'https://ror.org/01jj26143', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210107523']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesco Angrilli', 'raw_affiliation_strings': ['Department of Hematology, Ospedale Santo Spirito, Pescara, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, Ospedale Santo Spirito, Pescara, Italy', 'institution_ids': ['https://openalex.org/I4210107523']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038163660', 'display_name': 'Annalisa Chiarenza', 'orcid': 'https://orcid.org/0000-0002-8759-4854'}, 'institutions': [{'id': 'https://openalex.org/I4210129599', 'display_name': 'Policlinico Universitario di Catania', 'ror': 'https://ror.org/033xwx807', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129599']}, {'id': 'https://openalex.org/I39063666', 'display_name': 'University of Catania', 'ror': 'https://ror.org/03a64bh57', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I39063666']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Annalisa Chiarenza', 'raw_affiliation_strings': ['Division of Hematology, AOU Policlinico-OVE, University of Catania, Catania, Italy'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology, AOU Policlinico-OVE, University of Catania, Catania, Italy', 'institution_ids': ['https://openalex.org/I4210129599', 'https://openalex.org/I39063666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003334973', 'display_name': 'Giovanna Cutrona', 'orcid': 'https://orcid.org/0000-0002-3335-1101'}, 'institutions': [{'id': 'https://openalex.org/I4210146472', 'display_name': 'Ospedale Policlinico San Martino', 'ror': 'https://ror.org/04d7es448', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146472', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giovanna Cutrona', 'raw_affiliation_strings': ['UO Molecular Pathology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy'], 'affiliations': [{'raw_affiliation_string': 'UO Molecular Pathology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy', 'institution_ids': ['https://openalex.org/I4210146472']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108106704', 'display_name': 'Kari G. Chaffee', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kari G. Chaffee', 'raw_affiliation_strings': ['Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota'], 'affiliations': [{'raw_affiliation_string': 'Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota', 'institution_ids': ['https://openalex.org/I1330342723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009747339', 'display_name': 'Sameer A. Parikh', 'orcid': 'https://orcid.org/0000-0002-3221-7314'}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sameer A. Parikh', 'raw_affiliation_strings': ['Department of Internal Medicine, Division of Hematology, Mayo Clinic, Rochester, Minnesota'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Division of Hematology, Mayo Clinic, Rochester, Minnesota', 'institution_ids': ['https://openalex.org/I1330342723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009797638', 'display_name': 'Giovanni Tripepi', 'orcid': 'https://orcid.org/0000-0002-3580-4602'}, 'institutions': [{'id': 'https://openalex.org/I4210105756', 'display_name': 'Istituto di Biomedicina e di Immunologia Molecolare Alberto Monroy', 'ror': 'https://ror.org/01dy2q607', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210105756', 'https://openalex.org/I4210155236']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giovanni Tripepi', 'raw_affiliation_strings': ['Consiglio Nazionale delle Ricerche, Istituto di Biomedicina ed Immunologia Molecolare, Reggio Calabria, Italy'], 'affiliations': [{'raw_affiliation_string': 'Consiglio Nazionale delle Ricerche, Istituto di Biomedicina ed Immunologia Molecolare, Reggio Calabria, Italy', 'institution_ids': ['https://openalex.org/I4210105756']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067528896', 'display_name': 'Graziella D’Arrigo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210105756', 'display_name': 'Istituto di Biomedicina e di Immunologia Molecolare Alberto Monroy', 'ror': 'https://ror.org/01dy2q607', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210105756', 'https://openalex.org/I4210155236']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': "Graziella D'Arrigo", 'raw_affiliation_strings': ['Consiglio Nazionale delle Ricerche, Istituto