Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2810466533', 'doi': 'https://doi.org/10.1016/j.stemcr.2018.05.019', 'title': 'Suppressing Nodal Signaling Activity Predisposes Ectodermal Differentiation of Epiblast Stem Cells', 'display_name': 'Suppressing Nodal Signaling Activity Predisposes Ectodermal Differentiation of Epiblast Stem Cells', 'publication_year': 2018, 'publication_date': '2018-07-01', 'ids': {'openalex': 'https://openalex.org/W2810466533', 'doi': 'https://doi.org/10.1016/j.stemcr.2018.05.019', 'mag': '2810466533', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30008328', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6067151'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.stemcr.2018.05.019', 'pdf_url': 'http://www.cell.com/article/S2213671118302376/pdf', 'source': {'id': 'https://openalex.org/S2764425922', 'display_name': 'Stem Cell Reports', 'issn_l': '2213-6711', 'issn': ['2213-6711'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.cell.com/article/S2213671118302376/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100353254', 'display_name': 'Chang Liu', 'orcid': 'https://orcid.org/0000-0002-4585-5809'}, 'institutions': [{'id': 'https://openalex.org/I4210121447', 'display_name': 'Center for Excellence in Molecular Cell Science', 'ror': 'https://ror.org/02rrdvm96', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210121447']}, {'id': 'https://openalex.org/I4210165038', 'display_name': 'University of Chinese Academy of Sciences', 'ror': 'https://ror.org/05qbk4x57', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210165038']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chang Liu', 'raw_affiliation_strings': ['State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China', 'institution_ids': ['https://openalex.org/I4210121447', 'https://openalex.org/I4210165038']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100447526', 'display_name': 'Ran Wang', 'orcid': 'https://orcid.org/0000-0003-2644-6337'}, 'institutions': [{'id': 'https://openalex.org/I4210121447', 'display_name': 'Center for Excellence in Molecular Cell Science', 'ror': 'https://ror.org/02rrdvm96', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210121447']}, {'id': 'https://openalex.org/I4210165038', 'display_name': 'University of Chinese Academy of Sciences', 'ror': 'https://ror.org/05qbk4x57', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210165038']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ran Wang', 'raw_affiliation_strings': ['State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China', 'institution_ids': ['https://openalex.org/I4210121447', 'https://openalex.org/I4210165038']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079025262', 'display_name': 'Zhisong He', 'orcid': 'https://orcid.org/0000-0002-1502-4801'}, 'institutions': [{'id': 'https://openalex.org/I4210121447', 'display_name': 'Center for Excellence in Molecular Cell Science', 'ror': 'https://ror.org/02rrdvm96', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210121447']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhisong He', 'raw_affiliation_strings': ['CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai 200031, China'], 'affiliations': [{'raw_affiliation_string': 'CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai 200031, China', 'institution_ids': ['https://openalex.org/I4210121447']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025640981', 'display_name': 'Pierre Osteil', 'orcid': 'https://orcid.org/0000-0002-5832-6703'}, 'institutions': [{'id': 'https://openalex.org/I146584863', 'display_name': "Children's Medical Research Institute", 'ror': 'https://ror.org/01bsaey45', 'country_code': 'AU', 'type': 'facility', 'lineage': ['https://openalex.org/I146584863']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Pierre Osteil', 'raw_affiliation_strings': ["Embryology Unit, Children's Medical Research Institute, Westmead, NSW 2145, Australia"], 'affiliations': [{'raw_affiliation_string': "Embryology Unit, Children's Medical Research Institute, Westmead, NSW 2145, Australia", 'institution_ids': ['https://openalex.org/I146584863']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080026383', 'display_name': 'Emilie Wilkie', 'orcid': 'https://orcid.org/0000-0002-6008-8193'}, 'institutions': [{'id': 'https://openalex.org/I146584863', 'display_name': "Children's Medical Research Institute", 'ror': 'https://ror.org/01bsaey45', 'country_code': 'AU', 'type': 'facility', 'lineage': ['https://openalex.org/I146584863']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Emilie