Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2810650461', 'doi': 'https://doi.org/10.1158/1538-7445.am2018-2', 'title': 'Abstract 2: CXCR2+ tumor cells mediate vascular mimicry driving anti-angiogenic therapy (AAT) resistance in glioblastoma (GBM)', 'display_name': 'Abstract 2: CXCR2+ tumor cells mediate vascular mimicry driving anti-angiogenic therapy (AAT) resistance in glioblastoma (GBM)', 'publication_year': 2018, 'publication_date': '2018-07-01', 'ids': {'openalex': 'https://openalex.org/W2810650461', 'doi': 'https://doi.org/10.1158/1538-7445.am2018-2', 'mag': '2810650461'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2018-2', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': 'https://doi.org/10.1158/1538-7445.am2018-2', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5051125144', 'display_name': 'Kartik Angara', 'orcid': 'https://orcid.org/0000-0002-6334-9301'}, 'institutions': [{'id': 'https://openalex.org/I25041050', 'display_name': 'Augusta University', 'ror': 'https://ror.org/012mef835', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I25041050']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kartik P. Angara', 'raw_affiliation_strings': ['Augusta University, Augusta, GA.'], 'affiliations': [{'raw_affiliation_string': 'Augusta University, Augusta, GA.', 'institution_ids': ['https://openalex.org/I25041050']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025286087', 'display_name': 'Thaiz F. Borin', 'orcid': 'https://orcid.org/0000-0003-1464-9823'}, 'institutions': [{'id': 'https://openalex.org/I25041050', 'display_name': 'Augusta University', 'ror': 'https://ror.org/012mef835', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I25041050']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Thaiz F. Borin', 'raw_affiliation_strings': ['Augusta University, Augusta, GA.'], 'affiliations': [{'raw_affiliation_string': 'Augusta University, Augusta, GA.', 'institution_ids': ['https://openalex.org/I25041050']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084045313', 'display_name': 'Mohammad H. Rashid', 'orcid': 'https://orcid.org/0000-0003-1056-4910'}, 'institutions': [{'id': 'https://openalex.org/I25041050', 'display_name': 'Augusta University', 'ror': 'https://ror.org/012mef835', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I25041050']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mohammad H. Rashid', 'raw_affiliation_strings': ['Augusta University, Augusta, GA.'], 'affiliations': [{'raw_affiliation_string': 'Augusta University, Augusta, GA.', 'institution_ids': ['https://openalex.org/I25041050']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109447362', 'display_name': 'Roxan Ara', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I25041050', 'display_name': 'Augusta University', 'ror': 'https://ror.org/012mef835', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I25041050']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Roxan Ara', 'raw_affiliation_strings': ['Augusta University, Augusta, GA.'], 'affiliations': [{'raw_affiliation_string': 'Augusta University, Augusta, GA.', 'institution_ids': ['https://openalex.org/I25041050']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000876055', 'display_name': 'Bhagelu R. Achyut', 'orcid': 'https://orcid.org/0000-0001-5670-6983'}, 'institutions': [{'id': 'https://openalex.org/I25041050', 'display_name': 'Augusta University', 'ror': 'https://ror.org/012mef835', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I25041050']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bhagelu R. Achyut', 'raw_affiliation_strings': ['Augusta University, Augusta, GA.'], 'affiliations': [{'raw_affiliation_string': 'Augusta University, Augusta, GA.', 'institution_ids': ['https://openalex.org/I25041050']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5011681716', 'display_name': 'Ali S. Arbab', 'orcid': 'https://orcid.org/0000-0003-2902-3671'}, 'institutions': [{'id': 