di Biomedicina ed Immunologia Molecolare, Reggio Calabria, Italy'], 'affiliations': [{'raw_affiliation_string': 'Consiglio Nazionale delle Ricerche, Istituto di Biomedicina ed Immunologia Molecolare, Reggio Calabria, Italy', 'institution_ids': ['https://openalex.org/I4210105756']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088942860', 'display_name': 'Ernesto Vigna', 'orcid': 'https://orcid.org/0000-0002-2123-6683'}, 'institutions': [{'id': 'https://openalex.org/I4210102769', 'display_name': 'Azienda Ospedaliera di Cosenza', 'ror': 'https://ror.org/01884b046', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210102769']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Ernesto Vigna', 'raw_affiliation_strings': ['Hematology Unit, Department of Onco-hematology, A.O. of Cosenza, Cosenza, Italy'], 'affiliations': [{'raw_affiliation_string': 'Hematology Unit, Department of Onco-hematology, A.O. of Cosenza, Cosenza, Italy', 'institution_ids': ['https://openalex.org/I4210102769']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063863499', 'display_name': 'Anna Grazia Recchia', 'orcid': 'https://orcid.org/0000-0001-5748-2002'}, 'institutions': [{'id': 'https://openalex.org/I4210141322', 'display_name': 'Azienda Sanitaria Locale CN2', 'ror': 'https://ror.org/036g5z675', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210141322']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Anna Grazia Recchia', 'raw_affiliation_strings': ['Biotechnology Research Unit, Azienda Sanitaria Provinciale di Cosenza, Aprigliano (CS), Italy'], 'affiliations': [{'raw_affiliation_string': 'Biotechnology Research Unit, Azienda Sanitaria Provinciale di Cosenza, Aprigliano (CS), Italy', 'institution_ids': ['https://openalex.org/I4210141322']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070924011', 'display_name': 'Agostino Cortelezzi', 'orcid': 'https://orcid.org/0000-0001-9283-4800'}, 'institutions': [{'id': 'https://openalex.org/I2803066834', 'display_name': "Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico", 'ror': 'https://ror.org/016zn0y21', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2803066834', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Agostino Cortelezzi', 'raw_affiliation_strings': ['Hematology Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico  Milan Italy'], 'affiliations': [{'raw_affiliation_string': 'Hematology Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico  Milan Italy', 'institution_ids': ['https://openalex.org/I2803066834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041745367', 'display_name': 'Gianluca Gaïdano', 'orcid': 'https://orcid.org/0000-0002-4681-0151'}, 'institutions': [{'id': 'https://openalex.org/I123338534', 'display_name': 'Università degli Studi del Piemonte Orientale “Amedeo Avogadro”', 'ror': 'https://ror.org/04387x656', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I123338534']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Gianluca Gaidano', 'raw_affiliation_strings': ['Division of Haematology, Department of Translational Medicine Università del Piemonte Orientale  Novara Italy'], 'affiliations': [{'raw_affiliation_string': 'Division of Haematology, Department of Translational Medicine Università del Piemonte Orientale  Novara Italy', 'institution_ids': ['https://openalex.org/I123338534']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034393745', 'display_name': 'Francesco Di Raimondo', 'orcid': 'https://orcid.org/0000-0002-7749-0293'}, 'institutions': [{'id': 'https://openalex.org/I4210129599', 'display_name': 'Policlinico Universitario di Catania', 'ror': 'https://ror.org/033xwx807', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129599']}, {'id': 'https://openalex.org/I39063666', 'display_name': 'University of Catania', 'ror': 'https://ror.org/03a64bh57', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I39063666']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesco Di Raimondo', 'raw_affiliation_strings': ['Division of Hematology, AOU Policlinico-OVE, University of Catania, Catania, Italy'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology, AOU Policlinico-OVE, University of Catania, Catania, Italy', 'institution_ids': ['https://openalex.org/I4210129599', 'https://openalex.org/I39063666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063912176', 'display_name': 'Franco Fais', 