Wilkie', 'raw_affiliation_strings': ["Bioinformatics Group, Children's Medical Research Institute, Westmead, NSW 2145, Australia", "Embryology Unit, Children's Medical Research Institute, Westmead, NSW 2145, Australia"], 'affiliations': [{'raw_affiliation_string': "Embryology Unit, Children's Medical Research Institute, Westmead, NSW 2145, Australia", 'institution_ids': ['https://openalex.org/I146584863']}, {'raw_affiliation_string': "Bioinformatics Group, Children's Medical Research Institute, Westmead, NSW 2145, Australia", 'institution_ids': ['https://openalex.org/I146584863']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044354699', 'display_name': 'Xiong-Li Yang', 'orcid': 'https://orcid.org/0000-0002-6843-8055'}, 'institutions': [{'id': 'https://openalex.org/I30809798', 'display_name': 'ShanghaiTech University', 'ror': 'https://ror.org/030bhh786', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I30809798']}, {'id': 'https://openalex.org/I4210121447', 'display_name': 'Center for Excellence in Molecular Cell Science', 'ror': 'https://ror.org/02rrdvm96', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210121447']}, {'id': 'https://openalex.org/I4210165038', 'display_name': 'University of Chinese Academy of Sciences', 'ror': 'https://ror.org/05qbk4x57', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210165038']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xianfa Yang', 'raw_affiliation_strings': ['School of Life Science and Technology, ShanghaiTech University, 100 Haike Road, Shanghai 201210, China', 'State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China'], 'affiliations': [{'raw_affiliation_string': 'School of Life Science and Technology, ShanghaiTech University, 100 Haike Road, Shanghai 201210, China', 'institution_ids': ['https://openalex.org/I30809798']}, {'raw_affiliation_string': 'State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China', 'institution_ids': ['https://openalex.org/I4210121447', 'https://openalex.org/I4210165038']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100450177', 'display_name': 'Jun Chen', 'orcid': 'https://orcid.org/0000-0002-3312-1074'}, 'institutions': [{'id': 'https://openalex.org/I4210121447', 'display_name': 'Center for Excellence in Molecular Cell Science', 'ror': 'https://ror.org/02rrdvm96', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210121447']}, {'id': 'https://openalex.org/I4210165038', 'display_name': 'University of Chinese Academy of Sciences', 'ror': 'https://ror.org/05qbk4x57', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210165038']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jun Chen', 'raw_affiliation_strings': ['State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China', 'institution_ids': ['https://openalex.org/I4210121447', 'https://openalex.org/I4210165038']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081472314', 'display_name': 'Guizhong Cui', 'orcid': 'https://orcid.org/0000-0001-6394-2773'}, 'institutions': [{'id': 'https://openalex.org/I4210121447', 'display_name': 'Center for Excellence in Molecular Cell Science', 'ror': 'https://ror.org/02rrdvm96', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210121447']}, {'id': 'https://openalex.org/I4210165038', 'display_name': 'University of Chinese Academy of Sciences', 'ror': 'https://ror.org/05qbk4x57', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210165038']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Guizhong Cui', 'raw_affiliation_strings': ['State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China', 'institution_ids': ['https://openalex.org/I4210121447', 'https://openalex.org/I4210165038']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013665915', 'display_name': 'Wenxiu Guo', 'orcid': 'https://orcid.org/0000-0001-8248-5889'}, 'institutions': [{'id': 'https://openalex.org/I30809798', 'display_name': 'ShanghaiTech University', 'ror': 'https://ror.org/030bhh786', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I30809798']}, {'id': 'https://openalex.org/I4210121447', 'display_name': 'Center for Excellence in Molecular Cell Science', 'ror': 'https://ror.org/02rrdvm96', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210121447']}, {'id': 'https://openalex.org/I4210165038', 'display_name': 'University of Chinese Academy of Sciences', 'ror': 'https://ror.org/05qbk4x57', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210165038']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wenke Guo', 'raw_affiliation_strings': ['School of