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'disability': [33], 'due': [34], 'to': [35, 76, 158], 'amputation': [36], 'patient.': [39, 207], 'Although': [40], 'a': [41, 46, 96, 104, 134, 185, 232], 'proportion': [42], 'patients': [44, 83, 244], 'achieve': [45], 'spontaneous': [47], 'closure': [48], 'ulcers,': [50], 'others': [51], 'require': [52], 'medical': [53], 'or': [54, 88, 112, 118, 248], 'surgical': [55], 'treatment.Objective:': [56], 'To': [57], 'determine': [58], 'cost-effectiveness': [60], 'intra-': [63, 119, 225], 'perilesional': [65, 121, 227], 'application': [66, 228], 'recombinant': [68], 'human': [69], 'epidermal': [70], 'growth': [71], 'factor': [72, 179], '(rhEGF),': [73], 'as': [74, 257], 'opposed': [75], 'conventional': [77, 116, 192, 238], 'therapy': [78, 239], 'for': [79, 162, 212, 222, 262], 'management': [81], 'diagnosed': [84], 'with': [85, 107, 191, 199, 245], "Wagner's": [86, 110, 246], '3': [87, 111, 247], '4': [89, 113, 249], 'ulcer': [92, 114], 'Colombia.Methodology:': [94], 'Using': [95], 'Markov': [97], 'model,': [98], 'process': [100], 'diagnosis': [108], 'receiving': [115], 'treatment,': [117], 'rhEGF,': [122], 'is': [123, 231, 254], 'configured.': [124], 'The': [125, 208, 224], 'evaluation': [126], 'cycles': [127], 'treatments': [130], 'weekly': [132], 'over': [133], '5-year': [135], 'horizon': [136], 'outcomes': [139], 'evaluated': [140], 'quality-adjusted': [142], 'life': [143], 'years': [144], '(QALYs)': [145], 'number': [148], 'amputations': [150], 'avoided': [151], 'by': [152], 'each': [153], 'treatment': [154, 242], 'scheme,': [155], 'addition': [157], 'total': [160], 'treatments.Results:': [163], 'For': [164], 'analysed': [166], 'base': [167, 214], 'case,': [168], 'outcome': [171, 259], 'amputations,': [173, 183], 'it': [174], 'was': [175], 'found': [176], 'that': [177], 'presents': [180], '39': [181], 'fewer': [182], 'cohort': [186], '100': [188], 'patients,': [189], 'compared': [190], 'treatment.': [193], 'Likewise,': [194], 'QALYs': [195, 261], '0.65': [197], 'more': [198, 233], 'use': [201], 'rhEGF': [203, 230], 'average': [206], 'estimated': [209], 'cost-utility': [210], 'ratio': [211], 'case': [215], 'would': [216], 'be': [217], 'below': [218], 'threshold': [220], 'established': [221], 'Colombia.Conclusions:': [223], 'effective': [234], 'therapeutic': [235], 'option': [236], 'than': [237], 'cost-effective,': [255], 'taking': [256], 'Colombia': [263], 'from': [264], 'perspective': [266], 'system.': [270]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2811327717', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 5}], 'updated_date': '2024-12-12T23:16:53.659735', 'created_date': '2018-07-10'}