'orcid': 'https://orcid.org/0000-0002-6643-7083'}, 'institutions': [{'id': 'https://openalex.org/I4210146472', 'display_name': 'Ospedale Policlinico San Martino', 'ror': 'https://ror.org/04d7es448', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146472', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I83816512', 'display_name': 'University of Genoa', 'ror': 'https://ror.org/0107c5v14', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I83816512']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Franco Fais', 'raw_affiliation_strings': ['Department of Experimental Medicine, University of Genova, Genoa, Italy', 'UO Molecular Pathology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy'], 'affiliations': [{'raw_affiliation_string': 'UO Molecular Pathology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy', 'institution_ids': ['https://openalex.org/I4210146472']}, {'raw_affiliation_string': 'Department of Experimental Medicine, University of Genova, Genoa, Italy', 'institution_ids': ['https://openalex.org/I83816512']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009431453', 'display_name': 'Robin Foà', 'orcid': 'https://orcid.org/0000-0002-5021-3026'}, 'institutions': [{'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Robin Foà', 'raw_affiliation_strings': ["Hematology, Department of Cellular Biotechnologies and Hematology, 'Sapienza' University, Rome, Italy"], 'affiliations': [{'raw_affiliation_string': "Hematology, Department of Cellular Biotechnologies and Hematology, 'Sapienza' University, Rome, Italy", 'institution_ids': ['https://openalex.org/I861853513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042629318', 'display_name': 'Antonino Neri', 'orcid': 'https://orcid.org/0000-0001-9047-5912'}, 'institutions': [{'id': 'https://openalex.org/I2803066834', 'display_name': "Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico", 'ror': 'https://ror.org/016zn0y21', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2803066834', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Antonino Neri', 'raw_affiliation_strings': ['Hematology Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico  Milan Italy'], 'affiliations': [{'raw_affiliation_string': 'Hematology Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico  Milan Italy', 'institution_ids': ['https://openalex.org/I2803066834']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5028725821', 'display_name': 'Manlio Ferrarini', 'orcid': 'https://orcid.org/0000-0002-6154-2570'}, 'institutions': [{'id': 'https://openalex.org/I83816512', 'display_name': 'University of Genoa', 'ror': 'https://ror.org/0107c5v14', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I83816512']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Manlio Ferrarini', 'raw_affiliation_strings': ['Department of Experimental Medicine, University of Genova, Genoa, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Experimental Medicine, University of Genova, Genoa, Italy', 'institution_ids': ['https://openalex.org/I83816512']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 16, 'corresponding_author_ids': ['https://openalex.org/A5022153283'], 'corresponding_institution_ids': ['https://openalex.org/I4210141322'], 'apc_list': {'value': 4940, 'currency': 'USD', 'value_usd': 4940, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 16, 'citation_normalized_percentile': {'value': 0.768345, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '93', 'issue': '9', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11157', 'display_name': 'Chronic Lymphocytic Leukemia Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11157', 'display_name': 'Chronic Lymphocytic Leukemia Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11725', 'display_name': 'Immunodeficiency and Autoimmune Disorders', 'score': 0.991, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10185', 'display_name': 'Lymphoma Diagnosis and Treatment', 'score': 0.9876, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ighv@', 'display_name': 'IGHV@', 'score': 0.9917543}, {'id': 'https://openalex.org/keywords/immunoglobulin-heavy-chain', 'display_name': 'Immunoglobulin heavy chain', 'score': 0.5648384}], 'concepts': [{'id': 'https://openalex.org/C2777609679', 'wikidata': 'https://www.wikidata.org/wiki/Q5971015', 'display_name': 'IGHV@', 'level': 4, 'score': 0.9917543}, {'id': 