Life Science and Technology, ShanghaiTech University, 100 Haike Road, Shanghai 201210, China', 'State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China'], 'affiliations': [{'raw_affiliation_string': 'School of Life Science and Technology, ShanghaiTech University, 100 Haike Road, Shanghai 201210, China', 'institution_ids': ['https://openalex.org/I30809798']}, {'raw_affiliation_string': 'State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China', 'institution_ids': ['https://openalex.org/I4210121447', 'https://openalex.org/I4210165038']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100394751', 'display_name': 'Yingying Chen', 'orcid': 'https://orcid.org/0000-0002-5049-8092'}, 'institutions': [{'id': 'https://openalex.org/I30809798', 'display_name': 'ShanghaiTech University', 'ror': 'https://ror.org/030bhh786', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I30809798']}, {'id': 'https://openalex.org/I4210121447', 'display_name': 'Center for Excellence in Molecular Cell Science', 'ror': 'https://ror.org/02rrdvm96', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210121447']}, {'id': 'https://openalex.org/I4210165038', 'display_name': 'University of Chinese Academy of Sciences', 'ror': 'https://ror.org/05qbk4x57', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210165038']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yingying Chen', 'raw_affiliation_strings': ['School of Life Science and Technology, ShanghaiTech University, 100 Haike Road, Shanghai 201210, China', 'State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China'], 'affiliations': [{'raw_affiliation_string': 'School of Life Science and Technology, ShanghaiTech University, 100 Haike Road, Shanghai 201210, China', 'institution_ids': ['https://openalex.org/I30809798']}, {'raw_affiliation_string': 'State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China', 'institution_ids': ['https://openalex.org/I4210121447', 'https://openalex.org/I4210165038']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064706706', 'display_name': 'Guangdun Peng', 'orcid': 'https://orcid.org/0000-0002-8586-0637'}, 'institutions': [{'id': 'https://openalex.org/I4210121447', 'display_name': 'Center for Excellence in Molecular Cell Science', 'ror': 'https://ror.org/02rrdvm96', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210121447']}, {'id': 'https://openalex.org/I4210165038', 'display_name': 'University of Chinese Academy of Sciences', 'ror': 'https://ror.org/05qbk4x57', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210165038']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Guangdun Peng', 'raw_affiliation_strings': ['State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China', 'institution_ids': ['https://openalex.org/I4210121447', 'https://openalex.org/I4210165038']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049883489', 'display_name': 'Patrick Tam', 'orcid': 'https://orcid.org/0000-0001-6950-8388'}, 'institutions': [{'id': 'https://openalex.org/I146584863', 'display_name': "Children's Medical Research Institute", 'ror': 'https://ror.org/01bsaey45', 'country_code': 'AU', 'type': 'facility', 'lineage': ['https://openalex.org/I146584863']}, {'id': 'https://openalex.org/I129604602', 'display_name': 'University of Sydney', 'ror': 'https://ror.org/0384j8v12', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I129604602']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Patrick P.L. Tam', 'raw_affiliation_strings': ["Embryology Unit, Children's Medical Research Institute, Westmead, NSW 2145, Australia", 'School of Medical Sciences, Sydney Medical School, University of Sydney, Westmead, NSW 2145, Australia'], 'affiliations': [{'raw_affiliation_string': "Embryology Unit, Children's Medical Research Institute, Westmead, NSW 2145, Australia", 'institution_ids': ['https://openalex.org/I146584863']}, {'raw_affiliation_string': 'School of Medical Sciences, Sydney Medical School, University of Sydney, Westmead, NSW 2145, Australia', 'institution_ids': ['https://openalex.org/I129604602']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5019291511', 'display_name': 'Naihe Jing', 'orcid': 'https://orcid.org/0000-0003-1509-6378'}, 'institutions': [{'id': 'https://openalex.org/I30809798', 'display_name': 'ShanghaiTech University', 'ror': 'https://ror.org/030bhh786', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I30809798']}, {'id': 'https://openalex.org/I4210121447', 'display_name': 'Center for Excellence in Molecular Cell Science', 'ror': 