'https://openalex.org/I25041050', 'display_name': 'Augusta University', 'ror': 'https://ror.org/012mef835', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I25041050']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ali S. Arbab', 'raw_affiliation_strings': ['Augusta University, Augusta, GA.'], 'affiliations': [{'raw_affiliation_string': 'Augusta University, Augusta, GA.', 'institution_ids': ['https://openalex.org/I25041050']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.755, 'has_fulltext': False, 'cited_by_count': 10, 'citation_normalized_percentile': {'value': 0.564557, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 85, 'max': 86}, 'biblio': {'volume': '78', 'issue': '13_Supplement', 'first_page': '2', 'last_page': '2'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10422', 'display_name': 'Angiogenesis and VEGF in Cancer', 'score': 0.9953, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10129', 'display_name': 'Glioma Diagnosis and Treatment', 'score': 0.992, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cxc-chemokine-receptors', 'display_name': 'CXC chemokine receptors', 'score': 0.6112467}], 'concepts': [{'id': 'https://openalex.org/C84913492', 'wikidata': 'https://www.wikidata.org/wiki/Q5014892', 'display_name': 'CXC chemokine receptors', 'level': 5, 'score': 0.6112467}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5799325}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.52471197}, {'id': 'https://openalex.org/C2780394083', 'wikidata': 'https://www.wikidata.org/wiki/Q539568', 'display_name': 'Angiogenesis', 'level': 2, 'score': 0.5043918}, {'id': 'https://openalex.org/C2778271429', 'wikidata': 'https://www.wikidata.org/wiki/Q1281049', 'display_name': 'Neovascularization', 'level': 3, 'score': 0.46842635}, {'id': 'https://openalex.org/C13373296', 'wikidata': 'https://www.wikidata.org/wiki/Q421866', 'display_name': 'Chemokine', 'level': 3, 'score': 0.3523478}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.34397614}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.325463}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.18843496}, {'id': 'https://openalex.org/C12823836', 'wikidata': 'https://www.wikidata.org/wiki/Q24720618', 'display_name': 'Chemokine receptor', 'level': 4, 'score': 0.18442875}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2018-2', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2018-2', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.85, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W73242545', 'https://openalex.org/W2460667757', 'https://openalex.org/W2414879916', 'https://openalex.org/W2146672236', 'https://openalex.org/W2114498041', 'https://openalex.org/W2104752154', 'https://openalex.org/W2051449188', 'https://openalex.org/W1967767097', 'https://openalex.org/W1946062636', 'https://openalex.org/W13443198'], 'abstract_inverted_index': {'Abstract': [0], 'Glioblastoma': [1], '(GBM)': [2, 344], 'is': [3, 90], 'a': [4, 150, 292], 'hypervascular': [5], 'and': [6, 40, 46, 57, 73, 101, 130, 153, 179, 182, 199, 222, 235, 262, 286, 289, 299, 309], 'hypoxic': [7], 'neoplasia': [8], 'of': [9, 19, 52, 59, 71, 94, 108, 133, 145, 176, 241, 348], 'the': [10, 35, 63, 83, 91, 122, 127, 134, 142, 164, 186, 194, 220, 238, 349], 'central': [11], 'nervous': [12], 'system': [13, 120], 'with': [14, 126, 168, 206, 303], 'an': [15, 32, 118, 246], 'extremely': [16], 'high': [17], 'rate': [18], 'mortality.': [20], 'Owing': [21], 'to': [22, 34, 42, 81, 97, 124, 140, 159, 215, 264, 280, 295], 'its': [23], 'hypervascularity,': [24], 'anti-angiogenic': [25, 338], 'therapies': [26], '(AAT)': [27, 340], 'have': [28, 54, 291], 'been': [29, 55], 'used': [30], 'as': [31, 117], 'adjuvant': [33], 'traditional': [36], 'surgical': [37], 'resection,': [38], 'chemotherapy,': [39], 'radiation': [41], 'normalize': [43], 'blood': [44, 111], 'vessels': [45], 'control': [47], 'abnormal': [48], 'vasculature.': [49], 'The': [50, 