'https://openalex.org/C2777938653', 'wikidata': 'https://www.wikidata.org/wiki/Q1088156', 'display_name': 'Chronic lymphocytic leukemia', 'level': 3, 'score': 0.789731}, {'id': 'https://openalex.org/C109825262', 'wikidata': 'https://www.wikidata.org/wiki/Q1139164', 'display_name': 'Germline', 'level': 3, 'score': 0.73836756}, {'id': 'https://openalex.org/C96007430', 'wikidata': 'https://www.wikidata.org/wiki/Q3776943', 'display_name': 'Immunoglobulin heavy chain', 'level': 3, 'score': 0.5648384}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5310643}, {'id': 'https://openalex.org/C13514818', 'wikidata': 'https://www.wikidata.org/wiki/Q5552256', 'display_name': 'Germline mutation', 'level': 4, 'score': 0.5010941}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.49742606}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.45423454}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.44102004}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.37013158}, {'id': 'https://openalex.org/C2778461978', 'wikidata': 'https://www.wikidata.org/wiki/Q29496', 'display_name': 'Leukemia', 'level': 2, 'score': 0.32271025}], 'mesh': [{'descriptor_ui': 'D007143', 'descriptor_name': 'Immunoglobulin Heavy Chains', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D007135', 'descriptor_name': 'Immunoglobulin Variable Region', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D015451', 'descriptor_name': 'Leukemia, Lymphocytic, Chronic, B-Cell', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007143', 'descriptor_name': 'Immunoglobulin Heavy Chains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007135', 'descriptor_name': 'Immunoglobulin Variable Region', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007558', 'descriptor_name': 'Italy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015451', 'descriptor_name': 'Leukemia, Lymphocytic, Chronic, B-Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011110', 'descriptor_name': 'Polymorphism, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061665', 'descriptor_name': 'Time-to-Treatment', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/ajh.25206', 'pdf_url': 'https://rss.onlinelibrary.wiley.com/doi/am-pdf/10.1002/ajh.25206', 'source': {'id': 'https://openalex.org/S199810014', 'display_name': 'American Journal of Hematology', 'issn_l': '0361-8609', 'issn': ['0361-8609', '1096-8652'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/2434/583013', 'pdf_url': 'https://air.unimi.it/bitstream/2434/583013/2/Morabito_American%20J%20Hematol_2018.pdf', 'source': {'id': 'https://openalex.org/S4306400516', 'display_name': 'Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I189158943', 'host_organization_name': 'University of Milan', 'host_organization_lineage': ['https://openalex.org/I189158943'], 'host_organization_lineage_names': ['University of Milan'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29984867', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/ajh.25206', 'pdf_url': 'https://rss.onlinelibrary.wiley.com/doi/am-pdf/10.1002/ajh.25206', 'source': {'id': 'https://openalex.org/S199810014', 'display_name': 'American Journal of Hematology', 'issn_l': '0361-8609', 'issn': ['0361-8609', '1096-8652'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [{'score': 0.76, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320338276', 'funder_display_name': 'Division of Antarctic Infrastructure and Logistics', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 14, 'referenced_works': ['https://openalex.org/W1243376384', 'https://openalex.org/W1429374962', 'https://openalex.org/W1527161131', 'https://openalex.org/W1868209784', 'https://openalex.org/W2008713578', 'https://openalex.org/W2037049243', 'https://openalex.org/W2072290485', 'https://openalex.org/W2090147047', 'https://openalex.org/W2095913486', 'https://openalex.org/W2111609050', 'https://openalex.org/W2257827709', 'https://openalex.org/W2769052922', 'https://openalex.org/W2775055706', 'https://openalex.org/W4251594820'], 'related_works': ['https://openalex.org/W344354797', 'https://openalex.org/W2913288684', 'https://openalex.org/W2767669578', 'https://openalex.org/W2606039306', 'https://openalex.org/W2582299606', 'https://openalex.org/W2558613206', 'https://openalex.org/W2558062410', 'https://openalex.org/W2146523291', 'https://openalex.org/W2126386241', 'https://openalex.org/W1965035229'], 