'https://ror.org/02rrdvm96', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210121447']}, {'id': 'https://openalex.org/I4210165038', 'display_name': 'University of Chinese Academy of Sciences', 'ror': 'https://ror.org/05qbk4x57', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210165038']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Naihe Jing', 'raw_affiliation_strings': ['School of Life Science and Technology, ShanghaiTech University, 100 Haike Road, Shanghai 201210, China', 'State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China'], 'affiliations': [{'raw_affiliation_string': 'School of Life Science and Technology, ShanghaiTech University, 100 Haike Road, Shanghai 201210, China', 'institution_ids': ['https://openalex.org/I30809798']}, {'raw_affiliation_string': 'State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China', 'institution_ids': ['https://openalex.org/I4210121447', 'https://openalex.org/I4210165038']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 5, 'corresponding_author_ids': ['https://openalex.org/A5019291511'], 'corresponding_institution_ids': ['https://openalex.org/I30809798', 'https://openalex.org/I4210121447', 'https://openalex.org/I4210165038'], 'apc_list': {'value': 3500, 'currency': 'USD', 'value_usd': 3500, 'provenance': 'doaj'}, 'apc_paid': {'value': 3500, 'currency': 'USD', 'value_usd': 3500, 'provenance': 'doaj'}, 'fwci': 1.098, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 18, 'citation_normalized_percentile': {'value': 0.671968, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '11', 'issue': '1', 'first_page': '43', 'last_page': '57'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10505', 'display_name': 'Induction and Differentiation of Pluripotent Stem Cells', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10505', 'display_name': 'Induction and Differentiation of Pluripotent Stem Cells', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10268', 'display_name': 'Notch Signaling Pathway in Development and Disease', 'score': 0.9944, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10222', 'display_name': 'Regulation of Chromatin Structure and Function', 'score': 0.9902, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/epiblast', 'display_name': 'Epiblast', 'score': 0.9590048}, {'id': 'https://openalex.org/keywords/germ-layer', 'display_name': 'Germ layer', 'score': 0.8993555}, {'id': 'https://openalex.org/keywords/nodal-signaling', 'display_name': 'Nodal signaling', 'score': 0.68825424}, {'id': 'https://openalex.org/keywords/epigenetic-remodeling', 'display_name': 'Epigenetic Remodeling', 'score': 0.533996}, {'id': 'https://openalex.org/keywords/embryonic-stem-cells', 'display_name': 'Embryonic Stem Cells', 'score': 0.522836}, {'id': 'https://openalex.org/keywords/neuroectoderm', 'display_name': 'Neuroectoderm', 'score': 0.5223859}, {'id': 'https://openalex.org/keywords/embryonic-development', 'display_name': 'Embryonic Development', 'score': 0.515257}, {'id': 'https://openalex.org/keywords/epigenetics', 'display_name': 'Epigenetics', 'score': 0.50468}], 'concepts': [{'id': 'https://openalex.org/C75059768', 'wikidata': 'https://www.wikidata.org/wiki/Q519516', 'display_name': 'Epiblast', 'level': 5, 'score': 0.9590048}, {'id': 'https://openalex.org/C2779329299', 'wikidata': 'https://www.wikidata.org/wiki/Q272474', 'display_name': 'Ectoderm', 'level': 4, 'score': 0.900339}, {'id': 'https://openalex.org/C18155467', 'wikidata': 'https://www.wikidata.org/wiki/Q660498', 'display_name': 'Germ layer', 'level': 5, 'score': 0.8993555}, {'id': 'https://openalex.org/C83330619', 'wikidata': 'https://www.wikidata.org/wiki/Q21124872', 'display_name': 'NODAL', 'level': 2, 'score': 0.80058634}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7922268}, {'id': 'https://openalex.org/C205583638', 'wikidata': 'https://www.wikidata.org/wiki/Q7046607', 'display_name': 'Nodal signaling', 'level': 5, 'score': 0.68825424}, {'id': 'https://openalex.org/C129536746', 'wikidata': 'https://www.wikidata.org/wiki/Q1141026', 'display_name': 'Gastrulation', 'level': 4, 'score': 0.6692593}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6446169}, {'id': 'https://openalex.org/C135073763', 'wikidata': 'https://www.wikidata.org/wiki/Q1271432', 'display_name': 'Neuroectoderm', 'level': 5, 'score': 0.5223859}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.51650923}, {'id': 'https://openalex.org/C2780915607', 'wikidata': 'https://www.wikidata.org/wiki/Q323438', 'display_name': 'Mesoderm', 'level': 4, 'score': 0.4665757}, {'id': 'https://openalex.org/C145103041', 