Title: Chemo‐enzymatic Total Synthesis of Oxosorbicillinol, Sorrentanone, Rezishanones B and C, Sorbicatechol A, Bisvertinolone, and (+)‐Epoxysorbicillinol
Abstract: Abstract The sorbicillinoids are a large family of fungal natural products, many of which possess highly challenging molecular architectures. Depending on their individual structures they exhibit strong biological activities ranging from radical scavenging and anti‐infective properties to cytotoxicity. Despite the resulting strong biomedical potential of these natural products and the interest of synthetic chemists owing to their fascinating structures, many sorbicillinoids are currently not synthetically accessible, thus hampering in‐depth biological characterization and structural diversification. By using recombinant oxidoreductase SorbC and readily accessible sorbicillin‐type synthetic precursors, we have developed enantioselective, one‐pot chemo‐enzymatic routes to a broad range of sorbicillinoids, thereby establishing total syntheses of oxosorbicillinol, sorrentanone, rezishanones B and C, sorbicatechol A, bisvertinolone, and (+)‐epoxysorbicillinol.
Publication Year: 2018
Publication Date: 2018-06-25
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 34
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