'abstract_inverted_index': {'The': [0, 24, 55, 162, 314, 405, 494, 774, 1410, 1432], 'mutation': [1, 287, 305, 331, 451, 460, 468, 475, 513, 680, 803, 865], 'status': [2], 'of': [3, 26, 38, 58, 121, 127, 155, 164, 182, 199, 215, 274, 286, 299, 302, 326, 363, 366, 375, 416, 421, 486, 490, 536, 544, 552, 564, 576, 589, 619, 626, 644, 678, 685, 729, 765, 810, 821, 852, 862, 1254, 1290, 1306, 1313, 1349, 1418, 1423, 1442], 'the': [4, 35, 68, 77, 117, 125, 140, 151, 186, 200, 235, 243, 256, 272, 278, 283, 295, 300, 324, 360, 364, 369, 392, 432, 437, 444, 449, 484, 502, 511, 542, 550, 561, 565, 577, 586, 617, 624, 639, 654, 676, 683, 697, 703, 710, 754, 763, 818, 830, 843, 849, 860, 863, 876, 916, 919, 1346, 1350, 1353, 1361, 1389, 1421, 1438, 1448, 1460, 1464], 'immunoglobulin': [5, 141], 'heavy': [6], 'chain': [7], 'variable': [8], 'region': [9], 'gene': [10, 166, 280, 304, 621, 802], '(IGHV)': [11], 'is': [12, 239, 1434], 'a': [13, 59, 100, 174, 179, 205, 218, 290, 307, 311, 334, 355, 372, 411, 466, 473, 506, 573, 581, 597, 604, 609, 612, 631, 641, 648, 725, 780, 798, 805, 814, 879, 898, 1151], 'well-recognized': [14], 'prognostic': [15, 220, 297, 361, 606, 741, 772], 'indicator': [16], 'in': [17, 31, 46, 76, 225, 242, 252, 277, 354, 371, 391, 431, 443, 483, 501, 534, 541, 560, 653, 700, 708, 717, 829, 874, 902, 923], 'patients': [18, 47, 216, 253, 341, 382, 491, 1390], 'with': [19, 48, 217, 255, 343, 603, 675, 724, 746, 813, 840, 1420], 'chronic': [20], 'lymphocytic': [21], 'leukemia': [22], '(CLL).': [23], 'occurrence': [25], 'IGHV': [27, 70, 122, 165, 279, 303, 587, 620, 679, 726, 801, 864], 'somatic': [28], 'hypermutations': [29], '(SHM)': [30], 'CLL': [32, 49, 590, 686, 838], 'cells1': [33], 'and': [34, 108, 259, 266, 352, 426, 469, 592, 712, 734, 748, 823, 954, 1169, 1219, 1236, 1277, 1318, 1344, 1356, 1359, 1391], 'predictive': [36], 'value': [37, 57, 112, 181, 208, 238, 336], 'its': [39], 'presence': [40], 'or': [41, 337, 1440], 'absence': [42], 'have': [43, 132, 333, 1415], 'been': [44, 74, 133], 'recognized': [45], 'for': [50, 330, 611, 651, 878, 897, 1437, 1463], 'roughly': [51], '20': [52], 'years.2,': [53], '3': [54, 488, 704], 'cut-off': [56, 91, 111, 180, 207, 230, 237, 452, 807, 845], '2%': [60, 130, 206, 236, 474, 800], 'deviation': [61], 'from': [62, 84, 124, 195, 383], '(or': [63], '≤': [64, 799], '98%': [65, 583], 'identity': [66], 'with)': [67], 'corresponding': [69, 1461], 'germline': [71, 126, 187], 'sequence': [72, 156], 'has': [73], 'used': [75], 'initial': [78], 'studies': [79, 202], 'to': [80, 104, 129, 136, 170, 185, 191, 211, 289, 294, 340, 516, 519, 538, 549, 600, 682, 732, 736, 762, 768, 872, 882, 888, 915, 1459], 'distinguish': [81, 192, 212, 601], '"mutated"': [82], '(M-CLL)': [83], '"unmutated"': [85], '(UM-CLL)': [86], 'cases.': [87, 854], 'Based': [88], 'on': [89, 116, 368, 410, 448, 696, 743], 'this': [90, 629, 718, 794, 924, 1424], 'value,': [92], 'it': [93, 835, 886], 'was': [94, 113, 168, 209, 268, 408, 635, 693, 1268, 1326], 'determined': [95], 'that': [96, 119, 160, 178, 204, 262, 344, 797, 837, 1413], 'unmutated': [97, 194, 462, 824, 853], 'cases': [98, 418, 439, 546, 563, 687, 699, 723, 812, 825, 839], 'had': [99, 505], 'significantly': [101], 'shorter': [102], 'time': [103], 'first': [105], 'treatment': [106], '(TTFT)': [107], 'outcome.2-4': [109], 'This': [110, 691, 1266], 'selected': [114], 'based': [115, 447, 615, 858], 'consideration': [118], 'differences': [120, 480, 531], 'genes': [123, 588], 'up': [128], 'might': [131], 'related': [134], 'also': [135, 148], 'allele': [137], 'polymorphisms': [138, 167], 'within': [139], 'loci.5': [142], 'These': [143], 'somewhat': [144], 'conservative': [145], 'parameters': [146], 'were': [147, 388, 481, 532, 558, 706], 'suggested': [149], 'by': [150, 173, 271, 319, 350, 522, 759, 779, 909, 1328, 1447], 'relative': [152], 'scanty': [153], 'number': [154, 643], 'data': [157, 427], 'available': [158, 707], 'at': [159, 870], 'time.': [161], 'frequency': [163], 'reported': [169, 908], 'be': [171, 189, 539, 827, 883, 889, 895, 1457], '0.0005%': [172], 'subsequent': [175, 201, 264], 'study': [176, 316, 795], 'suggesting': [177], '99.99%': [183], 'homology': [184, 584], 'would': [188], 'sufficient': [190], 'truly': [193, 847], 'mutated': [196, 500, 545, 822], 'cases.6': [197], 'Some': [198], 'indicated': [203], 