113], 'benefits': [51], 'AAT': [53, 68, 84, 146, 265, 282], 'transient,': [56], 'evidence': [58], 'relapse': [60], 'exemplified': [61], 'in': [62, 77, 163, 193, 219, 245, 247, 267, 284, 307, 342], 'progressive': [64], 'tumor': [65, 95, 217, 274, 332], 'growth': [66], 'following': [67, 204], 'reflects': [69], 'development': [70], 'resistance': [72, 266, 283, 298, 341], 'alternative': [74], 'neovascularization': [75], 'mechanisms': [76, 144], 'these': [78, 183], 'resilient': [79], 'tumors': [80, 123, 166], 'counter': [82], 'therapy': [85, 339], 'insult.': [86], 'Vascular': [87], 'mimicry': [88, 336], '(VM)': [89], 'uncanny': [92], 'ability': [93], 'cells': [96, 184, 230, 244, 259, 333], 'acquire': [98], 'endothelial-like': [99, 180, 200], 'properties': [100], 'lay': [102], 'down': [103, 212], 'vascular': [104, 188, 225, 335], 'patterned': [105], 'networks': [106], 'reminiscent': [107], 'host': [109], 'endothelial': [110], 'vessels.': [112], 'VM': [114, 261], 'channels': [115], 'serve': [116], 'irrigation': [119], 'for': [121, 352], 'meet': [125], 'increasing': [128], 'metabolic': [129], 'nutrient': [131], 'demands': [132], 'tumor.': [135], 'In': [136], 'our': [137, 254], 'current': [138], 'studies': [139], 'understand': [141], 'tumor-inherent': [143], 'resistance,': [147], 'we': [148], 'identified': [149], 'crucial': [151], 'pro-migratory': [152], 'pro-angiogenic': [154], 'chemokine,': [155], 'CXCL8': [156], 'or': [157, 208], 'IL-8,': [158], 'be': [160, 301], 'highly': [161], 'upregulated': [162], 'GBM': [165, 229, 243, 258, 285], 'treated': [167], 'AAT.': [169], 'AAT-treated': [170], 'groups': [171], 'had': [172], 'significantly': [173], 'higher': [174], 'populations': [175, 201], 'CXCR2+': [177, 228, 257, 331], 'stem': [178, 197], 'subpopulations': [181], 'lined': [185], 'VM-like': [187], 'structures': [189, 226], 'carrying': [190], 'functional': [191], 'RBCs': [192], 'tumors.': [195], 'These': [196], 'cell-like': [198], 'were': [202], 'decreased': [203], 'treatment': [205], 'HET0016': [207, 234, 288], 'SB225002.': [209], 'Furthermore,': [210], 'knocking': [211], 'CXCR2': [213], 'led': [214], 'smaller': [216], 'size': [218], 'animals': [221], 'improperly': [223], 'developed': [224], 'without': [227], 'lining': [231], 'them.': [232], 'Also,': [233], 'SB225002': [236, 290], 'disrupt': [237], 'tube-forming': [239], 'capability': [240], 'U251': [242], 'vitro': [248], 'Matrigel': [249], 'angiogenesis': [250], 'assay.': [251], 'This': [252], 'confirms': [253], 'hypothesis': [255], 'that': [256, 273, 287], 'initiate': [260], 'contribute': [263], 'GBM.': [268], 'Our': [269], 'present': [270], 'study': [271], 'suggests': [272], 'cell': [275], 'autonomous': [276], 'IL-8/CXCR2': [277], 'pathway': [278], 'contributes': [279], 'VM-mediated': [281], 'great': [293], 'potential': [294], 'target': [296], 'therapeutic': [297], 'can': [300], 'combined': [302], 'other': [304], 'chemotherapeutic': [305], 'agents': [306], 'preclinical': [308], 'clinical': [310], 'trials.': [311], 'Citation': [312], 'Format:': [313], 'Kartik': [314], 'P.': [315], 'Angara,': [316], 'Thaiz': [317], 'F.': [318], 'Borin,': [319], 'Mohammad': [320], 'H.': [321], 'Rashid,': [322], 'Roxan': [323], 'Ara,': [324], 'Bhagelu': [325], 'R.': [326], 'Achyut,': [327], 'Ali': [328], 'S.': [329], 'Arbab.': [330], 'mediate': [334], 'driving': [337], 'glioblastoma': [343], '[abstract].': [345], 'In:': [346], 'Proceedings': [347], 'American': [350], 'Association': [351], 'Cancer': [353, 366], 'Research': [354], 'Annual': [355], 'Meeting': [356], '2018;': [357], '2018': [358], 'Apr': [359], '14-18;': [360], 'Chicago,': [361], 'IL.': [362], 'Philadelphia': [363], '(PA):': [364], 'AACR;': [365], 'Res': [367], '2018;78(13': [368], 'Suppl):Abstract': [369], 'nr': [370], '2.': [371]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2810650461', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-12-12T01:13:27.321636', 'created_date': '2018-07-10'}