'wikidata': 'https://www.wikidata.org/wiki/Q1151519', 'display_name': 'Embryonic stem cell', 'level': 3, 'score': 0.41948238}, {'id': 'https://openalex.org/C148738053', 'wikidata': 'https://www.wikidata.org/wiki/Q210861', 'display_name': 'Cellular differentiation', 'level': 3, 'score': 0.41363052}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.31321624}, {'id': 'https://openalex.org/C107459253', 'wikidata': 'https://www.wikidata.org/wiki/Q674925', 'display_name': 'Induced pluripotent stem cell', 'level': 4, 'score': 0.2991724}, {'id': 'https://openalex.org/C196843134', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryo', 'level': 2, 'score': 0.26192784}, {'id': 'https://openalex.org/C87073359', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryogenesis', 'level': 3, 'score': 0.2591282}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004475', 'descriptor_name': 'Ectoderm', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D004475', 'descriptor_name': 'Ectoderm', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005855', 'descriptor_name': 'Germ Layers', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D005855', 'descriptor_name': 'Germ Layers', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D055457', 'descriptor_name': 'Nodal Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019070', 'descriptor_name': 'Cell Lineage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004475', 'descriptor_name': 'Ectoderm', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': False}, {'descriptor_ui': 'D004475', 'descriptor_name': 'Ectoderm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047108', 'descriptor_name': 'Embryonic Development', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D047108', 'descriptor_name': 'Embryonic Development', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044127', 'descriptor_name': 'Epigenesis, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005455', 'descriptor_name': 'Fluorescent Antibody Technique', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020869', 'descriptor_name': 'Gene Expression Profiling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005855', 'descriptor_name': 'Germ Layers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055457', 'descriptor_name': 'Nodal Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D060449', 'descriptor_name': 'Wnt Signaling Pathway', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.stemcr.2018.05.019', 'pdf_url': 'http://www.cell.com/article/S2213671118302376/pdf', 'source': {'id': 'https://openalex.org/S2764425922', 'display_name': 'Stem Cell Reports', 'issn_l': '2213-6711', 'issn': ['2213-6711'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/1e0ecb938c0c49e383516bae07d49f5a', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6067151', 'pdf_url': 'https://europepmc.org/articles/pmc6067151?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067151', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30008328', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.stemcr.2018.05.019', 'pdf_url': 'http://www.cell.com/article/S2213671118302376/pdf', 'source': {'id': 'https://openalex.org/S2764425922', 'display_name': 'Stem Cell Reports', 'issn_l': '2213-6711', 'issn': ['2213-6711'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '31661143042'}, {'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '31430058'}, {'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '31571513'}, {'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '91519314'}, {'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '31630043'}, {'funder': 'https://openalex.org/F4320321133', 'funder_display_name': 'Chinese Academy of Sciences', 'award_id': 'XDA16020404'}, {'funder': 'https://openalex.org/F4320321133', 'funder_display_name': 'Chinese Academy of Sciences', 'award_id': 'XDA16020501'}, {'funder': 'https://openalex.org/F4320321589', 'funder_display_name': 'Fondation pour la Recherche Médicale', 'award_id': 'FRM SPE20140129375'}, {'funder': 'https://openalex.org/F4320334704', 'funder_display_name': 'Australian Research Council', 'award_id': 'DP\xa0160100933'}, {'funder': 'https://openalex.org/F4320334705', 'funder_display_name': 'National Health and Medical Research Council', 'award_id': '1003100'}, {'funder': 'https://openalex.org/F4320334705', 'funder_display_name': 'National Health and Medical Research Council', 'award_id': '1110751'}, {'funder': 'https://openalex.org/F4320335777', 'funder_display_name': 'National Key Research and Development Program of China', 'award_id': '2015CB964500'}, {'funder': 