'adequate': [210, 828], '2': [213], 'subgroups': [214], 'different': [219, 229, 512, 605, 689, 815], 'expectation7-9': [221], 'while': [222, 753], 'others,': [223], 'virtually': [224], 'equal': [226], 'numbers,': [227], 'proposed': [228], 'values.10-12': [231], 'Despite': [232], 'these': [233, 487], 'discrepancies,': [234], 'generally': [240], 'adopted': [241, 318], 'current': [244, 831], 'clinical': [245, 832, 904, 1393], 'practice.': [246, 833], 'Recently,': [247], 'Jain': [248, 320, 523, 910], 'et': [249, 321, 524, 911], 'al.13': [250, 912], 'demonstrated': [251], 'treated': [254, 342, 540], 'fludarabine,': [257], 'cyclophosphamide,': [258], 'rituximab': [260], 'regimen': [261], 'their': [263, 328, 593], 'course': [265], 'survival': [267], 'greatly': [269], 'influenced': [270], 'amount': [273], 'mutations': [275], 'present': [276, 458], 'segment.': [281], 'Thus,': [282, 580], 'higher': [284], 'levels': [285], 'corresponded': [288], 'better': [291], 'outcome,': [292], 'pointing': [293], 'potential': [296], 'relevance': [298], 'percentage': [301], 'as': [306, 347, 441, 499, 906], 'continuous': [308], 'rather': [309], 'than': [310, 1453], 'dichotomized': [312], 'variable.13': [313], 'particular': [315, 345], 'design': [317], 'al.': [322, 525], 'raises': [323], 'question': [325], 'whether': [327, 891], 'criteria': [329, 517], 'evaluation': [332], 'universal': [335], 'apply': [338], 'only': [339, 722], 'protocol,': [346, 504], 'pointed': [348], 'out': [349, 695, 778], 'Gocke': [351], 'Richardson': [353], 'recent': [356], 'commentary.14': [357], 'We': [358], 'assessed': [359], 'significance': [362], 'extent': [365, 551, 618, 677, 764, 861], 'SHM': [367, 553], 'TTFT': [370, 485, 652], 'large': [373], 'cohort': [374, 415, 568], '467': [376], 'newly': [377], 'diagnosed': [378], 'Binet': [379], 'stage': [380, 659, 750], 'A': [381], 'several': [384], 'Italian': [385, 1288, 1304, 1311], 'institutions': [386], 'who': [387], 'prospectively': [389], 'enrolled': [390], 'O-CLL': [393, 445, 503, 578, 711], 'protocol': [394, 446], '(training': [395], 'cohort,': [396], 'median': [397], 'follow-up': [398, 420], '84': [399], 'months;': [400], 'clinicaltrial.gov': [401], 'identifier:': [402], '115': [403], 'NCT00917540).': [404], 'same': [406, 775], 'analysis': [407, 634, 692, 776], 'performed': [409, 636], 'Mayo': [412, 566, 713], 'Clinic': [413, 567, 714], 'validation': [414, 575], '536': [417, 562], '(median': [419], '78': [422], 'months).': [423], 'Further': [424], 'details': [425], 'analyses': [428], 'are': [429], 'described': [430], 'Supporting': [433, 1428], 'Information': [434, 789], 'Appendix.': [435], 'Among': [436], '141': [438], 'classified': [440, 498], 'UM-CLL': [442], '≤2%': [450, 737], 'point,': [453], '94': [454], '(67%)': [455], 'did': [456], 'not': [457, 867, 1435], 'any': [459, 1443], '(truly': [461], 'cases),': [463], '31(22%)': [464], 'presented': [465, 472], '1%': [467], '16': [470], '(11%)': [471], '(Figure': [476, 492, 526, 554, 569, 751], '1A).': [477, 527], 'No': [478], 'significant': [479, 530, 649], 'noted': [482], 'groups': [489, 543, 602], '1B).': [493], 'remaining': [495, 755], '326': [496], 'cases,': [497], 'more': [507, 899], 'even': [508], 'distribution': [509], 'among': [510], 'categories': [514], 'according': [515, 548, 761], 'similar': [518, 786], 'those': [520, 907], 'employed': [521], 'However,': [528], 'no': [529, 1416], 'observed': [533, 559], 'terms': [535], 'risk': [537], 'stratified': [547], '1C).': [555], 'Similar': [556], 'results': [557, 787], '1D-F),': [570], 'which': [571, 646, 701], 'provided': [572, 785], 'further': [574, 613, 627], 'data.': [579], '≥': [582], 'between': [585], 'clones': [591], 'normal': [594], 'counterpart': [595], 'represents': [596, 804], 'valid': [598], 'discriminant': [599, 650], 'likelihood,': [607], 'without': [608], 'need': [610], 'stratification': [614, 684, 760, 856, 893], 'upon': [616, 859], 'mutation.': [622], 'With': [623], 'aim': [625], 'validating': [628], 'result,': [630], 'Cox': [632, 655, 782], 'multivariable': [633, 720], 'introducing': [637], 'into': [638, 688], 'model': [640, 784], 'minimal': [642], 'variables': [645, 705], 'represented': [647], 'univariate': [656], 'analysis—ie,': [657], 'Rai': [658, 749], '(H.R.': [660, 668], '2.5,': [661], 'C.I.': [662, 670], '2.0-3.2,': [663], 'P': [664, 672], '<': [665, 673], '.0001),': [666], 'β2M': [667, 747], '2.3,': [669], '1.8-2.9,': [671], '.0001)—together': [674], 'leading': [681], 'groups.': [690], 'carried': [694, 777], '870': [698], 'all': [702], 'both': [709], 'cohorts.': [715], 'Notably,': [716], 'minimalistic': [719], 'model,': [721], 'mutational': [727], 'load': [728], '0%,': [730], '>0': [731], '<1%': [733], '1': [735], 'maintained': [738], 'an': [739, 770], 'independent': [740, 771], 'impact': [742], 'TTFT,': [744], 'together': [745], '2),': [752], 'patient': [756, 881], 'groups,': [757], 'obtained': [758], 'SHM,': [766], 'failed': [767], 'maintain': [769], 'relevance.': [773], 'bootstrapping': [781], 'regression': [783], '(Supporting': [788], 'Table': [790], 'S1).': [791], 'In': [792, 913], 'conclusion,': [793], 'indicates': [796], 'suitable': [806], 'level': [808], 'capable': [809], 'discriminating': [811], 'prognosis.': [816], 'Hence,': [817], 'classic': [819], 'distinction': [820], 'may': [826, 894], 'Furthermore,': [834], 'appears': [836], 'values': [841], 'below': [842], 'set': [844], 'point': [846], 'represent': [848], 'vast': [850], 'majority': [851], 'Finally,': [855], 'methods': [857], 'do': [866], 'seem': [868], '[superfluous': [869], 'least]': [871], 'add': [873], 'determining': [875], 'chance': [877], 'given': [880], 'treated,': [884], 'although': [885], 'remains': [887], 'seen': [890], 'such': [892], 'needed': [896], 'accurate': [900], 'prognostication': [901], 'special': [903], 'situations': [905], 'addition': [914], 'listed': [917], 'Authors,': [918], 'following': [920], 'Investigators': [921], 'participated': [922], 'study:': [925], 'Gianni': [926], 'Quintana,': [927], 'Divisione': [928, 958, 1050, 1127, 1160, 1239, 1259], 'di': [929, 938, 948, 959, 969, 988, 998, 1002, 1006, 1015, 1027, 1051, 1063, 1068, 1078, 1082, 1097, 1110, 1119, 1128, 1137, 1147, 1161, 1164, 1182, 1191, 1199, 1211, 1223, 1226, 1240, 1243, 1251, 1260], 'Ematologia,': [930, 949, 960, 970, 978, 991, 1043, 1052, 1058, 1069, 1098, 1120, 1129, 1138, 1162, 1183, 1212, 1224, 1241, 1252, 1261], 'Presidio': [931], 'Ospedaliero': [932], '"A.Perrino",': [933], 'Brindisi;': [934], 'Giovanni': [935, 1092], 'Bertoldero,': [936], 'Dipartimento': [937, 947, 987, 1067, 1181, 1225], 'Oncologia,': [939, 1028], 'Ospedale': [940, 971, 1017, 1029, 1036, 1053, 1070, 1086, 1099, 1109, 1121, 1130, 1175, 1184, 1193, 1213, 1245, 1262], 'Civile,': [941], 'Noale,': [942], 'Venezia;': [943], 'Paolo': [944, 1009], 'Di': [945, 966, 1234, 1399, 1404], 'Tonno,': [946], 'Venere,': [950], 'Bari;': [951, 1011], 'Robin': [952], 'Foà': [953], 'Francesca': [955], 'R': [956], 'Mauro,': [957, 1397], 'Università': [961, 981, 1163, 1242], 'La': [962, 982], 'Sapienza,': [963, 983], 'Roma;': [964, 984, 1074], 'Nicola': [965, 1075, 1101], 'Renzo,': [967, 1400], 'Unità': [968, 997, 1077, 1096, 1117, 1135, 1210, 1222, 1250], 'Vito': [972], 'Fazzi,': [973], 'Lecce;': [974], 'Maria': [975, 1124, 1140], 'Cristina': [976], 'Cox,': [977], 'A.O.': [979, 1044, 1253], "Sant'Andrea,": [980], 'Stefano': [985], 'Molica,': [986], 'Oncologia': [989, 1007, 1107], 'ed': [990], 'Pugliese-Ciaccio': [992], 'Hospital,': [993, 1231], 'Catanzaro;': [994], 'Attilio': [995], 'Guarini,': [996], 'Ematologia': [999, 1079, 1168], 'e': [1000, 1020, 1080, 1149], 'Trapianto': [1001, 1081], 'Cellule': [1003, 1083], 'Staminali,': [1004, 1084], 'Istituto': [1005, 1146], '"Giovanni': [1008], 'II",': [1010], 'Antonio': [1012], 'Abbadessa,': [1013], 'U.O.C.': [1014, 1026], 'Oncoematologia': [1016], '"S.': [1018], 'Anna': [1019, 1115], 'S.': [1021], 'Sebastiano",': [1022], 'Caserta;': [1023], 'Francesco': [1024, 1133, 1179, 1233], 'Iuliano,': [1025], 'Giannettasio,': [1030], 'Rossano': [1031], 'Calabro,': [1032], 'Cosenza;': [1033], 'Omar': [1034], 'Racchi,': [1035], 'Villa': [1037], 'Scassi': [1038], 'Sampierdarena,': [1039], 'Genova;': [1040, 1047], 'Mauro': [1041], 'Spriano,': [1042], 'San': [1045, 1091, 1100, 1214], 'Martino,': [1046], 'Felicetto': [1048], 'Ferrara,': [1049], 'Cardarelli,': [1054], 'Napoli;': [1055], 'Monica': [1056], 'Crugnola,': [1057], 'CTMO,': [1059, 1170], 'Azienda': [1060, 1203], 'Ospedaliera': [1061], 'Universitaria': [1062], 'Parma;': [1064], 'Alessandro': [1065], 'Andriani,': [1066], 'Nuovo': [1071], 'Regina': [1072], 'Margherita,': [1073], 'Cascavilla,': [1076], 'IRCCS': [1085, 1172], 'Casa': [1087], 'Sollievo': [1088], 'della': [1089], 