'https://openalex.org/F4320335777', 'funder_display_name': 'National Key Research and Development Program of China', 'award_id': '2014CB964804'}, {'funder': 'https://openalex.org/F4320335777', 'funder_display_name': 'National Key Research and Development Program of China', 'award_id': '2017YFA0102700'}], 'datasets': [], 'versions': [], 'referenced_works_count': 47, 'referenced_works': ['https://openalex.org/W1541821200', 'https://openalex.org/W1828975488', 'https://openalex.org/W1973387539', 'https://openalex.org/W1988643971', 'https://openalex.org/W2005617468', 'https://openalex.org/W2010856041', 'https://openalex.org/W2022710905', 'https://openalex.org/W2026519680', 'https://openalex.org/W2041573813', 'https://openalex.org/W2044830131', 'https://openalex.org/W2045523681', 'https://openalex.org/W2045708662', 'https://openalex.org/W2045899482', 'https://openalex.org/W2048638417', 'https://openalex.org/W2054328435', 'https://openalex.org/W2057093077', 'https://openalex.org/W2057159461', 'https://openalex.org/W2064990000', 'https://openalex.org/W2069693786', 'https://openalex.org/W2076812266', 'https://openalex.org/W2090260381', 'https://openalex.org/W2092125592', 'https://openalex.org/W2097065948', 'https://openalex.org/W2105427659', 'https://openalex.org/W2109262751', 'https://openalex.org/W2116870178', 'https://openalex.org/W2140909735', 'https://openalex.org/W2141458291', 'https://openalex.org/W2142482111', 'https://openalex.org/W2147350988', 'https://openalex.org/W2147373137', 'https://openalex.org/W2158544588', 'https://openalex.org/W2158789637', 'https://openalex.org/W2159686118', 'https://openalex.org/W2160857717', 'https://openalex.org/W2162614738', 'https://openalex.org/W2166002240', 'https://openalex.org/W2166820820', 'https://openalex.org/W2168250872', 'https://openalex.org/W2170551349', 'https://openalex.org/W2170830174', 'https://openalex.org/W2171808845', 'https://openalex.org/W2172111284', 'https://openalex.org/W2178570213', 'https://openalex.org/W2217679076', 'https://openalex.org/W2306104084', 'https://openalex.org/W2531450431'], 'related_works': ['https://openalex.org/W4377088459', 'https://openalex.org/W2810466533', 'https://openalex.org/W2254714669', 'https://openalex.org/W2178570213', 'https://openalex.org/W2164563970', 'https://openalex.org/W2059792351', 'https://openalex.org/W2049784241', 'https://openalex.org/W2030075458', 'https://openalex.org/W2011458783', 'https://openalex.org/W1988253438'], 'abstract_inverted_index': {'The': [0, 45], 'molecular': [1, 143], 'mechanism': [2], 'underpinning': [3], 'the': [4, 7, 48, 54, 73, 92, 95, 103, 119, 125, 132, 142, 146], 'specification': [5, 117], 'of': [6, 47, 53, 57, 75, 118, 127, 145], 'ectoderm,': [8], 'a': [9, 20, 26], 'transient': [10], 'germ-layer': [11], 'tissue,': [12], 'during': [13], 'mouse': [14, 35, 63], 'gastrulation': [15], 'was': [16], 'examined': [17], 'here': [18], 'in': [19, 87, 98, 108, 111], 'stem': [21, 37, 134], 'cell-based': [22], 'model.': [23], 'We': [24], 'captured': [25], 'self-renewing': [27], 'cell': [28], 'population': [29], 'with': [30], 'enhanced': [31, 84, 123], 'ectoderm': [32, 76, 85, 97, 120], 'potency': [33], 'from': [34], 'epiblast': [36, 56], 'cells': [38, 135], '(EpiSCs)': [39], 'by': [40, 68, 124], 'suppressing': [41], 'Nodal': [42, 128], 'signaling': [43, 129], 'activity.': [44], 'transcriptome': [46], 'Nodal-inhibited': [49, 81], 'EpiSCs': [50, 82], 'resembles': [51], 'that': [52, 71, 116], 'anterior': [55], 'embryonic': [58], 'day': [59], '(E)7.0': [60], 'and': [61, 89, 94, 110, 131], 'E7.5': [62], 'embryo,': [64], 'which': [65], 'is': [66, 122], 'accompanied': [67], 'chromatin': [69], 'modifications': [70], 'reflect': [72], 'priming': [74], 'lineage-related': [77], 'genes': [78], 'for': [79, 105], 'expression.': [80], 'show': [83, 115], 'differentiation': [86, 107], 'vitro': [88, 109], 'contribute': [90], 'to': [91, 140], 'neuroectoderm': [93], 'surface': [96], 'postimplantation': [99], 'chimeras': [100], 'but': [101], 'lose': [102], 'propensity': [104], 'mesendoderm': [106], 'chimeras.': [112], 'Our': [113], 'findings': [114], 'progenitors': [121], 'repression': [126], 'activity,': [130], 'ectoderm-like': [133], 'provide': [136], 'an': [137], 'experimental': [138], 'model': [139], 'investigate': [141], 'characters': [144], 'epiblast-derived': [147], 'ectoderm.': [148]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2810466533', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 6}], 'updated_date': '2024-09-11T22:13:02.830724', 'created_date': '2018-07-10'}