'Sofferenza,': [1090], 'Rotondo;': [1093], 'Lucia': [1094], 'Ciuffreda,': [1095], 'Pellegrino,': [1102], 'Trani;': [1103], 'Graziella': [1104], 'Pinotti,': [1105], 'U.O.': [1106], 'Medica,': [1108], 'Circolo': [1111], 'Fondazione': [1112, 1278, 1337], 'Macchi,': [1113], 'Varese;': [1114], 'Pascarella,': [1116], 'Operativa': [1118, 1136], "dell'Angelo,": [1122], 'Venezia-Mestre;': [1123], 'Grazia': [1125], 'Lipari,': [1126], 'Policlinico,': [1131, 1156, 1177], 'Palermo,': [1132], 'Merli,': [1134], 'A.O.S.': [1139], 'Nuova,': [1141], 'Reggio': [1142, 1255], 'Emilia;': [1143], 'Luca': [1144], 'Baldini': [1145], 'Ricovero': [1148], 'Cura': [1150], 'Carattere': [1152], 'Scientifico': [1153], 'Cà': [1154], 'Granda-Maggiore': [1155], 'Milano;': [1157, 1178], 'Caterina': [1158], 'Musolino,': [1159], 'Messina;': [1165], 'Agostino': [1166], 'Cortelezzi,': [1167, 1407], 'Foundation': [1171], "Ca'": [1173], 'Granda': [1174], 'Maggiore': [1176], 'Angrilli,': [1180, 1401, 1402, 1403], 'Santo': [1185], 'Spirito,': [1186], 'Pescara;': [1187], 'Ugo': [1188], 'Consoli,': [1189], 'U.O.S.': [1190], 'Emato-Oncologia,': [1192], 'Garibaldi-Nesima,': [1194], 'Catania;': [1195, 1247], 'Gianluca': [1196], 'Festini,': [1197], 'Centro': [1198], 'Riferimento': [1200], 'Ematologico-Seconda': [1201], 'Medicina,': [1202], 'Ospedaliero-Universitaria,': [1204], 'Ospedali': [1205], 'Riuniti,': [1206], 'Trieste;': [1207], 'Giuseppe': [1208], 'Longo,': [1209], 'Vincenzo,': [1215], 'Taormina;': [1216], 'Daniele': [1217], 'Vallisa': [1218], 'Annalisa': [1220, 1237], 'Arcari,': [1221], 'Onco-Ematologia,': [1227], 'Guglielmo': [1228], 'da': [1229], 'Saliceto': [1230], 'Piacenza;': [1232], 'Raimondo': [1235], 'Chiarenza,': [1238], 'Catania': [1244], 'Ferrarotto,': [1246], 'Iolanda': [1248], 'Vincelli,': [1249], 'Calabria;': [1256], 'Donato': [1257], 'Mannina,': [1258], 'Papardo,': [1263], 'Messina,': [1264], 'Italy.': [1265], 'work': [1267], 'supported': [1269, 1327], 'by:': [1270], 'Associazione': [1271, 1329], 'Italiana': [1272, 1330], 'Ricerca': [1273], 'sul': [1274], 'Cancro': [1275], '(AIRC)': [1276], 'CaRiCal': [1279], 'co-financed': [1280], 'Multi-Unit': [1281], 'Regional': [1282], 'Grant': [1283], '2014': [1284], 'n.16695': [1285], '(to': [1286, 1302, 1322], 'F.M.)': [1287], 'Ministry': [1289, 1305, 1312], 'Health': [1291, 1307, 1314], '5x1000': [1292, 1308, 1315], 'funds': [1293, 1309, 1316], '2014;': [1294], 'Gilead': [1295], 'Fellowship': [1296], 'program': [1297], '2017': [1298], 'project': [1299], 'n': [1300], '8878': [1301], 'G.C.),': [1303], '2013,': [1310], '2015': [1317], 'AIRC': [1319], 'IG': [1320], '15426': [1321], 'F.F.).': [1323], 'A.G': [1324], 'R.': [1325], 'contro': [1331], 'le': [1332], 'Leucemie-Linfomi-Mielomi': [1333], '(AIL)': [1334], 'Cosenza': [1335], '-': [1336], 'Amelia': [1338], 'Scorza': [1339], '(FAS).': [1340], 'All': [1341], 'authors': [1342, 1411], 'read': [1343], 'approved': [1345], 'final': [1347], 'version': [1348], 'article.': [1351, 1425, 1465], 'Designed': [1352], 'study,': [1354], 'analyzed,': [1355], 'interpreted': [1357], 'data,': [1358], 'wrote': [1360], 'article:': [1362, 1395], 'Morabito,': [1363], 'Shanafelt,': [1364], 'Gentile,': [1365, 1374], 'Foà,': [1366], 'Neri,': [1367, 1385], 'Gaidano,': [1368, 1406], 'Fais,': [1369, 1386], 'Ferrarini': [1370], 'Performed': [1371, 1379], 'statistical': [1372], 'analysis:': [1373], 'Tripepi,': [1375], "D'Arrigo,": [1376], 'Chaffee,': [1377], 'Morabito': [1378, 1387], 'central': [1380], 'laboratory': [1381], 'tests:': [1382], 'Cutrona,': [1383], 'Recchia,': [1384], 'Provided': [1388], 'collected': [1392], 'data:': [1394], 'Reda,': [1396], 'Rossi,': [1398], 'Raimondo,': [1405], 'Parikh,': [1408], 'Vigna': [1409], 'declare': [1412], 'they': [1414], 'conflict': [1417], 'interest': [1419], 'contents': [1422], 'Appendix': [1426], 'S1:': [1427], 'information': [1429, 1445], 'Please': [1430], 'note:': [1431], 'publisher': [1433], 'responsible': [1436], 'content': [1439], 'functionality': [1441], 'supporting': [1444], 'supplied': [1446], 'authors.': [1449], 'Any': [1450], 'queries': [1451], '(other': [1452], 'missing': [1454], 'content)': [1455], 'should': [1456], 'directed': [1458], 'author': [1462]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2818760726', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-12-24T08:50:44.992283', 'created_date': '2018-07-19'}